JP2021113191A5 - - Google Patents

Info

Publication number

JP2021113191A5

JP2021113191A5 JP2021044152A JP2021044152A JP2021113191A5 JP 2021113191 A5 JP2021113191 A5 JP 2021113191A5 JP 2021044152 A JP2021044152 A JP 2021044152A JP 2021044152 A JP2021044152 A JP 2021044152A JP 2021113191 A5 JP2021113191 A5 JP 2021113191A5

Authority

JP

Japan

Prior art keywords

formula

compound

antibody

allylen

antigen

Prior art date

2021-03-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 150000001875 compounds Chemical class 0.000 claims 24
• 230000027455 binding Effects 0.000 claims 14
• 238000009739 binding Methods 0.000 claims 14
• 239000000427 antigen Substances 0.000 claims 11
• 102000036639 antigens Human genes 0.000 claims 11
• 108091007433 antigens Proteins 0.000 claims 11
• 239000012634 fragment Substances 0.000 claims 11
• 125000005647 linker group Chemical group 0.000 claims 9
• 125000005842 heteroatom Chemical group 0.000 claims 8
• 238000000034 method Methods 0.000 claims 8
• 125000000732 arylene group Chemical group 0.000 claims 5
• 125000005549 heteroarylene group Chemical group 0.000 claims 5
• 125000000539 amino acid group Chemical group 0.000 claims 4
• 239000011230 binding agent Substances 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• 230000021615 conjugation Effects 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
• 108060008539 Transglutaminase Proteins 0.000 claims 2
• 229940125644 antibody drug Drugs 0.000 claims 2
• 239000000611 antibody drug conjugate Substances 0.000 claims 2
• 229940049595 antibody-drug conjugate Drugs 0.000 claims 2
• 125000006850 spacer group Chemical group 0.000 claims 2
• 102000003601 transglutaminase Human genes 0.000 claims 2
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
• 150000001408 amides Chemical class 0.000 claims 1
• 239000003638 chemical reducing agent Substances 0.000 claims 1
• 235000018417 cysteine Nutrition 0.000 claims 1
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1