JP2021104048A5 - - Google Patents
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- Publication number
- JP2021104048A5 JP2021104048A5 JP2021063957A JP2021063957A JP2021104048A5 JP 2021104048 A5 JP2021104048 A5 JP 2021104048A5 JP 2021063957 A JP2021063957 A JP 2021063957A JP 2021063957 A JP2021063957 A JP 2021063957A JP 2021104048 A5 JP2021104048 A5 JP 2021104048A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- mil
- bone marrow
- mils
- expressing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013255 MILs Substances 0.000 claims 26
- 210000001185 bone marrow Anatomy 0.000 claims 25
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 21
- 229910052760 oxygen Inorganic materials 0.000 claims 21
- 239000001301 oxygen Substances 0.000 claims 21
- 210000004698 lymphocyte Anatomy 0.000 claims 18
- 206010021143 Hypoxia Diseases 0.000 claims 16
- 230000001146 hypoxic effect Effects 0.000 claims 16
- 210000004027 cell Anatomy 0.000 claims 9
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 6
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 208000034578 Multiple myelomas Diseases 0.000 claims 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 102000008070 Interferon-gamma Human genes 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 239000011324 bead Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229960003130 interferon gamma Drugs 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 1
- 230000008595 infiltration Effects 0.000 claims 1
- 238000001764 infiltration Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462045782P | 2014-09-04 | 2014-09-04 | |
| US62/045,782 | 2014-09-04 | ||
| US201562186040P | 2015-06-29 | 2015-06-29 | |
| US62/186,040 | 2015-06-29 | ||
| JP2017512293A JP6865160B2 (ja) | 2014-09-04 | 2015-09-04 | 正常酸素条件と交互になった低酸素条件における骨髄浸潤リンパ球の活性化 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512293A Division JP6865160B2 (ja) | 2014-09-04 | 2015-09-04 | 正常酸素条件と交互になった低酸素条件における骨髄浸潤リンパ球の活性化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021104048A JP2021104048A (ja) | 2021-07-26 |
| JP2021104048A5 true JP2021104048A5 (enExample) | 2021-11-18 |
| JP7197213B2 JP7197213B2 (ja) | 2022-12-27 |
Family
ID=55440392
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512293A Expired - Fee Related JP6865160B2 (ja) | 2014-09-04 | 2015-09-04 | 正常酸素条件と交互になった低酸素条件における骨髄浸潤リンパ球の活性化 |
| JP2021063957A Active JP7197213B2 (ja) | 2014-09-04 | 2021-04-05 | 正常酸素条件と交互になった低酸素条件における骨髄浸潤リンパ球の活性化 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512293A Expired - Fee Related JP6865160B2 (ja) | 2014-09-04 | 2015-09-04 | 正常酸素条件と交互になった低酸素条件における骨髄浸潤リンパ球の活性化 |
Country Status (13)
| Country | Link |
|---|---|
| US (7) | US9687510B2 (enExample) |
| EP (2) | EP3188740B1 (enExample) |
| JP (2) | JP6865160B2 (enExample) |
| KR (1) | KR20170067751A (enExample) |
| CN (1) | CN107109364A (enExample) |
| AU (2) | AU2015311761B2 (enExample) |
| CA (1) | CA2959994C (enExample) |
| DK (1) | DK3188740T3 (enExample) |
| ES (1) | ES2877108T3 (enExample) |
| IL (2) | IL250746B (enExample) |
| MX (1) | MX391017B (enExample) |
| PT (1) | PT3188740T (enExample) |
| WO (1) | WO2016037054A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015157636A1 (en) | 2014-04-10 | 2015-10-15 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy |
| WO2016037054A1 (en) | 2014-09-04 | 2016-03-10 | The Johns Hopkins University | Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions |
| JP2018520679A (ja) | 2015-06-29 | 2018-08-02 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 免疫チェックポイントキメラ抗原受容体療法 |
| WO2017008019A1 (en) * | 2015-07-08 | 2017-01-12 | The Johns Hopkins University | Marrow infiltrating lymphocytes (mils) as a source of t-cells for chimeric antigen receptor (car) therapy |
| HUE066460T2 (hu) | 2016-10-26 | 2024-08-28 | Iovance Biotherapeutics Inc | A kriokonzervált tumor infiltráló limfociták restimulációja |
| TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
| KR102618948B1 (ko) | 2016-11-17 | 2023-12-27 | 이오반스 바이오테라퓨틱스, 인크. | 잔유 종양 침윤 림프구 및 그의 제조 및 사용 방법 |
| AU2017382243A1 (en) * | 2016-12-22 | 2019-05-02 | Windmil Therapeutics, Inc. | Compositions and methods for modulating the immune system |
| CA3049165A1 (en) | 2017-01-06 | 2018-07-12 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof |
| US11254913B1 (en) | 2017-03-29 | 2022-02-22 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| JOP20190224A1 (ar) | 2017-03-29 | 2019-09-26 | Iovance Biotherapeutics Inc | عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي |
| EP3737743A1 (en) | 2018-01-08 | 2020-11-18 | Iovance Biotherapeutics, Inc. | Processes for generating til products enriched for tumor antigen-specific t-cells |
| JP2021516666A (ja) * | 2018-03-22 | 2021-07-08 | ウィンドミル セラピューティクス インコーポレイテッド | 前立腺がん特異的髄浸潤リンパ球およびその使用 |
| WO2019217753A1 (en) | 2018-05-10 | 2019-11-14 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| US12611427B2 (en) | 2018-11-05 | 2026-04-28 | Iovance Biotherapeutics, Inc. | Treatment of NSCLC patients refractory for anti-PD-1 antibody |
| US20210338730A1 (en) * | 2018-11-05 | 2021-11-04 | Windmil Therapeutics, Inc. | Marrow Infiltrating Lymphocytes With Increased Clonality and Uses Thereof |
| MY210603A (en) | 2018-11-05 | 2025-10-01 | Iovance Biotherapeutics Inc | Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy |
| MX2021006399A (es) * | 2018-11-30 | 2021-07-15 | Windmil Therapeutics Inc | Linfocitos infiltrantes de medula osea (mils) que expresan receptores de antigenos quimericos (car), metodo de fabricacion de los mismos y metodo de uso en terapia. |
| CN114072158A (zh) * | 2019-03-22 | 2022-02-18 | 温德弥尔治疗公司 | 肺癌特异性骨髓浸润淋巴细胞及其用途 |
| US20230100744A1 (en) * | 2020-02-28 | 2023-03-30 | Windmil Therapeutics, Inc. | Methods for enriching marrow infiltrating lymphocytes ("mils"), compositions containing enriched mils, and methods of using enriched mils |
| WO2022066872A1 (en) * | 2020-09-24 | 2022-03-31 | Windmil Therapeutics, Inc. | Marrow infiltrating lymphocytes (mils) expressing t cell receptors, methods of manufacturing same, and method of using in therapy |
| JP2023546359A (ja) | 2020-10-06 | 2023-11-02 | アイオバンス バイオセラピューティクス，インコーポレイテッド | 腫瘍浸潤リンパ球療法によるｎｓｃｌｃ患者の治療 |
| JP2024512029A (ja) | 2021-03-25 | 2024-03-18 | アイオバンス バイオセラピューティクス，インコーポレイテッド | Ｔ細胞共培養効力アッセイのための方法及び組成物、ならびに細胞療法製品との使用 |
| JP2025512401A (ja) | 2022-04-15 | 2025-04-17 | アイオバンス バイオセラピューティクス，インコーポレイテッド | 特定のサイトカインの組み合わせ及び／またはＡＫＴｉ処理を使用したＴＩＬ拡張プロセス |
| WO2025160242A1 (en) * | 2024-01-23 | 2025-07-31 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Method of generating tils from cerebro spinal fluid for leptomeningeal disease |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3243600A (en) | 1999-02-23 | 2000-09-14 | Kathleen S. Carswell | Improved method of culturing t cells |
| US6811788B2 (en) * | 2000-01-19 | 2004-11-02 | Baofa Yu | Combinations and methods for treating neoplasms |
| EP2111231A4 (en) * | 2007-02-13 | 2010-12-15 | Univ Northeastern | METHOD AND COMPOSITIONS FOR IMPROVING IMMUNE REACTIONS |
| WO2014085437A2 (en) * | 2012-11-27 | 2014-06-05 | The Johns Hopkins University | Use of post-transplant cyclophosphamide treated allogeneic marrow infiltrating lymphocytes to augment anti-tumor immunity |
| EP2364152A4 (en) * | 2008-11-03 | 2013-02-13 | Univ Johns Hopkins | METHOD FOR PRODUCING AND USING MARKINFILTRATING LYMPHOCYTES (MILS) |
| BR112014007947A2 (pt) * | 2011-10-03 | 2017-04-18 | Univ Los Andes | método para monitoramento, diagnóstico e/ou prognóstico de distúrbios relacionados à hipoxia usando nfat5 |
| EP2804625A4 (en) | 2012-01-17 | 2015-10-28 | Univ Northeastern | METHOD AND COMPOSITIONS FOR THE EXPANSION OF IMMUNOSUPPRESSIVE REGULATORY T CELLS IN VITRO AND USES THEREOF |
| JP2014090678A (ja) * | 2012-11-01 | 2014-05-19 | Ito En Ltd | 容器詰野菜汁及び／又は果汁含有飲料及びその製造方法、並びに容器詰野菜汁及び／又は果汁含有飲料の呈味劣化防止方法 |
| WO2016037054A1 (en) | 2014-09-04 | 2016-03-10 | The Johns Hopkins University | Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions |
| AU2017382243A1 (en) * | 2016-12-22 | 2019-05-02 | Windmil Therapeutics, Inc. | Compositions and methods for modulating the immune system |
| JP2021516666A (ja) * | 2018-03-22 | 2021-07-08 | ウィンドミル セラピューティクス インコーポレイテッド | 前立腺がん特異的髄浸潤リンパ球およびその使用 |
| MX2021006399A (es) * | 2018-11-30 | 2021-07-15 | Windmil Therapeutics Inc | Linfocitos infiltrantes de medula osea (mils) que expresan receptores de antigenos quimericos (car), metodo de fabricacion de los mismos y metodo de uso en terapia. |
-
2015
- 2015-09-04 WO PCT/US2015/048536 patent/WO2016037054A1/en not_active Ceased
- 2015-09-04 EP EP15838358.8A patent/EP3188740B1/en active Active
- 2015-09-04 KR KR1020177009084A patent/KR20170067751A/ko not_active Abandoned
- 2015-09-04 DK DK15838358.8T patent/DK3188740T3/da active
- 2015-09-04 JP JP2017512293A patent/JP6865160B2/ja not_active Expired - Fee Related
- 2015-09-04 US US15/112,353 patent/US9687510B2/en active Active
- 2015-09-04 PT PT158383588T patent/PT3188740T/pt unknown
- 2015-09-04 CN CN201580059448.3A patent/CN107109364A/zh active Pending
- 2015-09-04 CA CA2959994A patent/CA2959994C/en active Active
- 2015-09-04 ES ES15838358T patent/ES2877108T3/es active Active
- 2015-09-04 EP EP21167891.7A patent/EP3922254A1/en not_active Withdrawn
- 2015-09-04 MX MX2017002852A patent/MX391017B/es unknown
- 2015-09-04 AU AU2015311761A patent/AU2015311761B2/en not_active Ceased
-
2017
- 2017-02-23 IL IL250746A patent/IL250746B/en active IP Right Grant
- 2017-05-26 US US15/606,766 patent/US10406178B2/en active Active
- 2017-05-26 US US15/606,951 patent/US10172887B2/en active Active
-
2018
- 2018-12-03 US US16/207,864 patent/US11160830B2/en not_active Expired - Fee Related
-
2019
- 2019-07-30 US US16/526,656 patent/US11406666B2/en active Active
-
2020
- 2020-07-28 IL IL276347A patent/IL276347B/en unknown
-
2021
- 2021-02-02 AU AU2021200648A patent/AU2021200648A1/en not_active Abandoned
- 2021-04-05 JP JP2021063957A patent/JP7197213B2/ja active Active
- 2021-09-30 US US17/490,691 patent/US20220016172A1/en not_active Abandoned
-
2022
- 2022-07-14 US US17/864,546 patent/US20230000919A1/en active Pending
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