JP2021101720A5 - - Google Patents

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Publication number

JP2021101720A5

JP2021101720A5 JP2021053470A JP2021053470A JP2021101720A5 JP 2021101720 A5 JP2021101720 A5 JP 2021101720A5 JP 2021053470 A JP2021053470 A JP 2021053470A JP 2021053470 A JP2021053470 A JP 2021053470A JP 2021101720 A5 JP2021101720 A5 JP 2021101720A5

Authority

JP

Japan

Prior art keywords

seq

amino acid

acid sequence

antibody

sequence shown

Prior art date

2021-03-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 125000003275 alpha amino acid group Chemical group 0.000 claims description 151
• 239000000427 antigen Substances 0.000 claims description 61
• 102000036639 antigens Human genes 0.000 claims description 61
• 108091007433 antigens Proteins 0.000 claims description 61
• 239000012634 fragment Substances 0.000 claims description 61
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 26
• 108010074864 Factor XI Proteins 0.000 claims description 26
• 238000004519 manufacturing process Methods 0.000 claims description 21
• 210000004027 cell Anatomy 0.000 claims description 20
• 230000004913 activation Effects 0.000 claims description 12
• 102100030563 Coagulation factor XI Human genes 0.000 claims description 10
• 150000007523 nucleic acids Chemical class 0.000 claims description 10
• 102000039446 nucleic acids Human genes 0.000 claims description 10
• 108020004707 nucleic acids Proteins 0.000 claims description 10
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 7
• 102100022641 Coagulation factor IX Human genes 0.000 claims description 6
• 108010076282 Factor IX Proteins 0.000 claims description 6
• 108010080805 Factor XIa Proteins 0.000 claims description 6
• 229960004222 factor ix Drugs 0.000 claims description 6
• 230000001404 mediated effect Effects 0.000 claims description 6
• 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 4
• 210000004978 chinese hamster ovary cell Anatomy 0.000 claims description 4
• 239000003085 diluting agent Substances 0.000 claims description 4
• 201000010099 disease Diseases 0.000 claims description 4
• 208000035475 disorder Diseases 0.000 claims description 4
• 239000003937 drug carrier Substances 0.000 claims description 4
• 230000001605 fetal effect Effects 0.000 claims description 4
• 230000002538 fungal effect Effects 0.000 claims description 4
• 210000003734 kidney Anatomy 0.000 claims description 4
• 230000009424 thromboembolic effect Effects 0.000 claims description 4
• 238000000034 method Methods 0.000 claims description 3
• 238000012258 culturing Methods 0.000 claims description 2
• 230000004988 N-glycosylation Effects 0.000 claims 1
• 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 description 13
• 238000007792 addition Methods 0.000 description 11
• 238000012217 deletion Methods 0.000 description 11
• 230000037430 deletion Effects 0.000 description 11
• 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 2
• 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 2
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
• 239000003814 drug Substances 0.000 description 1
• 229910052739 hydrogen Inorganic materials 0.000 description 1
• 239000001257 hydrogen Substances 0.000 description 1
• 238000012986 modification Methods 0.000 description 1
• 230000004048 modification Effects 0.000 description 1