NI201800134A - Anticuerpos antifactor de la coagulación xi - Google Patents

Anticuerpos antifactor de la coagulación xi

Info

Publication number
NI201800134A
NI201800134A NI201800134A NI201800134A NI201800134A NI 201800134 A NI201800134 A NI 201800134A NI 201800134 A NI201800134 A NI 201800134A NI 201800134 A NI201800134 A NI 201800134A NI 201800134 A NI201800134 A NI 201800134A
Authority
NI
Nicaragua
Prior art keywords
antibodies
antifactor
coagulation
fxi
activation
Prior art date
Application number
NI201800134A
Other languages
English (en)
Inventor
Chen Zhu
P Ellsworth Kenneth
Milligan James
Oldham Elizabeth
Seiffert Dietmar
Ganti Vaishnavi
Tabrizifard Mohammad
Prinz Bianka
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of NI201800134A publication Critical patent/NI201800134A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)

Abstract

Se describen anticuerpos que se unen al dominio appla 3 del factor de la coagulación humano XI e inhiben la activación del FXI por el factor de la coagulación XIIa, así como la activación del FXI por el FXa.
NI201800134A 2016-06-14 2018-12-10 Anticuerpos antifactor de la coagulación xi NI201800134A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662349888P 2016-06-14 2016-06-14

Publications (1)

Publication Number Publication Date
NI201800134A true NI201800134A (es) 2019-03-05

Family

ID=59078269

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201800134A NI201800134A (es) 2016-06-14 2018-12-10 Anticuerpos antifactor de la coagulación xi

Country Status (28)

Country Link
US (6) US10676536B2 (es)
EP (1) EP3469002A1 (es)
JP (2) JP7022081B2 (es)
KR (2) KR102379580B1 (es)
CN (2) CN116425879A (es)
AR (1) AR108717A1 (es)
AU (3) AU2017286432B2 (es)
BR (1) BR112018075858A2 (es)
CA (2) CA3025869A1 (es)
CL (1) CL2018003565A1 (es)
CO (1) CO2018013434A2 (es)
CR (1) CR20180583A (es)
DO (1) DOP2018000284A (es)
EA (1) EA201892716A1 (es)
EC (1) ECSP18091593A (es)
GE (1) GEP20227382B (es)
IL (1) IL263272A (es)
JO (1) JOP20180121A1 (es)
MA (1) MA45234A (es)
MX (1) MX2018015757A (es)
MY (1) MY201852A (es)
NI (1) NI201800134A (es)
PE (1) PE20190416A1 (es)
PH (1) PH12018502586A1 (es)
SG (2) SG10202103120UA (es)
TN (1) TN2018000417A1 (es)
TW (2) TWI752964B (es)
WO (1) WO2017218371A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20200312A1 (ar) 2015-06-26 2017-06-16 Novartis Ag الأجسام المضادة للعامل xi وطرق الاستخدام
TW201802121A (zh) 2016-05-25 2018-01-16 諾華公司 抗因子XI/XIa抗體之逆轉結合劑及其用途
SG10202103120UA (en) * 2016-06-14 2021-05-28 Merck Sharp & Dohme Anti-coagulation factor xi antibodies
US11168147B2 (en) 2016-12-23 2021-11-09 Novartis Ag Factor XI antibodies and methods of use
CN110423278B (zh) * 2019-08-08 2020-07-17 上海博槿生物科技有限公司 一种抗凝血因子XI活化形式因子XIa的抗体及其制备方法和应用
JP2023532251A (ja) * 2020-07-02 2023-07-27 北京拓界生物医薬科技有限公司 抗ＦＸＩ／ＦＸＩａ抗体、その抗原結合断片と医薬用途
WO2022002233A1 (zh) * 2020-07-03 2022-01-06 苏州康宁杰瑞生物科技有限公司 凝血因子xi(fxi)结合蛋白
EP4291579A1 (en) * 2021-02-09 2023-12-20 Arxx Therapeutics AS Anti-s100a4 humanized antibodies, uses and methods
CN116199782A (zh) * 2021-11-30 2023-06-02 苏州康宁杰瑞生物科技有限公司 预防和/或治疗血栓栓塞性疾病的方法

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JP2021101720A (ja) 2021-07-15
TWI752964B (zh) 2022-01-21
KR102218714B1 (ko) 2021-02-24
US20200317811A1 (en) 2020-10-08
JOP20180121A1 (ar) 2018-12-12
ECSP18091593A (es) 2019-01-31
US10676536B2 (en) 2020-06-09
US20230287141A1 (en) 2023-09-14
JP7277500B2 (ja) 2023-05-19
AU2020210233B2 (en) 2024-03-07
US11485794B2 (en) 2022-11-01
AU2024201084A1 (en) 2024-03-14
WO2017218371A1 (en) 2017-12-21
IL263272A (en) 2018-12-31
DOP2018000284A (es) 2019-01-31
US11512142B2 (en) 2022-11-29
CN109476758B (zh) 2023-05-23
MA45234A (fr) 2019-04-17
TN2018000417A1 (en) 2020-06-15
AR108717A1 (es) 2018-09-19
CN116425879A (zh) 2023-07-14
PE20190416A1 (es) 2019-03-19
GEP20227382B (en) 2022-05-25
AU2020210233A1 (en) 2020-08-20
TW201802120A (zh) 2018-01-16
US20200308302A1 (en) 2020-10-01
CR20180583A (es) 2019-07-02
MX2018015757A (es) 2019-05-30
SG11201810763TA (en) 2018-12-28
PH12018502586A1 (en) 2019-10-07
CA3025869A1 (en) 2017-12-21
TWI802193B (zh) 2023-05-11
US11479615B2 (en) 2022-10-25
KR20190018504A (ko) 2019-02-22
US20200255542A1 (en) 2020-08-13
US20200270364A1 (en) 2020-08-27
CA3172367A1 (en) 2017-12-21
US11661460B2 (en) 2023-05-30
AU2017286432A1 (en) 2018-12-06
AU2017286432B2 (en) 2020-09-24
KR102379580B1 (ko) 2022-03-29
CO2018013434A2 (es) 2018-12-28
MY201852A (en) 2024-03-20
US20170355780A1 (en) 2017-12-14
EP3469002A1 (en) 2019-04-17
TW202214702A (zh) 2022-04-16
CN109476758A (zh) 2019-03-15
SG10202103120UA (en) 2021-05-28
JP2019521978A (ja) 2019-08-08
EA201892716A1 (ru) 2019-05-31
KR20210021124A (ko) 2021-02-24
JP7022081B2 (ja) 2022-02-17
BR112018075858A2 (pt) 2019-04-02
CL2018003565A1 (es) 2019-03-22

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