CR20180583A - Anticuerpos antifactor de la coagulación xi - Google Patents
Anticuerpos antifactor de la coagulación xiInfo
- Publication number
- CR20180583A CR20180583A CR20180583A CR20180583A CR20180583A CR 20180583 A CR20180583 A CR 20180583A CR 20180583 A CR20180583 A CR 20180583A CR 20180583 A CR20180583 A CR 20180583A CR 20180583 A CR20180583 A CR 20180583A
- Authority
- CR
- Costa Rica
- Prior art keywords
- antibodies
- antifactor
- coagulation
- fxi
- coagulation factor
- Prior art date
Links
- 230000015271 coagulation Effects 0.000 title 1
- 238000005345 coagulation Methods 0.000 title 1
- 101710161089 Coagulation factor XI Proteins 0.000 abstract 2
- 102100030563 Coagulation factor XI Human genes 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 2
- 108010071241 Factor XIIa Proteins 0.000 abstract 1
- 101001062768 Homo sapiens Coagulation factor XI Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Se describen anticuerpos que se unen al dominio apple 3 del factor de la coagulación humano XI e inhiben la activación del FXI por el factor de la coagulación XIIa, así como la activación del FXI por el FXa.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662349888P | 2016-06-14 | 2016-06-14 | |
PCT/US2017/036940 WO2017218371A1 (en) | 2016-06-14 | 2017-06-12 | Anti-coagulation factor xi antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20180583A true CR20180583A (es) | 2019-07-02 |
Family
ID=59078269
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20180583A CR20180583A (es) | 2016-06-14 | 2017-06-12 | Anticuerpos antifactor de la coagulación xi |
Country Status (27)
Country | Link |
---|---|
US (6) | US10676536B2 (es) |
EP (1) | EP3469002A1 (es) |
JP (2) | JP7022081B2 (es) |
KR (2) | KR102379580B1 (es) |
CN (2) | CN116425879A (es) |
AR (1) | AR108717A1 (es) |
AU (3) | AU2017286432B2 (es) |
BR (1) | BR112018075858A2 (es) |
CA (2) | CA3025869A1 (es) |
CL (1) | CL2018003565A1 (es) |
CO (1) | CO2018013434A2 (es) |
CR (1) | CR20180583A (es) |
DO (1) | DOP2018000284A (es) |
EA (1) | EA201892716A1 (es) |
EC (1) | ECSP18091593A (es) |
GE (1) | GEP20227382B (es) |
IL (1) | IL263272A (es) |
JO (1) | JOP20180121A1 (es) |
MA (1) | MA45234A (es) |
MX (1) | MX2018015757A (es) |
NI (1) | NI201800134A (es) |
PE (1) | PE20190416A1 (es) |
PH (1) | PH12018502586A1 (es) |
SG (2) | SG11201810763TA (es) |
TN (1) | TN2018000417A1 (es) |
TW (2) | TWI802193B (es) |
WO (1) | WO2017218371A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JOP20200312A1 (ar) | 2015-06-26 | 2017-06-16 | Novartis Ag | الأجسام المضادة للعامل xi وطرق الاستخدام |
TW201802121A (zh) | 2016-05-25 | 2018-01-16 | 諾華公司 | 抗因子XI/XIa抗體之逆轉結合劑及其用途 |
WO2017218371A1 (en) * | 2016-06-14 | 2017-12-21 | Merck Sharp & Dohme Corp. | Anti-coagulation factor xi antibodies |
WO2018116255A1 (en) | 2016-12-23 | 2018-06-28 | Novartis Ag | Factor xi antibodies and methods of use |
CN110423278B (zh) * | 2019-08-08 | 2020-07-17 | 上海博槿生物科技有限公司 | 一种抗凝血因子XI活化形式因子XIa的抗体及其制备方法和应用 |
US20230220111A1 (en) * | 2020-07-02 | 2023-07-13 | Beijing Tuo Jie Biopharmaceutical Co. Ltd. | Anti-fxi/fxia antibody, antigen-binding fragment thereof, and pharmaceutical use thereof |
AU2021302199A1 (en) * | 2020-07-03 | 2023-02-23 | Suzhou Alphamab Co., Ltd. | Coagulation factor XI (FXI) binding protein |
JP2024509701A (ja) * | 2021-02-09 | 2024-03-05 | アークス セラピューティクス エーエス | 抗s100a4ヒト化抗体、使用及び方法 |
WO2023098637A1 (zh) * | 2021-11-30 | 2023-06-08 | 苏州康宁杰瑞生物科技有限公司 | 预防和/或治疗血栓栓塞性疾病的方法 |
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2017
- 2017-06-12 WO PCT/US2017/036940 patent/WO2017218371A1/en unknown
- 2017-06-12 JP JP2018565042A patent/JP7022081B2/ja active Active
- 2017-06-12 TW TW110149482A patent/TWI802193B/zh active
- 2017-06-12 EA EA201892716A patent/EA201892716A1/ru unknown
- 2017-06-12 PE PE2018003203A patent/PE20190416A1/es unknown
- 2017-06-12 US US15/619,620 patent/US10676536B2/en active Active
- 2017-06-12 EP EP17731444.0A patent/EP3469002A1/en active Pending
- 2017-06-12 MX MX2018015757A patent/MX2018015757A/es unknown
- 2017-06-12 KR KR1020217004608A patent/KR102379580B1/ko active IP Right Grant
- 2017-06-12 CR CR20180583A patent/CR20180583A/es unknown
- 2017-06-12 GE GEAP201714983A patent/GEP20227382B/en unknown
- 2017-06-12 CN CN202310501882.9A patent/CN116425879A/zh active Pending
- 2017-06-12 AU AU2017286432A patent/AU2017286432B2/en active Active
- 2017-06-12 AR ARP170101603A patent/AR108717A1/es unknown
- 2017-06-12 TN TNP/2018/000417A patent/TN2018000417A1/en unknown
- 2017-06-12 BR BR112018075858-2A patent/BR112018075858A2/pt unknown
- 2017-06-12 TW TW106119391A patent/TWI752964B/zh active
- 2017-06-12 CA CA3025869A patent/CA3025869A1/en active Pending
- 2017-06-12 KR KR1020197001266A patent/KR102218714B1/ko active IP Right Grant
- 2017-06-12 MA MA045234A patent/MA45234A/fr unknown
- 2017-06-12 SG SG11201810763TA patent/SG11201810763TA/en unknown
- 2017-06-12 CN CN201780037421.3A patent/CN109476758B/zh active Active
- 2017-06-12 SG SG10202103120UA patent/SG10202103120UA/en unknown
- 2017-06-12 CA CA3172367A patent/CA3172367A1/en active Pending
- 2017-06-16 JO JOP/2018/0121A patent/JOP20180121A1/ar unknown
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2018
- 2018-11-25 IL IL263272A patent/IL263272A/en unknown
- 2018-12-06 PH PH12018502586A patent/PH12018502586A1/en unknown
- 2018-12-10 NI NI201800134A patent/NI201800134A/es unknown
- 2018-12-11 CL CL2018003565A patent/CL2018003565A1/es unknown
- 2018-12-11 EC ECSENADI201891593A patent/ECSP18091593A/es unknown
- 2018-12-12 CO CONC2018/0013434A patent/CO2018013434A2/es unknown
- 2018-12-13 DO DO2018000284A patent/DOP2018000284A/es unknown
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2020
- 2020-05-01 US US16/864,570 patent/US11512142B2/en active Active
- 2020-05-01 US US16/864,577 patent/US11485794B2/en active Active
- 2020-05-01 US US16/864,583 patent/US11479615B2/en active Active
- 2020-05-01 US US16/864,559 patent/US11661460B2/en active Active
- 2020-07-30 AU AU2020210233A patent/AU2020210233B2/en active Active
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2021
- 2021-03-26 JP JP2021053470A patent/JP7277500B2/ja active Active
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2023
- 2023-04-18 US US18/302,033 patent/US20230287141A1/en active Pending
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2024
- 2024-02-20 AU AU2024201084A patent/AU2024201084A1/en active Pending
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