|
US4711955A
(en)
|
1981-04-17 |
1987-12-08 |
Yale University |
Modified nucleotides and methods of preparing and using same
|
|
CA1223831A
(en)
|
1982-06-23 |
1987-07-07 |
Dean Engelhardt |
Modified nucleotides, methods of preparing and utilizing and compositions containing the same
|
|
DE3538677A1
(de)
|
1985-10-31 |
1987-05-07 |
Schloemann Siemag Ag |
Wendehaspel
|
|
JP2823959B2
(ja)
|
1991-10-24 |
1998-11-11 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
改良された取り込みおよびその他の性質を持つ誘導化オリゴヌクレオチド
|
|
US5792608A
(en)
|
1991-12-12 |
1998-08-11 |
Gilead Sciences, Inc. |
Nuclease stable and binding competent oligomers and methods for their use
|
|
NL9201440A
(nl)
|
1992-08-11 |
1994-03-01 |
Univ Leiden |
Triantennaire clusterglycosiden, hun bereiding en toepassing.
|
|
JP2002502222A
(ja)
*
|
1992-11-06 |
2002-01-22 |
ノバーティス アクチエンゲゼルシャフト |
Ｂ型肝炎表面抗原に対して活性なヒトモノクローナル抗体の生産
|
|
US20040157780A1
(en)
|
1993-11-29 |
2004-08-12 |
Epimmune Inc. |
CTL inducing peptides from c-erb2 (HER-2/neu)
|
|
WO1995027072A1
(en)
|
1994-04-05 |
1995-10-12 |
Pharmagenics, Inc. |
Determination and identification of active compounds in a compound library
|
|
US5525711A
(en)
|
1994-05-18 |
1996-06-11 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Pteridine nucleotide analogs as fluorescent DNA probes
|
|
JP3756313B2
(ja)
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
|
EP2341058A3
(en)
|
1997-09-12 |
2011-11-23 |
Exiqon A/S |
Oligonucleotide Analogues
|
|
NZ513402A
(en)
|
1999-02-12 |
2003-06-30 |
Sankyo Co |
Novel nucleosides and oligonucleotide analogues
|
|
PT1178999E
(pt)
|
1999-05-04 |
2007-06-26 |
Santaris Pharma As |
Análogos de l-ribo-lna
|
|
US6617442B1
(en)
|
1999-09-30 |
2003-09-09 |
Isis Pharmaceuticals, Inc. |
Human Rnase H1 and oligonucleotide compositions thereof
|
|
WO2003022987A2
(en)
|
2001-07-26 |
2003-03-20 |
Eos Biotechnology, Inc. |
Methods of diagnosis of hepatitis c infection, compositions and methods of screening for modulators of hepatitis c infection
|
|
JP2006507841A
(ja)
*
|
2002-11-14 |
2006-03-09 |
ダーマコン， インコーポレイテッド |
機能的ｓｉＲＮＡおよび超機能的ｓｉＲＮＡ
|
|
DK2284269T3
(en)
|
2002-11-18 |
2017-10-23 |
Roche Innovation Ct Copenhagen As |
Antisense design
|
|
US20060257851A1
(en)
|
2002-11-26 |
2006-11-16 |
Itzhak Bentwich |
Bioinformatically detectable group of novel viral regulatory genes and uses thereof
|
|
JP4980716B2
(ja)
|
2003-06-12 |
2012-07-18 |
アルナイラム ファーマシューティカルズ， インコーポレイテッド |
遺伝子サイレンシングに有用な保存されたｈｂｖ及びｈｃｖ配列
|
|
US7374927B2
(en)
|
2004-05-03 |
2008-05-20 |
Affymetrix, Inc. |
Methods of analysis of degraded nucleic acid samples
|
|
EP1752536A4
(en)
|
2004-05-11 |
2008-04-16 |
Alphagen Co Ltd |
POLYNUCLEOTIDE CAUSING RNA INTERFERENCE AND METHOD OF REGULATING GENE EXPRESSION WITH THE USE OF THE SAME
|
|
US20080125583A1
(en)
|
2005-02-11 |
2008-05-29 |
International Business Machines Corporation |
Ribonucleic acid interference molecules
|
|
WO2007031091A2
(en)
|
2005-09-15 |
2007-03-22 |
Santaris Pharma A/S |
Rna antagonist compounds for the modulation of p21 ras expression
|
|
JP5342881B2
(ja)
|
2006-01-27 |
2013-11-13 |
アイシス ファーマシューティカルズ， インコーポレーテッド |
６−修飾された二環式核酸類似体
|
|
WO2007106407A2
(en)
|
2006-03-10 |
2007-09-20 |
Wyeth |
Microarray for monitoring gene expression in multiple strains of streptococcus pneumoniae
|
|
CN103554205A
(zh)
|
2006-05-05 |
2014-02-05 |
Isis制药公司 |
调节gccr的表达的化合物和方法
|
|
AU2007249349B2
(en)
|
2006-05-11 |
2012-03-08 |
Isis Pharmaceuticals, Inc. |
5'-Modified bicyclic nucleic acid analogs
|
|
US7666854B2
(en)
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
|
KR20090071603A
(ko)
|
2006-09-19 |
2009-07-01 |
노파르티스 아게 |
Ｒａｆ 억제제에 대한 표적 조절, 효능, 진단 및/또는 예후의 바이오마커
|
|
DK2410054T4
(da)
|
2006-10-18 |
2020-02-10 |
Ionis Pharmaceuticals Inc |
Antisenseforbindelser
|
|
DK2149605T3
(da)
|
2007-03-22 |
2013-09-30 |
Santaris Pharma As |
Korte RNA antagonist forbindelser til modulering af det ønskede mRNA
|
|
US8278425B2
(en)
|
2007-05-30 |
2012-10-02 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
|
EP2173760B2
(en)
|
2007-06-08 |
2015-11-04 |
Isis Pharmaceuticals, Inc. |
Carbocyclic bicyclic nucleic acid analogs
|
|
CN101796062B
(zh)
|
2007-07-05 |
2014-07-30 |
Isis制药公司 |
6-双取代双环核酸类似物
|
|
CA2701895A1
(en)
|
2007-10-04 |
2009-04-09 |
Santaris Pharma A/S |
Short rna antagonist compounds for the modulation of hif1alpha
|
|
WO2009067647A1
(en)
|
2007-11-21 |
2009-05-28 |
Isis Pharmaceuticals, Inc. |
Carbocyclic alpha-l-bicyclic nucleic acid analogs
|
|
JP5611834B2
(ja)
|
2007-12-27 |
2014-10-22 |
アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ |
抗Ｔ．ｃｒｕｚｉ抗体及び使用方法
|
|
WO2009090182A1
(en)
|
2008-01-14 |
2009-07-23 |
Santaris Pharma A/S |
C4'-substituted - dna nucleotide gapmer oligonucleotides
|
|
EP2285819B1
(en)
|
2008-04-04 |
2013-10-16 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising neutrally linked terminal bicyclic nucleosides
|
|
EP2310021A4
(en)
|
2008-07-10 |
2012-06-27 |
Merck Sharp & Dohme |
METHODS OF USING COMPOSITIONS COMPRISING MIR-192 AND / OR MIR-215 FOR THE TREATMENT OF CANCER
|
|
DK2356129T3
(da)
|
2008-09-24 |
2013-05-13 |
Isis Pharmaceuticals Inc |
Substituerede alpha-L-bicykliske nukleosider
|
|
EP2177615A1
(en)
|
2008-10-10 |
2010-04-21 |
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. |
Method for a genome wide identification of expression regulatory sequences and use of genes and molecules derived thereof for the diagnosis and therapy of metabolic and/or tumorous diseases
|
|
AU2009336191B2
(en)
|
2008-12-18 |
2017-08-24 |
Dicerna Pharmaceuticals, Inc. |
Extended dicer substrate agents and methods for the specific inhibition of gene expression
|
|
WO2010093788A2
(en)
|
2009-02-11 |
2010-08-19 |
Dicerna Pharmaceuticals, Inc. |
Multiplex dicer substrate rna interference molecules having joining sequences
|
|
EP2462153B1
(en)
|
2009-08-06 |
2015-07-29 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
|
JP2013126374A
(ja)
|
2010-03-04 |
2013-06-27 |
Kyushu Univ |
イソフラボン類の作用に関連する遺伝子
|
|
US8846637B2
(en)
|
2010-06-08 |
2014-09-30 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-amino and 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
CA2807307C
(en)
|
2010-08-17 |
2021-02-09 |
Merck Sharp & Dohme Corp. |
Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina)
|
|
DK3124610T3
(da)
|
2010-10-28 |
2019-06-11 |
Benitec Biopharma Ltd |
Hbv-behandling
|
|
US10017764B2
(en)
|
2011-02-08 |
2018-07-10 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
|
SG10201604074TA
(en)
|
2011-04-21 |
2016-07-28 |
Isis Pharmaceuticals Inc |
Modulation of hepatitis b virus (hbv) expression
|
|
MX342731B
(es)
|
2011-06-30 |
2016-10-11 |
Arrowhead Res Corp |
Composiciones y metodos para inhibir la expresion genica del virus de hepatitis b.
|
|
EP2742136B1
(en)
|
2011-08-11 |
2017-09-27 |
Ionis Pharmaceuticals, Inc. |
Gapped oligomeric compounds comprising 5'-modified deoxyribonucleosides in the gap and uses thereof
|
|
EP3640332A1
(en)
|
2011-08-29 |
2020-04-22 |
Ionis Pharmaceuticals, Inc. |
Oligomer-conjugate complexes and their use
|
|
AU2012304358B2
(en)
|
2011-09-07 |
2017-07-20 |
Marina Biotech Inc. |
Synthesis and uses of nucleic acid compounds with conformationally restricted monomers
|
|
WO2013113326A1
(en)
|
2012-01-31 |
2013-08-08 |
Curevac Gmbh |
Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen
|
|
EP2850092B1
(en)
|
2012-04-09 |
2017-03-01 |
Ionis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
|
RU2014145017A
(ru)
*
|
2012-04-10 |
2016-05-27 |
Виб Взв |
Новые маркеры для детекции нестабильности микросателлитов при злокачественной опухоли и определении синтетической летальности с ингибированием пути эксцизионной репарации оснований днк
|
|
WO2013159109A1
(en)
|
2012-04-20 |
2013-10-24 |
Isis Pharmaceuticals, Inc. |
Modulation of hepatitis b virus (hbv) expression
|
|
WO2013166264A2
(en)
|
2012-05-02 |
2013-11-07 |
University Of Georgia Research Foundation, Inc. |
Methods for altering virus replication
|
|
KR20220139425A
(ko)
|
2012-07-13 |
2022-10-14 |
웨이브 라이프 사이언시스 리미티드 |
키랄 제어
|
|
US20150232837A1
(en)
|
2012-08-31 |
2015-08-20 |
Aptamir Therapeutics, Inc. |
Mirna modulators of chronic visceral inflammation
|
|
JP2016503300A
(ja)
|
2012-11-15 |
2016-02-04 |
ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブＲｏｃｈｅ Ｉｎｎｏｖａｔｉｏｎ Ｃｅｎｔｅｒ Ｃｏｐｅｎｈａｇｅｎ Ａ／Ｓ |
抗ＡｐｏＢアンチセンス複合体化合物
|
|
CN104955952A
(zh)
*
|
2013-01-30 |
2015-09-30 |
弗·哈夫曼-拉罗切有限公司 |
Lna寡核苷酸碳水化合物缀合物
|
|
EP2992009B1
(en)
|
2013-05-01 |
2020-06-24 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating apolipoprotein (a) expression
|
|
WO2014204723A1
(en)
*
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Oncogenic models based on delivery and use of the crispr-cas systems, vectors and compositions
|
|
DK3013959T3
(da)
|
2013-06-27 |
2020-02-17 |
Roche Innovation Ct Copenhagen As |
Antisense-oligomerer og konjugater målrettet pcsk9
|
|
JP2016533752A
(ja)
|
2013-08-28 |
2016-11-04 |
カリス ライフ サイエンシズ スウィッツァーランド ホー |
オリゴヌクレオチドプローブおよびその使用
|
|
EP2845607A1
(en)
*
|
2013-09-09 |
2015-03-11 |
University of Vienna |
Antisense oligonucleotides with improved pharmacokinetic properties
|
|
JP2017505623A
(ja)
|
2014-01-30 |
2017-02-23 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
生物切断性コンジュゲートを有するポリオリゴマー化合物
|
|
SG11201605970QA
(en)
|
2014-01-30 |
2016-08-30 |
Hoffmann La Roche |
Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection
|
|
CA2948080A1
(en)
|
2014-05-13 |
2015-11-19 |
F. Hoffmann-La Roche Ag |
Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection
|
|
GB201408623D0
(en)
*
|
2014-05-15 |
2014-07-02 |
Santaris Pharma As |
Oligomers and oligomer conjugates
|
|
FR3026868B1
(fr)
|
2014-10-02 |
2019-08-16 |
Dav |
Dispositif et procede de commande pour vehicule automobile
|
|
KR20170068469A
(ko)
|
2014-10-10 |
2017-06-19 |
에프. 호프만-라 로슈 아게 |
ＧａｌＮＡｃ 포스포라미다이트, 그의 핵산 컨쥬게이트 및 그의 용도
|
|
US9637485B2
(en)
|
2014-11-03 |
2017-05-02 |
Hoffmann-La Roche Inc. |
6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection
|
|
JP2017536366A
(ja)
|
2014-11-19 |
2017-12-07 |
ロシュ イノベーション センター コペンハーゲン エーエス |
Ｌｎａキラルホスホロチオエート
|
|
CA2968541A1
(en)
*
|
2014-11-21 |
2016-05-26 |
Caris Science, Inc. |
Oligonucleotide probes and uses thereof
|
|
JP6689279B2
(ja)
|
2014-12-16 |
2020-05-20 |
ロシュ イノベーション センター コペンハーゲン エーエス |
キラル毒性のスクリーニング方法
|
|
WO2016107832A1
(en)
|
2014-12-30 |
2016-07-07 |
F. Hoffmann-La Roche Ag |
Novel tetrahydropyridopyrimidines and tetrahydropyridopyridines for the treatment and prophylaxis of hepatitis b virus infection
|
|
WO2016127002A1
(en)
*
|
2015-02-04 |
2016-08-11 |
Bristol-Myers Squibb Company |
Lna oligonucleotides with alternating flanks
|
|
EP3256471B1
(en)
|
2015-02-11 |
2018-12-12 |
F. Hoffmann-La Roche AG |
Novel 2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection
|
|
EP3292120B1
(en)
|
2015-05-04 |
2019-06-19 |
H. Hoffnabb-La Roche Ag |
Tetrahydropyridopyrimidines and tetrahydropyridopyridines as inhibitors of hbsag (hbv surface antigen) and hbv dna production for the treatment of hepatitis b virus infections
|
|
AU2016296592B2
(en)
|
2015-07-17 |
2021-08-19 |
Arcturus Therapeutics, Inc. |
Compositions and agents against Hepatitis B virus and uses thereof
|
|
KR20180038465A
(ko)
|
2015-08-07 |
2018-04-16 |
애로우헤드 파마슈티컬스 인코포레이티드 |
Ｂ형 간염 바이러스 감염에 대한 ｒｎａｉ 치료법
|
|
WO2017066712A2
(en)
|
2015-10-16 |
2017-04-20 |
The Children's Medical Center Corporation |
Modulators of telomere disease
|
|
WO2017066796A2
(en)
*
|
2015-10-16 |
2017-04-20 |
The Children's Medical Center Corporation |
Modulators of telomere disease
|
|
AU2017235278C1
(en)
*
|
2016-03-14 |
2022-03-10 |
F. Hoffmann-La Roche Ag |
Oligonucleotides for reduction of PD-L1 expression
|
|
WO2017178656A1
(en)
|
2016-04-14 |
2017-10-19 |
Roche Innovation Center Copenhagen A/S |
TRITYL-MONO-GalNAc COMPOUNDS AND THEIR USE
|
|
MA45496A
(fr)
*
|
2016-06-17 |
2019-04-24 |
Hoffmann La Roche |
Molécules d'acide nucléique pour la réduction de l'arnm de padd5 ou pad7 pour le traitement d'une infection par l'hépatite b
|
|
WO2018059718A1
(en)
|
2016-09-30 |
2018-04-05 |
Rijk Zwaan Zaadteelt En Zaadhandel B.V. |
Peronospora resistance in spinacia oleracea
|
|
US10953034B2
(en)
|
2017-10-16 |
2021-03-23 |
Hoffmann-La Roche Inc. |
Nucleic acid molecule for reduction of PAPD5 and PAPD7 mRNA for treating hepatitis B infection
|
|
CL2020001638A1
(es)
|
2017-10-16 |
2020-10-16 |
Hoffmann La Roche |
Molécula de ácidos nucleicos para la reducción del arnm de papd5 y papd7 en el tratamiento de la infección de la hepatitis b. (divisional solicitud 202000945)
|
|
KR20200113206A
(ko)
*
|
2018-01-29 |
2020-10-06 |
에프. 호프만-라 로슈 아게 |
GalNAc 올리고뉴클레오티드 접합체의 제조 방법
|
|
CL2019000945A1
(es)
|
2019-04-09 |
2019-07-12 |
Energy Harvest As |
Dispositivo de válvula rotatoria y sus métodos.
|
