JP2021063053A - 環境汚染物質によるダメージ抑制剤、化粧料及び飲食品 - Google Patents
環境汚染物質によるダメージ抑制剤、化粧料及び飲食品 Download PDFInfo
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- 150000008163 sugars Chemical class 0.000 description 1
- XTQHKBHJIVJGKJ-UHFFFAOYSA-N sulfur monoxide Chemical class S=O XTQHKBHJIVJGKJ-UHFFFAOYSA-N 0.000 description 1
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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Abstract
Description
〔2〕環境汚染物質によるタンパク質カルボニル化を抑制する用途及び/又は環境汚染物質による炎症関連遺伝子の発現上昇を抑制する用途に用いられる、請求項1に記載の環境汚染物質によるダメージ抑制剤。
〔3〕スターフルーツ(Averrhoa carambola L.)の果実からの抽出物を配合したことを特徴とする、環境汚染物質によるダメージ抑制用化粧料。
〔4〕スターフルーツ(Averrhoa carambola L.)の果実からの抽出物を配合したことを特徴とする、環境汚染物質によるダメージ抑制用飲食品。
本実施形態の環境汚染物質によるダメージ抑制剤は、スターフルーツの果実からの抽出物を有効成分とするものである。また、本実施形態の化粧料及び飲食品は、環境汚染物質によるダメージ抑制用途に用いられるものであって、スターフルーツの果実からの抽出物が配合されるものである。
以上のようにして得られるスターフルーツの果実からの抽出物(以下、単に「スターフルーツ果実抽出物」ということがある。)は、環境汚染物質によるダメージ抑制作用において優れた作用を有しているため、環境汚染物質によるダメージ抑制剤の有効成分として用いることができる。本実施形態に係る、環境汚染物質によるダメージ抑制剤は、医薬品、医薬部外品、化粧品等の幅広い用途に使用することができる。なお、本実施形態に係る、環境汚染物質によるダメージ抑制剤を、それぞれ単に「ダメージ抑制剤」と記載することがある。作用及び用途についても同様である。
ただし、本実施形態のダメージ抑制剤は、これらの用途以外にも、環境汚染物質によるダメージを抑制することに意義のあるすべての用途に用いることができる。
スターフルーツ果実抽出物は、ダメージ抑制作用において優れた作用を有しているため、化粧料に配合するのに好適である。この場合、スターフルーツ果実抽出物をそのまま配合してもよいし、スターフルーツ果実抽出物から製剤化したダメージ抑制剤を配合してもよい。
スターフルーツ果実抽出物は、ダメージ抑制作用において優れた作用を有しているため、飲食品に配合するのに好適である。この場合、スターフルーツ果実抽出物をそのまま配合してもよいし、スターフルーツ果実抽出物から製剤化したダメージ抑制剤を配合してもよい。スターフルーツ果実抽出物又は上記ダメージ抑制剤を配合することにより、ダメージ抑制用途に好適な飲食品とすることができる。
スターフルーツ(学名:Averrhoa carambola L.)の果実の粗粉砕物100gを抽出溶媒1500mlに投入し、45〜55℃で4時間、穏やかに攪拌しながら抽出を行った。その後ろ過し、ろ液を60℃で減圧下にて濃縮し、さらに減圧乾燥機で乾燥してスターフルーツの果実抽出物を得た。抽出物の収率は表1のとおりであった。
スターフルーツ果実抽出物(試料1)について、以下のようにして、環境汚染物質による角層タンパク質カルボニル化抑制作用を試験した。
式中の各項はそれぞれ以下を表す。
A:排気ガス処理・被験試料処理のカルボニル化レベル
B:排気ガス処理・被験試料無処理(コントロール)のカルボニル化レベル
C:排気ガス無処理・被験試料無処理(ブランク)のカルボニル化レベル
結果を表2に示す。
スターフルーツ果実抽出物(試料1)について、以下のようにして、環境汚染物質によるIL−1αの発現上昇抑制作用を試験した。
式中の各項はそれぞれ以下を表す。
A:トンネル粉塵無添加・被験試料無添加での補正値
B:トンネル粉塵添加・被験試料無添加での補正値
C:トンネル粉塵添加・被験試料添加での補正値
結果を表3に示す。
スターフルーツ果実抽出物(試料1)について、以下のようにして、環境汚染物質によるCOX−2の発現上昇抑制作用を試験した。
式中の各項はそれぞれ以下を表す。
A:トンネル粉塵無添加・被験試料無添加での補正値
B:トンネル粉塵添加・被験試料無添加での補正値
C:トンネル粉塵添加・被験試料添加での補正値
結果を表4に示す。
スターフルーツ果実抽出物(試料1)について、以下のようにして、環境汚染物質によるMMP−9の発現上昇抑制作用を試験した。
式中の各項はそれぞれ以下を表す。
A:トンネル粉塵無添加・被験試料無添加での補正値
B:トンネル粉塵添加・被験試料無添加での補正値
C:トンネル粉塵添加・被験試料添加での補正値
結果を表5に示す。
下記組成に従い、乳液を常法により製造した。
スターフルーツ果実抽出物 0.01g
ホホバオイル 4.00g
1,3−ブチレングリコール 3.00g
アルブチン 3.00g
ポリオキシエチレンセチルエーテル(20E.O.) 2.50g
オリーブオイル 2.00g
スクワラン 2.00g
セタノール 2.00g
モノステアリン酸グリセリル 2.00g
オレイン酸ポリオキシエチレンソルビタン(20E.O.) 2.00g
パラオキシ安息香酸メチル 0.15g
グリチルレチン酸ステアリル 0.10g
黄杞エキス 0.10g
グリチルリチン酸ジカリウム 0.10g
イチョウ葉エキス 0.10g
コンキオリン 0.10g
オウバクエキス 0.10g
カミツレエキス 0.10g
香料 0.05g
精製水 残部(全量を100gとする)
下記組成のクリームを常法により製造した。
スターフルーツ果実抽出物 0.05g
クジンエキス 0.1g
オウゴンエキス 0.1g
流動パラフィン 5.0g
サラシミツロウ 4.0g
スクワラン 10.0g
セタノール 3.0g
ラノリン 2.0g
ステアリン酸 1.0g
オレイン酸ポリオキシエチレンソルビタン(20E.O.) 1.5g
モノステアリン酸グリセリル 3.0g
油溶性甘草エキス 0.1g
1,3−ブチレングリコール 6.0g
パラオキシ安息香酸メチル 1.5g
香料 0.1g
精製水 残部(全量を100gとする)
下記組成の美容液を常法により製造した。
スターフルーツ果実抽出物 0.01g
カミツレエキス 0.1g
ニンジンエキス 0.1g
キサンタンガム 0.3g
ヒドロキシエチルセルロース 0.1g
カルボキシビニルポリマー 0.1g
1,3−ブチレングリコール 4.0g
グリチルリチン酸ジカリウム 0.1g
グリセリン 2.0g
水酸化カリウム 0.25g
香料 0.01g
防腐剤(パラオキシ安息香酸メチル) 0.15g
エタノール 2.0g
精製水 残部(全量を100gとする)
下記組成のヘアートニックを常法により製造した。
スターフルーツ果実抽出物 0.5g
塩酸ピリドキシン 0.1g
レゾルシン 0.01g
D−パントテニルアルコール 0.1g
グリチルリチン酸ジカリウム 0.1g
L−メントール 0.05g
1,3−ブチレングリコール 4.0g
ニンジンエキス 0.2g
エタノール 25.0g
香料 適量
精製水 残部(全量を100gとする)
常法により、以下の組成を有する錠剤を製造した。
スターフルーツ果実抽出物 5.0mg
ドロマイト(カルシウム20%、マグネシウム10%含有) 83.4mg
カゼインホスホペプチド 16.7mg
ビタミンC 33.4mg
マルチトール 136.8mg
コラーゲン 12.7mg
ショ糖脂肪酸エステル 12.0mg
常法により、以下の組成を有する経口液状製剤を製造した。
<1アンプル(1本100mL)中の組成>
スターフルーツ果実抽出物 0.3質量%
ソルビット 12.0質量%
安息香酸ナトリウム 0.1質量%
香料 1.0質量%
硫酸カルシウム 0.5質量%
精製水 残部(100質量%)
Claims (4)
- スターフルーツ(Averrhoa carambola L.)の果実からの抽出物を有効成分とすることを特徴とする、環境汚染物質によるダメージ抑制剤。
- 環境汚染物質によるタンパク質カルボニル化を抑制する用途及び/又は環境汚染物質による炎症関連遺伝子の発現上昇を抑制する用途に用いられる、請求項1に記載の環境汚染物質によるダメージ抑制剤。
- スターフルーツ(Averrhoa carambola L.)の果実からの抽出物を配合したことを特徴とする、環境汚染物質によるダメージ抑制用化粧料。
- スターフルーツ(Averrhoa carambola L.)の果実からの抽出物を配合したことを特徴とする、環境汚染物質によるダメージ抑制用飲食品。
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