JP2020536543A5 - - Google Patents
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- JP2020536543A5 JP2020536543A5 JP2020519704A JP2020519704A JP2020536543A5 JP 2020536543 A5 JP2020536543 A5 JP 2020536543A5 JP 2020519704 A JP2020519704 A JP 2020519704A JP 2020519704 A JP2020519704 A JP 2020519704A JP 2020536543 A5 JP2020536543 A5 JP 2020536543A5
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- 108091008324 binding proteins Proteins 0.000 claims description 25
- 210000004027 cell Anatomy 0.000 claims description 12
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 129
- 229920001184 polypeptide Polymers 0.000 claims 48
- 102000004196 processed proteins & peptides Human genes 0.000 claims 48
- 108090000765 processed proteins & peptides Proteins 0.000 claims 48
- 238000006467 substitution reaction Methods 0.000 claims 32
- 102000014914 Carrier Proteins Human genes 0.000 claims 23
- 239000000427 antigen Substances 0.000 claims 22
- 102000036639 antigens Human genes 0.000 claims 22
- 108091007433 antigens Proteins 0.000 claims 22
- 102000040430 polynucleotide Human genes 0.000 claims 17
- 108091033319 polynucleotide Proteins 0.000 claims 17
- 239000002157 polynucleotide Substances 0.000 claims 17
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 14
- 150000001413 amino acids Chemical class 0.000 claims 11
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 7
- 102000052645 human CD38 Human genes 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 108060003951 Immunoglobulin Proteins 0.000 claims 4
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 4
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 4
- 102000018358 immunoglobulin Human genes 0.000 claims 4
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 3
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 3
- 102000018697 Membrane Proteins Human genes 0.000 claims 3
- 108010052285 Membrane Proteins Proteins 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 108010032595 Antibody Binding Sites Proteins 0.000 claims 2
- 241000282693 Cercopithecidae Species 0.000 claims 2
- 101100166600 Homo sapiens CD28 gene Proteins 0.000 claims 2
- 101100438926 Macaca fascicularis CD38 gene Proteins 0.000 claims 2
- 102000001708 Protein Isoforms Human genes 0.000 claims 2
- 108010029485 Protein Isoforms Proteins 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000003950 B-cell lymphoma Diseases 0.000 claims 1
- 241000282465 Canis Species 0.000 claims 1
- 102000009109 Fc receptors Human genes 0.000 claims 1
- 108010087819 Fc receptors Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 208000025113 myeloid leukemia Diseases 0.000 claims 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 11
- 108090000695 Cytokines Proteins 0.000 description 4
- 102000004127 Cytokines Human genes 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 230000003442 weekly effect Effects 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 102100036301 C-C chemokine receptor type 7 Human genes 0.000 description 2
- 101000716065 Homo sapiens C-C chemokine receptor type 7 Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 102000023732 binding proteins Human genes 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
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- 239000000463 material Substances 0.000 description 2
- 238000010172 mouse model Methods 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 108091008048 CMVpp65 Proteins 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 108090000978 Interleukin-4 Proteins 0.000 description 1
- GAOZTHIDHYLHMS-UHFFFAOYSA-N Monensin A Natural products O1C(CC)(C2C(CC(O2)C2C(CC(C)C(O)(CO)O2)C)C)CCC1C(O1)(C)CCC21CC(O)C(C)C(C(C)C(OC)C(C)C(O)=O)O2 GAOZTHIDHYLHMS-UHFFFAOYSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000005917 in vivo anti-tumor Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 210000003289 regulatory T cell Anatomy 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022031377A JP7387780B2 (ja) | 2017-10-10 | 2022-03-02 | 抗ｃｄ３８抗体および使用方法 |
| JP2023193393A JP7733711B2 (ja) | 2017-10-10 | 2023-11-14 | 抗ｃｄ３８抗体および使用方法 |
| JP2025136683A JP2025175288A (ja) | 2017-10-10 | 2025-08-20 | 抗ｃｄ３８抗体および使用方法 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762570655P | 2017-10-10 | 2017-10-10 | |
| US62/570,655 | 2017-10-10 | ||
| US201762570660P | 2017-10-11 | 2017-10-11 | |
| US62/570,660 | 2017-10-11 | ||
| US201862676221P | 2018-05-24 | 2018-05-24 | |
| US62/676,221 | 2018-05-24 | ||
| EP18187186 | 2018-08-03 | ||
| EP18187186.4 | 2018-08-03 | ||
| PCT/US2018/055084 WO2019074973A2 (en) | 2017-10-10 | 2018-10-09 | ANTI-CD38 ANTIBODIES AND METHODS OF USE |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022031377A Division JP7387780B2 (ja) | 2017-10-10 | 2022-03-02 | 抗ｃｄ３８抗体および使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020536543A JP2020536543A (ja) | 2020-12-17 |
| JP2020536543A5 true JP2020536543A5 (https=) | 2021-10-07 |
| JP7036909B2 JP7036909B2 (ja) | 2022-03-15 |
Family
ID=63963620
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020519704A Active JP7036909B2 (ja) | 2017-10-10 | 2018-10-09 | 抗ｃｄ３８抗体および使用方法 |
| JP2022031377A Active JP7387780B2 (ja) | 2017-10-10 | 2022-03-02 | 抗ｃｄ３８抗体および使用方法 |
| JP2023193393A Active JP7733711B2 (ja) | 2017-10-10 | 2023-11-14 | 抗ｃｄ３８抗体および使用方法 |
| JP2025136683A Pending JP2025175288A (ja) | 2017-10-10 | 2025-08-20 | 抗ｃｄ３８抗体および使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022031377A Active JP7387780B2 (ja) | 2017-10-10 | 2022-03-02 | 抗ｃｄ３８抗体および使用方法 |
| JP2023193393A Active JP7733711B2 (ja) | 2017-10-10 | 2023-11-14 | 抗ｃｄ３８抗体および使用方法 |
| JP2025136683A Pending JP2025175288A (ja) | 2017-10-10 | 2025-08-20 | 抗ｃｄ３８抗体および使用方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US11186649B2 (https=) |
| EP (2) | EP4249068A3 (https=) |
| JP (4) | JP7036909B2 (https=) |
| KR (1) | KR20200061402A (https=) |
| CN (4) | CN117964758A (https=) |
| AR (1) | AR116718A1 (https=) |
| AU (1) | AU2018348093A1 (https=) |
| BR (1) | BR112020007002A2 (https=) |
| CA (1) | CA3078800A1 (https=) |
| ES (1) | ES2986579T3 (https=) |
| IL (1) | IL273871A (https=) |
| MA (1) | MA50359A (https=) |
| MX (1) | MX2020004129A (https=) |
| MY (1) | MY199781A (https=) |
| PH (1) | PH12020550408A1 (https=) |
| PY (1) | PY1888702A (https=) |
| SG (1) | SG11202003212PA (https=) |
| TW (4) | TW202342544A (https=) |
| UY (1) | UY37928A (https=) |
| WO (1) | WO2019074973A2 (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1914242A1 (en) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
| TWI588156B (zh) * | 2011-03-28 | 2017-06-21 | 賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| CA2898100C (en) | 2013-01-14 | 2023-10-10 | Xencor, Inc. | Novel heterodimeric proteins |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| BR112017011166A2 (pt) | 2014-11-26 | 2018-02-27 | Xencor, Inc. | anticorpos heterodiméricos que se ligam a cd3 e cd38 |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| CN110894240B (zh) | 2014-11-26 | 2022-04-15 | 森科股份有限公司 | 结合cd3和肿瘤抗原的异二聚体抗体 |
| CR20170383A (es) * | 2015-01-23 | 2017-11-22 | Sanofi Sa | Anticuerpos anti-cd3, anticuerpos anti-cd-123 y anticuerpos biespecíficos que se unen específicamente a cd3 y/o cd123 |
| HRP20211528T1 (hr) | 2015-10-25 | 2021-12-24 | Sanofi | Trispecifični i/ili trovalentni vezujući proteini za prevenciju ili liječenje hiv infekcije |
| IL262241B2 (en) | 2016-04-13 | 2024-05-01 | Sanofi Sa | Trispecific and/or trivalent binding proteins with a crossover dual variable domain arm and a traditional antibody fab arm, pharmaceutical composition comprising said binding proteins and their uses in preventing and/or treating cancer or inflammatory diseases |
| HRP20231188T1 (hr) | 2016-04-13 | 2024-02-02 | Sanofi | Trispecifični i/ili trovalentni vezujući proteini |
| WO2018005706A1 (en) | 2016-06-28 | 2018-01-04 | Xencor, Inc. | Heterodimeric antibodies that bind somatostatin receptor 2 |
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| JP2021502100A (ja) | 2017-11-08 | 2021-01-28 | ゼンコア インコーポレイテッド | 新規抗ｐｄ−１配列を用いた二重特異性および単一特異性抗体 |
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| JP7332627B2 (ja) | 2018-04-25 | 2023-08-23 | プロメテウス バイオサイエンシーズ，インク． | 最適化された抗ｔｌ１ａ抗体 |
| CA3115679A1 (en) * | 2018-10-09 | 2020-04-16 | Sanofi | Trispecific anti-cd38, anti-cd28, and anti-cd3 binding proteins and methods of use for treating viral infection |
| JP7776987B2 (ja) | 2019-04-05 | 2025-11-27 | テネオバイオ， インコーポレイテッド | Ｐｓｍａに結合する重鎖抗体 |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| PH12021500041A1 (en) * | 2019-04-09 | 2022-06-06 | Sanofi Sa | Trispecific binding proteins, methods, and uses thereof |
| WO2021003074A1 (en) | 2019-07-03 | 2021-01-07 | Crystal Bioscience Inc. | Anti-cd38 antibody and methods of use thereof |
| AU2020337999A1 (en) * | 2019-08-30 | 2022-03-24 | Dragonfly Therapeutics, Inc. | Pharmaceutical formulations and dosage regimens for multi-specific binding proteins that bind HER2, NKG2D, and CD16 for cancer treatment |
| KR20220103721A (ko) | 2019-10-24 | 2022-07-22 | 프로메테우스 바이오사이언시즈, 인크. | Tnf 유사 리간드 1a(tl1a)에 대한 인간화 항체 및 그의 용도 |
| US20210123926A1 (en) | 2019-10-25 | 2021-04-29 | Sanofi | Methods for analyzing chain mispairing in multispecific binding proteins |
| CN112876563B (zh) * | 2019-11-29 | 2022-08-16 | 康诺亚生物医药科技（成都）有限公司 | 药物组合物及其制备方法和应用 |
| AU2021263448B2 (en) * | 2020-04-29 | 2026-02-05 | Teneobio, Inc. | Multispecific heavy chain antibodies with modified heavy chain constant regions |
| TWI838621B (zh) * | 2020-04-29 | 2024-04-11 | 美商泰尼歐萬公司 | 具有經修飾重鏈恆定區之多特異性重鏈抗體 |
| WO2021231976A1 (en) | 2020-05-14 | 2021-11-18 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3 |
| CA3192204A1 (en) | 2020-08-19 | 2022-02-24 | Xencor, Inc. | Anti-cd28 and/or anti-b7h3 compositions |
| US11905332B2 (en) | 2020-09-18 | 2024-02-20 | Regeneron Pharmaceuticals, Inc. | Antigen-binding molecules that bind CD38 and/or CD28, and uses thereof |
| AU2022227686A1 (en) | 2021-02-25 | 2023-07-27 | Lyell Immunopharma, Inc. | Ror1 targeting chimeric antigen receptor |
| JP2024511319A (ja) | 2021-03-09 | 2024-03-13 | ゼンコア インコーポレイテッド | Ｃｄ３及びｃｌｄｎ６に結合するヘテロ二量体抗体 |
| JP2024509274A (ja) | 2021-03-10 | 2024-02-29 | ゼンコア インコーポレイテッド | Ｃｄ３及びｇｐｃ３に結合するヘテロ二量体抗体 |
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| US20250277051A1 (en) * | 2021-08-02 | 2025-09-04 | Hangzhou Unogen Biotech, Ltd | Anti-cd38 antibodies, anti-cd3 antibodies, and bispecific antibodies, and uses thereof |
| JP2024531364A (ja) * | 2021-08-20 | 2024-08-29 | ノバルティス アーゲー | キメラ抗原受容体発現細胞を作製する方法 |
| CN119110809A (zh) | 2022-02-23 | 2024-12-10 | Xencor股份有限公司 | 抗CD28 x抗PSMA抗体 |
| IL317083A (en) | 2022-06-17 | 2025-01-01 | Apogee Biologics Inc | Antibodies that bind interleukin 13 and methods of use |
| WO2023246911A1 (zh) * | 2022-06-24 | 2023-12-28 | 北京可瑞生物科技有限公司 | 基于t细胞受体的双特异性多肽分子及其用途 |
| EP4688860A2 (en) * | 2023-03-28 | 2026-02-11 | Nkarta, Inc. | Antibodies and chimeric antigen receptors specific for cd38 |
| WO2025027003A1 (en) | 2023-07-31 | 2025-02-06 | Sanofi | Methods and uses for anti-cd38 t cell engagers in treatment of peripheral t-cell lymphomas |
| WO2025209593A1 (zh) * | 2024-04-06 | 2025-10-09 | 华深智药生物科技(苏州)有限公司 | 一种多特异性抗体t细胞衔接器 |
| TW202602945A (zh) * | 2024-04-06 | 2026-01-16 | 大陸商華深智藥生物科技（蘇州）有限公司 | 抗ｇｕｃｙ２ｃ抗體及其多特異性抗體的用途 |
| WO2026019667A1 (en) * | 2024-07-17 | 2026-01-22 | Jn Biosciences Llc | Trispecific antibodies for activation of immune cells |
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| BR112017004270B1 (pt) | 2014-09-04 | 2023-03-07 | Stemcell Technologies Inc | Método de ativação de células t ou células nk |
| CN107207594B (zh) * | 2014-12-23 | 2019-05-07 | 百时美施贵宝公司 | 针对tigit的抗体 |
| CR20170383A (es) | 2015-01-23 | 2017-11-22 | Sanofi Sa | Anticuerpos anti-cd3, anticuerpos anti-cd-123 y anticuerpos biespecíficos que se unen específicamente a cd3 y/o cd123 |
| WO2016196740A1 (en) | 2015-06-02 | 2016-12-08 | The Rockefeller University | Tri-specific antibodies for hiv therapy |
| HRP20211528T1 (hr) | 2015-10-25 | 2021-12-24 | Sanofi | Trispecifični i/ili trovalentni vezujući proteini za prevenciju ili liječenje hiv infekcije |
| CN105837688B (zh) | 2015-11-20 | 2019-02-26 | 北京大学深圳研究生院 | 单域抗体及其编码基因，免疫毒素及其编码基因、制备方法、表达载体、应用，及宿主细胞 |
| IL262241B2 (en) | 2016-04-13 | 2024-05-01 | Sanofi Sa | Trispecific and/or trivalent binding proteins with a crossover dual variable domain arm and a traditional antibody fab arm, pharmaceutical composition comprising said binding proteins and their uses in preventing and/or treating cancer or inflammatory diseases |
| EP3575319A4 (en) | 2016-12-30 | 2021-03-10 | Shanghai Sinobio Biotech Co., Ltd. | BIFUNCTIONAL MOLECULE AND USE OF IT |
| WO2018151841A1 (en) | 2017-02-17 | 2018-08-23 | Sanofi | Multispecific binding molecules having specificity to dystroglycan and laminin-2 |
| CA3078800A1 (en) | 2017-10-10 | 2019-04-18 | Sanofi | Anti-cd38 antibodies and methods of use |
| CA3115679A1 (en) | 2018-10-09 | 2020-04-16 | Sanofi | Trispecific anti-cd38, anti-cd28, and anti-cd3 binding proteins and methods of use for treating viral infection |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
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