JP2020533976A5 - - Google Patents
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- JP2020533976A5 JP2020533976A5 JP2020512854A JP2020512854A JP2020533976A5 JP 2020533976 A5 JP2020533976 A5 JP 2020533976A5 JP 2020512854 A JP2020512854 A JP 2020512854A JP 2020512854 A JP2020512854 A JP 2020512854A JP 2020533976 A5 JP2020533976 A5 JP 2020533976A5
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- JP
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- Prior art keywords
- gla
- protein
- component
- domain
- vesicles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 23
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 6
- 229940096437 Protein S Drugs 0.000 claims 4
- 108010066124 Protein S Proteins 0.000 claims 4
- 102000029301 Protein S Human genes 0.000 claims 4
- -1 CD41a Proteins 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 102100025390 Integrin beta-2 Human genes 0.000 claims 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 2
- 230000003197 catalytic effect Effects 0.000 claims 2
- 210000001808 exosome Anatomy 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- UHBYWPGGCSDKFX-VKHMYHEASA-N gamma-carboxy-L-glutamic acid Chemical compound OC(=O)[C@@H](N)CC(C(O)=O)C(O)=O UHBYWPGGCSDKFX-VKHMYHEASA-N 0.000 claims 2
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 1
- 102100022749 Aminopeptidase N Human genes 0.000 claims 1
- 101100009548 Arabidopsis thaliana DHFS gene Proteins 0.000 claims 1
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 1
- 102000049320 CD36 Human genes 0.000 claims 1
- 108010045374 CD36 Antigens Proteins 0.000 claims 1
- 108010029697 CD40 Ligand Proteins 0.000 claims 1
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 102100032937 CD40 ligand Human genes 0.000 claims 1
- 102100032912 CD44 antigen Human genes 0.000 claims 1
- 102100025222 CD63 antigen Human genes 0.000 claims 1
- 102100027221 CD81 antigen Human genes 0.000 claims 1
- 102100027217 CD82 antigen Human genes 0.000 claims 1
- 102100037904 CD9 antigen Human genes 0.000 claims 1
- 101100289995 Caenorhabditis elegans mac-1 gene Proteins 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 102000006395 Globulins Human genes 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 1
- 102100031487 Growth arrest-specific protein 6 Human genes 0.000 claims 1
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims 1
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 1
- 101000934368 Homo sapiens CD63 antigen Proteins 0.000 claims 1
- 101000914479 Homo sapiens CD81 antigen Proteins 0.000 claims 1
- 101000914469 Homo sapiens CD82 antigen Proteins 0.000 claims 1
- 101000738354 Homo sapiens CD9 antigen Proteins 0.000 claims 1
- 101000923005 Homo sapiens Growth arrest-specific protein 6 Proteins 0.000 claims 1
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 claims 1
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims 1
- 101000980823 Homo sapiens Leukocyte surface antigen CD53 Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims 1
- 102100032818 Integrin alpha-4 Human genes 0.000 claims 1
- 108010041012 Integrin alpha4 Proteins 0.000 claims 1
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims 1
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims 1
- 101150117895 LAMP2 gene Proteins 0.000 claims 1
- 101150048357 Lamp1 gene Proteins 0.000 claims 1
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 claims 1
- 102100024221 Leukocyte surface antigen CD53 Human genes 0.000 claims 1
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims 1
- 102000004067 Osteocalcin Human genes 0.000 claims 1
- 108090000573 Osteocalcin Proteins 0.000 claims 1
- 102100037765 Periostin Human genes 0.000 claims 1
- 101710199268 Periostin Proteins 0.000 claims 1
- 101800004937 Protein C Proteins 0.000 claims 1
- 102000017975 Protein C Human genes 0.000 claims 1
- 108010010469 Qa-SNARE Proteins Proteins 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 101100216053 Saccharomycopsis fibuligera GLA1 gene Proteins 0.000 claims 1
- 101800001700 Saposin-D Proteins 0.000 claims 1
- 102000047466 Syntaxin-3 Human genes 0.000 claims 1
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims 1
- 108700031126 Tetraspanins Proteins 0.000 claims 1
- 102000043977 Tetraspanins Human genes 0.000 claims 1
- 108090000190 Thrombin Proteins 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000000804 electron spin resonance spectroscopy Methods 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 claims 1
- 102000034287 fluorescent proteins Human genes 0.000 claims 1
- 108091006047 fluorescent proteins Proteins 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 102000043253 matrix Gla protein Human genes 0.000 claims 1
- 108010057546 matrix Gla protein Proteins 0.000 claims 1
- 108010025221 plasma protein Z Proteins 0.000 claims 1
- 229960000856 protein c Drugs 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 229960004072 thrombin Drugs 0.000 claims 1
- 108091005703 transmembrane proteins Proteins 0.000 claims 1
- 102000035160 transmembrane proteins Human genes 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024041903A JP2024073589A (ja) | 2017-09-05 | 2024-03-18 | エキソソームを標的化する方法 |
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762554530P | 2017-09-05 | 2017-09-05 | |
| US201762554533P | 2017-09-05 | 2017-09-05 | |
| US62/554,533 | 2017-09-05 | ||
| US62/554,530 | 2017-09-05 | ||
| US201762569403P | 2017-10-06 | 2017-10-06 | |
| US201762569411P | 2017-10-06 | 2017-10-06 | |
| US62/569,411 | 2017-10-06 | ||
| US62/569,403 | 2017-10-06 | ||
| US201762584565P | 2017-11-10 | 2017-11-10 | |
| US62/584,565 | 2017-11-10 | ||
| US201762593014P | 2017-11-30 | 2017-11-30 | |
| US62/593,014 | 2017-11-30 | ||
| PCT/US2018/049619 WO2019050998A1 (en) | 2017-09-05 | 2018-09-05 | METHOD FOR TARGETING EXOSOMES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024041903A Division JP2024073589A (ja) | 2017-09-05 | 2024-03-18 | エキソソームを標的化する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020533976A JP2020533976A (ja) | 2020-11-26 |
| JP2020533976A5 true JP2020533976A5 (https=) | 2021-10-14 |
Family
ID=63714024
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020512854A Pending JP2020533976A (ja) | 2017-09-05 | 2018-09-05 | エキソソームを標的化する方法 |
| JP2020534821A Pending JP2020533404A (ja) | 2017-09-05 | 2018-09-05 | 細胞内送達法 |
| JP2020534820A Active JP7365704B2 (ja) | 2017-09-05 | 2018-09-05 | 幹細胞へのペイロードの送達 |
| JP2024041903A Pending JP2024073589A (ja) | 2017-09-05 | 2024-03-18 | エキソソームを標的化する方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020534821A Pending JP2020533404A (ja) | 2017-09-05 | 2018-09-05 | 細胞内送達法 |
| JP2020534820A Active JP7365704B2 (ja) | 2017-09-05 | 2018-09-05 | 幹細胞へのペイロードの送達 |
| JP2024041903A Pending JP2024073589A (ja) | 2017-09-05 | 2024-03-18 | エキソソームを標的化する方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20200407421A1 (https=) |
| EP (3) | EP3679127A1 (https=) |
| JP (4) | JP2020533976A (https=) |
| KR (2) | KR20200050961A (https=) |
| CN (2) | CN111065733A (https=) |
| AU (2) | AU2018330427A1 (https=) |
| BR (2) | BR112020003945A2 (https=) |
| CA (2) | CA3074291A1 (https=) |
| IL (2) | IL272908A (https=) |
| MX (2) | MX2020002250A (https=) |
| PE (2) | PE20201462A1 (https=) |
| SG (2) | SG11202001535RA (https=) |
| WO (3) | WO2019050998A1 (https=) |
| ZA (2) | ZA202000650B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3524617T (pt) | 2013-03-15 | 2023-07-12 | Gladiator Biosciences Inc | Domínios gla como agentes terapêuticos |
| AU2018316166A1 (en) | 2017-08-07 | 2020-02-06 | The Regents Of The University Of California | Platform for generating safe cell therapeutics |
| SG11202001535RA (en) | 2017-09-05 | 2020-03-30 | Gladiator Biosciences Inc | Method of targeting exosomes |
| MY204234A (en) | 2018-08-27 | 2024-08-16 | Regeneron Pharma | Use of raman spectroscopy in downstream purification |
| CN110036976B (zh) * | 2019-05-08 | 2021-12-07 | 华南农业大学 | 一种阻断鸡禽白血病病毒垂直传播的方法及其应用 |
| CN110423777A (zh) * | 2019-07-23 | 2019-11-08 | 河南科技大学 | 无荧光染料标记外泌体及其制备方法 |
| CN110711249B (zh) * | 2019-09-19 | 2020-10-27 | 北京化工大学 | 一种溶酶体膜包覆纳米颗粒的制备方法 |
| PH12022550836A1 (en) * | 2019-10-09 | 2023-10-09 | Mayo Found Medical Education & Res | Canine distemper virus hemagglutinin and fusion polypeptides |
| KR102547446B1 (ko) * | 2019-11-29 | 2023-06-26 | 서울대학교산학협력단 | 무표지 폴리다이아세틸렌 리포좀 기반의 엑소좀의 검출 방법 |
| CN111803646B (zh) * | 2020-06-04 | 2022-07-05 | 苏州大学 | 一种实体肿瘤联合治疗组合物 |
| US20210393536A1 (en) * | 2020-06-23 | 2021-12-23 | Board Of Regents, The University Of Texas System | Methods and compositions related to extracellular vesicles |
| KR102659285B1 (ko) * | 2020-08-11 | 2024-04-22 | 경북대학교 산학협력단 | 암세포 유래 엑소좀에 선택적으로 결합하는 펩타이드 및 이의 용도 |
| CN112516110B (zh) * | 2020-10-13 | 2022-05-13 | 北京化工大学 | 一种细胞膜包覆纳米酶的方法 |
| CN112285195B (zh) * | 2020-10-27 | 2021-08-10 | 江南大学 | 一种牛奶外泌体的特征性糖蛋白标志物和牛奶外泌体的特征性标志物分离方法 |
| CN112553152B (zh) * | 2020-10-27 | 2024-09-17 | 重庆市铂而斐细胞生物技术有限公司 | 一种快速提高脂肪间充质干细胞外泌体产量的方法 |
| KR102285160B1 (ko) * | 2020-12-24 | 2021-08-03 | 주식회사 타임바이오 | 전구세포에서 유래한 다기능성 엑소좀을 포함하는 피부염 예방 또는 치료용 약학적 조성물 |
| KR102739746B1 (ko) * | 2021-10-25 | 2024-12-10 | 인하대학교 산학협력단 | 바르토넬라 헨셀라이 유래 세포외 소포체를 이용한 바르토넬라 감염증 진단 방법 |
| CN114940967B (zh) * | 2022-05-09 | 2024-05-31 | 中山大学 | 母乳细胞外囊泡及其在制备骨修复材料中的应用 |
| TWI872888B (zh) * | 2022-12-30 | 2025-02-11 | 財團法人工業技術研究院 | 用於穩定血液中游離核酸及/或外泌體核酸的組成物、含其之試劑與套組以及其用途 |
| CN116421738B (zh) * | 2023-02-28 | 2024-03-19 | 中国医科大学附属第一医院 | 捕获抗原的溶瘤病毒及其药物组合与制备和应用 |
| KR20240154736A (ko) * | 2023-04-18 | 2024-10-28 | 가톨릭대학교 산학협력단 | 면역관문 억제제의 표적화된 전달을 위한 세포외소포체의 용도 |
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