JP2020531538A5 - - Google Patents
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- Publication number
- JP2020531538A5 JP2020531538A5 JP2020511447A JP2020511447A JP2020531538A5 JP 2020531538 A5 JP2020531538 A5 JP 2020531538A5 JP 2020511447 A JP2020511447 A JP 2020511447A JP 2020511447 A JP2020511447 A JP 2020511447A JP 2020531538 A5 JP2020531538 A5 JP 2020531538A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- mannitol
- composition
- liposomes
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 239000000203 mixture Substances 0.000 claims 17
- 239000002502 liposome Substances 0.000 claims 15
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 12
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 12
- 229930195725 Mannitol Natural products 0.000 claims 12
- 235000010355 mannitol Nutrition 0.000 claims 12
- 239000000594 mannitol Substances 0.000 claims 12
- 238000005461 lubrication Methods 0.000 claims 9
- GZDFHIJNHHMENY-UHFFFAOYSA-N Dimethyl dicarbonate Chemical compound COC(=O)OC(=O)OC GZDFHIJNHHMENY-UHFFFAOYSA-N 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 230000007704 transition Effects 0.000 claims 6
- 239000012530 fluid Substances 0.000 claims 3
- 238000002347 injection Methods 0.000 claims 3
- 239000007924 injection Substances 0.000 claims 3
- 230000007794 irritation Effects 0.000 claims 3
- 230000003204 osmotic effect Effects 0.000 claims 3
- 230000035939 shock Effects 0.000 claims 3
- 239000000725 suspension Substances 0.000 claims 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 229960003160 hyaluronic acid Drugs 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 208000012659 Joint disease Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022080859A JP7383759B2 (ja) | 2017-08-22 | 2022-05-17 | 関節潤滑のためのリポソーム製剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762548429P | 2017-08-22 | 2017-08-22 | |
| US62/548,429 | 2017-08-22 | ||
| PCT/IL2018/050923 WO2019038763A1 (en) | 2017-08-22 | 2018-08-21 | LIPOSOMAL FORMULATION FOR JOINT LUBRICATION |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022080859A Division JP7383759B2 (ja) | 2017-08-22 | 2022-05-17 | 関節潤滑のためのリポソーム製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020531538A JP2020531538A (ja) | 2020-11-05 |
| JP2020531538A5 true JP2020531538A5 (enExample) | 2021-09-30 |
| JP7082336B2 JP7082336B2 (ja) | 2022-06-08 |
Family
ID=65439381
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020511447A Active JP7082336B2 (ja) | 2017-08-22 | 2018-08-21 | 関節潤滑のためのリポソーム製剤 |
| JP2022080859A Active JP7383759B2 (ja) | 2017-08-22 | 2022-05-17 | 関節潤滑のためのリポソーム製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022080859A Active JP7383759B2 (ja) | 2017-08-22 | 2022-05-17 | 関節潤滑のためのリポソーム製剤 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US11123293B2 (enExample) |
| EP (2) | EP4223284A1 (enExample) |
| JP (2) | JP7082336B2 (enExample) |
| KR (2) | KR102607729B1 (enExample) |
| CN (2) | CN114601799B (enExample) |
| AU (3) | AU2018319594B2 (enExample) |
| BR (1) | BR112020003767B1 (enExample) |
| CA (2) | CA3073368C (enExample) |
| DK (1) | DK3672653T3 (enExample) |
| EA (1) | EA202090476A1 (enExample) |
| ES (1) | ES2948715T3 (enExample) |
| FI (1) | FI3672653T3 (enExample) |
| HR (1) | HRP20230566T1 (enExample) |
| HU (1) | HUE062030T2 (enExample) |
| IL (3) | IL272630B2 (enExample) |
| LT (1) | LT3672653T (enExample) |
| MA (1) | MA49959B1 (enExample) |
| MX (2) | MX2020002041A (enExample) |
| MY (1) | MY197149A (enExample) |
| PH (1) | PH12020500331A1 (enExample) |
| PL (1) | PL3672653T3 (enExample) |
| PT (1) | PT3672653T (enExample) |
| SG (1) | SG11202000773QA (enExample) |
| SI (1) | SI3672653T1 (enExample) |
| WO (1) | WO2019038763A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI782181B (zh) * | 2019-02-11 | 2022-11-01 | 以色列商莫比斯醫療有限公司 | 用於關節潤滑的脂質體調配物 |
| JP2021013788A (ja) * | 2020-11-10 | 2021-02-12 | 株式会社三洋物産 | 遊技機 |
| CN118678947A (zh) * | 2022-01-02 | 2024-09-20 | 莫比斯医疗有限公司 | 脂质体捕集体积的测定 |
| CN119816311A (zh) | 2023-01-19 | 2025-04-11 | 莫比斯医疗有限公司 | 一种治疗关节障碍中的疼痛的长效脂质体组合物 |
| KR20250018222A (ko) * | 2023-07-26 | 2025-02-05 | 차의과학대학교 산학협력단 | 미토콘드리아가 캡슐화된 세포막 융합유도 리포좀을 포함하는 골관절염 치료를 위한 약학 조성물 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5403592A (en) | 1987-08-25 | 1995-04-04 | Macnaught Pty Limited | Lubricant composition for rheumatism |
| EP0319638A1 (en) * | 1987-12-08 | 1989-06-14 | Estee Lauder Inc. | Liposome containing cosmetic and pharmaceutical compositions and methods for utilizing such compositions |
| US5941909A (en) * | 1995-02-14 | 1999-08-24 | Mentor Corporation | Filling material for soft tissue implant prostheses and implants made therewith |
| AUPN723395A0 (en) | 1995-12-19 | 1996-01-18 | Macnaught Medical Pty Limited | Lubrication methods |
| US6379648B1 (en) * | 1999-02-01 | 2002-04-30 | The Curators Of The University Of Missouri | Biodegradable glass compositions and methods for radiation therapy |
| US6800298B1 (en) * | 2000-05-11 | 2004-10-05 | Clemson University | Biological lubricant composition and method of applying lubricant composition |
| US20040047807A1 (en) * | 2001-01-24 | 2004-03-11 | Dominik Meyer | Use of neurotoxic substances in producing a medicament for treating joint pains |
| US6509027B2 (en) * | 2001-02-12 | 2003-01-21 | Supergen, Inc. | Injectable pharmaceutical composition comprising coated particles of camptothecin |
| AU2002255993B2 (en) * | 2001-03-29 | 2008-05-01 | Optimer Pharmaceuticals | Formulations comprising entrapped active ingredients and uses thereof |
| EP1423081A4 (en) | 2001-06-25 | 2005-05-25 | Depuy Int Ltd | COMPOSITION WITH GLYCOSAMINOGYCANES AND HYALURONIDASE INHIBITORS FOR THE TREATMENT OF ARTHRITIC JOINTS |
| JP2004535434A (ja) | 2001-06-25 | 2004-11-25 | デピユイ | 関節炎にかかった関節の処置のためのグリコサミノグリカン類のリポソームカプセル化 |
| IL159334A0 (en) * | 2001-06-25 | 2004-06-01 | Yissum Res Dev Co | A method for preparation of vesicles loaded with biological material and different uses thereof |
| DE10255106A1 (de) * | 2002-11-24 | 2004-06-09 | Novosom Ag | Liposomale Glucocorticoide |
| US7205006B2 (en) | 2003-09-25 | 2007-04-17 | Prime Pharmaceutical Corporation | Mahonia aquifolium extract, extraction process and pharmaceutical composition containing the same |
| US7749485B2 (en) | 2004-06-03 | 2010-07-06 | Bracco Research S.A. | Liposomal assembly for therapeutic and/or diagnostic use |
| CN101027065A (zh) * | 2004-06-15 | 2007-08-29 | 陈献 | 磷脂组合物及其制备和使用方法 |
| US20070071840A1 (en) | 2005-09-27 | 2007-03-29 | Sridevi Dhanaraj | Method for treatment of cartilage disorders with centella extract |
| ITPD20060202A1 (it) | 2006-05-22 | 2007-11-23 | Univ Degli Studi Trieste | Miscele polimeriche di polisaccaridi anionici e cationici e loro impiego |
| JP5072275B2 (ja) * | 2006-07-03 | 2012-11-14 | テルモ株式会社 | 閉鎖小胞の分離方法、製剤の製造方法および評価方法 |
| US20080027554A1 (en) * | 2006-07-31 | 2008-01-31 | Talmadge Karen D | Kit and methods of treatment of an intervertebral disc |
| CN101541308B (zh) * | 2006-09-28 | 2012-02-01 | 哈达斯特医疗研究服务和开发有限公司 | 甘油磷脂用于关节润滑的用途 |
| US8834920B2 (en) | 2006-12-21 | 2014-09-16 | Alza Corporation | Liposome composition for targeting egfr receptor |
| FR2918276B1 (fr) | 2007-07-02 | 2010-01-22 | Anteis Sa | "utilisation d'un gel de polysaccharide(s)naturel(s)pour la preparation d'une formulation injectable de traitement des degenerescences articulaires" |
| US20110171288A1 (en) | 2008-02-20 | 2011-07-14 | Fatemeh Mohammadi | Topical compositions and methods for whitening skin |
| BR112012032153A2 (pt) | 2010-06-17 | 2017-08-08 | Yeda Res And Development Company Ltd | método para a lubrificação de uma ou mais superfícies não biológicas, método para a lubrificação de uma ou mais superfícies de um tecido biológico em um indivíduo mamífero, uso de lipossomas na fase em gel e lipossoma misto |
| IL206739A (en) * | 2010-06-30 | 2016-06-30 | David Segal | An injectable drug containing silitol as an active substance |
| US20140038917A1 (en) | 2011-04-19 | 2014-02-06 | Anteis S.A. | Sterile and injectable aqueous formulation for administration in the intra-articular space of an intra-articular joint |
| US8623839B2 (en) | 2011-06-30 | 2014-01-07 | Depuy Mitek, Llc | Compositions and methods for stabilized polysaccharide formulations |
| GB201206486D0 (en) * | 2012-04-12 | 2012-05-30 | Sequessome Technology Holdings Ltd | Vesicular formulations and uses thereof |
| KR102176971B1 (ko) * | 2012-07-05 | 2020-11-11 | 타이완 리포좀 캄파니 리미티드 | 관절염의 치료 방법 |
| CN104688721A (zh) | 2014-10-11 | 2015-06-10 | 黄萍 | 一种含紫杉醇脂质体的抗类风湿性关节炎药物凝胶剂及其制备方法 |
-
2018
- 2018-08-21 HR HRP20230566TT patent/HRP20230566T1/hr unknown
- 2018-08-21 DK DK18847493.6T patent/DK3672653T3/da active
- 2018-08-21 PL PL18847493.6T patent/PL3672653T3/pl unknown
- 2018-08-21 CN CN202210282704.7A patent/CN114601799B/zh active Active
- 2018-08-21 EA EA202090476A patent/EA202090476A1/ru unknown
- 2018-08-21 WO PCT/IL2018/050923 patent/WO2019038763A1/en not_active Ceased
- 2018-08-21 JP JP2020511447A patent/JP7082336B2/ja active Active
- 2018-08-21 CN CN201880053772.8A patent/CN111065423B/zh active Active
- 2018-08-21 FI FIEP18847493.6T patent/FI3672653T3/fi active
- 2018-08-21 PT PT188474936T patent/PT3672653T/pt unknown
- 2018-08-21 MA MA49959A patent/MA49959B1/fr unknown
- 2018-08-21 CA CA3073368A patent/CA3073368C/en active Active
- 2018-08-21 AU AU2018319594A patent/AU2018319594B2/en active Active
- 2018-08-21 KR KR1020207006061A patent/KR102607729B1/ko active Active
- 2018-08-21 EP EP23160029.7A patent/EP4223284A1/en active Pending
- 2018-08-21 CA CA3219776A patent/CA3219776A1/en active Pending
- 2018-08-21 ES ES18847493T patent/ES2948715T3/es active Active
- 2018-08-21 IL IL272630A patent/IL272630B2/en unknown
- 2018-08-21 US US16/337,188 patent/US11123293B2/en active Active
- 2018-08-21 IL IL301801A patent/IL301801B2/en unknown
- 2018-08-21 MY MYPI2020000726A patent/MY197149A/en unknown
- 2018-08-21 SI SI201830942T patent/SI3672653T1/sl unknown
- 2018-08-21 EP EP18847493.6A patent/EP3672653B1/en active Active
- 2018-08-21 HU HUE18847493A patent/HUE062030T2/hu unknown
- 2018-08-21 MX MX2020002041A patent/MX2020002041A/es unknown
- 2018-08-21 BR BR112020003767-2A patent/BR112020003767B1/pt active IP Right Grant
- 2018-08-21 LT LTEPPCT/IL2018/050923T patent/LT3672653T/lt unknown
- 2018-08-21 KR KR1020237040609A patent/KR102808544B1/ko active Active
- 2018-08-21 SG SG11202000773QA patent/SG11202000773QA/en unknown
- 2018-08-21 IL IL312816A patent/IL312816A/en unknown
-
2020
- 2020-02-13 PH PH12020500331A patent/PH12020500331A1/en unknown
- 2020-02-21 MX MX2023009082A patent/MX2023009082A/es unknown
-
2021
- 2021-08-15 US US17/445,089 patent/US12214077B2/en active Active
-
2022
- 2022-05-17 JP JP2022080859A patent/JP7383759B2/ja active Active
-
2023
- 2023-05-26 AU AU2023203309A patent/AU2023203309B2/en active Active
-
2024
- 2024-12-17 US US18/984,974 patent/US20250114304A1/en active Pending
-
2025
- 2025-01-07 AU AU2025200077A patent/AU2025200077A1/en active Pending
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