JP7082336B2 - 関節潤滑のためのリポソーム製剤 - Google Patents

関節潤滑のためのリポソーム製剤 Download PDF

Info

Publication number
JP7082336B2
JP7082336B2 JP2020511447A JP2020511447A JP7082336B2 JP 7082336 B2 JP7082336 B2 JP 7082336B2 JP 2020511447 A JP2020511447 A JP 2020511447A JP 2020511447 A JP2020511447 A JP 2020511447A JP 7082336 B2 JP7082336 B2 JP 7082336B2
Authority
JP
Japan
Prior art keywords
pharmaceutical composition
liposome
mannitol
liposomes
dmpc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020511447A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020531538A5 (enExample
JP2020531538A (ja
Inventor
イェチェズケル バレンホルツ
ヤニヴ ドレヴ
カレン トゥルジェマン
ガディ サルファティ
マティ アヤル－ヘルシュコヴィッツ
Original Assignee
モエビウス メディカル リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by モエビウス メディカル リミテッド filed Critical モエビウス メディカル リミテッド
Publication of JP2020531538A publication Critical patent/JP2020531538A/ja
Publication of JP2020531538A5 publication Critical patent/JP2020531538A5/ja
Priority to JP2022080859A priority Critical patent/JP7383759B2/ja
Application granted granted Critical
Publication of JP7082336B2 publication Critical patent/JP7082336B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/22—Lipids, fatty acids, e.g. prostaglandins, oils, fats, waxes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/10—Materials for lubricating medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2020511447A 2017-08-22 2018-08-21 関節潤滑のためのリポソーム製剤 Active JP7082336B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022080859A JP7383759B2 (ja) 2017-08-22 2022-05-17 関節潤滑のためのリポソーム製剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762548429P 2017-08-22 2017-08-22
US62/548,429 2017-08-22
PCT/IL2018/050923 WO2019038763A1 (en) 2017-08-22 2018-08-21 LIPOSOMAL FORMULATION FOR JOINT LUBRICATION

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022080859A Division JP7383759B2 (ja) 2017-08-22 2022-05-17 関節潤滑のためのリポソーム製剤

Publications (3)

Publication Number Publication Date
JP2020531538A JP2020531538A (ja) 2020-11-05
JP2020531538A5 JP2020531538A5 (enExample) 2021-09-30
JP7082336B2 true JP7082336B2 (ja) 2022-06-08

Family

ID=65439381

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020511447A Active JP7082336B2 (ja) 2017-08-22 2018-08-21 関節潤滑のためのリポソーム製剤
JP2022080859A Active JP7383759B2 (ja) 2017-08-22 2022-05-17 関節潤滑のためのリポソーム製剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022080859A Active JP7383759B2 (ja) 2017-08-22 2022-05-17 関節潤滑のためのリポソーム製剤

Country Status (25)

Country Link
US (3) US11123293B2 (enExample)
EP (2) EP4223284A1 (enExample)
JP (2) JP7082336B2 (enExample)
KR (2) KR102607729B1 (enExample)
CN (2) CN114601799B (enExample)
AU (3) AU2018319594B2 (enExample)
BR (1) BR112020003767B1 (enExample)
CA (2) CA3073368C (enExample)
DK (1) DK3672653T3 (enExample)
EA (1) EA202090476A1 (enExample)
ES (1) ES2948715T3 (enExample)
FI (1) FI3672653T3 (enExample)
HR (1) HRP20230566T1 (enExample)
HU (1) HUE062030T2 (enExample)
IL (3) IL272630B2 (enExample)
LT (1) LT3672653T (enExample)
MA (1) MA49959B1 (enExample)
MX (2) MX2020002041A (enExample)
MY (1) MY197149A (enExample)
PH (1) PH12020500331A1 (enExample)
PL (1) PL3672653T3 (enExample)
PT (1) PT3672653T (enExample)
SG (1) SG11202000773QA (enExample)
SI (1) SI3672653T1 (enExample)
WO (1) WO2019038763A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI782181B (zh) * 2019-02-11 2022-11-01 以色列商莫比斯醫療有限公司 用於關節潤滑的脂質體調配物
JP2021013788A (ja) * 2020-11-10 2021-02-12 株式会社三洋物産 遊技機
CN118678947A (zh) * 2022-01-02 2024-09-20 莫比斯医疗有限公司 脂质体捕集体积的测定
CN119816311A (zh) 2023-01-19 2025-04-11 莫比斯医疗有限公司 一种治疗关节障碍中的疼痛的长效脂质体组合物
KR20250018222A (ko) * 2023-07-26 2025-02-05 차의과학대학교 산학협력단 미토콘드리아가 캡슐화된 세포막 융합유도 리포좀을 포함하는 골관절염 치료를 위한 약학 조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010540406A (ja) 2006-09-28 2010-12-24 ハダシット メディカルリサーチサービセス アンド ディベロップメント リミテッド ジョイント部の潤滑に関するグリセロリン脂質の使用
JP2015512926A (ja) 2012-04-12 2015-04-30 シクエスサム テクノロジー ホールディングス リミテッド 関節の疼痛または低減した可動性の治療用の小胞製剤

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5403592A (en) 1987-08-25 1995-04-04 Macnaught Pty Limited Lubricant composition for rheumatism
EP0319638A1 (en) * 1987-12-08 1989-06-14 Estee Lauder Inc. Liposome containing cosmetic and pharmaceutical compositions and methods for utilizing such compositions
US5941909A (en) * 1995-02-14 1999-08-24 Mentor Corporation Filling material for soft tissue implant prostheses and implants made therewith
AUPN723395A0 (en) 1995-12-19 1996-01-18 Macnaught Medical Pty Limited Lubrication methods
US6379648B1 (en) * 1999-02-01 2002-04-30 The Curators Of The University Of Missouri Biodegradable glass compositions and methods for radiation therapy
US6800298B1 (en) * 2000-05-11 2004-10-05 Clemson University Biological lubricant composition and method of applying lubricant composition
US20040047807A1 (en) * 2001-01-24 2004-03-11 Dominik Meyer Use of neurotoxic substances in producing a medicament for treating joint pains
US6509027B2 (en) * 2001-02-12 2003-01-21 Supergen, Inc. Injectable pharmaceutical composition comprising coated particles of camptothecin
AU2002255993B2 (en) * 2001-03-29 2008-05-01 Optimer Pharmaceuticals Formulations comprising entrapped active ingredients and uses thereof
EP1423081A4 (en) 2001-06-25 2005-05-25 Depuy Int Ltd COMPOSITION WITH GLYCOSAMINOGYCANES AND HYALURONIDASE INHIBITORS FOR THE TREATMENT OF ARTHRITIC JOINTS
JP2004535434A (ja) 2001-06-25 2004-11-25 デピユイ 関節炎にかかった関節の処置のためのグリコサミノグリカン類のリポソームカプセル化
IL159334A0 (en) * 2001-06-25 2004-06-01 Yissum Res Dev Co A method for preparation of vesicles loaded with biological material and different uses thereof
DE10255106A1 (de) * 2002-11-24 2004-06-09 Novosom Ag Liposomale Glucocorticoide
US7205006B2 (en) 2003-09-25 2007-04-17 Prime Pharmaceutical Corporation Mahonia aquifolium extract, extraction process and pharmaceutical composition containing the same
US7749485B2 (en) 2004-06-03 2010-07-06 Bracco Research S.A. Liposomal assembly for therapeutic and/or diagnostic use
CN101027065A (zh) * 2004-06-15 2007-08-29 陈献 磷脂组合物及其制备和使用方法
US20070071840A1 (en) 2005-09-27 2007-03-29 Sridevi Dhanaraj Method for treatment of cartilage disorders with centella extract
ITPD20060202A1 (it) 2006-05-22 2007-11-23 Univ Degli Studi Trieste Miscele polimeriche di polisaccaridi anionici e cationici e loro impiego
JP5072275B2 (ja) * 2006-07-03 2012-11-14 テルモ株式会社 閉鎖小胞の分離方法、製剤の製造方法および評価方法
US20080027554A1 (en) * 2006-07-31 2008-01-31 Talmadge Karen D Kit and methods of treatment of an intervertebral disc
US8834920B2 (en) 2006-12-21 2014-09-16 Alza Corporation Liposome composition for targeting egfr receptor
FR2918276B1 (fr) 2007-07-02 2010-01-22 Anteis Sa "utilisation d'un gel de polysaccharide(s)naturel(s)pour la preparation d'une formulation injectable de traitement des degenerescences articulaires"
US20110171288A1 (en) 2008-02-20 2011-07-14 Fatemeh Mohammadi Topical compositions and methods for whitening skin
BR112012032153A2 (pt) 2010-06-17 2017-08-08 Yeda Res And Development Company Ltd método para a lubrificação de uma ou mais superfícies não biológicas, método para a lubrificação de uma ou mais superfícies de um tecido biológico em um indivíduo mamífero, uso de lipossomas na fase em gel e lipossoma misto
IL206739A (en) * 2010-06-30 2016-06-30 David Segal An injectable drug containing silitol as an active substance
US20140038917A1 (en) 2011-04-19 2014-02-06 Anteis S.A. Sterile and injectable aqueous formulation for administration in the intra-articular space of an intra-articular joint
US8623839B2 (en) 2011-06-30 2014-01-07 Depuy Mitek, Llc Compositions and methods for stabilized polysaccharide formulations
KR102176971B1 (ko) * 2012-07-05 2020-11-11 타이완 리포좀 캄파니 리미티드 관절염의 치료 방법
CN104688721A (zh) 2014-10-11 2015-06-10 黄萍 一种含紫杉醇脂质体的抗类风湿性关节炎药物凝胶剂及其制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010540406A (ja) 2006-09-28 2010-12-24 ハダシット メディカルリサーチサービセス アンド ディベロップメント リミテッド ジョイント部の潤滑に関するグリセロリン脂質の使用
JP2015512926A (ja) 2012-04-12 2015-04-30 シクエスサム テクノロジー ホールディングス リミテッド 関節の疼痛または低減した可動性の治療用の小胞製剤

Also Published As

Publication number Publication date
IL272630B2 (en) 2023-09-01
JP7383759B2 (ja) 2023-11-20
CN111065423B (zh) 2022-04-12
BR112020003767B1 (pt) 2023-10-10
CA3219776A1 (en) 2019-02-28
JP2022110090A (ja) 2022-07-28
KR102808544B1 (ko) 2025-05-19
US20200170948A1 (en) 2020-06-04
MY197149A (en) 2023-05-26
ES2948715T3 (es) 2023-09-18
EP3672653A4 (en) 2021-01-13
IL301801A (en) 2023-05-01
HRP20230566T1 (hr) 2023-08-18
US20210369613A1 (en) 2021-12-02
IL301801B1 (en) 2024-06-01
IL272630A (en) 2020-03-31
US20250114304A1 (en) 2025-04-10
HUE062030T2 (hu) 2023-09-28
WO2019038763A1 (en) 2019-02-28
PL3672653T3 (pl) 2023-08-14
PH12020500331A1 (en) 2020-10-05
EA202090476A1 (ru) 2020-06-29
LT3672653T (lt) 2023-07-10
IL272630B1 (en) 2023-05-01
IL312816A (en) 2024-07-01
CN111065423A (zh) 2020-04-24
BR112020003767A2 (pt) 2020-09-01
AU2023203309B2 (en) 2024-10-10
IL301801B2 (en) 2024-10-01
CA3073368A1 (en) 2019-02-28
US11123293B2 (en) 2021-09-21
SI3672653T1 (sl) 2023-08-31
AU2018319594B2 (en) 2023-06-15
MX2023009082A (es) 2023-08-08
SG11202000773QA (en) 2020-03-30
US12214077B2 (en) 2025-02-04
EP3672653B1 (en) 2023-03-29
AU2018319594A1 (en) 2020-02-20
MA49959A (fr) 2020-07-01
MX2020002041A (es) 2020-08-13
MA49959B1 (fr) 2023-07-31
CA3073368C (en) 2024-01-02
KR20200044006A (ko) 2020-04-28
DK3672653T3 (da) 2023-06-12
EP3672653A1 (en) 2020-07-01
KR20230166148A (ko) 2023-12-06
CN114601799A (zh) 2022-06-10
AU2025200077A1 (en) 2025-01-23
NZ761298A (en) 2024-03-22
EP4223284A1 (en) 2023-08-09
CN114601799B (zh) 2023-09-26
JP2020531538A (ja) 2020-11-05
AU2023203309A1 (en) 2023-06-22
PT3672653T (pt) 2023-06-29
KR102607729B1 (ko) 2023-11-29
FI3672653T3 (fi) 2023-06-07

Similar Documents

Publication Publication Date Title
JP7383759B2 (ja) 関節潤滑のためのリポソーム製剤
EP2079442B1 (en) Use of glycerophospholipids for joint lubrication
TWI782181B (zh) 用於關節潤滑的脂質體調配物
HK40030411B (en) Liposomal formulation for joint lubrication
HK40030411A (en) Liposomal formulation for joint lubrication
EA042384B1 (ru) Липосомальный состав для обеспечения смазывающей среды сустава
BR122022020806B1 (pt) Composição farmacêutica que compreende lipossomas, processo para a preparação da mesma e usos da dita composição para lubrificar uma articulação e tratar dor ou irritação em uma articulação

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210818

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210818

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20210818

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20211021

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20211025

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20211214

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220311

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20220419

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20220517

R150 Certificate of patent or registration of utility model

Ref document number: 7082336

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250