BR112020003767B1 - Composição farmacêutica que compreende lipossomas e uso da dita composição para tratar dor ou irritação em uma articulação - Google Patents

Composição farmacêutica que compreende lipossomas e uso da dita composição para tratar dor ou irritação em uma articulação Download PDF

Info

Publication number
BR112020003767B1
BR112020003767B1 BR112020003767-2A BR112020003767A BR112020003767B1 BR 112020003767 B1 BR112020003767 B1 BR 112020003767B1 BR 112020003767 A BR112020003767 A BR 112020003767A BR 112020003767 B1 BR112020003767 B1 BR 112020003767B1
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
dmpc
joint
liposomes
composition
Prior art date
Application number
BR112020003767-2A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112020003767A2 (pt
Inventor
Yechezkel Barenholz
Yaniv DOLEV
Keren TURJEMAN
Gadi Sarfati
Maty Ayal-Hershkovitz
Original Assignee
Moebius Medical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Moebius Medical Ltd filed Critical Moebius Medical Ltd
Publication of BR112020003767A2 publication Critical patent/BR112020003767A2/pt
Publication of BR112020003767B1 publication Critical patent/BR112020003767B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/22—Lipids, fatty acids, e.g. prostaglandins, oils, fats, waxes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/10—Materials for lubricating medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BR112020003767-2A 2017-08-22 2018-08-21 Composição farmacêutica que compreende lipossomas e uso da dita composição para tratar dor ou irritação em uma articulação BR112020003767B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762548429P 2017-08-22 2017-08-22
US62/548,429 2017-08-22
PCT/IL2018/050923 WO2019038763A1 (en) 2017-08-22 2018-08-21 LIPOSOMAL FORMULATION FOR JOINT LUBRICATION

Publications (2)

Publication Number Publication Date
BR112020003767A2 BR112020003767A2 (pt) 2020-09-01
BR112020003767B1 true BR112020003767B1 (pt) 2023-10-10

Family

ID=65439381

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112020003767-2A BR112020003767B1 (pt) 2017-08-22 2018-08-21 Composição farmacêutica que compreende lipossomas e uso da dita composição para tratar dor ou irritação em uma articulação

Country Status (25)

Country Link
US (3) US11123293B2 (enExample)
EP (2) EP4223284A1 (enExample)
JP (2) JP7082336B2 (enExample)
KR (2) KR102607729B1 (enExample)
CN (2) CN111065423B (enExample)
AU (3) AU2018319594B2 (enExample)
BR (1) BR112020003767B1 (enExample)
CA (2) CA3219776A1 (enExample)
DK (1) DK3672653T3 (enExample)
EA (1) EA202090476A1 (enExample)
ES (1) ES2948715T3 (enExample)
FI (1) FI3672653T3 (enExample)
HR (1) HRP20230566T1 (enExample)
HU (1) HUE062030T2 (enExample)
IL (3) IL312816A (enExample)
LT (1) LT3672653T (enExample)
MA (1) MA49959B1 (enExample)
MX (2) MX2020002041A (enExample)
MY (1) MY197149A (enExample)
PH (1) PH12020500331A1 (enExample)
PL (1) PL3672653T3 (enExample)
PT (1) PT3672653T (enExample)
SG (1) SG11202000773QA (enExample)
SI (1) SI3672653T1 (enExample)
WO (1) WO2019038763A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI782181B (zh) * 2019-02-11 2022-11-01 以色列商莫比斯醫療有限公司 用於關節潤滑的脂質體調配物
JP2021013788A (ja) * 2020-11-10 2021-02-12 株式会社三洋物産 遊技機
AU2022425700A1 (en) * 2022-01-02 2024-07-18 Moebius Medical Ltd. Determination of the trapped volume of a liposome
CN119816311A (zh) 2023-01-19 2025-04-11 莫比斯医疗有限公司 一种治疗关节障碍中的疼痛的长效脂质体组合物
KR20250018222A (ko) * 2023-07-26 2025-02-05 차의과학대학교 산학협력단 미토콘드리아가 캡슐화된 세포막 융합유도 리포좀을 포함하는 골관절염 치료를 위한 약학 조성물

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5403592A (en) 1987-08-25 1995-04-04 Macnaught Pty Limited Lubricant composition for rheumatism
EP0319638A1 (en) * 1987-12-08 1989-06-14 Estee Lauder Inc. Liposome containing cosmetic and pharmaceutical compositions and methods for utilizing such compositions
US5941909A (en) * 1995-02-14 1999-08-24 Mentor Corporation Filling material for soft tissue implant prostheses and implants made therewith
AUPN723395A0 (en) 1995-12-19 1996-01-18 Macnaught Medical Pty Limited Lubrication methods
US6379648B1 (en) * 1999-02-01 2002-04-30 The Curators Of The University Of Missouri Biodegradable glass compositions and methods for radiation therapy
US6800298B1 (en) 2000-05-11 2004-10-05 Clemson University Biological lubricant composition and method of applying lubricant composition
US20040047807A1 (en) * 2001-01-24 2004-03-11 Dominik Meyer Use of neurotoxic substances in producing a medicament for treating joint pains
US6509027B2 (en) 2001-02-12 2003-01-21 Supergen, Inc. Injectable pharmaceutical composition comprising coated particles of camptothecin
MXPA03008812A (es) 2001-03-29 2004-10-15 Scripps Research Inst Formulaciones que comprenden ingredientes activos atrapados y usos de los mismos.
JP2005521629A (ja) 2001-06-25 2005-07-21 デピユイ・インターナシヨナル・リミテツド 関節炎の関節を治療するためのグリコサミノグリカンとヒアルロニダーゼ阻害剤を含んで成る組成物
EP1404298A2 (en) 2001-06-25 2004-04-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem A method for preparation of vesicles loaded with biological material and different uses thereof
JP2004535434A (ja) 2001-06-25 2004-11-25 デピユイ 関節炎にかかった関節の処置のためのグリコサミノグリカン類のリポソームカプセル化
DE10255106A1 (de) * 2002-11-24 2004-06-09 Novosom Ag Liposomale Glucocorticoide
US7205006B2 (en) 2003-09-25 2007-04-17 Prime Pharmaceutical Corporation Mahonia aquifolium extract, extraction process and pharmaceutical composition containing the same
WO2005117832A1 (en) 2004-06-03 2005-12-15 Bracco Research Sa Liposomal assembly for therapeutic and/or diagnostic use
US20050287180A1 (en) 2004-06-15 2005-12-29 Chen Andrew X Phospholipid compositions and methods for their preparation and use
US20070071840A1 (en) 2005-09-27 2007-03-29 Sridevi Dhanaraj Method for treatment of cartilage disorders with centella extract
ITPD20060202A1 (it) 2006-05-22 2007-11-23 Univ Degli Studi Trieste Miscele polimeriche di polisaccaridi anionici e cationici e loro impiego
JP5072275B2 (ja) * 2006-07-03 2012-11-14 テルモ株式会社 閉鎖小胞の分離方法、製剤の製造方法および評価方法
US20080027554A1 (en) * 2006-07-31 2008-01-31 Talmadge Karen D Kit and methods of treatment of an intervertebral disc
CA2664944C (en) * 2006-09-28 2016-06-14 Hadasit Medical Research Services & Development Limited Use of glycerophospholipids for joint lubrication
US8834920B2 (en) 2006-12-21 2014-09-16 Alza Corporation Liposome composition for targeting egfr receptor
FR2918276B1 (fr) 2007-07-02 2010-01-22 Anteis Sa "utilisation d'un gel de polysaccharide(s)naturel(s)pour la preparation d'une formulation injectable de traitement des degenerescences articulaires"
MX2010008891A (es) 2008-02-20 2011-06-01 Elc Man Llc Composiciones topicas y metodos para blanquear la piel.
WO2011158237A1 (en) 2010-06-17 2011-12-22 Yeda Research And Development Co. Ltd., Phosphatidylcholine lipid liposomes as boundary lubricants in aqueous media
IL206739A (en) * 2010-06-30 2016-06-30 David Segal An injectable drug containing silitol as an active substance
US20140038917A1 (en) * 2011-04-19 2014-02-06 Anteis S.A. Sterile and injectable aqueous formulation for administration in the intra-articular space of an intra-articular joint
US8623839B2 (en) 2011-06-30 2014-01-07 Depuy Mitek, Llc Compositions and methods for stabilized polysaccharide formulations
GB201206486D0 (en) 2012-04-12 2012-05-30 Sequessome Technology Holdings Ltd Vesicular formulations and uses thereof
LT2854769T (lt) * 2012-07-05 2023-07-10 Taiwan Liposome Company, Ltd. Artrito gydymo būdai
CN104688721A (zh) * 2014-10-11 2015-06-10 黄萍 一种含紫杉醇脂质体的抗类风湿性关节炎药物凝胶剂及其制备方法

Also Published As

Publication number Publication date
AU2023203309A1 (en) 2023-06-22
JP2022110090A (ja) 2022-07-28
US20210369613A1 (en) 2021-12-02
JP7383759B2 (ja) 2023-11-20
CN111065423A (zh) 2020-04-24
CA3073368C (en) 2024-01-02
AU2023203309B2 (en) 2024-10-10
ES2948715T3 (es) 2023-09-18
PH12020500331A1 (en) 2020-10-05
CN114601799A (zh) 2022-06-10
IL272630B1 (en) 2023-05-01
FI3672653T3 (fi) 2023-06-07
HRP20230566T1 (hr) 2023-08-18
IL301801A (en) 2023-05-01
IL312816A (en) 2024-07-01
DK3672653T3 (da) 2023-06-12
AU2018319594B2 (en) 2023-06-15
AU2025200077A1 (en) 2025-01-23
SI3672653T1 (sl) 2023-08-31
US20250114304A1 (en) 2025-04-10
CN114601799B (zh) 2023-09-26
EA202090476A1 (ru) 2020-06-29
EP3672653A1 (en) 2020-07-01
KR102808544B1 (ko) 2025-05-19
PL3672653T3 (pl) 2023-08-14
HUE062030T2 (hu) 2023-09-28
IL301801B1 (en) 2024-06-01
IL272630A (en) 2020-03-31
IL272630B2 (en) 2023-09-01
CA3073368A1 (en) 2019-02-28
PT3672653T (pt) 2023-06-29
US12214077B2 (en) 2025-02-04
LT3672653T (lt) 2023-07-10
US20200170948A1 (en) 2020-06-04
EP3672653A4 (en) 2021-01-13
US11123293B2 (en) 2021-09-21
KR20200044006A (ko) 2020-04-28
KR102607729B1 (ko) 2023-11-29
IL301801B2 (en) 2024-10-01
AU2018319594A1 (en) 2020-02-20
MY197149A (en) 2023-05-26
EP3672653B1 (en) 2023-03-29
BR112020003767A2 (pt) 2020-09-01
KR20230166148A (ko) 2023-12-06
SG11202000773QA (en) 2020-03-30
MX2023009082A (es) 2023-08-08
MA49959A (fr) 2020-07-01
MX2020002041A (es) 2020-08-13
CA3219776A1 (en) 2019-02-28
EP4223284A1 (en) 2023-08-09
WO2019038763A1 (en) 2019-02-28
MA49959B1 (fr) 2023-07-31
CN111065423B (zh) 2022-04-12
JP7082336B2 (ja) 2022-06-08
JP2020531538A (ja) 2020-11-05
NZ761298A (en) 2024-03-22

Similar Documents

Publication Publication Date Title
AU2023203309B2 (en) Liposomal formulation for joint lubrication
Sivan et al. Liposomes act as effective biolubricants for friction reduction in human synovial joints
US8895054B2 (en) Methods for joint lubrication and cartilage wear prevention making use of glycerophospholipids
Hilšer et al. A new insight into more effective viscosupplementation based on the synergy of hyaluronic acid and phospholipids for cartilage friction reduction
BR122022020806B1 (pt) Composição farmacêutica que compreende lipossomas, processo para a preparação da mesma e usos da dita composição para lubrificar uma articulação e tratar dor ou irritação em uma articulação
TWI782181B (zh) 用於關節潤滑的脂質體調配物
EA042384B1 (ru) Липосомальный состав для обеспечения смазывающей среды сустава
HK40030411B (en) Liposomal formulation for joint lubrication
HK40030411A (en) Liposomal formulation for joint lubrication
Schroeder et al. Surface Active Phospholipids as Cartilage Lubricants

Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 21/08/2018, OBSERVADAS AS CONDICOES LEGAIS