IL312816A - Liposomal formulation for joint lubrication - Google Patents

Liposomal formulation for joint lubrication

Info

Publication number
IL312816A
IL312816A IL312816A IL31281624A IL312816A IL 312816 A IL312816 A IL 312816A IL 312816 A IL312816 A IL 312816A IL 31281624 A IL31281624 A IL 31281624A IL 312816 A IL312816 A IL 312816A
Authority
IL
Israel
Prior art keywords
pharmaceutical composition
dmpc
liposome
mannitol
liposomes
Prior art date
Application number
IL312816A
Other languages
English (en)
Hebrew (he)
Inventor
Ayal-Hershkovitz Maty
Barenholz Yechezkel
Dolev Yaniv
Turjeman Keren
Sarfati Gadi
Original Assignee
Moebius Medical Ltd
Maty Ayal Hershkovitz
Barenholz Yechezkel
Dolev Yaniv
Turjeman Keren
Sarfati Gadi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Moebius Medical Ltd, Maty Ayal Hershkovitz, Barenholz Yechezkel, Dolev Yaniv, Turjeman Keren, Sarfati Gadi filed Critical Moebius Medical Ltd
Publication of IL312816A publication Critical patent/IL312816A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/22—Lipids, fatty acids, e.g. prostaglandins, oils, fats, waxes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/10—Materials for lubricating medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL312816A 2017-08-22 2018-08-21 Liposomal formulation for joint lubrication IL312816A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762548429P 2017-08-22 2017-08-22
PCT/IL2018/050923 WO2019038763A1 (en) 2017-08-22 2018-08-21 LIPOSOMAL FORMULATION FOR JOINT LUBRICATION

Publications (1)

Publication Number Publication Date
IL312816A true IL312816A (en) 2024-07-01

Family

ID=65439381

Family Applications (3)

Application Number Title Priority Date Filing Date
IL301801A IL301801B2 (en) 2017-08-22 2018-08-21 Liposomal formulation for joint lubrication
IL272630A IL272630B2 (en) 2017-08-22 2018-08-21 Liposomal formulations for joint lubrication
IL312816A IL312816A (en) 2017-08-22 2018-08-21 Liposomal formulation for joint lubrication

Family Applications Before (2)

Application Number Title Priority Date Filing Date
IL301801A IL301801B2 (en) 2017-08-22 2018-08-21 Liposomal formulation for joint lubrication
IL272630A IL272630B2 (en) 2017-08-22 2018-08-21 Liposomal formulations for joint lubrication

Country Status (25)

Country Link
US (3) US11123293B2 (enExample)
EP (2) EP4223284A1 (enExample)
JP (2) JP7082336B2 (enExample)
KR (2) KR102808544B1 (enExample)
CN (2) CN111065423B (enExample)
AU (3) AU2018319594B2 (enExample)
BR (1) BR112020003767B1 (enExample)
CA (2) CA3073368C (enExample)
DK (1) DK3672653T3 (enExample)
EA (1) EA202090476A1 (enExample)
ES (1) ES2948715T3 (enExample)
FI (1) FI3672653T3 (enExample)
HR (1) HRP20230566T1 (enExample)
HU (1) HUE062030T2 (enExample)
IL (3) IL301801B2 (enExample)
LT (1) LT3672653T (enExample)
MA (1) MA49959B1 (enExample)
MX (2) MX2020002041A (enExample)
MY (1) MY197149A (enExample)
PH (1) PH12020500331A1 (enExample)
PL (1) PL3672653T3 (enExample)
PT (1) PT3672653T (enExample)
SG (1) SG11202000773QA (enExample)
SI (1) SI3672653T1 (enExample)
WO (1) WO2019038763A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
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TWI782181B (zh) * 2019-02-11 2022-11-01 以色列商莫比斯醫療有限公司 用於關節潤滑的脂質體調配物
JP2021013788A (ja) * 2020-11-10 2021-02-12 株式会社三洋物産 遊技機
KR20240156359A (ko) * 2022-01-02 2024-10-29 뫼비우스 메디칼 리미티드 리포솜의 포획된 용적의 결정
AU2024209031A1 (en) 2023-01-19 2025-01-02 Moebius Medical Ltd. A long-acting liposomal composition for treatment of pain in articular disorders
KR20250018222A (ko) * 2023-07-26 2025-02-05 차의과학대학교 산학협력단 미토콘드리아가 캡슐화된 세포막 융합유도 리포좀을 포함하는 골관절염 치료를 위한 약학 조성물

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Also Published As

Publication number Publication date
CA3219776A1 (en) 2019-02-28
BR112020003767B1 (pt) 2023-10-10
IL301801A (en) 2023-05-01
CA3073368C (en) 2024-01-02
ES2948715T3 (es) 2023-09-18
PT3672653T (pt) 2023-06-29
NZ761298A (en) 2024-03-22
US11123293B2 (en) 2021-09-21
EA202090476A1 (ru) 2020-06-29
US20200170948A1 (en) 2020-06-04
SI3672653T1 (sl) 2023-08-31
PL3672653T3 (pl) 2023-08-14
IL272630A (en) 2020-03-31
KR20200044006A (ko) 2020-04-28
LT3672653T (lt) 2023-07-10
AU2025200077A1 (en) 2025-01-23
KR20230166148A (ko) 2023-12-06
MA49959A (fr) 2020-07-01
MX2020002041A (es) 2020-08-13
US20210369613A1 (en) 2021-12-02
IL272630B1 (en) 2023-05-01
HUE062030T2 (hu) 2023-09-28
AU2023203309B2 (en) 2024-10-10
AU2018319594A1 (en) 2020-02-20
US20250114304A1 (en) 2025-04-10
KR102808544B1 (ko) 2025-05-19
JP7082336B2 (ja) 2022-06-08
CN111065423A (zh) 2020-04-24
MX2023009082A (es) 2023-08-08
EP3672653A4 (en) 2021-01-13
PH12020500331A1 (en) 2020-10-05
CN114601799B (zh) 2023-09-26
MA49959B1 (fr) 2023-07-31
HRP20230566T1 (hr) 2023-08-18
JP7383759B2 (ja) 2023-11-20
IL272630B2 (en) 2023-09-01
US12214077B2 (en) 2025-02-04
AU2023203309A1 (en) 2023-06-22
EP4223284A1 (en) 2023-08-09
CA3073368A1 (en) 2019-02-28
EP3672653B1 (en) 2023-03-29
MY197149A (en) 2023-05-26
CN114601799A (zh) 2022-06-10
EP3672653A1 (en) 2020-07-01
DK3672653T3 (da) 2023-06-12
IL301801B1 (en) 2024-06-01
CN111065423B (zh) 2022-04-12
BR112020003767A2 (pt) 2020-09-01
KR102607729B1 (ko) 2023-11-29
AU2018319594B2 (en) 2023-06-15
IL301801B2 (en) 2024-10-01
FI3672653T3 (fi) 2023-06-07
JP2020531538A (ja) 2020-11-05
SG11202000773QA (en) 2020-03-30
WO2019038763A1 (en) 2019-02-28
JP2022110090A (ja) 2022-07-28

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