KR102808544B1 - 관절 윤활용 리포좀 제형 - Google Patents

관절 윤활용 리포좀 제형 Download PDF

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Publication number
KR102808544B1
KR102808544B1 KR1020237040609A KR20237040609A KR102808544B1 KR 102808544 B1 KR102808544 B1 KR 102808544B1 KR 1020237040609 A KR1020237040609 A KR 1020237040609A KR 20237040609 A KR20237040609 A KR 20237040609A KR 102808544 B1 KR102808544 B1 KR 102808544B1
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pharmaceutical composition
joint
liposome
dmpc
range
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Korean (ko)
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KR20230166148A (ko
Inventor
예체즈켈 바렌홀즈
야니브 돌레브
케렌 투르제만
가디 사르파티
매티 아얄-허쉬코비츠
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뫼비우스 메디칼 리미티드
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/22—Lipids, fatty acids, e.g. prostaglandins, oils, fats, waxes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/10—Materials for lubricating medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020237040609A 2017-08-22 2018-08-21 관절 윤활용 리포좀 제형 Active KR102808544B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762548429P 2017-08-22 2017-08-22
US62/548,429 2017-08-22
PCT/IL2018/050923 WO2019038763A1 (en) 2017-08-22 2018-08-21 LIPOSOMAL FORMULATION FOR JOINT LUBRICATION
KR1020207006061A KR102607729B1 (ko) 2017-08-22 2018-08-21 관절 윤활용 리포좀 제형

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020207006061A Division KR102607729B1 (ko) 2017-08-22 2018-08-21 관절 윤활용 리포좀 제형

Publications (2)

Publication Number Publication Date
KR20230166148A KR20230166148A (ko) 2023-12-06
KR102808544B1 true KR102808544B1 (ko) 2025-05-19

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KR1020207006061A Active KR102607729B1 (ko) 2017-08-22 2018-08-21 관절 윤활용 리포좀 제형

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Country Status (25)

Country Link
US (3) US11123293B2 (enExample)
EP (2) EP4223284A1 (enExample)
JP (2) JP7082336B2 (enExample)
KR (2) KR102808544B1 (enExample)
CN (2) CN114601799B (enExample)
AU (3) AU2018319594B2 (enExample)
BR (1) BR112020003767B1 (enExample)
CA (2) CA3219776A1 (enExample)
DK (1) DK3672653T3 (enExample)
EA (1) EA202090476A1 (enExample)
ES (1) ES2948715T3 (enExample)
FI (1) FI3672653T3 (enExample)
HR (1) HRP20230566T1 (enExample)
HU (1) HUE062030T2 (enExample)
IL (3) IL272630B2 (enExample)
LT (1) LT3672653T (enExample)
MA (1) MA49959B1 (enExample)
MX (2) MX2020002041A (enExample)
MY (1) MY197149A (enExample)
PH (1) PH12020500331A1 (enExample)
PL (1) PL3672653T3 (enExample)
PT (1) PT3672653T (enExample)
SG (1) SG11202000773QA (enExample)
SI (1) SI3672653T1 (enExample)
WO (1) WO2019038763A1 (enExample)

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TWI782181B (zh) * 2019-02-11 2022-11-01 以色列商莫比斯醫療有限公司 用於關節潤滑的脂質體調配物
JP2021013788A (ja) * 2020-11-10 2021-02-12 株式会社三洋物産 遊技機
US20250114303A1 (en) * 2022-01-02 2025-04-10 Moebius Medical Ltd. Determination of the trapped volume of a liposome
CN119816311A (zh) 2023-01-19 2025-04-11 莫比斯医疗有限公司 一种治疗关节障碍中的疼痛的长效脂质体组合物
KR20250018222A (ko) * 2023-07-26 2025-02-05 차의과학대학교 산학협력단 미토콘드리아가 캡슐화된 세포막 융합유도 리포좀을 포함하는 골관절염 치료를 위한 약학 조성물

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US20170128473A1 (en) 2012-04-12 2017-05-11 Sequessome Technology Holdings Limited Vesicular Formulations for Use in the Treatment of Pain or Reduced Mobility of a Joint

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WO2008038292A2 (en) 2006-09-28 2008-04-03 Hadasit Medical Research Services & Development Limited Use of glycerophospholipids for joint lubrication
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US20170128473A1 (en) 2012-04-12 2017-05-11 Sequessome Technology Holdings Limited Vesicular Formulations for Use in the Treatment of Pain or Reduced Mobility of a Joint

Also Published As

Publication number Publication date
IL272630B1 (en) 2023-05-01
SG11202000773QA (en) 2020-03-30
PT3672653T (pt) 2023-06-29
MA49959B1 (fr) 2023-07-31
EP3672653A4 (en) 2021-01-13
ES2948715T3 (es) 2023-09-18
US12214077B2 (en) 2025-02-04
LT3672653T (lt) 2023-07-10
HUE062030T2 (hu) 2023-09-28
AU2023203309B2 (en) 2024-10-10
IL312816A (en) 2024-07-01
IL272630A (en) 2020-03-31
MX2023009082A (es) 2023-08-08
AU2025200077A1 (en) 2025-01-23
EP3672653A1 (en) 2020-07-01
IL272630B2 (en) 2023-09-01
IL301801B2 (en) 2024-10-01
EP3672653B1 (en) 2023-03-29
US11123293B2 (en) 2021-09-21
EA202090476A1 (ru) 2020-06-29
HRP20230566T1 (hr) 2023-08-18
US20250114304A1 (en) 2025-04-10
BR112020003767B1 (pt) 2023-10-10
CN111065423B (zh) 2022-04-12
CA3073368C (en) 2024-01-02
US20200170948A1 (en) 2020-06-04
KR20200044006A (ko) 2020-04-28
NZ761298A (en) 2024-03-22
MA49959A (fr) 2020-07-01
MX2020002041A (es) 2020-08-13
WO2019038763A1 (en) 2019-02-28
AU2018319594B2 (en) 2023-06-15
AU2023203309A1 (en) 2023-06-22
CN114601799B (zh) 2023-09-26
JP7383759B2 (ja) 2023-11-20
JP2022110090A (ja) 2022-07-28
CN114601799A (zh) 2022-06-10
KR102607729B1 (ko) 2023-11-29
CN111065423A (zh) 2020-04-24
SI3672653T1 (sl) 2023-08-31
DK3672653T3 (da) 2023-06-12
AU2018319594A1 (en) 2020-02-20
CA3073368A1 (en) 2019-02-28
CA3219776A1 (en) 2019-02-28
US20210369613A1 (en) 2021-12-02
MY197149A (en) 2023-05-26
IL301801A (en) 2023-05-01
EP4223284A1 (en) 2023-08-09
JP2020531538A (ja) 2020-11-05
PH12020500331A1 (en) 2020-10-05
KR20230166148A (ko) 2023-12-06
IL301801B1 (en) 2024-06-01
PL3672653T3 (pl) 2023-08-14
BR112020003767A2 (pt) 2020-09-01
FI3672653T3 (fi) 2023-06-07
JP7082336B2 (ja) 2022-06-08

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