EP1423081A4 - Composition comprising glycosaminogycans and hyaluronidase inhibitors for the treatment of arthritic joints - Google Patents

Composition comprising glycosaminogycans and hyaluronidase inhibitors for the treatment of arthritic joints

Info

Publication number
EP1423081A4
EP1423081A4 EP02739947A EP02739947A EP1423081A4 EP 1423081 A4 EP1423081 A4 EP 1423081A4 EP 02739947 A EP02739947 A EP 02739947A EP 02739947 A EP02739947 A EP 02739947A EP 1423081 A4 EP1423081 A4 EP 1423081A4
Authority
EP
European Patent Office
Prior art keywords
glycosaminogycans
treatment
composition
arthritic joints
hyaluronidase inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02739947A
Other languages
German (de)
French (fr)
Other versions
EP1423081A2 (en
Inventor
Jonathan Thompson
Anna Gosiewska
Susan Niemiec
Sridevi Dhanaraj
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DePuy International Ltd
Original Assignee
DePuy International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US30073401P priority Critical
Priority to US300734P priority
Priority to US74102A priority
Priority to WOPCT/US74/00001 priority
Application filed by DePuy International Ltd filed Critical DePuy International Ltd
Priority to PCT/US2002/019718 priority patent/WO2003000191A2/en
Publication of EP1423081A2 publication Critical patent/EP1423081A2/en
Publication of EP1423081A4 publication Critical patent/EP1423081A4/en
Application status is Withdrawn legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004Monosaccharides having only carbon, hydrogen and oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41521,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016Disaccharides, e.g. lactose, lactulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727Heparin; Heparan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728Hyaluronic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
EP02739947A 2001-06-25 2002-06-20 Composition comprising glycosaminogycans and hyaluronidase inhibitors for the treatment of arthritic joints Withdrawn EP1423081A4 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US30073401P true 2001-06-25 2001-06-25
US300734P 2001-06-25
US74102A true 2002-06-06 2002-06-06
WOPCT/US74/00001 2002-06-06
PCT/US2002/019718 WO2003000191A2 (en) 2001-06-25 2002-06-20 Composition comprising glycosaminogycans and hyaluronidase inhibitors for the treatment of arthritic joints

Publications (2)

Publication Number Publication Date
EP1423081A2 EP1423081A2 (en) 2004-06-02
EP1423081A4 true EP1423081A4 (en) 2005-05-25

Family

ID=26668090

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02739947A Withdrawn EP1423081A4 (en) 2001-06-25 2002-06-20 Composition comprising glycosaminogycans and hyaluronidase inhibitors for the treatment of arthritic joints

Country Status (4)

Country Link
EP (1) EP1423081A4 (en)
JP (1) JP2005521629A (en)
CA (1) CA2451248A1 (en)
WO (1) WO2003000191A2 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4703948B2 (en) * 2003-05-20 2011-06-15 丸善製薬株式会社 Anti-allergic agent, anti-aging agent and anti-aging skin external preparation
US20060040894A1 (en) * 2004-08-13 2006-02-23 Angiotech International Ag Compositions and methods using hyaluronic acid
AU2013270451B2 (en) * 2005-10-03 2016-05-12 Mark A. Pinsky Compositions and methods for improved skin care
EP2019647A4 (en) * 2006-05-19 2010-04-28 Univ Boston Novel hydrophilic polymers as medical lubricants and gels
CA2686505A1 (en) * 2007-05-11 2008-11-20 Galderma Research & Development Pharmaceutical or cosmetic preparations for topical and/or parenteral application, preparation methods thereof and use of same
WO2008139123A2 (en) * 2007-05-11 2008-11-20 Galderma Research & Development Pharmaceutical or cosmetic preparations for topical and/or parenteral application, preparation methods thereof and use of same
US8394782B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
ITMI20072348A1 (en) 2007-12-17 2009-06-18 Medichem Srl Method for cell regeneration of hyaluronic acid and its cosmetic composition
WO2009142893A2 (en) * 2008-05-19 2009-11-26 The University Of North Carolina At Chapel Hill Methods and compositions for the delivery of bioactive compounds
ITMI20090779A1 (en) * 2009-05-08 2010-11-09 Vitrupharm Srl Nutritional Compositions based on resveratrol cysteine ​​or its derivatives or metabolites, and astaxanthin
US9913810B2 (en) 2009-07-23 2018-03-13 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using phospholipids and astaxanthin
US8557275B2 (en) 2009-07-23 2013-10-15 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using a mixture of fish oil and fish oil derived, choline based, phospholipid bound fatty acid mixture including polyunsaturated EPA and DHA
US9399047B2 (en) 2009-07-23 2016-07-26 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using phospholipids and roe extract
US9216164B2 (en) 2009-07-23 2015-12-22 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using a mixture of fish oil and fish oil derived, choline based, phospholipid bound fatty acid mixture including polyunsaturated EPA and DHA
US8481072B2 (en) 2009-07-23 2013-07-09 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain
US9402857B2 (en) 2009-07-23 2016-08-02 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using low molecular weight hyaluronic acid and astaxanthin
US9238043B2 (en) 2009-07-23 2016-01-19 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using algae based oils
US8637569B2 (en) 2009-10-22 2014-01-28 Api Genesis, Llc Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds
CN102711743A (en) * 2009-10-22 2012-10-03 Api起源有限责任公司 Methods of making and using compositions comprising flavonoids
WO2011160146A1 (en) * 2010-06-23 2011-12-29 Croma-Pharma Gesellschaft M.B.H. Pharmaceutical preparation containing dextran and sodium hyaluronate for the treatment of joint disorders
US8716204B2 (en) 2010-07-27 2014-05-06 Zimmer, Inc. Synthetic synovial fluid compositions and methods for making the same
ITRM20100614A1 (en) * 2010-11-24 2012-05-25 D M G Italia S R L Pharmaceutical Preparations of 18 beta glycyrrhetinic acid and / or its derivatives for intra-articular infiltration for the treatment of inflammatory arthropathies
FR2991876B1 (en) * 2012-06-13 2014-11-21 Vivacy Lab Composition, in aqueous medium, comprising at least one hyaluronic acid and at least one water-soluble salt of sucrose octasulfate
WO2017025635A1 (en) * 2015-08-13 2017-02-16 Newven Sprl Composition for the treatment of joint conditions
DE102016208567A1 (en) * 2016-05-19 2017-11-23 Heraeus Medical Gmbh Polymer solution for viscous supplementation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990012561A1 (en) * 1989-04-20 1990-11-01 Bukh Meditec A/S (Niels Bukh A/S) Cosmetic composition
WO2000074662A2 (en) * 1999-06-07 2000-12-14 University Of Sheffield Arthritis treatment

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2374910B1 (en) * 1976-10-23 1981-07-10 Choay Sa
US4743596A (en) * 1987-06-16 1988-05-10 Lapin Alfred R Anti-arthritic preparation
WO2000018352A2 (en) * 1998-09-28 2000-04-06 Merck & Co., Inc. A method for treating inflammatory diseases by administering a thrombin inhibitor
US6136795A (en) * 1998-11-18 2000-10-24 Omni Nutraceuticals, Inc Dietary regimen of nutritional supplements for relief of symptoms of arthritis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990012561A1 (en) * 1989-04-20 1990-11-01 Bukh Meditec A/S (Niels Bukh A/S) Cosmetic composition
WO2000074662A2 (en) * 1999-06-07 2000-12-14 University Of Sheffield Arthritis treatment

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KUPPUSAMY U R ET AL: "STRUCTURE-ACTIVITY STUDIES OF FLAVONOIDS AS INHIBITORS OF HYALURONIDASE", BIOCHEMICAL PHARMACOLOGY, vol. 40, no. 2, 1990, pages 397 - 401, XP002322723, ISSN: 0006-2952 *
See also references of WO03000191A3 *
TORSTEINSDOTTIR I ET AL: "Production and elimination of hyaluronan in rheumatoid arthritis patients: estimation with a loading test", SEMINARS IN ARTHRITIS AND RHEUMATISM, XX, XX, vol. 28, no. 4, February 1999 (1999-02-01), pages 268 - 279, XP004680850, ISSN: 0049-0172 *

Also Published As

Publication number Publication date
WO2003000191A2 (en) 2003-01-03
WO2003000191A3 (en) 2004-03-11
JP2005521629A (en) 2005-07-21
CA2451248A1 (en) 2003-01-03
EP1423081A2 (en) 2004-06-02

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Legal Events

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Countries concerned: ALLTLVMKROSI

17P Request for examination filed

Effective date: 20040120

RIC1 Classification (correction)

Ipc: 7A 61K 31/72 A

Ipc: 7A 61K 31/725 B

Ipc: 7A 61K 9/127 B

Ipc: 7A 61K 31/715 B

RAP1 Transfer of rights of an ep published application

Owner name: DEPUY INTERNATIONAL LIMITED

RIC1 Classification (correction)

Ipc: 7A 61K 31/4152 B

Ipc: 7A 61K 31/715 A

Ipc: 7A 61K 33/24 B

Ipc: 7A 61P 29/00 B

Ipc: 7A 61K 31/728 B

Ipc: 7A 61K 31/726 B

Ipc: 7A 61K 31/352 B

Ipc: 7A 61K 9/127 B

Ipc: 7A 61K 31/727 B

A4 Despatch of supplementary search report

Effective date: 20050412

18D Deemed to be withdrawn

Effective date: 20060904