JP2020531511A5 - - Google Patents

Info

Publication number

JP2020531511A5

JP2020531511A5 JP2020511176A JP2020511176A JP2020531511A5 JP 2020531511 A5 JP2020531511 A5 JP 2020531511A5 JP 2020511176 A JP2020511176 A JP 2020511176A JP 2020511176 A JP2020511176 A JP 2020511176A JP 2020531511 A5 JP2020531511 A5 JP 2020531511A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

compound

patient

eye

micrograms

Prior art date

2018-08-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 25
• 239000003889 eye drop Substances 0.000 claims 14
• 229940126062 Compound A Drugs 0.000 claims 8
• NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 8
• 229940012356 eye drops Drugs 0.000 claims 8
• 208000003556 Dry Eye Syndromes Diseases 0.000 claims 6
• 230000004489 tear production Effects 0.000 claims 6
• 239000013543 active substance Substances 0.000 claims 4
• LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 claims 3
• 150000001875 compounds Chemical class 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000012530 fluid Substances 0.000 claims 1