JP2020531511A - 眼球用医薬組成物 - Google Patents
眼球用医薬組成物 Download PDFInfo
- Publication number
- JP2020531511A JP2020531511A JP2020511176A JP2020511176A JP2020531511A JP 2020531511 A JP2020531511 A JP 2020531511A JP 2020511176 A JP2020511176 A JP 2020511176A JP 2020511176 A JP2020511176 A JP 2020511176A JP 2020531511 A JP2020531511 A JP 2020531511A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- active agent
- pharmaceutically acceptable
- formula
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *Nc1nc(O*)nc(Nc2ccccc2)n1 Chemical compound *Nc1nc(O*)nc(Nc2ccccc2)n1 0.000 description 2
- LONBLURXLSDGME-UHFFFAOYSA-N CCN(CC)/C(/N=C(\N)/OC(C(F)(F)F)C(F)(F)F)=N/C(C)Nc1ccccc1 Chemical compound CCN(CC)/C(/N=C(\N)/OC(C(F)(F)F)C(F)(F)F)=N/C(C)Nc1ccccc1 LONBLURXLSDGME-UHFFFAOYSA-N 0.000 description 1
- IQWQRKAECXHZKW-UHFFFAOYSA-N CNc1nc(Nc2ccccc2)nc(OC(C(F)(F)F)C(F)(F)F)n1 Chemical compound CNc1nc(Nc2ccccc2)nc(OC(C(F)(F)F)C(F)(F)F)n1 IQWQRKAECXHZKW-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762549872P | 2017-08-24 | 2017-08-24 | |
| US62/549,872 | 2017-08-24 | ||
| PCT/US2018/048025 WO2019040919A1 (en) | 2017-08-24 | 2018-08-24 | OCULAR PHARMACEUTICAL COMPOSITIONS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020531511A true JP2020531511A (ja) | 2020-11-05 |
| JP2020531511A5 JP2020531511A5 (https=) | 2021-09-30 |
Family
ID=65439930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020511176A Pending JP2020531511A (ja) | 2017-08-24 | 2018-08-24 | 眼球用医薬組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US11839616B2 (https=) |
| EP (1) | EP3672598A4 (https=) |
| JP (1) | JP2020531511A (https=) |
| KR (1) | KR20200044873A (https=) |
| CN (1) | CN111629730A (https=) |
| AU (1) | AU2018321926B2 (https=) |
| CA (1) | CA3073718A1 (https=) |
| WO (1) | WO2019040919A1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023541261A (ja) * | 2020-09-10 | 2023-09-29 | バンダ・ファーマシューティカルズ・インコーポレイテッド | Pdeiv媒介性の疾患又は状態を処置する方法 |
| US11839616B2 (en) | 2017-08-24 | 2023-12-12 | The Regents Of The University Of California | Ocular pharmaceutical compositions |
| US12065412B2 (en) | 2015-12-24 | 2024-08-20 | The Regents Of The University Of California | CFTR regulators and methods of use thereof |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11957413B2 (en) * | 2019-08-06 | 2024-04-16 | University of Pittsburgh—of the Commonwealth System of Higher Education | Solitary wave-based trans-lid tonometer |
| BR112022010871A2 (pt) * | 2019-12-05 | 2022-08-23 | Vanda Pharmaceuticals Inc | Composições farmacêuticas oftalmológicas |
| WO2025179141A1 (en) * | 2024-02-22 | 2025-08-28 | Vanda Pharmaceuticals, Inc. | Treatment of dry eye disease |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0008864A1 (en) | 1978-08-15 | 1980-03-19 | FISONS plc | Pyridopyrazine and quinoxaline derivatives, processes for their preparation, and pharmaceutical compositions containing them |
| JPS62126178A (ja) | 1985-11-26 | 1987-06-08 | Mitsubishi Petrochem Co Ltd | 新規トリアジン誘導体及びこれを含む除草剤 |
| US5236952A (en) | 1986-03-11 | 1993-08-17 | Hoffmann-La Roche Inc. | Catechol derivatives |
| AU5433594A (en) | 1992-11-19 | 1994-06-08 | Dainippon Pharmaceutical Co. Ltd. | 3,4-dihydro-1-(2-hydroxyphenyl)-2(1h)-quinoxalinone derivative and related compound |
| EP1004307B1 (en) * | 1998-01-30 | 2002-09-04 | R-Tech Ueno, Ltd. | Ophthalmic composition |
| EP0945447A1 (en) | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections |
| KR20010042298A (ko) | 1998-03-31 | 2001-05-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 인자 Xa 및 트롬빈과 같은 세린 프로테아제억제제로서의 퀴녹살리논 |
| EP1246823A1 (en) | 1999-12-28 | 2002-10-09 | Pharmacopeia, Inc. | Pyrimidine and triazine kinase inhibitors |
| WO2003024926A2 (en) | 2001-09-21 | 2003-03-27 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
| US7163943B2 (en) | 2001-09-21 | 2007-01-16 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
| AU2003272740A1 (en) | 2002-10-01 | 2004-04-23 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | 4,6-diaminosubstituted-2-[oxy or aminoxy]-[1,3,5]triazines as protein tyrosine kinase inhibitors |
| WO2005009980A1 (en) | 2003-07-22 | 2005-02-03 | Neurogen Corporation | Substituted pyridin-2-ylamine analogues |
| MXPA06008606A (es) | 2004-01-30 | 2007-04-13 | Vertex Pharma | Moduladores de transportadores con casete de union a atp. |
| US7335770B2 (en) | 2004-03-24 | 2008-02-26 | Reddy U5 Therapeutics, Inc. | Triazine compounds and their analogs, compositions, and methods |
| DE102004023332A1 (de) | 2004-05-12 | 2006-01-19 | Bayer Cropscience Gmbh | Chinoxalin-2-on-derivate, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung und deren Verwendung |
| WO2007095812A1 (en) | 2006-02-27 | 2007-08-30 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Substituted [1,3,5] triazine compounds, their processes for preparation and uses thereof |
| CA2657093A1 (en) | 2006-07-07 | 2008-01-10 | Steven P. Govek | Bicyclic heteroaryl inhibitors of pde4 |
| MX2009012610A (es) | 2007-05-22 | 2009-12-11 | Astellas Pharma Inc | Compuesto de tetrahidroisoquinolina 1-sustituido. |
| US20090105240A1 (en) | 2007-10-17 | 2009-04-23 | Tomas Mustelin | Methods for treating leukemia and myelodysplastic syndrome, and methods for identifying agents for treating same |
| WO2009091388A2 (en) | 2007-12-21 | 2009-07-23 | Progenics Pharmaceuticals, Inc. | Triazines and related compounds having antiviral activity, compositions and methods thereof |
| EP2247580B1 (en) | 2008-03-05 | 2015-07-08 | Merck Patent GmbH | Quinoxalinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes |
| US8314239B2 (en) | 2008-10-23 | 2012-11-20 | Vertex Pharmaceutical Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| WO2010073011A2 (en) | 2008-12-23 | 2010-07-01 | Betagenon Ab | Compounds useful as medicaments |
| SI2408750T1 (sl) | 2009-03-20 | 2015-11-30 | Vertex Pharmaceuticals Incorporated | Postopek za izdelavo modulatorjev cistično-fibroznega transmembranskega regulatorja prevodnosti |
| FR2958645B1 (fr) | 2010-04-09 | 2012-08-31 | Commissariat Energie Atomique | Hemi-anticorps a auto-assemblage |
| ES2608474T3 (es) | 2010-04-22 | 2017-04-11 | Vertex Pharmaceuticals Incorporated | Proceso de producción de compuestos indol cycloalkylcarboxamido |
| WO2012092471A2 (en) | 2010-12-29 | 2012-07-05 | Development Center For Biotechnology | Novel tubulin inhibitors and methods of using the same |
| US9303035B2 (en) | 2012-12-19 | 2016-04-05 | Novartis Ag | Substituted pyrazino[1′,2′:1,2]pyrrolo[3,4-d]pyrimidines, pyrimido[4′,5′:3,4]pyrrolo[2,1-c][1,4]oxazines and pyrimido[4′,5′:3,4]pyrrolo[1,2-d][1,4]oxazepines for inhibiting the CFTR channel |
| HUE040366T2 (hu) * | 2013-08-08 | 2019-03-28 | Galapagos Nv | CFTR modulátor tieno[2,3-c]piránok |
| WO2015168079A1 (en) | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Pyrimidine or pyridine derivatives useful as pi3k inhibitors |
| CA2996854C (en) | 2015-09-11 | 2022-11-29 | Ion-Tof Technologies Gmbh | Secondary ion mass spectrometer and secondary ion mass spectrometric method |
| US10035962B2 (en) * | 2015-12-21 | 2018-07-31 | Exxonmobil Research And Engineering Company | Trim dewaxing of distillate fuel |
| JP6894902B2 (ja) | 2015-12-24 | 2021-06-30 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | Cftr制御因子及びこの使用方法 |
| MX383072B (es) | 2015-12-24 | 2025-03-13 | Univ California | Reguladores del cftr y métodos para su uso |
| CN109302846B (zh) | 2015-12-24 | 2021-05-11 | 莱斯彼维特有限公司 | 吲哚啉酮化合物及其在纤维化疾病治疗中的用途 |
| ES2913051T3 (es) * | 2015-12-24 | 2022-05-31 | Univ California | Reguladores de CFTR y métodos de uso de los mismos |
| JP2020531511A (ja) | 2017-08-24 | 2020-11-05 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | 眼球用医薬組成物 |
-
2018
- 2018-08-24 JP JP2020511176A patent/JP2020531511A/ja active Pending
- 2018-08-24 US US16/641,621 patent/US11839616B2/en active Active
- 2018-08-24 WO PCT/US2018/048025 patent/WO2019040919A1/en not_active Ceased
- 2018-08-24 CA CA3073718A patent/CA3073718A1/en active Pending
- 2018-08-24 KR KR1020207008360A patent/KR20200044873A/ko not_active Ceased
- 2018-08-24 AU AU2018321926A patent/AU2018321926B2/en active Active
- 2018-08-24 EP EP18849250.8A patent/EP3672598A4/en active Pending
- 2018-08-24 CN CN201880069116.7A patent/CN111629730A/zh active Pending
-
2023
- 2023-10-30 US US18/497,962 patent/US20240156828A1/en not_active Abandoned
-
2025
- 2025-08-11 US US19/296,874 patent/US20250367207A1/en active Pending
Non-Patent Citations (6)
| Title |
|---|
| "点眼薬", 慶應義塾大学病院ホームページ, JPN6023012383, May 2017 (2017-05-01), ISSN: 0005027640 * |
| AMER. J. VET. RES., vol. 71, no. 6, JPN6023012381, 2010, pages 671 - 676, ISSN: 0005027638 * |
| INVEST. OPHTHAL. VIS. SCI., vol. 50, no. 5, JPN6022025178, 2009, pages 2132 - 2138, ISSN: 0005027637 * |
| J. MED. CHEM., vol. 60, JPN6022025177, January 2017 (2017-01-01), pages 1210 - 1218, ISSN: 0005027636 * |
| OCUL. SURF., vol. 14, no. 2, JPN6023012384, 2016, pages 264 - 316, ISSN: 0005027641 * |
| 比較眼科雑誌, vol. 32, JPN6023012382, 2013, pages 3 - 13, ISSN: 0005027639 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12065412B2 (en) | 2015-12-24 | 2024-08-20 | The Regents Of The University Of California | CFTR regulators and methods of use thereof |
| US11839616B2 (en) | 2017-08-24 | 2023-12-12 | The Regents Of The University Of California | Ocular pharmaceutical compositions |
| JP2023541261A (ja) * | 2020-09-10 | 2023-09-29 | バンダ・ファーマシューティカルズ・インコーポレイテッド | Pdeiv媒介性の疾患又は状態を処置する方法 |
| JP7826294B2 (ja) | 2020-09-10 | 2026-03-09 | バンダ・ファーマシューティカルズ・インコーポレイテッド | Pdeiv媒介性の疾患又は状態を処置する方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20250367207A1 (en) | 2025-12-04 |
| US11839616B2 (en) | 2023-12-12 |
| EP3672598A4 (en) | 2021-04-28 |
| KR20200044873A (ko) | 2020-04-29 |
| RU2020111560A (ru) | 2021-09-24 |
| WO2019040919A1 (en) | 2019-02-28 |
| AU2018321926A1 (en) | 2020-03-12 |
| CA3073718A1 (en) | 2019-02-28 |
| US20240156828A1 (en) | 2024-05-16 |
| US20210154201A1 (en) | 2021-05-27 |
| RU2020111560A3 (https=) | 2021-10-29 |
| EP3672598A1 (en) | 2020-07-01 |
| AU2018321926B2 (en) | 2023-09-21 |
| CN111629730A (zh) | 2020-09-04 |
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