JP2020531481A - エーテル化合物およびその使用 - Google Patents

エーテル化合物およびその使用 Download PDF

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Publication number
JP2020531481A
JP2020531481A JP2020509482A JP2020509482A JP2020531481A JP 2020531481 A JP2020531481 A JP 2020531481A JP 2020509482 A JP2020509482 A JP 2020509482A JP 2020509482 A JP2020509482 A JP 2020509482A JP 2020531481 A JP2020531481 A JP 2020531481A
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substituted
unsubstituted
compound according
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alkyl
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JP2020531481A5 (enExample
Inventor
カイル ダブリュー．エイチ． チャン，
カイル ダブリュー．エイチ． チャン，
ポール イー． エルドマン，
ポール イー． エルドマン，
リア ファン，
リア ファン，
デイビッド アーロン ヘクト，
デイビッド アーロン ヘクト，
フランク メルキューリオ，
フランク メルキューリオ，
ロバート サリバン，
ロバート サリバン，
Original Assignee
バイオセリックス， インコーポレイテッド
バイオセリックス， インコーポレイテッド
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Publication of JP2020531481A publication Critical patent/JP2020531481A/ja
Publication of JP2020531481A5 publication Critical patent/JP2020531481A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2020509482A 2017-08-25 2018-08-07 エーテル化合物およびその使用 Pending JP2020531481A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762550489P 2017-08-25 2017-08-25
US62/550,489 2017-08-25
PCT/US2018/045626 WO2019040274A1 (en) 2017-08-25 2018-08-07 ETHER COMPOUNDS AND USES THEREOF

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JP2020531481A true JP2020531481A (ja) 2020-11-05
JP2020531481A5 JP2020531481A5 (enExample) 2021-09-16

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JP2020509482A Pending JP2020531481A (ja) 2017-08-25 2018-08-07 エーテル化合物およびその使用

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US (2) US10513515B2 (enExample)
EP (1) EP3672955A1 (enExample)
JP (1) JP2020531481A (enExample)
CN (1) CN111247138A (enExample)
AU (1) AU2018321567A1 (enExample)
CA (1) CA3072543A1 (enExample)
TW (2) TWI742303B (enExample)
WO (1) WO2019040274A1 (enExample)

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CN113896711A (zh) * 2020-07-06 2022-01-07 北京诺诚健华医药科技有限公司 杂环类免疫调节剂
WO2022012622A1 (en) * 2020-07-16 2022-01-20 Beigene, Ltd. Degradation of (egfr) by conjugation of egfr inhibitors with e3 ligase ligand and methods of use
BR112023000817A2 (pt) 2020-07-20 2023-02-07 Jiangsu Hengrui Pharmaceuticals Co Ltd Derivado de isoindolina contendo enxofre, e método de preparação do mesmo e uso médico do mesmo
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KR20240020735A (ko) 2021-05-07 2024-02-15 카이메라 쎄라퓨틱스 인코포레이티드 Cdk2 분해제 및 그 용도
WO2022251588A1 (en) * 2021-05-27 2022-12-01 Halda Therapeutics Opco, Inc. Heterobifunctional compounds and methods of treating disease
KR20240053589A (ko) * 2021-07-30 2024-04-24 하이노바 파마슈티컬스 인코포레이티드 이중 기능성 키메라 헤테로 고리 화합물 및 이의 안드로겐 수용체 분해제로서의 용도
WO2023025136A1 (zh) * 2021-08-27 2023-03-02 杭州格博生物医药有限公司 异吲哚啉酮化合物及其用途
US12419962B2 (en) 2022-03-16 2025-09-23 Biotheryx, Inc. Quinazolines, pharmaceutical compositions, and therapeutic applications
CN118019736A (zh) * 2022-09-08 2024-05-10 标新生物医药科技(上海)有限公司 基于cereblon蛋白设计的分子胶化合物及其应用
WO2024064358A1 (en) 2022-09-23 2024-03-28 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
CN119684303A (zh) * 2023-12-28 2025-03-25 上海超阳药业有限公司 一种双功能可降解雄激素受体的杂环化合物及其应用
TW202543650A (zh) 2024-03-08 2025-11-16 美商海爾達醫療運營公司 異雙官能化合物及其在治療疾病中之用途
DE102024129145A1 (de) 2024-10-09 2026-04-09 Balluff Gmbh Sensorelement

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