|
US10323236B2
(en)
|
2011-07-22 |
2019-06-18 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
US9228207B2
(en)
|
2013-09-06 |
2016-01-05 |
President And Fellows Of Harvard College |
Switchable gRNAs comprising aptamers
|
|
US20150165054A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
|
US10077453B2
(en)
|
2014-07-30 |
2018-09-18 |
President And Fellows Of Harvard College |
CAS9 proteins including ligand-dependent inteins
|
|
EP3234134B1
(en)
|
2014-12-17 |
2020-05-27 |
ProQR Therapeutics II B.V. |
Targeted rna editing
|
|
IL310721B2
(en)
|
2015-10-23 |
2025-11-01 |
Harvard College |
Nucleobase editors and uses thereof
|
|
WO2017220751A1
(en)
|
2016-06-22 |
2017-12-28 |
Proqr Therapeutics Ii B.V. |
Single-stranded rna-editing oligonucleotides
|
|
CN110214183A
(zh)
|
2016-08-03 |
2019-09-06 |
哈佛大学的校长及成员们 |
腺苷核碱基编辑器及其用途
|
|
WO2018031683A1
(en)
|
2016-08-09 |
2018-02-15 |
President And Fellows Of Harvard College |
Programmable cas9-recombinase fusion proteins and uses thereof
|
|
US11542509B2
(en)
|
2016-08-24 |
2023-01-03 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
CN110352244B
(zh)
|
2016-09-01 |
2023-03-21 |
ProQR治疗上市公司Ⅱ |
化学修饰的编辑rna的单链寡核苷酸
|
|
KR102622411B1
(ko)
|
2016-10-14 |
2024-01-10 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵염기 에디터의 aav 전달
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
EP3571300A1
(en)
|
2017-01-19 |
2019-11-27 |
ProQR Therapeutics II B.V. |
Oligonucleotide complexes for use in rna editing
|
|
US12390514B2
(en)
|
2017-03-09 |
2025-08-19 |
President And Fellows Of Harvard College |
Cancer vaccine
|
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
|
US11542496B2
(en)
|
2017-03-10 |
2023-01-03 |
President And Fellows Of Harvard College |
Cytosine to guanine base editor
|
|
KR20240116572A
(ko)
|
2017-03-23 |
2024-07-29 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
CN111801345A
(zh)
|
2017-07-28 |
2020-10-20 |
哈佛大学的校长及成员们 |
使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
|
|
US11970720B2
(en)
|
2017-08-22 |
2024-04-30 |
Salk Institute For Biological Studies |
RNA targeting methods and compositions
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
SG11202002481RA
(en)
|
2017-09-19 |
2020-04-29 |
Tropic Biosciences Uk Ltd |
Modifying the specificity of non-coding rna molecules for silencing gene expression in eukaryotic cells
|
|
AU2018338318B2
(en)
*
|
2017-09-21 |
2022-12-22 |
Massachusetts Institute Of Technology |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
WO2019071048A1
(en)
*
|
2017-10-04 |
2019-04-11 |
The Broad Institute, Inc. |
SYSTEMS, METHODS AND COMPOSITIONS FOR TARGETED NUCLEIC ACID EDITION
|
|
KR20250107288A
(ko)
|
2017-10-16 |
2025-07-11 |
더 브로드 인스티튜트, 인코퍼레이티드 |
아데노신 염기 편집제의 용도
|
|
WO2019084062A1
(en)
*
|
2017-10-23 |
2019-05-02 |
The Broad Institute, Inc. |
SYSTEMS, METHODS AND COMPOSITIONS FOR TARGETED NUCLEIC ACID EDITION
|
|
US12406749B2
(en)
|
2017-12-15 |
2025-09-02 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
EP3788155A1
(en)
|
2018-05-01 |
2021-03-10 |
Wake Forest University Health Sciences |
Lentiviral-based vectors and related systems and methods for eukaryotic gene editing
|
|
AU2019265019B2
(en)
|
2018-05-11 |
2025-11-06 |
Beam Therapeutics Inc. |
Methods of substituting pathogenic amino acids using programmable base editor systems
|
|
GB201808146D0
(en)
|
2018-05-18 |
2018-07-11 |
Proqr Therapeutics Ii Bv |
Stereospecific Linkages in RNA Editing Oligonucleotides
|
|
US12157760B2
(en)
|
2018-05-23 |
2024-12-03 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
US12522807B2
(en)
|
2018-07-09 |
2026-01-13 |
The Broad Institute, Inc. |
RNA programmable epigenetic RNA modifiers and uses thereof
|
|
WO2020043750A1
(en)
*
|
2018-08-28 |
2020-03-05 |
Roche Innovation Center Copenhagen A/S |
Neoantigen engineering using splice modulating compounds
|
|
EP3847254A4
(en)
|
2018-09-07 |
2022-08-10 |
Beam Therapeutics Inc. |
COMPOSITIONS AND METHODS FOR DELIVERING A NUCLEOBASE EDITING SYSTEM
|
|
WO2020051562A2
(en)
|
2018-09-07 |
2020-03-12 |
Beam Therapeutics Inc. |
Compositions and methods for improving base editing
|
|
AU2019343045A1
(en)
|
2018-09-18 |
2021-05-13 |
Vnv Newco Inc. |
ARC-based capsids and uses thereof
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
US12258594B2
(en)
|
2018-12-05 |
2025-03-25 |
The Broad Institute, Inc. |
Cas proteins with reduced immunogenicity and methods of screening thereof
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
US12398393B2
(en)
|
2019-01-28 |
2025-08-26 |
Proqr Therapeutics Ii B.V. |
RNA-editing oligonucleotides for the treatment of usher syndrome
|
|
US20220145297A1
(en)
*
|
2019-01-29 |
2022-05-12 |
The Regents Of The University Of California |
Rna-targeting cas enzymes
|
|
AU2020215730A1
(en)
*
|
2019-01-31 |
2021-07-29 |
Beam Therapeutics Inc. |
Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors
|
|
US20230140953A1
(en)
*
|
2019-02-13 |
2023-05-11 |
Beam Therapeutics Inc. |
Methods of editing a disease-associated gene using adenosine deaminase base editors, including for the treatment of genetic disease
|
|
CA3128755C
(en)
|
2019-02-13 |
2024-06-04 |
Beam Therapeutics Inc. |
Compositions and methods for treating hemoglobinopathies
|
|
KR20210126680A
(ko)
*
|
2019-02-13 |
2021-10-20 |
빔 테라퓨틱스, 인크. |
알파-1 항트립신 결핍증을 치료하기 위한 조성물 및 방법
|
|
WO2020168088A1
(en)
*
|
2019-02-13 |
2020-08-20 |
Beam Therapeutics Inc. |
Compositions and methods for treating glycogen storage disease type 1a
|
|
US20220098593A1
(en)
*
|
2019-02-13 |
2022-03-31 |
Beam Therapeutics Inc. |
Splice acceptor site disruption of a disease-associated gene using adenosine deaminase base editors, including for the treatment of genetic disease
|
|
CN120174005A
(zh)
|
2019-02-13 |
2025-06-20 |
比姆医疗股份有限公司 |
具有用于修饰靶标序列中核碱基的腺苷脱氨酶碱基编辑器的经修饰的免疫细胞
|
|
US20230053540A1
(en)
|
2019-02-19 |
2023-02-23 |
Massachusetts Institute Of Technology |
Treatment of liver injury
|
|
US12215382B2
(en)
|
2019-03-01 |
2025-02-04 |
The General Hospital Corporation |
Liver protective MARC variants and uses thereof
|
|
US20220154282A1
(en)
|
2019-03-12 |
2022-05-19 |
The Broad Institute, Inc. |
Detection means, compositions and methods for modulating synovial sarcoma cells
|
|
US12419915B2
(en)
|
2019-03-13 |
2025-09-23 |
The Broad Institute, Inc. |
Microglial progenitors for regeneration of functional microglia in the central nervous system and therapeutics uses thereof
|
|
GB201903520D0
(en)
*
|
2019-03-14 |
2019-05-01 |
Tropic Biosciences Uk Ltd |
Modifying the specificity of non-coding rna molecules for silencing genes in eukaryotic cells
|
|
EP3937969A1
(en)
|
2019-03-14 |
2022-01-19 |
The Broad Institute, Inc. |
Compositions and methods for modulating cgrp signaling to regulate intestinal innate lymphoid cells
|
|
EP3942023A1
(en)
|
2019-03-18 |
2022-01-26 |
The Broad Institute, Inc. |
Compositions and methods for modulating metabolic regulators of t cell pathogenicity
|
|
US12534714B2
(en)
|
2019-03-18 |
2026-01-27 |
The Broad Institute, Inc. |
Type VII CRISPR proteins and systems
|
|
US20220152148A1
(en)
|
2019-03-18 |
2022-05-19 |
The Broad Institute, Inc. |
Modulation of type 2 immunity by targeting clec-2 signaling
|
|
WO2020191233A1
(en)
|
2019-03-19 |
2020-09-24 |
The Broad Institute, Inc. |
Methods and compositions for editing nucleotide sequences
|
|
US20220195514A1
(en)
|
2019-03-29 |
2022-06-23 |
The Broad Institute, Inc. |
Construct for continuous monitoring of live cells
|
|
CN111793627A
(zh)
*
|
2019-04-08 |
2020-10-20 |
中国科学院上海生命科学研究院 |
利用人工构建rna编辑酶进行rna定点编辑及相关应用
|
|
US12473543B2
(en)
|
2019-04-17 |
2025-11-18 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
WO2020232271A1
(en)
|
2019-05-14 |
2020-11-19 |
The Broad Institute, Inc. |
Compositions and methods for targeting multinucleated cells
|
|
US20220251640A1
(en)
|
2019-05-17 |
2022-08-11 |
The Broad Institute, Inc. |
Methods of determination of genome architecture and epigenetic profile
|
|
US20220226464A1
(en)
|
2019-05-28 |
2022-07-21 |
Massachusetts Institute Of Technology |
Methods and compositions for modulating immune responses
|
|
WO2020243661A1
(en)
|
2019-05-31 |
2020-12-03 |
The Broad Institute, Inc. |
Methods for treating metabolic disorders by targeting adcy5
|
|
WO2021030627A1
(en)
|
2019-08-13 |
2021-02-18 |
The General Hospital Corporation |
Methods for predicting outcomes of checkpoint inhibition and treatment thereof
|
|
US12421557B2
(en)
|
2019-08-16 |
2025-09-23 |
The Broad Institute, Inc. |
Methods for predicting outcomes and treating colorectal cancer using a cell atlas
|
|
EP4047087A4
(en)
*
|
2019-08-19 |
2023-08-23 |
Southern Medical University |
CONSTRUCTION AND APPLICATION OF HIGH-FIDELITY CRISPR/ASCPF1 MUTANTS
|
|
CN110511286B
(zh)
*
|
2019-08-29 |
2022-08-02 |
上海科技大学 |
一种rna碱基编辑分子
|
|
WO2021046155A1
(en)
|
2019-09-03 |
2021-03-11 |
Voyager Therapeutics, Inc. |
Vectorized editing of nucleic acids to correct overt mutations
|
|
JP7738323B2
(ja)
*
|
2019-09-27 |
2025-09-12 |
学校法人福岡大学 |
オリゴヌクレオチド及び標的ｒｎａの部位特異的編集方法
|
|
EP4034138A4
(en)
*
|
2019-09-27 |
2024-07-31 |
Beam Therapeutics, Inc. |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS
|
|
US11981922B2
(en)
|
2019-10-03 |
2024-05-14 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
|
|
US12195725B2
(en)
|
2019-10-03 |
2025-01-14 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for modulating and detecting tissue specific TH17 cell pathogenicity
|
|
US11793787B2
(en)
|
2019-10-07 |
2023-10-24 |
The Broad Institute, Inc. |
Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
WO2021076060A1
(en)
*
|
2019-10-18 |
2021-04-22 |
Nanyang Technological University |
Programmable rna editing platform
|
|
US11844800B2
(en)
|
2019-10-30 |
2023-12-19 |
Massachusetts Institute Of Technology |
Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia
|
|
US12195723B2
(en)
|
2019-11-08 |
2025-01-14 |
The Broad Institute, Inc. |
Engineered antigen presenting cells and uses thereof
|
|
US20220330832A1
(en)
*
|
2019-11-27 |
2022-10-20 |
The Board Of Trustees Of The Leland Stanford Junior University |
Modulating Photosensitive Proteins with Mechanoluminescent Particles
|
|
AU2020395113A1
(en)
|
2019-12-02 |
2022-06-09 |
Shape Therapeutics Inc. |
Therapeutic editing
|
|
WO2021113264A1
(en)
*
|
2019-12-02 |
2021-06-10 |
The Regents Of The University Of California |
Engineering circular guide rnas
|
|
US12241830B2
(en)
|
2019-12-06 |
2025-03-04 |
Broad Institute, Inc. |
Living biosensors
|
|
US20230059753A1
(en)
*
|
2019-12-09 |
2023-02-23 |
Astellas Pharma Inc. |
Antisense guide rna with added functional region for editing target rna
|
|
WO2021119435A1
(en)
*
|
2019-12-12 |
2021-06-17 |
The Trustees Of The University Of Pennsylvania |
High performance platform for combinatorial genetic screening
|
|
IL292517A
(en)
*
|
2019-12-17 |
2022-06-01 |
Sigma Aldrich Co Llc |
Genome editing in Bacteroidetes
|
|
CA3158528A1
(en)
|
2019-12-23 |
2021-07-01 |
Jim SWILDENS |
Antisense oligonucleotides for nucleotide deamination in the treatment of stargardt disease
|
|
WO2021146641A1
(en)
|
2020-01-17 |
2021-07-22 |
The Broad Institute, Inc. |
Small type ii-d cas proteins and methods of use thereof
|
|
US12165747B2
(en)
|
2020-01-23 |
2024-12-10 |
The Broad Institute, Inc. |
Molecular spatial mapping of metastatic tumor microenvironment
|
|
CN115315519A
(zh)
|
2020-02-28 |
2022-11-08 |
辉大(上海)生物科技有限公司 |
VI-E型和VI-F型CRISPR-Cas系统及其用途
|
|
BR112022017704A2
(pt)
*
|
2020-03-04 |
2022-11-01 |
Suzhou Qi Biodesign Biotechnology Company Ltd |
Método e sistema de edição de genoma multiplex
|
|
EP4118206A1
(en)
*
|
2020-03-11 |
2023-01-18 |
The Broad Institute Inc. |
Stat3-targeted base editor therapeutics for the treatment of melanoma and other cancers
|
|
MX2022012683A
(es)
*
|
2020-04-09 |
2023-01-11 |
Verve Therapeutics Inc |
Edicion de bases de pcsk9 y metodos de uso de la misma para el tratamiento de enfermedades.
|
|
US20230346978A1
(en)
*
|
2020-04-14 |
2023-11-02 |
University Of Massachusetts |
Dcas13-mediated therapeutic rna base editing for in vivo gene therapy
|
|
IL297761A
(en)
|
2020-05-08 |
2022-12-01 |
Broad Inst Inc |
Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence
|
|
EP4150090A1
(en)
*
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of otoferlin (otof)
|
|
WO2021231685A1
(en)
*
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of transmembrane channel-like protein 1 (tmc1)
|
|
WO2021231698A1
(en)
*
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of argininosuccinate lyase (asl)
|
|
EP4150087A1
(en)
*
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of gap junction protein beta 2 (gjb2)
|
|
CA3187135A1
(en)
*
|
2020-06-30 |
2022-01-06 |
Pairwise Plants Services, Inc. |
Compositions, systems, and methods for base diversification
|
|
US20230272379A1
(en)
|
2020-07-06 |
2023-08-31 |
Edigene Therapeutics (Beijing ) Inc. |
Improved rna editing method
|
|
EP4192486A4
(en)
|
2020-08-07 |
2024-05-01 |
The Broad Institute, Inc. |
THERAPEUTIC TARGETING OF PHOSPHATE DISREGULATION IN CANCER VIA THE XPR1 PROTEIN COMPLEX: KIDINS220
|
|
CN112126645B
(zh)
*
|
2020-09-11 |
2021-06-01 |
广州吉赛生物科技股份有限公司 |
一种环形rna敲低方法及其应用
|
|
JP2023540797A
(ja)
*
|
2020-09-11 |
2023-09-26 |
メタゲノミ，インコーポレイテッド |
塩基編集酵素
|
|
CA3196831A1
(en)
|
2020-09-25 |
2022-03-31 |
Beam Therapeutics Inc. |
Fratricide resistant modified immune cells and methods of using the same
|
|
WO2022109275A2
(en)
*
|
2020-11-19 |
2022-05-27 |
Wake Forest University Health Sciences |
Vectors, systems and methods for eukaryotic gene editing
|
|
CN114560946B
(zh)
*
|
2020-11-27 |
2024-07-30 |
华东师范大学 |
无pam限制的腺嘌呤单碱基编辑产品、方法和应用
|
|
KR102685619B1
(ko)
*
|
2020-12-01 |
2024-07-17 |
한양대학교 산학협력단 |
티민-사이토신 서열 특이적 사이토신 교정 활성이 증진된 아데닌 염기교정 유전자가위 및 이의 용도
|
|
US20240150754A1
(en)
|
2020-12-25 |
2024-05-09 |
Astellas Pharma Inc. |
Guide rna for editing polyadenylation signal sequence of target rna
|
|
CN112877314B
(zh)
*
|
2021-03-08 |
2023-06-13 |
四川大学 |
一种诱导型碱基编辑系统及其应用
|
|
EP4330389A4
(en)
*
|
2021-04-30 |
2025-04-30 |
Alnylam Pharmaceuticals, Inc. |
RISC REORIENTATION FOR RNA EDITING
|
|
JP2024521811A
(ja)
|
2021-05-28 |
2024-06-04 |
サナ バイオテクノロジー，インコーポレイテッド |
短縮型ヒヒ内在性レトロウイルス（ＢａＥＶ）エンベロープ糖タンパク質を含む脂質粒子、ならびに関連する方法及び使用
|
|
CN115678872A
(zh)
*
|
2021-06-04 |
2023-02-03 |
中国科学院脑科学与智能技术卓越创新中心 |
新型Cas13蛋白及其筛选方法和应用
|
|
CN113667734B
(zh)
*
|
2021-07-16 |
2022-05-24 |
四川大学华西医院 |
Shank3片段序列甲基化检测试剂在制备精神分裂症诊断试剂盒中的用途
|
|
JP2024535677A
(ja)
|
2021-08-11 |
2024-10-02 |
サナ バイオテクノロジー，インコーポレイテッド |
即時血液媒介性炎症反応を減少させるための同種細胞療法を目的とした遺伝子改変細胞
|
|
AU2022325232A1
(en)
|
2021-08-11 |
2024-02-08 |
Sana Biotechnology, Inc. |
Genetically modified primary cells for allogeneic cell therapy
|
|
EP4384598A1
(en)
|
2021-08-11 |
2024-06-19 |
Sana Biotechnology, Inc. |
Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions
|
|
US20240358761A1
(en)
|
2021-08-11 |
2024-10-31 |
Sana Biotechnology, Inc. |
Genetically modified cells for allogeneic cell therapy
|
|
WO2023024504A1
(en)
*
|
2021-08-22 |
2023-03-02 |
Huigene Therapeutics Co., Ltd. |
Crispr-cas13 system for treating sod1-associated diseases
|
|
CN113519456B
(zh)
*
|
2021-08-27 |
2022-09-06 |
三江县连兴科技有限公司 |
一种五步蛇养殖方法
|
|
CN115772512B
(zh)
*
|
2021-09-07 |
2025-12-23 |
华东师范大学 |
腺嘌呤脱氨酶、包含其的腺嘌呤碱基编辑器及其应用
|
|
WO2023039373A2
(en)
*
|
2021-09-08 |
2023-03-16 |
The Regents Of The University Of California |
Crispr-cas effector polypeptides and method of use thereof
|
|
US20250102522A1
(en)
|
2021-10-07 |
2025-03-27 |
Hepatx Corporation |
Methods of tracking donor cells in a recipient
|
|
WO2023064923A2
(en)
*
|
2021-10-15 |
2023-04-20 |
Mammoth Biosciences, Inc. |
Fusion effector proteins and uses thereof
|
|
US20250313861A1
(en)
|
2021-10-22 |
2025-10-09 |
Sana Biotechnology, Inc. |
Methods of engineering allogeneic t cells with a transgene in a tcr locus and associated compositions and methods
|
|
CN116083398B
(zh)
*
|
2021-11-05 |
2024-01-05 |
广州瑞风生物科技有限公司 |
分离的Cas13蛋白及其应用
|
|
WO2023081855A1
(en)
|
2021-11-05 |
2023-05-11 |
Metagenomi, Inc. |
Base editing enzymes
|
|
CN116200368A
(zh)
*
|
2021-11-30 |
2023-06-02 |
上海科技大学 |
一种基于c2c9核酸酶的新型基因组编辑系统及其应用
|
|
US20250059239A1
(en)
|
2021-12-17 |
2025-02-20 |
Sana Biotechnology, Inc. |
Modified paramyxoviridae fusion glycoproteins
|
|
WO2023115041A1
(en)
|
2021-12-17 |
2023-06-22 |
Sana Biotechnology, Inc. |
Modified paramyxoviridae attachment glycoproteins
|
|
EP4463135A2
(en)
|
2022-01-10 |
2024-11-20 |
Sana Biotechnology, Inc. |
Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
|
|
CN114480491A
(zh)
*
|
2022-01-19 |
2022-05-13 |
南京市妇幼保健院 |
一种grin2a基因突变认知障碍小鼠模型的构建和应用
|
|
EP4472646A1
(en)
|
2022-02-01 |
2024-12-11 |
Sana Biotechnology, Inc. |
Cd3-targeted lentiviral vectors and uses thereof
|
|
WO2023150647A1
(en)
|
2022-02-02 |
2023-08-10 |
Sana Biotechnology, Inc. |
Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses
|
|
EP4479535A1
(en)
|
2022-02-14 |
2024-12-25 |
ProQR Therapeutics II B.V. |
Guide oligonucleotides for nucleic acid editing in the treatment of hypercholesterolemia
|
|
EP4479416A1
(en)
|
2022-02-17 |
2024-12-25 |
Sana Biotechnology, Inc. |
Engineered cd47 proteins and uses thereof
|
|
WO2023185878A1
(en)
*
|
2022-03-28 |
2023-10-05 |
Huidagene Therapeutics Co., Ltd. |
Engineered crispr-cas13f system and uses thereof
|
|
IL316038A
(en)
|
2022-04-04 |
2024-11-01 |
Univ California |
Preparations and methods for genetic complementation
|
|
CN114634923B
(zh)
*
|
2022-04-07 |
2024-02-23 |
尧唐(上海)生物科技有限公司 |
腺苷脱氨酶、碱基编辑器融合蛋白、碱基编辑器系统及用途
|
|
CN114774468B
(zh)
*
|
2022-04-20 |
2022-12-20 |
温氏食品集团股份有限公司 |
一种等位基因分子标记及抗蓝耳病猪群体组建方法
|
|
US20250382631A1
(en)
*
|
2022-05-20 |
2025-12-18 |
William Marsh Rice University |
Protac-cid systems for use in multiplex gene regulation
|
|
WO2023237063A1
(en)
*
|
2022-06-08 |
2023-12-14 |
Huidagene Therapeutics Co., Ltd. |
Novel guide nucleic acids for rna base editing systems and uses thereof
|
|
CN115820691B
(zh)
*
|
2022-07-25 |
2023-08-22 |
安徽农业大学 |
一种基于LbCpf1变体的水稻碱基编辑系统和应用
|
|
US20260055146A1
(en)
|
2022-08-24 |
2026-02-26 |
Sana Biotechnology, Inc. |
Delivery of heterologous proteins
|
|
US20260077026A1
(en)
*
|
2022-09-07 |
2026-03-19 |
The University Of Chicago |
Methods for treating cancer with hyperactive adar enzymes
|
|
WO2024064838A1
(en)
|
2022-09-21 |
2024-03-28 |
Sana Biotechnology, Inc. |
Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof
|
|
WO2024081820A1
(en)
|
2022-10-13 |
2024-04-18 |
Sana Biotechnology, Inc. |
Viral particles targeting hematopoietic stem cells
|
|
EP4601672A1
(en)
*
|
2022-10-14 |
2025-08-20 |
Spark Therapeutics, Inc. |
Gene editing for controlled expression of episomal genes
|
|
WO2024097313A1
(en)
|
2022-11-02 |
2024-05-10 |
Sana Biotechnology, Inc. |
Methods for producing t cell therapy products
|
|
WO2024119157A1
(en)
|
2022-12-02 |
2024-06-06 |
Sana Biotechnology, Inc. |
Lipid particles with cofusogens and methods of producing and using the same
|
|
CN118207185A
(zh)
*
|
2022-12-15 |
2024-06-18 |
上海科技大学 |
一种碱基编辑系统及碱基编辑方法
|
|
WO2024151541A1
(en)
|
2023-01-09 |
2024-07-18 |
Sana Biotechnology, Inc. |
Type-1 diabetes autoimmune mouse
|
|
WO2024192141A1
(en)
|
2023-03-13 |
2024-09-19 |
Dana-Farber Cancer Institute, Inc. |
Treatment of cancers having a drug-resistant mesenchymal cell state
|
|
WO2024197185A1
(en)
|
2023-03-21 |
2024-09-26 |
The Broad Institute, Inc. |
Methods and compositions for dissecting organelle physiology
|
|
EP4698666A1
(en)
|
2023-04-18 |
2026-02-25 |
Sana Biotechnology, Inc. |
Universal protein g fusogens and adapter systems thereof and related lipid particles and uses
|
|
WO2024220598A2
(en)
|
2023-04-18 |
2024-10-24 |
Sana Biotechnology, Inc. |
Lentiviral vectors with two or more genomes
|
|
WO2024220560A1
(en)
|
2023-04-18 |
2024-10-24 |
Sana Biotechnology, Inc. |
Engineered protein g fusogens and related lipid particles and methods thereof
|
|
WO2024226838A2
(en)
|
2023-04-25 |
2024-10-31 |
The Brigham And Women's Hospital, Inc. |
Treatment of autoimmune diseases having a pathogenic t cell state
|
|
AU2024264889A1
(en)
|
2023-05-03 |
2025-11-13 |
Sana Biotechnology, Inc. |
Methods of dosing and administration of engineered islet cells
|
|
EP4716541A2
(en)
|
2023-05-22 |
2026-04-01 |
Sana Biotechnology, Inc. |
Methods of delivery of islet cells and related methods
|
|
EP4716750A1
(en)
|
2023-05-23 |
2026-04-01 |
Sana Biotechnology, Inc. |
Tandem fusogens and related lipid particles
|
|
WO2025049788A1
(en)
|
2023-08-29 |
2025-03-06 |
The Broad Institute, Inc. |
Optical genetic screens of intracellular and intercellular transcriptional circuits with perturb-fish
|
|
CN117210435A
(zh)
*
|
2023-08-29 |
2023-12-12 |
苏州湃芮生物科技有限公司 |
一种用于调控rna甲基化修饰的编辑系统及其应用
|
|
WO2025054202A1
(en)
|
2023-09-05 |
2025-03-13 |
Sana Biotechnology, Inc. |
Method of screening a sample comprising a transgene with a unique barcode
|
|
WO2025059533A1
(en)
|
2023-09-13 |
2025-03-20 |
The Broad Institute, Inc. |
Crispr enzymes and systems
|
|
WO2025096916A1
(en)
|
2023-11-03 |
2025-05-08 |
The Broad Institute, Inc. |
Multi-site editing in living cells
|
|
WO2025129158A1
(en)
|
2023-12-15 |
2025-06-19 |
The Broad Institute, Inc. |
Engineered arc delivery vesicles and uses thereof
|
|
CN117778445B
(zh)
*
|
2023-12-31 |
2025-07-04 |
云南师范大学 |
毕赤酵母基因在提高毕赤酵母植酸酶酶活或表达量中的应用
|
|
WO2025151838A1
(en)
|
2024-01-12 |
2025-07-17 |
Sana Biotechnology, Inc. |
Safety switches to control in vitro and in vivo proliferation of cell therapy products
|
|
WO2025155911A1
(en)
|
2024-01-18 |
2025-07-24 |
Proqr Therapeutics Ii B.V. |
Antisense oligonucleotides for the treatment of hurler syndrome
|
|
WO2025166261A1
(en)
*
|
2024-02-01 |
2025-08-07 |
University Of Virginia Patent Foundation |
Method and system for calculating insulin dosing parameters in computer aided dosing
|
|
WO2025184529A1
(en)
|
2024-03-01 |
2025-09-04 |
Sana Biotechnology, Inc. |
Viral particles with fusogen display and related compositions and methods
|
|
WO2025206105A1
(ja)
*
|
2024-03-29 |
2025-10-02 |
株式会社Frest |
標的アデノシンに対する部位特異的編集を誘導するオリゴヌクレオチド
|
|
WO2025212519A1
(en)
|
2024-04-01 |
2025-10-09 |
Moonlight Bio, Inc. |
Dll3 binding proteins and uses thereof
|
|
WO2025250808A1
(en)
|
2024-05-29 |
2025-12-04 |
The Brigham And Women’S Hospital, Inc. |
Anti-crispr delivery compositions and methods
|