JP2020525492A - イモーテルのエッセンシャルオイル及びオリガヌムの抽出物を含む化粧品組成物 - Google Patents
イモーテルのエッセンシャルオイル及びオリガヌムの抽出物を含む化粧品組成物 Download PDFInfo
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/591—Mixtures of compounds not provided for by any of the codes A61K2800/592 - A61K2800/596
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- Cosmetics (AREA)
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Abstract
Description
−飽和直鎖C2−C10(好ましくはC6−C10)の酸及び飽和直鎖C10−C18(好ましくはC10−C14)のモノアルコールのモノ及びポリエステル、飽和直鎖C10−C20の酸及び分岐又は不飽和C3−C20(好ましくはC3−C10)のモノアルコールのモノ及びポリエステル;分岐又は不飽和C5−C20の酸及び分岐又は不飽和C5−C20のモノアルコールのモノ及びポリエステル;分岐又は不飽和C5−C20の酸及び直鎖C2−C4のモノアルコールのモノ及びポリエステルから選択される酸及びモノアルコールのエステル;
−カプリル酸及びカプリン酸トリグリセリド及びトリヘプタノインなどのC6−C12の脂肪酸トリグリセリド;
−(リノール酸、ラウリン酸、及びミリスチン酸などの)分岐及び/又は不飽和C10−C20脂肪酸;
−(オクチルドデカノール及びオレイルアルコールなどの)分岐及び/又は不飽和C10−C20脂肪アルコール;
−特にオリーブオイルから抽出される植物性スクワラン(C30)及びヘミスクワラン(C15)などの炭化水素;
−炭酸ジカプリリル及び炭酸ジエチルヘキシルなどの炭酸ジアルキル;
−ジカプリリルエーテルなどのジアルキルエーテル;並びに
−それらの混合物が挙げられる。
−多糖粉末、具体的に天然デンプン粉末、変性デンプン粉末又はセルロース粉末;ポリ(メチルメタクリレート)などのアクリルポリマー、ポリアミド、又はポリオレフィンの粉末;サンゴモなどの乾燥藻の粉末;などの有機充填剤;
−シリカ、クレイ、パーライト及びタルクなどの無機充填剤;
−並びにそれらの混合物から選択され得る。
トランスクリプトーム分析を、皮膚内に特定の遺伝子の発現において、本発明による植物の組み合わせの効果を示すために、行った。
サンプル調整
マヨラナ種(Origanum majorana)の葉の水性抽出物、水蒸気蒸留により得られた、イモーテル(Helichrysum italicum)のエッセンシャルオイル、又は二つの抽出物の組み合わせを、活着条件の下、皮膚外植体の存在中に置いた。イモーテルのエッセンシャルオイルを、培地中に塗布される前に、ジメチルスルホキシド(DMSO)中に10%で溶解させた。マヨラナ抽出物を培地に直接希釈した。
培養後、皮膚外植体を、RNeasy RNA抽出ミニキット(Qiagen, Hilden,ドイツ)の製作者により推薦される緩衝液内に置き、その後総RNAを同様のキットを使用して抽出した。総RNAを定量化し、その後その質を、BIOanalyzer2100電気泳動装置とそのRNA 6000 Nano LabChip Kit分析キット(Agilent Technologies, Santa Clara,アメリカ)を使用して検証した。
1”x3”のガラスカバーガラス(SurePrint G3 Human Gene Expression 8x60K v2 Microarray - G4851B, Agilent Technologies, Santa Clara, アメリカ)上の60量体のオリヌクレオチドチップを遺伝子発現分析に使用した。
2a)抗酸化防御:Nrf2経路の活性
下記表は、マヨナラ抽出物、イモーテルのエッセンシャルオイル及びそれらの組み合わせでの皮膚外植体の処理を受けて、抗酸化防御のNrf2経路に関する遺伝子の発現の差異を表す。
下記表3は、マヨナラ抽出物、イモーテルのエッセンシャルオイル及びそれらの組み合わせでの皮膚外植体の処理を受けて、表皮分化に関する遺伝子の発現の差異を表す。
DNAチップを用いて生体外トランスクリプトーム分析の方法により、本実施例は、本発明の組成物が、表皮の再生、及び酸化的ストレス管理に特に関する遺伝子を刺激することを可能にし、それにより、特に、酸化的ストレスを生む外部刺激による、皮膚の老化に対抗すること、及び皮膚のバリア機能を強化することを可能にすることを示した。
下記組成物を、当業者にとって従来の方法で、下記に示される質量比で原料を混合することにより、調整した。
Claims (8)
- イモーテルのエッセンシャルオイル及びオリガヌム(origanum)属の少なくとも一つの植物のテルペン抽出物を含む、化粧品組成物。
- 前記イモーテルが、カレープラント(Helichrysum italicum)、ヘリクリスムアレナリウム(Helichrysum arenarium)及びヘリクリスムストエカス(Helichrysum stoechas)から選択され、好ましくはカレープラントであることを特徴とする、請求項1に記載の組成物。
- 前記イモーテルのエッセンシャルオイルが、植物の地上部分(aerial parts)、特に花又は頭花から得られることを特徴とする、請求項1又は2に記載の組成物。
- 前記オリガヌム属の植物が、マヨラナ(Origanum majorana)種に属することを特徴とする、請求項1〜3のいずれか一項に記載の組成物。
- 前記オリガヌムの抽出物が、茎、葉及びそれらの混合物、より好ましくは葉から選択される植物の地上部分から得られることを特徴とする、請求項1〜4のいずれか一項に記載の組成物。
- 前記オリガヌム(origanum)の抽出物が、水、(エタノール又はイソプロパノールなどの)モノアルコール、(プロピレングリコール又はブチレングリコールなどの)グリコール、(キシリトールなどの)ポリオールおよびそれらの混合物から選択される、少なくとも一つの溶媒を含む、好ましくはからなる、プロトン性極性溶媒を使用した抽出により得られることを特徴とする、請求項1〜5のいずれか一項に記載の組成物。
- 特に、UV照射及び/若しくはブルーライト、喫煙、並びに/又は汚染への暴露により引き起こされる、皮膚老化の兆候、特にしわの形成、皮膚のたるみ及び顔色の輝きの減少に対抗するための、及び/又は皮膚の乾燥に対抗するための、請求項1〜6のいずれか一項に記載の組成物の使用。
- 特に、UV照射及び/若しくはブルーライト、喫煙、並びに/又は汚染への暴露により引き起こされる、皮膚老化の兆候、特にしわの形成、皮膚のたるみ及び顔色の輝きの減少に対抗するための、及び/又は皮膚の乾燥に対抗するための、請求項1〜6のいずれか一項に記載の組成物を皮膚に局所的に塗布することを含む、化粧方法。
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FR1756021 | 2017-06-29 | ||
FR1756021A FR3068251B1 (fr) | 2017-06-29 | 2017-06-29 | Composition cosmetique comprenant une huile essentielle d'immortelle et un extrait d'origanum |
PCT/FR2018/051412 WO2019002714A1 (fr) | 2017-06-29 | 2018-06-14 | Composition cosmétique comprenant une huile essentielle d'immortelle et un extrait d'origanum |
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US (1) | US11376296B2 (ja) |
EP (1) | EP3645127B1 (ja) |
JP (1) | JP7239500B2 (ja) |
CN (1) | CN110913957B (ja) |
ES (1) | ES2927568T3 (ja) |
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WO (1) | WO2019002714A1 (ja) |
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WO2020242516A1 (en) | 2019-05-27 | 2020-12-03 | Codex Beauty Llc | Skin treatment composition and preservation system |
CN113905717A (zh) * | 2019-06-14 | 2022-01-07 | 蔻代丝美妆股份有限公司 | 用于治疗氧化应激和恢复皮肤健康的天然护肤组合物及方法 |
US11141373B2 (en) | 2019-06-14 | 2021-10-12 | Codex Beauty Corporation | Natural skin care compositions and methods for treating oxidative stress and restoring skin health |
US11141374B2 (en) | 2019-06-14 | 2021-10-12 | Codex Beauty Corporation | Natural skin care compositions and methods for treating oxidative stress and restoring skin health |
JP7328073B2 (ja) * | 2019-08-20 | 2023-08-16 | 株式会社ノエビア | Clsp及び/又はtincr発現促進剤 |
CN111700830B (zh) * | 2020-06-29 | 2022-07-22 | 广州睿森生物科技有限公司 | 一种组合物及其在制备抗糖基化的化妆品中的应用 |
CN111991258B (zh) * | 2020-10-12 | 2022-06-14 | 上海辉文生物技术股份有限公司 | 一种皮肤解毒和抗氧化组合物及其应用 |
CN113735922B (zh) * | 2021-10-22 | 2024-03-01 | 河南大学 | 一种从墨角兰中提取木脂素类或萜类化合物的方法 |
CN114392219B (zh) * | 2022-01-29 | 2023-07-28 | 清远市望莎生物科技有限公司 | 具有舒缓功效的牡丹提取物组合物及其制备方法与应用 |
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CN110913957A (zh) | 2020-03-24 |
CN110913957B (zh) | 2022-12-02 |
US20200113959A1 (en) | 2020-04-16 |
EP3645127A1 (fr) | 2020-05-06 |
US11376296B2 (en) | 2022-07-05 |
JP7239500B2 (ja) | 2023-03-14 |
WO2019002714A1 (fr) | 2019-01-03 |
FR3068251B1 (fr) | 2019-08-23 |
ES2927568T3 (es) | 2022-11-08 |
FR3068251A1 (fr) | 2019-01-04 |
EP3645127B1 (fr) | 2022-07-20 |
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