JP2020521761A5 - - Google Patents
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- JP2020521761A5 JP2020521761A5 JP2019565281A JP2019565281A JP2020521761A5 JP 2020521761 A5 JP2020521761 A5 JP 2020521761A5 JP 2019565281 A JP2019565281 A JP 2019565281A JP 2019565281 A JP2019565281 A JP 2019565281A JP 2020521761 A5 JP2020521761 A5 JP 2020521761A5
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- human subject
- antigen
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- 238000000034 method Methods 0.000 claims 4
- 208000002389 Pouchitis Diseases 0.000 claims 3
- 230000001684 chronic effect Effects 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 230000009266 disease activity Effects 0.000 claims 1
Claims (1)
- ヒト対象における慢性回腸嚢炎を治療する方法であって、前記方法が、慢性回腸嚢炎を有するヒト対象を選択することと、慢性回腸嚢炎が治療されるように、治療的有効用量の抗α４β７抗体、またはその抗原結合断片を前記対象に投与することと、を含み、前記抗α４β７抗体、またはその抗原結合断片が、配列番号４に記載されるＣＤＲ３ドメイン、配列番号３に記載されるＣＤＲ２ドメイン、及び配列番号２に記載されるＣＤＲ１ドメインを含む重鎖可変領域を含み、かつ配列番号８に記載されるＣＤＲ３ドメイン、配列番号７に記載されるＣＤＲ２ドメイン、及び配列番号６に記載されるＣＤＲ１ドメインを含む軽鎖可変領域を含み、前記ヒト対象が、選択時に６の内視鏡的回腸嚢炎疾患活性指数（ＰＤＡＩ）サブスコアを有しており、及び／または選択時にＴＮＦαナイーブであった、前記方法。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024022711A JP2024069230A (ja) | 2017-05-26 | 2024-02-19 | 慢性回腸嚢炎の治療のための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762511832P | 2017-05-26 | 2017-05-26 | |
| US62/511,832 | 2017-05-26 | ||
| PCT/IB2018/053760 WO2018215995A1 (en) | 2017-05-26 | 2018-05-26 | Methods for the treatment of chronic pouchitis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024022711A Division JP2024069230A (ja) | 2017-05-26 | 2024-02-19 | 慢性回腸嚢炎の治療のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020521761A JP2020521761A (ja) | 2020-07-27 |
| JP2020521761A5 true JP2020521761A5 (ja) | 2021-07-26 |
| JP7497159B2 JP7497159B2 (ja) | 2024-06-10 |
Family
ID=64395342
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019565281A Active JP7497159B2 (ja) | 2017-05-26 | 2018-05-26 | 慢性回腸嚢炎の治療のための方法 |
| JP2024022711A Pending JP2024069230A (ja) | 2017-05-26 | 2024-02-19 | 慢性回腸嚢炎の治療のための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024022711A Pending JP2024069230A (ja) | 2017-05-26 | 2024-02-19 | 慢性回腸嚢炎の治療のための方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20200087401A1 (ja) |
| EP (1) | EP3630184A4 (ja) |
| JP (2) | JP7497159B2 (ja) |
| KR (1) | KR20200011457A (ja) |
| AU (1) | AU2018274749A1 (ja) |
| BR (1) | BR112019024875A2 (ja) |
| CA (1) | CA3065000A1 (ja) |
| IL (1) | IL270819A (ja) |
| MX (1) | MX2019014090A (ja) |
| RU (1) | RU2019143659A (ja) |
| WO (1) | WO2018215995A1 (ja) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170327584A1 (en) | 2014-11-26 | 2017-11-16 | Millennium Pharmaceuticals, Inc. | Vedolizumab for the Treatment of Fistulizing Crohn's Disease |
| WO2023163883A1 (en) * | 2022-02-22 | 2023-08-31 | First Wave BioPharma, Inc. | Compositions and methods for treating pouchitis |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6551593B1 (en) * | 1995-02-10 | 2003-04-22 | Millennium Pharmaceuticals, Inc. | Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through α 4 β 7 and its ligands and madcam |
| UA116189C2 (uk) * | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| WO2016105572A1 (en) * | 2014-12-24 | 2016-06-30 | Millennium Pharmaceuticals, Inc. | PREDICTING OUTCOME OF TREATMENT WITH AN ANTI-α4β7 INTEGRIN ANTIBODY |
-
2018
- 2018-05-26 MX MX2019014090A patent/MX2019014090A/es unknown
- 2018-05-26 JP JP2019565281A patent/JP7497159B2/ja active Active
- 2018-05-26 WO PCT/IB2018/053760 patent/WO2018215995A1/en unknown
- 2018-05-26 EP EP18806578.3A patent/EP3630184A4/en active Pending
- 2018-05-26 RU RU2019143659A patent/RU2019143659A/ru unknown
- 2018-05-26 US US16/617,254 patent/US20200087401A1/en not_active Abandoned
- 2018-05-26 CA CA3065000A patent/CA3065000A1/en active Pending
- 2018-05-26 KR KR1020197037702A patent/KR20200011457A/ko not_active Application Discontinuation
- 2018-05-26 BR BR112019024875-7A patent/BR112019024875A2/pt unknown
- 2018-05-26 AU AU2018274749A patent/AU2018274749A1/en active Pending
-
2019
- 2019-11-21 IL IL270819A patent/IL270819A/en unknown
-
2022
- 2022-03-18 US US17/655,541 patent/US20230043949A1/en active Pending
-
2024
- 2024-02-19 JP JP2024022711A patent/JP2024069230A/ja active Pending
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