|
JP3101690B2
(ja)
|
1987-03-18 |
2000-10-23 |
エス・ビィ・2・インコーポレイテッド |
変性抗体の、または変性抗体に関する改良
|
|
US7247302B1
(en)
|
1996-08-02 |
2007-07-24 |
Bristol-Myers Squibb Company |
Method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis
|
|
ES2308787T3
(es)
|
1996-08-16 |
2008-12-01 |
Schering Corporation |
Antigenos de superficie de celular de mamiferos; reactivos relacionados.
|
|
US6111090A
(en)
|
1996-08-16 |
2000-08-29 |
Schering Corporation |
Mammalian cell surface antigens; related reagents
|
|
WO2001040464A1
(en)
|
1999-11-30 |
2001-06-07 |
Genentech, Inc. |
Interleukin-1-receptor associated kinase-3 (irak3) and its use in promotion or inhibition of angiogenesis and cardiovascularization
|
|
GB9625074D0
(en)
|
1996-12-02 |
1997-01-22 |
Pharmacia & Upjohn Spa |
Receptor belonging to the TNF/NGF receptor family
|
|
WO2000032778A2
(en)
|
1998-12-01 |
2000-06-08 |
Genentech, Inc. |
Methods and compositions for inhibiting neoplastic cell growth
|
|
JP2001520039A
(ja)
|
1997-10-21 |
2001-10-30 |
ヒューマン ジノーム サイエンシーズ, インコーポレイテッド |
ヒト腫瘍壊死因子レセプター様タンパク質、tr11,tr11sv1およびtr11sv2
|
|
WO1999025834A1
(en)
|
1997-11-18 |
1999-05-27 |
Genentech, Inc. |
Dna19355 polypeptide, a tumor necrosis factor homolog
|
|
AU2591599A
(en)
|
1998-02-09 |
1999-08-23 |
Genentech Inc. |
Novel tumor necrosis factor receptor homolog and nucleic acids encoding the same
|
|
EP1095142A2
(en)
|
1998-07-22 |
2001-05-02 |
Incyte Pharmaceuticals, Inc. |
Molecules associated with cell proliferation
|
|
JP3695642B2
(ja)
|
1998-12-01 |
2005-09-14 |
ジェネンテック・インコーポレーテッド |
血管形成及び心臓血管新生の促進又は阻害
|
|
WO2000050459A1
(en)
|
1999-02-24 |
2000-08-31 |
Human Genome Sciences, Inc. |
Human tumor necrosis factor receptor-like proteins tr11, tr11sv1, and tr11sv2
|
|
WO2001003720A2
(en)
|
1999-07-12 |
2001-01-18 |
Genentech, Inc. |
Promotion or inhibition of angiogenesis and cardiovascularization by tumor necrosis factor ligand/receptor homologs
|
|
JP5004390B2
(ja)
|
1999-08-23 |
2012-08-22 |
デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド |
新規b7−4分子およびその用途
|
|
PL354286A1
(en)
|
1999-08-23 |
2003-12-29 |
Dana-Farber Cancer Institutedana-Farber Cancer Institute |
Pd-1, a receptor for b7-4, and uses therefor
|
|
AU783473B2
(en)
|
1999-12-23 |
2005-10-27 |
Zymogenetics Inc. |
Soluble interleukin-20 receptor
|
|
EP1244708B8
(en)
|
1999-12-23 |
2007-03-07 |
ZymoGenetics, Inc. |
Method for treating inflammation
|
|
WO2001075166A2
(en)
|
2000-03-31 |
2001-10-11 |
Genentech, Inc. |
Compositions and methods for detecting and quantifying gene expression
|
|
AU2001274888A1
(en)
|
2000-05-19 |
2001-12-03 |
Human Genome Sciences, Inc. |
Nucleic acids, proteins, and antibodies
|
|
ATE333888T1
(de)
|
2000-09-15 |
2006-08-15 |
Zymogenetics Inc |
Verwendung eines polypeptids, welches die extrazelluläre domäne von il-20ra und il-20rb enthält, zur behandlung von entzündungen
|
|
EP1399472B1
(en)
|
2001-03-09 |
2009-06-03 |
ZymoGenetics, Inc. |
Soluble heterodimeric cytokine receptor
|
|
WO2003006058A1
(en)
|
2001-07-12 |
2003-01-23 |
Wyeth |
Cd25+ differential markers and uses thereof
|
|
AUPS054702A0
(en)
|
2002-02-14 |
2002-03-07 |
Immunaid Pty Ltd |
Cancer therapy
|
|
IL149820A0
(en)
|
2002-05-23 |
2002-11-10 |
Curetech Ltd |
Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
|
|
US20060281146A1
(en)
|
2002-09-11 |
2006-12-14 |
Genetech, Inc. |
Novel compositions and methods for the treatment of immune related diseases
|
|
EP2322200A3
(en)
|
2002-10-29 |
2011-07-27 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
JP2011516026A
(ja)
|
2002-11-26 |
2011-05-26 |
ジェネンテック・インコーポレーテッド |
免疫関連疾患の治療のための組成物と方法
|
|
CN101899114A
(zh)
|
2002-12-23 |
2010-12-01 |
惠氏公司 |
抗pd-1抗体及其用途
|
|
US7618632B2
(en)
|
2003-05-23 |
2009-11-17 |
Wyeth |
Method of treating or ameliorating an immune cell associated pathology using GITR ligand antibodies
|
|
WO2005007190A1
(en)
|
2003-07-11 |
2005-01-27 |
Schering Corporation |
Agonists or antagonists of the clucocorticoid-induced tumour necrosis factor receptor (gitr) or its ligand for the treatment of immune disorders, infections and cancer
|
|
GB0407315D0
(en)
|
2003-07-15 |
2004-05-05 |
Cambridge Antibody Tech |
Human antibody molecules
|
|
WO2005019258A2
(en)
|
2003-08-11 |
2005-03-03 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
WO2005052001A2
(en)
|
2003-11-21 |
2005-06-09 |
Zymogenetics, Inc. |
Anti-il-20 receptor antibodies and binding partners and methods of using in inflammation
|
|
PT1737891E
(pt)
|
2004-04-13 |
2013-04-16 |
Hoffmann La Roche |
Anticorpos anti p-selectina
|
|
CA2585776A1
(en)
|
2004-10-29 |
2006-05-11 |
University Of Southern California |
Combination cancer immunotherapy with co-stimulatory molecules
|
|
US20060099171A1
(en)
|
2004-11-05 |
2006-05-11 |
Masahide Tone |
Mouse glucocorticoid-induced TNF receptor ligand is costimulatory for T cells
|
|
US20090145493A1
(en)
|
2004-11-23 |
2009-06-11 |
Pip Co., Ltd. |
Built-in wall water service box
|
|
AU2006206343A1
(en)
|
2005-01-19 |
2006-07-27 |
Genzyme Corporation |
GITR antibodies for the diagnosis of NSCLC
|
|
PT2343320T
(pt)
|
2005-03-25 |
2018-01-23 |
Gitr Inc |
Anticorpos anti-gitr e as suas utilizações
|
|
DK2439273T3
(da)
|
2005-05-09 |
2019-06-03 |
Ono Pharmaceutical Co |
Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika
|
|
WO2006124269A2
(en)
|
2005-05-16 |
2006-11-23 |
Amgen Fremont Inc. |
Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders
|
|
JP4984160B2
(ja)
|
2005-06-07 |
2012-07-25 |
国立大学法人 東京大学 |
抗体の作製方法
|
|
CA2611814A1
(en)
|
2005-06-20 |
2007-01-04 |
Medarex, Inc. |
Cd19 antibodies and their uses
|
|
PT1907424E
(pt)
|
2005-07-01 |
2015-10-09 |
Squibb & Sons Llc |
Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1)
|
|
EP2441846A3
(en)
|
2006-01-09 |
2012-07-25 |
The Regents Of the University of California |
Immunostimulatory combinations of TNFRSF, TLR, NLR, RHR, purinergic receptor, and cytokine receptor agoinsts for vaccines and tumor immunotherapy
|
|
WO2007133822A1
(en)
|
2006-01-19 |
2007-11-22 |
Genzyme Corporation |
Gitr antibodies for the treatment of cancer
|
|
PT2099823E
(pt)
|
2006-12-01 |
2014-12-22 |
Seattle Genetics Inc |
Agentes de ligação ao alvo variantes e suas utilizações
|
|
CL2007003622A1
(es)
|
2006-12-13 |
2009-08-07 |
Medarex Inc |
Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales.
|
|
JP2008278814A
(ja)
|
2007-05-11 |
2008-11-20 |
Igaku Seibutsugaku Kenkyusho:Kk |
アゴニスティック抗ヒトgitr抗体による免疫制御の解除とその応用
|
|
KR20080105674A
(ko)
|
2007-05-31 |
2008-12-04 |
울산대학교 산학협력단 |
항-마우스 gitrl 단일클론 항체 또는 항-인간aitrl 단일클론 항체 및 이를 유효성분으로 함유하는염증성 장질환의 예방 및 치료용 조성물
|
|
BR122017025062B8
(pt)
|
2007-06-18 |
2021-07-27 |
Merck Sharp & Dohme |
anticorpo monoclonal ou fragmento de anticorpo para o receptor de morte programada humano pd-1, polinucleotídeo e composição compreendendo o referido anticorpo ou fragmento
|
|
US8591886B2
(en)
|
2007-07-12 |
2013-11-26 |
Gitr, Inc. |
Combination therapies employing GITR binding molecules
|
|
WO2009014708A2
(en)
|
2007-07-23 |
2009-01-29 |
Cell Genesys, Inc. |
Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof
|
|
ES2526355T3
(es)
|
2007-10-01 |
2015-01-09 |
Bristol-Myers Squibb Company |
Anticuerpos humanos que se adhieren a mesotelina, y usos de los mismos
|
|
CL2008003526A1
(es)
|
2007-11-30 |
2010-01-11 |
Medarex Inc |
Conjugado de anticuerpo-molécula asociada que comprende un anticuerpo monoclonal humano anti b7-h4/08e/b7x/b7s1/bl-cam/b3/leu-14/lyb-8 humana; composición que lo comprende; método in vitro de inhibición de célula tumoral que expresa b7-h4/08e/b7x/b7s1/bl-cam/b3/leu-14/lyb-8; y uso para tratar cancer.
|
|
CL2008003527A1
(es)
|
2007-11-30 |
2009-10-09 |
Medarex Inc |
Conjugado de anticuerpo o porcion de union de antigeno del mismo, que se une a la proteina tirosina quinasa 7 (ptk-7/cck4); composicion que lo comprende; acido nulceico cidificante del anticuerpo; vector y celula huesped; uso del conjugado para tratar o prevenir una enfermedad de celulas tumorales que expresan ptk7
|
|
KR20160070165A
(ko)
|
2008-02-08 |
2016-06-17 |
메디뮨 엘엘씨 |
Fc 리간드 친화성이 감소된 항-IFNAR1 항체
|
|
EP2262837A4
(en)
|
2008-03-12 |
2011-04-06 |
Merck Sharp & Dohme |
PD-1 BINDING PROTEINS
|
|
EP2604279A1
(en)
|
2008-03-27 |
2013-06-19 |
ZymoGenetics, Inc. |
Compositions and methods for inhibiting PDGFRBETA and VEGF-A
|
|
AR072999A1
(es)
|
2008-08-11 |
2010-10-06 |
Medarex Inc |
Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
|
|
AU2009288730B2
(en)
|
2008-08-25 |
2013-06-20 |
Amplimmune, Inc. |
Compositions of PD-1 antagonists and methods of use
|
|
EP3255060A1
(en)
|
2008-12-09 |
2017-12-13 |
F. Hoffmann-La Roche AG |
Anti-pd-l1 antibodies and their use to enhance t-cell function
|
|
KR101790802B1
(ko)
|
2009-09-03 |
2017-10-27 |
머크 샤프 앤드 돔 코포레이션 |
항-gitr 항체
|
|
US10150808B2
(en)
|
2009-09-24 |
2018-12-11 |
Chugai Seiyaku Kabushiki Kaisha |
Modified antibody constant regions
|
|
PL2504364T3
(pl)
|
2009-11-24 |
2017-12-29 |
Medimmune Limited |
Ukierunkowane środki wiążące przeciwko B7-H1
|
|
CA3253628A1
(en)
|
2010-03-05 |
2025-11-29 |
The Johns Hopkins University |
Compositions and methods for targeted immunomodulatory antibodies and fusion proteins
|
|
JP2013528357A
(ja)
|
2010-03-29 |
2013-07-11 |
ザイムワークス,インコーポレイテッド |
強化又は抑制されたエフェクター機能を有する抗体
|
|
US8907053B2
(en)
|
2010-06-25 |
2014-12-09 |
Aurigene Discovery Technologies Limited |
Immunosuppression modulating compounds
|
|
AU2011283694B2
(en)
|
2010-07-29 |
2017-04-13 |
Xencor, Inc. |
Antibodies with modified isoelectric points
|
|
WO2012087928A2
(en)
|
2010-12-20 |
2012-06-28 |
The Rockefeller University |
Modulating agonistic tnfr antibodies
|
|
WO2012098113A1
(en)
|
2011-01-17 |
2012-07-26 |
Novo Nordisk A/S |
Il-21 ligands
|
|
PT2691112T
(pt)
*
|
2011-03-31 |
2018-07-10 |
Merck Sharp & Dohme |
Formulações estáveis de anticorpos para o recetor pd-1 humano de morte programada e tratamentos relacionados
|
|
JP6072771B2
(ja)
|
2011-04-20 |
2017-02-01 |
メディミューン,エルエルシー |
B7−h1およびpd−1に結合する抗体およびその他の分子
|
|
US9574002B2
(en)
|
2011-06-06 |
2017-02-21 |
Amgen Inc. |
Human antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor
|
|
CA2840018C
(en)
|
2011-07-24 |
2019-07-16 |
Curetech Ltd. |
Variants of humanized immunomodulatory monoclonal antibodies
|
|
MX368257B
(es)
|
2011-08-01 |
2019-09-26 |
Genentech Inc |
Antagonistas de unión al eje pd-1e inhibidores de mek y sus usos en el tratamiento de cáncer.
|
|
WO2013039954A1
(en)
|
2011-09-14 |
2013-03-21 |
Sanofi |
Anti-gitr antibodies
|
|
WO2013043569A1
(en)
|
2011-09-20 |
2013-03-28 |
Vical Incorporated |
Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
|
|
KR101764096B1
(ko)
|
2011-11-28 |
2017-08-02 |
메르크 파텐트 게엠베하 |
항-pd-l1 항체 및 그의 용도
|
|
US20150073043A1
(en)
|
2012-01-19 |
2015-03-12 |
Institut Pasteur Of Shanghai, Chinese Academy Of Sciences |
Use of phosphorylation pathway-related factor in regulating function of regulatory t cell
|
|
WO2013119202A1
(en)
*
|
2012-02-06 |
2013-08-15 |
Providence Health & Services - Oregon |
Cancer treatment and monitoring methods using ox40 agonists
|
|
HK1203971A1
(en)
|
2012-05-15 |
2015-11-06 |
Bristol-Myers Squibb Company |
Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
|
|
US8945553B2
(en)
|
2012-05-22 |
2015-02-03 |
Bristol-Myers Squibb Company |
Bispecific antibodies to IL-23 and IL-17A/F
|
|
KR101566539B1
(ko)
|
2012-06-08 |
2015-11-05 |
국립암센터 |
신규한 Th2 세포 전환용 에피토프 및 이의 용도
|
|
EP3508215A3
(en)
|
2012-12-03 |
2019-10-02 |
Bristol-Myers Squibb Company |
Enhancing anti-cancer activity of immunomodulatory fc fusion proteins
|
|
WO2015116178A1
(en)
|
2014-01-31 |
2015-08-06 |
Thomas Jefferson University |
Fusion proteins for modulating regulatory and effector t cells
|
|
AR097306A1
(es)
*
|
2013-08-20 |
2016-03-02 |
Merck Sharp & Dohme |
Modulación de la inmunidad tumoral
|
|
TW201605896A
(zh)
|
2013-08-30 |
2016-02-16 |
安美基股份有限公司 |
Gitr抗原結合蛋白
|
|
JP6595458B2
(ja)
|
2013-09-20 |
2019-10-23 |
ブリストル−マイヤーズ スクイブ カンパニー |
腫瘍を処置するための抗lag−3抗体と抗pd−1抗体との組合せ
|
|
PE20170255A1
(es)
*
|
2014-01-24 |
2017-03-22 |
Dana Farber Cancer Inst Inc |
Moleculas de anticuerpo que se unen a pd-1 y usos de las mismas
|
|
SI3148579T1
(sl)
|
2014-05-28 |
2021-07-30 |
Agenus Inc. |
Proti GITR antitelesa in postopki z njihovo uporabo
|
|
PE20170441A1
(es)
|
2014-06-06 |
2017-04-26 |
Bristol Myers Squibb Co |
Anticuerpos contra el receptor del factor de necrosis tumoral inducido por glucocorticoides (gitr) y sus usos
|
|
RU2017115315A
(ru)
|
2014-10-03 |
2018-11-08 |
Дана-Фарбер Кэнсер Инститьют, Инк. |
Антитела к рецептору глюкокортикоид-индуцированного фактора некроза опухоли (gitr) и способы их применения
|
|
MA41044A
(fr)
|
2014-10-08 |
2017-08-15 |
Novartis Ag |
Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
|
|
CN105669867A
(zh)
|
2014-11-21 |
2016-06-15 |
上海中信国健药业股份有限公司 |
抗gitr/ctla-4双特异性抗体及其制备方法和用途
|
|
JP6668345B2
(ja)
|
2014-11-21 |
2020-03-18 |
ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company |
修飾された重鎖定常領域を含む抗体
|
|
MA41460A
(fr)
|
2015-02-03 |
2017-12-12 |
Oncomed Pharm Inc |
Agents de liaison à la tnfrsf et leurs utilisations
|
|
KR20250004095A
(ko)
*
|
2015-04-17 |
2025-01-07 |
브리스톨-마이어스 스큅 컴퍼니 |
항-pd-1 항체 및 또 다른 항체의 조합물을 포함하는 조성물
|
|
MX2017015260A
(es)
|
2015-06-03 |
2018-02-19 |
Squibb Bristol Myers Co |
Anticuerpos anti receptor de factor de necrosis tumoral inducible por glucocorticoide (gitr) para diagnostico del cancer.
|
|
MX2018000948A
(es)
|
2015-07-23 |
2018-09-27 |
Inhibrx Inc |
Proteinas de fusion que se unen a gitir multivalentes y multiespecificas.
|
|
JP2018522571A
(ja)
|
2015-08-12 |
2018-08-16 |
メディミューン リミテッド |
Gitrl融合タンパク質およびその使用
|
|
CN105175545B
(zh)
*
|
2015-10-20 |
2019-01-25 |
安徽瀚海博兴生物技术有限公司 |
一种抗vegf-抗pd-1双功能抗体及其应用
|
|
EP3365371B1
(en)
|
2015-10-22 |
2025-10-08 |
Ablynx NV |
Gitr agonists
|
|
CA3002741A1
(en)
|
2015-10-23 |
2017-04-27 |
Apogenix Ag |
Single-chain gitr-receptor agonist proteins
|
|
AU2016356780A1
(en)
|
2015-11-19 |
2018-06-28 |
Bristol-Myers Squibb Company |
Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof
|
|
EP3496707A4
(en)
*
|
2016-08-09 |
2020-03-25 |
Angimmune, LLC |
Treatment of cancer using a combination of immunomodulation and check point inhibitors
|
|
CN110869392A
(zh)
|
2017-05-16 |
2020-03-06 |
百时美施贵宝公司 |
用抗gitr激动性抗体治疗癌症
|