JP2020519645A - 脂肪組織由来幹細胞による多発性硬化症の治療 - Google Patents
脂肪組織由来幹細胞による多発性硬化症の治療 Download PDFInfo
- Publication number
- JP2020519645A JP2020519645A JP2019562579A JP2019562579A JP2020519645A JP 2020519645 A JP2020519645 A JP 2020519645A JP 2019562579 A JP2019562579 A JP 2019562579A JP 2019562579 A JP2019562579 A JP 2019562579A JP 2020519645 A JP2020519645 A JP 2020519645A
- Authority
- JP
- Japan
- Prior art keywords
- hadsc
- cells
- adipose tissue
- pellet
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2523/00—Culture process characterised by temperature
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Developmental Biology & Embryology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762506006P | 2017-05-15 | 2017-05-15 | |
| US62/506,006 | 2017-05-15 | ||
| PCT/IL2018/050523 WO2018211498A1 (en) | 2017-05-15 | 2018-05-14 | Treatment of multiple sclerosis with adipose-derived stem cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020519645A true JP2020519645A (ja) | 2020-07-02 |
| JP2020519645A5 JP2020519645A5 (cg-RX-API-DMAC7.html) | 2021-05-06 |
Family
ID=64274150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019562579A Pending JP2020519645A (ja) | 2017-05-15 | 2018-05-14 | 脂肪組織由来幹細胞による多発性硬化症の治療 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11510946B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3624816A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2020519645A (cg-RX-API-DMAC7.html) |
| CN (1) | CN110573170A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2018270396B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3062123A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL269893B2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018211498A1 (cg-RX-API-DMAC7.html) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020519658A (ja) * | 2017-05-15 | 2020-07-02 | ステム セル メディスン リミテッド | 長時間作用性グラチラマー及び脂肪由来幹細胞での多発性硬化症の治療 |
| US11510946B2 (en) | 2017-05-15 | 2022-11-29 | Stem Cell Medicine Ltd. | Treatment of multiple sclerosis with adipose-derived stem cells |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL272145A (en) | 2020-01-20 | 2021-07-29 | Stem Cell Medicine Ltd | Cosmetic preparations with protein concentrate from a conditioned growth medium of stem cells from adipose tissue |
| CN115624571A (zh) * | 2022-12-21 | 2023-01-20 | 北京瑷格干细胞科技有限公司 | 人脂肪间充质干细胞在制备治疗硬皮病药物中的应用 |
| CN115624570A (zh) * | 2022-12-21 | 2023-01-20 | 北京瑷格干细胞科技有限公司 | 人脂肪间充质干细胞在制备治疗结缔组织疾病药物中的应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015511221A (ja) * | 2012-01-31 | 2015-04-16 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 神経炎症性障害の処置のための第xii因子阻害剤 |
| US20170065638A1 (en) * | 2014-02-10 | 2017-03-09 | Cytori Therapeutics, Inc. | Regenerative cell therapy for central nervous system (cns) disorders and ptsd |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL36670A (en) | 1971-04-21 | 1974-09-10 | Sela M | Therapeutic basic copolymers of amino acids |
| IL113812A (en) | 1994-05-24 | 2000-06-29 | Yeda Res & Dev | Copolymer-1 pharmaceutical compositions containing it and its use |
| US6214791B1 (en) | 1997-01-10 | 2001-04-10 | Yeda Research And Development Co. Ltd. | Treatment of multiple sclerosis through ingestion or inhalation of copolymer-1 |
| HK1054507B (zh) | 2000-01-20 | 2008-10-31 | 耶达研究及发展有限公司 | 共聚物1和相关肽和多肽及其处理过的t细胞在神经保护性治疗中的用途 |
| US8871241B2 (en) | 2002-05-07 | 2014-10-28 | Psivida Us, Inc. | Injectable sustained release delivery devices |
| PT1592384E (pt) | 2003-01-21 | 2013-01-28 | Yeda Res & Dev | Cop-1 para o tratamento de doenças inflamatórias do intestino |
| US7429378B2 (en) | 2003-05-13 | 2008-09-30 | Depuy Spine, Inc. | Transdiscal administration of high affinity anti-MMP inhibitors |
| EP1827108B1 (en) | 2004-11-29 | 2015-04-08 | Yeda Research And Development Co., Ltd. | Induction of neurogenesis and stem cell therapy in combination with copolymer 1 |
| WO2006060779A2 (en) | 2004-12-03 | 2006-06-08 | Case Western Reserve University | Novel methods, compositions and devices for inducing neovascularization |
| JP4654015B2 (ja) | 2004-12-08 | 2011-03-16 | 京セラ株式会社 | カメラ装置 |
| US20070003528A1 (en) | 2005-06-29 | 2007-01-04 | Paul Consigny | Intracoronary device and method of use thereof |
| KR101378874B1 (ko) | 2005-10-13 | 2014-03-27 | 안트로제네시스 코포레이션 | 태반 줄기세포를 이용한 면역 조절 |
| EP1795588A1 (en) | 2005-12-07 | 2007-06-13 | Cellerix, S.L. | Use of adipose tissue derived mesenchymal stem cells for the treatment of graft versus host disease |
| US8021882B2 (en) | 2006-08-24 | 2011-09-20 | Johnstone Brian H | Production of neural protective and regenerative factors from stem cells and treatment of nervous system conditions therewith |
| HUE036745T2 (hu) | 2006-11-03 | 2018-07-30 | Multiple Sclerosis Res Center Of New York | Csontvelõ eredetû mesenchimális õssejtek, mint a neurális progenitor sejtek forrásai |
| WO2011041240A1 (en) | 2009-09-30 | 2011-04-07 | The Brigham And Women's Hospital, Inc. | Tissue transplant compositions and methods for use |
| US8703180B1 (en) | 2007-10-23 | 2014-04-22 | Abbott Cardiovascular Systems Inc. | Multiple growth factor compositions, methods of fabrication, and methods of treatment |
| WO2009115581A2 (en) * | 2008-03-19 | 2009-09-24 | Cryo-Save Ag | Improved cryopreservation of adipose tissue for the isolation of mesenchymal stem cells |
| US20090291061A1 (en) | 2008-05-21 | 2009-11-26 | Riordan Neil H | Stem cell therapy for blood vessel degeneration |
| DK2285951T3 (en) | 2008-05-28 | 2018-10-22 | Univ Ramot | TREATMENT OF CNS DISEASES OF CNS DISEASES |
| US20110129450A1 (en) | 2008-08-01 | 2011-06-02 | Orly Lazarov | Method of promoting neurogenesis by modulating secretase activities |
| WO2010028051A2 (en) | 2008-09-03 | 2010-03-11 | Florida State University Research Foundation, Inc. | Substituted heterocyclic mercaptosulfonamide metalloprotease inhibitors |
| CA2740578A1 (en) | 2008-10-17 | 2010-04-22 | Baxter International Inc. | Methods of obtaining cell populations from adipose tissue |
| JP5515319B2 (ja) | 2009-02-23 | 2014-06-11 | 富士レビオ株式会社 | 脂肪細胞への分化誘導培地及び方法 |
| EP2451943B1 (en) | 2009-07-09 | 2016-11-23 | TiGenix, S.A.U. | Methods and compositions for use in cellular therapies |
| US8377885B2 (en) | 2010-01-04 | 2013-02-19 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
| MX349162B (es) | 2010-01-04 | 2017-07-14 | Mapi Pharma Ltd * | Sistemas de deposito que comprende glatiramer o una sal farmacologicamente aceptable del mismo. |
| EP3345998B1 (en) | 2010-02-18 | 2024-08-14 | Osiris Therapeutics, Inc. | Immunocompatible chorionic membrane products |
| EP2699317B1 (en) | 2011-04-21 | 2016-08-10 | Mapi Pharma Limited | Random pentapolymer for treatment of autoimmune diseases |
| US20130034524A1 (en) | 2011-08-03 | 2013-02-07 | Siamak Agha-Mohammadi | Non-Enzymatic Method for Harvesting Adipose-Derived Stromal Cells and Adipose-Derived Stem Cells from Fat and Lipo-Aspirate |
| SG2014013676A (en) | 2011-09-23 | 2014-05-29 | Cell Ideas Pty Ltd | Therapeutics using adipose cells and cell secretions |
| CL2011002642A1 (es) | 2011-10-24 | 2012-04-09 | Univ Del Desarrollo | Uso de una composicion formada por un glucocorticoide y una tiazolinediona que sirve para inducir la diferenciacion adipogenica en celulas madres. |
| CN104350146A (zh) | 2012-03-12 | 2015-02-11 | 新加坡国立大学 | 从间充质细胞制备棕色脂肪组织(bat) |
| CN104130975B (zh) * | 2013-05-03 | 2018-07-17 | 上海市东方医院 | 人源脂肪干细胞来源的神经元样细胞及其制备方法和应用 |
| TWI642781B (zh) * | 2014-02-06 | 2018-12-01 | 仲恩生醫科技股份有限公司 | 具優異細胞保護及免疫調節之quadri-正之基質細胞 |
| US20190046576A1 (en) | 2016-02-12 | 2019-02-14 | Cell Care Therapeutics | Adipose tissue derived mesenchymal stromal cell conditioned media and methods of making and using the same |
| US12161688B2 (en) | 2016-06-30 | 2024-12-10 | Mapi Pharma Ltd | Treatment of inflammatory bowel disease with long acting glatiramer and adipose-derived stem cells |
| WO2018211498A1 (en) | 2017-05-15 | 2018-11-22 | Stem Cell Medicine Ltd. | Treatment of multiple sclerosis with adipose-derived stem cells |
-
2018
- 2018-05-14 WO PCT/IL2018/050523 patent/WO2018211498A1/en not_active Ceased
- 2018-05-14 US US16/613,369 patent/US11510946B2/en active Active
- 2018-05-14 JP JP2019562579A patent/JP2020519645A/ja active Pending
- 2018-05-14 CN CN201880028213.1A patent/CN110573170A/zh active Pending
- 2018-05-14 CA CA3062123A patent/CA3062123A1/en active Pending
- 2018-05-14 AU AU2018270396A patent/AU2018270396B2/en active Active
- 2018-05-14 IL IL269893A patent/IL269893B2/en unknown
- 2018-05-14 EP EP18801976.4A patent/EP3624816A4/en not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015511221A (ja) * | 2012-01-31 | 2015-04-16 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 神経炎症性障害の処置のための第xii因子阻害剤 |
| US20170065638A1 (en) * | 2014-02-10 | 2017-03-09 | Cytori Therapeutics, Inc. | Regenerative cell therapy for central nervous system (cns) disorders and ptsd |
Non-Patent Citations (6)
| Title |
|---|
| MEDIATORS OF INFLAMMATION, 2016, VOL.2016, ARTICLE ID 5302120, JPN6021011511, ISSN: 0005065879 * |
| STEM CELLS INTERNATIONAL, 2015, VOL.2015, ARTICLE ID 146421, JPN6022009739, ISSN: 0005065880 * |
| WORLD J. STEM CELLS, 2014, VOL.6, NO.3, PP.312-321, JPN6022009737, ISSN: 0004727348 * |
| 中山 享之、加藤 栄史: "脂肪組織由来間葉系幹細胞を利用した細胞療法 −現状と展望−", 日本輸血細胞治療学会誌, vol. 59巻(2013)3号, JPN6022046305, 2013, JP, pages 450 - 456, ISSN: 0005065883 * |
| 吉良 潤一: "最新の多発性硬化症治療", 日本内科学会雑誌, vol. 105巻5号, JPN6022046303, 10 May 2016 (2016-05-10), JP, pages 894 - 904, ISSN: 0005065881 * |
| 風間 智彦: "間葉系幹細胞の基礎と臨床", 日大医学雑誌, vol. 75巻2号, JPN6022046304, 1 April 2016 (2016-04-01), JP, pages 61 - 66, ISSN: 0005065882 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020519658A (ja) * | 2017-05-15 | 2020-07-02 | ステム セル メディスン リミテッド | 長時間作用性グラチラマー及び脂肪由来幹細胞での多発性硬化症の治療 |
| JP7000458B2 (ja) | 2017-05-15 | 2022-02-10 | ステム セル メディスン リミテッド | 長時間作用性グラチラマー及び脂肪由来幹細胞での多発性硬化症の治療 |
| US11413311B2 (en) | 2017-05-15 | 2022-08-16 | Mapi Pharma Ltd. | Treatment of multiple sclerosis with long acting glatiramer and adipose-derived stem cells |
| US11510946B2 (en) | 2017-05-15 | 2022-11-29 | Stem Cell Medicine Ltd. | Treatment of multiple sclerosis with adipose-derived stem cells |
Also Published As
| Publication number | Publication date |
|---|---|
| IL269893B1 (en) | 2023-06-01 |
| IL269893A (cg-RX-API-DMAC7.html) | 2019-11-28 |
| EP3624816A1 (en) | 2020-03-25 |
| US20200188439A1 (en) | 2020-06-18 |
| WO2018211498A1 (en) | 2018-11-22 |
| CA3062123A1 (en) | 2018-11-22 |
| AU2018270396A1 (en) | 2020-01-02 |
| CN110573170A (zh) | 2019-12-13 |
| US11510946B2 (en) | 2022-11-29 |
| AU2018270396B2 (en) | 2025-03-20 |
| EP3624816A4 (en) | 2021-02-24 |
| IL269893B2 (en) | 2023-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020519645A (ja) | 脂肪組織由来幹細胞による多発性硬化症の治療 | |
| CN103340904B (zh) | 治疗骨关节炎的组合物 | |
| US20180353548A1 (en) | Scalable production of standardized extracellular vesicles, extracellular vesicle preparations and uses thereof | |
| JP2018531979A (ja) | 間葉幹細胞由来のエクソソームおよびその使用 | |
| JP2015526065A (ja) | 超音波キャビテーションによる脂肪組織からの幹細胞の単離および使用方法 | |
| US20210169940A1 (en) | Methods of treating or preventing neurological diseases | |
| JP2017501740A (ja) | 細胞培養方法 | |
| US10293003B2 (en) | Multilineage-differentiating stress enduring (MUSE) cells for treatment of chronic kidney disease | |
| US10596199B2 (en) | Methods of treating or preventing rheumatic disease | |
| WO2015175472A1 (en) | Compositions enriched for hox11+stem cells and methods of preparing the same | |
| JP7000458B2 (ja) | 長時間作用性グラチラマー及び脂肪由来幹細胞での多発性硬化症の治療 | |
| EP2931876B1 (en) | Treatment of diseases of endothelial dysfunction and inflammation | |
| JP6250706B2 (ja) | 変形性関節症の予防または治療における異系間質血管層細胞および異系間葉前駆細胞の使用 | |
| CN114591913A (zh) | 永生化猫干细胞或其用途 | |
| HK40032278A (en) | Treating or preventing rheumatic disease | |
| HK1196541A (en) | Methods of treating or preventing neurological diseases | |
| HK1196541B (en) | Methods of treating or preventing neurological diseases | |
| HK40014520A (en) | Treatment of diseases of endothelial dysfunction and inflammation | |
| HK1210209B (en) | Treatment of diseases of endothelial dysfunction and inflammation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210326 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20210326 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220315 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220614 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20220615 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20221101 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230301 |
|
| C60 | Trial request (containing other claim documents, opposition documents) |
Free format text: JAPANESE INTERMEDIATE CODE: C60 Effective date: 20230301 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20230301 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20230323 |
|
| C21 | Notice of transfer of a case for reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C21 Effective date: 20230328 |
|
| A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20230526 |