JP2020519645A5 - - Google Patents
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- JP2020519645A5 JP2020519645A5 JP2019562579A JP2019562579A JP2020519645A5 JP 2020519645 A5 JP2020519645 A5 JP 2020519645A5 JP 2019562579 A JP2019562579 A JP 2019562579A JP 2019562579 A JP2019562579 A JP 2019562579A JP 2020519645 A5 JP2020519645 A5 JP 2020519645A5
- Authority
- JP
- Japan
- Prior art keywords
- hadsc
- pellet
- tissue
- adipose tissue
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000000034 method Methods 0.000 claims 16
- 210000004027 cell Anatomy 0.000 claims 13
- 239000008188 pellet Substances 0.000 claims 9
- 210000000577 adipose tissue Anatomy 0.000 claims 8
- 201000006417 multiple sclerosis Diseases 0.000 claims 6
- 239000000725 suspension Substances 0.000 claims 6
- 108090000790 Enzymes Proteins 0.000 claims 5
- 102000004190 Enzymes Human genes 0.000 claims 5
- 238000005119 centrifugation Methods 0.000 claims 5
- 238000012258 culturing Methods 0.000 claims 5
- 229940088598 enzyme Drugs 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000003833 cell viability Effects 0.000 claims 4
- 230000008014 freezing Effects 0.000 claims 4
- 238000007710 freezing Methods 0.000 claims 4
- 239000002609 medium Substances 0.000 claims 4
- 230000000750 progressive effect Effects 0.000 claims 3
- 210000004003 subcutaneous fat Anatomy 0.000 claims 3
- 238000010257 thawing Methods 0.000 claims 3
- 102100022464 5'-nucleotidase Human genes 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 2
- 102100032912 CD44 antigen Human genes 0.000 claims 2
- 102000029816 Collagenase Human genes 0.000 claims 2
- 108060005980 Collagenase Proteins 0.000 claims 2
- 102100037241 Endoglin Human genes 0.000 claims 2
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 2
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 2
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 2
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 2
- 101000881679 Homo sapiens Endoglin Proteins 0.000 claims 2
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 2
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 2
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 2
- 102100022338 Integrin alpha-M Human genes 0.000 claims 2
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 2
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 2
- 239000000872 buffer Substances 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 229960002424 collagenase Drugs 0.000 claims 2
- 238000007914 intraventricular administration Methods 0.000 claims 2
- 206010063401 primary progressive multiple sclerosis Diseases 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 208000007118 chronic progressive multiple sclerosis Diseases 0.000 claims 1
- 108010007093 dispase Proteins 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 238000007913 intrathecal administration Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000012139 lysis buffer Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 201000008628 secondary progressive multiple sclerosis Diseases 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 239000012808 vapor phase Substances 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762506006P | 2017-05-15 | 2017-05-15 | |
| US62/506,006 | 2017-05-15 | ||
| PCT/IL2018/050523 WO2018211498A1 (en) | 2017-05-15 | 2018-05-14 | Treatment of multiple sclerosis with adipose-derived stem cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020519645A JP2020519645A (ja) | 2020-07-02 |
| JP2020519645A5 true JP2020519645A5 (cg-RX-API-DMAC7.html) | 2021-05-06 |
Family
ID=64274150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019562579A Pending JP2020519645A (ja) | 2017-05-15 | 2018-05-14 | 脂肪組織由来幹細胞による多発性硬化症の治療 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11510946B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3624816A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2020519645A (cg-RX-API-DMAC7.html) |
| CN (1) | CN110573170A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2018270396B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3062123A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL269893B2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018211498A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018211498A1 (en) | 2017-05-15 | 2018-11-22 | Stem Cell Medicine Ltd. | Treatment of multiple sclerosis with adipose-derived stem cells |
| AU2017414803B2 (en) | 2017-05-15 | 2025-02-13 | Mapi Pharma Ltd. | Treatment of multiple sclerosis with long acting glatiramer and adipose-derived stem cells |
| IL272145A (en) | 2020-01-20 | 2021-07-29 | Stem Cell Medicine Ltd | Cosmetic preparations with protein concentrate from a conditioned growth medium of stem cells from adipose tissue |
| CN115624571A (zh) * | 2022-12-21 | 2023-01-20 | 北京瑷格干细胞科技有限公司 | 人脂肪间充质干细胞在制备治疗硬皮病药物中的应用 |
| CN115624570A (zh) * | 2022-12-21 | 2023-01-20 | 北京瑷格干细胞科技有限公司 | 人脂肪间充质干细胞在制备治疗结缔组织疾病药物中的应用 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL36670A (en) | 1971-04-21 | 1974-09-10 | Sela M | Therapeutic basic copolymers of amino acids |
| IL113812A (en) | 1994-05-24 | 2000-06-29 | Yeda Res & Dev | Copolymer-1 pharmaceutical compositions containing it and its use |
| US6214791B1 (en) | 1997-01-10 | 2001-04-10 | Yeda Research And Development Co. Ltd. | Treatment of multiple sclerosis through ingestion or inhalation of copolymer-1 |
| HK1054507B (zh) | 2000-01-20 | 2008-10-31 | 耶达研究及发展有限公司 | 共聚物1和相关肽和多肽及其处理过的t细胞在神经保护性治疗中的用途 |
| US8871241B2 (en) | 2002-05-07 | 2014-10-28 | Psivida Us, Inc. | Injectable sustained release delivery devices |
| PT1592384E (pt) | 2003-01-21 | 2013-01-28 | Yeda Res & Dev | Cop-1 para o tratamento de doenças inflamatórias do intestino |
| US7429378B2 (en) | 2003-05-13 | 2008-09-30 | Depuy Spine, Inc. | Transdiscal administration of high affinity anti-MMP inhibitors |
| EP1827108B1 (en) | 2004-11-29 | 2015-04-08 | Yeda Research And Development Co., Ltd. | Induction of neurogenesis and stem cell therapy in combination with copolymer 1 |
| WO2006060779A2 (en) | 2004-12-03 | 2006-06-08 | Case Western Reserve University | Novel methods, compositions and devices for inducing neovascularization |
| JP4654015B2 (ja) | 2004-12-08 | 2011-03-16 | 京セラ株式会社 | カメラ装置 |
| US20070003528A1 (en) | 2005-06-29 | 2007-01-04 | Paul Consigny | Intracoronary device and method of use thereof |
| KR101378874B1 (ko) | 2005-10-13 | 2014-03-27 | 안트로제네시스 코포레이션 | 태반 줄기세포를 이용한 면역 조절 |
| EP1795588A1 (en) | 2005-12-07 | 2007-06-13 | Cellerix, S.L. | Use of adipose tissue derived mesenchymal stem cells for the treatment of graft versus host disease |
| US8021882B2 (en) | 2006-08-24 | 2011-09-20 | Johnstone Brian H | Production of neural protective and regenerative factors from stem cells and treatment of nervous system conditions therewith |
| HUE036745T2 (hu) | 2006-11-03 | 2018-07-30 | Multiple Sclerosis Res Center Of New York | Csontvelõ eredetû mesenchimális õssejtek, mint a neurális progenitor sejtek forrásai |
| WO2011041240A1 (en) | 2009-09-30 | 2011-04-07 | The Brigham And Women's Hospital, Inc. | Tissue transplant compositions and methods for use |
| US8703180B1 (en) | 2007-10-23 | 2014-04-22 | Abbott Cardiovascular Systems Inc. | Multiple growth factor compositions, methods of fabrication, and methods of treatment |
| WO2009115581A2 (en) * | 2008-03-19 | 2009-09-24 | Cryo-Save Ag | Improved cryopreservation of adipose tissue for the isolation of mesenchymal stem cells |
| US20090291061A1 (en) | 2008-05-21 | 2009-11-26 | Riordan Neil H | Stem cell therapy for blood vessel degeneration |
| DK2285951T3 (en) | 2008-05-28 | 2018-10-22 | Univ Ramot | TREATMENT OF CNS DISEASES OF CNS DISEASES |
| US20110129450A1 (en) | 2008-08-01 | 2011-06-02 | Orly Lazarov | Method of promoting neurogenesis by modulating secretase activities |
| WO2010028051A2 (en) | 2008-09-03 | 2010-03-11 | Florida State University Research Foundation, Inc. | Substituted heterocyclic mercaptosulfonamide metalloprotease inhibitors |
| CA2740578A1 (en) | 2008-10-17 | 2010-04-22 | Baxter International Inc. | Methods of obtaining cell populations from adipose tissue |
| JP5515319B2 (ja) | 2009-02-23 | 2014-06-11 | 富士レビオ株式会社 | 脂肪細胞への分化誘導培地及び方法 |
| EP2451943B1 (en) | 2009-07-09 | 2016-11-23 | TiGenix, S.A.U. | Methods and compositions for use in cellular therapies |
| US8377885B2 (en) | 2010-01-04 | 2013-02-19 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
| MX349162B (es) | 2010-01-04 | 2017-07-14 | Mapi Pharma Ltd * | Sistemas de deposito que comprende glatiramer o una sal farmacologicamente aceptable del mismo. |
| EP3345998B1 (en) | 2010-02-18 | 2024-08-14 | Osiris Therapeutics, Inc. | Immunocompatible chorionic membrane products |
| EP2699317B1 (en) | 2011-04-21 | 2016-08-10 | Mapi Pharma Limited | Random pentapolymer for treatment of autoimmune diseases |
| US20130034524A1 (en) | 2011-08-03 | 2013-02-07 | Siamak Agha-Mohammadi | Non-Enzymatic Method for Harvesting Adipose-Derived Stromal Cells and Adipose-Derived Stem Cells from Fat and Lipo-Aspirate |
| SG2014013676A (en) | 2011-09-23 | 2014-05-29 | Cell Ideas Pty Ltd | Therapeutics using adipose cells and cell secretions |
| CL2011002642A1 (es) | 2011-10-24 | 2012-04-09 | Univ Del Desarrollo | Uso de una composicion formada por un glucocorticoide y una tiazolinediona que sirve para inducir la diferenciacion adipogenica en celulas madres. |
| EP2623110A1 (en) * | 2012-01-31 | 2013-08-07 | CSL Behring GmbH | Factor XII inhibitors for the treatment of neurological inflammatory disorders |
| CN104350146A (zh) | 2012-03-12 | 2015-02-11 | 新加坡国立大学 | 从间充质细胞制备棕色脂肪组织(bat) |
| CN104130975B (zh) * | 2013-05-03 | 2018-07-17 | 上海市东方医院 | 人源脂肪干细胞来源的神经元样细胞及其制备方法和应用 |
| TWI642781B (zh) * | 2014-02-06 | 2018-12-01 | 仲恩生醫科技股份有限公司 | 具優異細胞保護及免疫調節之ｑｕａｄｒｉ－正之基質細胞 |
| WO2015120388A1 (en) * | 2014-02-10 | 2015-08-13 | Cytori Therapeutics, Inc. | Regenerative cell therapy for central nervous system (cns) disorders and ptsd |
| US20190046576A1 (en) | 2016-02-12 | 2019-02-14 | Cell Care Therapeutics | Adipose tissue derived mesenchymal stromal cell conditioned media and methods of making and using the same |
| US12161688B2 (en) | 2016-06-30 | 2024-12-10 | Mapi Pharma Ltd | Treatment of inflammatory bowel disease with long acting glatiramer and adipose-derived stem cells |
| WO2018211498A1 (en) | 2017-05-15 | 2018-11-22 | Stem Cell Medicine Ltd. | Treatment of multiple sclerosis with adipose-derived stem cells |
-
2018
- 2018-05-14 WO PCT/IL2018/050523 patent/WO2018211498A1/en not_active Ceased
- 2018-05-14 US US16/613,369 patent/US11510946B2/en active Active
- 2018-05-14 JP JP2019562579A patent/JP2020519645A/ja active Pending
- 2018-05-14 CN CN201880028213.1A patent/CN110573170A/zh active Pending
- 2018-05-14 CA CA3062123A patent/CA3062123A1/en active Pending
- 2018-05-14 AU AU2018270396A patent/AU2018270396B2/en active Active
- 2018-05-14 IL IL269893A patent/IL269893B2/en unknown
- 2018-05-14 EP EP18801976.4A patent/EP3624816A4/en not_active Ceased
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