SG10201607521PA - Generation of brown adipose tissue (bat) from mesenchymal cells - Google Patents

Generation of brown adipose tissue (bat) from mesenchymal cells

Info

Publication number
SG10201607521PA
SG10201607521PA SG10201607521PA SG10201607521PA SG10201607521PA SG 10201607521P A SG10201607521P A SG 10201607521PA SG 10201607521P A SG10201607521P A SG 10201607521PA SG 10201607521P A SG10201607521P A SG 10201607521PA SG 10201607521P A SG10201607521P A SG 10201607521PA
Authority
SG
Singapore
Prior art keywords
bat
generation
adipose tissue
mesenchymal cells
brown adipose
Prior art date
Application number
SG10201607521PA
Inventor
Michael Raghunath
Hui Ching Michelle Lee
Allan Sheppard
Original Assignee
Univ Singapore
Auckland Uniservices Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Singapore, Auckland Uniservices Ltd filed Critical Univ Singapore
Publication of SG10201607521PA publication Critical patent/SG10201607521PA/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0653—Adipocytes; Adipose tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/34—Sugars
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/33—Insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1353—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SG10201607521PA 2012-03-12 2013-03-12 Generation of brown adipose tissue (bat) from mesenchymal cells SG10201607521PA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261609456P 2012-03-12 2012-03-12

Publications (1)

Publication Number Publication Date
SG10201607521PA true SG10201607521PA (en) 2016-10-28

Family

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Family Applications (2)

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SG11201405257WA SG11201405257WA (en) 2012-03-12 2013-03-12 Generation of brown adipose tissue (bat) from mesenchymal cells
SG10201607521PA SG10201607521PA (en) 2012-03-12 2013-03-12 Generation of brown adipose tissue (bat) from mesenchymal cells

Family Applications Before (1)

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SG11201405257WA SG11201405257WA (en) 2012-03-12 2013-03-12 Generation of brown adipose tissue (bat) from mesenchymal cells

Country Status (5)

Country Link
US (2) US20150030662A1 (en)
EP (1) EP2825638A4 (en)
CN (1) CN104350146A (en)
SG (2) SG11201405257WA (en)
WO (1) WO2013137826A1 (en)

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Publication number Priority date Publication date Assignee Title
SG10201601853XA (en) 2011-03-11 2016-04-28 Univ Singapore Pericyte progenitors from peripheral blood
US20150216935A1 (en) * 2012-08-09 2015-08-06 Brown University Autologous Cell-Based Therapy for Treating Obesity
US11419916B2 (en) 2012-09-11 2022-08-23 Energesis Pharmaceuticals, Inc. Methods and compositions for inducing differentiation of human brown adipocyte progenitors
EP3110946B1 (en) * 2014-02-24 2021-09-01 Energesis Pharmaceuticals Inc. Methods and compositions for inducing differentiation of human brown adipocyte progenitors
CN108495930A (en) * 2015-08-07 2018-09-04 京都府公立大学法人 The preparation method of brown fat cell
US10085963B2 (en) * 2015-11-10 2018-10-02 Sami Labs Limited Process and compositions for achieving mammalian energy balance
EP3387112A4 (en) * 2015-12-07 2019-08-21 BioTime, Inc. Methods for the re-derivation of diverse pluripotent stem cell-derived brown fat cells
NL2015957B1 (en) 2015-12-14 2017-06-29 Scala Pharma B V Compositions and methods for inducing beige or brown fat tissue.
CN108472319B (en) * 2016-01-19 2021-12-28 国立大学法人大阪大学 Transplantation material for treating heart disease
WO2017198071A1 (en) * 2016-05-20 2017-11-23 国立东华大学 Applications of butylidenephthalide
WO2017223457A1 (en) * 2016-06-24 2017-12-28 The Brigham And Women's Hospital, Inc. Generation of brown adipose tissue from pluripotent stem cells in vitro
CN106754664B (en) * 2016-12-26 2020-09-11 广州赛莱拉干细胞科技股份有限公司 Culture medium for inducing adipogenic differentiation of skeletal muscle myogenic stem cells, application of culture medium and adipogenic differentiation method
CN110709091A (en) 2017-05-15 2020-01-17 干细胞医药有限公司 Treatment of multiple sclerosis using long-acting glatiramer and adipose derived stem cells
US11510946B2 (en) 2017-05-15 2022-11-29 Stem Cell Medicine Ltd. Treatment of multiple sclerosis with adipose-derived stem cells
CN107384855A (en) * 2017-07-24 2017-11-24 陈强 A kind of induced fibroblast is the method for adipocyte like cell
WO2019055594A1 (en) * 2017-09-13 2019-03-21 North Carolina State University Locally-induced adipose tissue browning by microneedle patch for obesity treatment
CN109666660A (en) * 2017-10-13 2019-04-23 浙江工商大学 A method of improving pancreatic lipase catalytic efficiency
US20200368174A1 (en) * 2018-02-21 2020-11-26 Texas Tech University System Particles for targeted delivery of active agents into adipose stromal cells
US20220079993A1 (en) * 2019-01-08 2022-03-17 University Of Georgia Research Foundation, Inc. Non-naturally occurring thermogenic adipocytes, methods of making, and methods of use thereof
CN112007025B (en) * 2019-05-30 2022-04-19 义慧科技(深圳)有限公司 Application of mirabegron in preparation of medicine for preventing and/or treating malignant tumor
WO2021106698A1 (en) * 2019-11-25 2021-06-03 株式会社片岡製作所 Composition for medium
CN111748521B (en) * 2020-07-14 2023-11-03 泸州君益生物医学研究有限公司 Preparation method for increasing glucose uptake of adipose-derived mesenchymal stem cells
CN113069440A (en) * 2021-04-08 2021-07-06 澳门大学 Novel application of thyroxine, method for culturing pluripotent stem cells and culture medium
CN113481270B (en) * 2021-06-08 2023-07-04 中国科学院海洋研究所 Method for extracting glycopeptide from scallop skirt

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6153432A (en) * 1999-01-29 2000-11-28 Zen-Bio, Inc Methods for the differentiation of human preadipocytes into adipocytes
WO2006130690A2 (en) * 2005-06-01 2006-12-07 Joslin Diabetes Center, Inc. Methods and compositions for inducing brown adipogenesis
CA2763548C (en) * 2008-05-27 2019-01-15 Energesis Pharmaceuticals, Inc. Brown adipocyte progenitors in human skeletal muscle
FR2932818B1 (en) * 2008-06-23 2015-12-04 Centre Nat Rech Scient HUMAN BROWN ADIPOCYTE LINE AND DIFFERENTIATION METHOD FROM HMADS CELL LINE.
CA2791846A1 (en) * 2010-03-02 2011-09-09 National University Of Singapore Culture additives to boost stem cell proliferation and differentiation response
WO2012031015A1 (en) * 2010-09-01 2012-03-08 The Regents Of The University Of California Cell culture screen for agents that control adipogenesis and myofibroblast differentiation

Also Published As

Publication number Publication date
WO2013137826A1 (en) 2013-09-19
EP2825638A4 (en) 2015-11-25
US20150030662A1 (en) 2015-01-29
US20170266237A1 (en) 2017-09-21
SG11201405257WA (en) 2014-09-26
EP2825638A1 (en) 2015-01-21
CN104350146A (en) 2015-02-11

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