JP2020513761A5 - - Google Patents
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- Publication number
- JP2020513761A5 JP2020513761A5 JP2019534656A JP2019534656A JP2020513761A5 JP 2020513761 A5 JP2020513761 A5 JP 2020513761A5 JP 2019534656 A JP2019534656 A JP 2019534656A JP 2019534656 A JP2019534656 A JP 2019534656A JP 2020513761 A5 JP2020513761 A5 JP 2020513761A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- seq
- light chain
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 147
- 230000035772 mutation Effects 0.000 claims 9
- 230000002327 eosinophilic effect Effects 0.000 claims 5
- 206010012438 Dermatitis atopic Diseases 0.000 claims 3
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims 3
- 101000960969 Homo sapiens Interleukin-5 Proteins 0.000 claims 3
- 208000006673 asthma Diseases 0.000 claims 3
- 201000008937 atopic dermatitis Diseases 0.000 claims 3
- 210000004899 c-terminal region Anatomy 0.000 claims 3
- 230000037430 deletion Effects 0.000 claims 3
- 238000012217 deletion Methods 0.000 claims 3
- 210000003979 eosinophil Anatomy 0.000 claims 3
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims 3
- 102000055228 human IL5 Human genes 0.000 claims 3
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000011580 syndromic disease Diseases 0.000 claims 3
- 108010002616 Interleukin-5 Proteins 0.000 claims 2
- 102000000743 Interleukin-5 Human genes 0.000 claims 2
- 208000000592 Nasal Polyps Diseases 0.000 claims 2
- 206010047115 Vasculitis Diseases 0.000 claims 2
- 206010020718 hyperplasia Diseases 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 2
- 241000700199 Cavia porcellus Species 0.000 claims 1
- 206010014950 Eosinophilia Diseases 0.000 claims 1
- 206010018691 Granuloma Diseases 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000010786 Interleukin-5 Receptors Human genes 0.000 claims 1
- 108010038484 Interleukin-5 Receptors Proteins 0.000 claims 1
- 241000282567 Macaca fascicularis Species 0.000 claims 1
- 101000960970 Sus scrofa Interleukin-5 Proteins 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 208000015768 polyposis Diseases 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000003156 vasculitic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662438502P | 2016-12-23 | 2016-12-23 | |
| US62/438,502 | 2016-12-23 | ||
| PCT/US2017/067475 WO2018119016A1 (en) | 2016-12-23 | 2017-12-20 | Anti-il-5 antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020513761A JP2020513761A (ja) | 2020-05-21 |
| JP2020513761A5 true JP2020513761A5 (cg-RX-API-DMAC7.html) | 2021-01-14 |
| JP7060906B2 JP7060906B2 (ja) | 2022-04-27 |
Family
ID=60972458
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019534656A Active JP7060906B2 (ja) | 2016-12-23 | 2017-12-20 | 抗ｉｌ－５抗体 |
Country Status (20)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201991552A1 (ru) * | 2016-12-23 | 2020-01-09 | Сефалон, Инк. | Анти-il-5 антитела |
| SMT202600240T1 (it) | 2017-05-26 | 2026-07-16 | Glaxosmithkline Ip Dev Ltd | Composizioni biofarmaceutiche e metodi correlati |
| CN113366016B (zh) * | 2018-12-12 | 2022-12-16 | 上海开拓者生物医药有限公司 | 抗人白细胞介素5(il-5)单克隆抗体及其应用 |
| JP7641908B2 (ja) | 2019-03-29 | 2025-03-07 | ジエンス ヘンルイ メデイシンカンパニー リミテッド | Ｉｌ－５に対する抗体を含有する医薬組成物及びその使用 |
| CN112745389B (zh) * | 2019-10-29 | 2022-11-25 | 瑞阳(苏州)生物科技有限公司 | 结合人il-5的单克隆抗体及其应用 |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0281604B1 (en) | 1986-09-02 | 1993-03-31 | Enzon Labs Inc. | Single polypeptide chain binding molecules |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| ATE199392T1 (de) | 1992-12-04 | 2001-03-15 | Medical Res Council | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
| US6056957A (en) * | 1994-08-04 | 2000-05-02 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-5 |
| US5683892A (en) * | 1994-12-23 | 1997-11-04 | Smithkline Beecham Corporation | DNA encoding recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders |
| JP2001523083A (ja) * | 1994-12-23 | 2001-11-20 | スミスクライン・ビーチャム・コーポレイション | Ｉｌ−５により媒介される疾病の治療に有用な組み換えｉｌ−５アンタゴニスト |
| AUPO591797A0 (en) | 1997-03-27 | 1997-04-24 | Commonwealth Scientific And Industrial Research Organisation | High avidity polyvalent and polyspecific reagents |
| ES2327830T3 (es) * | 2002-03-29 | 2009-11-04 | Schering Corporation | Anticuerpos monoclonales humanos anti-interleuquina-5 y metodos y composiciones que los contienen. |
| AU2008343589A1 (en) | 2007-12-19 | 2009-07-09 | Centocor Ortho Biotech Inc. | Design and generation of human de novo pIX phage display libraries via fusion to pIX or pVII, vectors, antibodies and methods |
| ES3053874T3 (en) | 2015-08-24 | 2026-01-27 | Glaxosmithkline Ip No 2 Ltd | Biopharmaceutical compositions |
| EP3365369A1 (en) * | 2015-10-23 | 2018-08-29 | Pfizer Inc | Anti-il-2 antibodies and compositions and uses thereof |
| EA201991552A1 (ru) * | 2016-12-23 | 2020-01-09 | Сефалон, Инк. | Анти-il-5 антитела |
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2017
- 2017-12-20 EA EA201991552A patent/EA201991552A1/ru unknown
- 2017-12-20 BR BR112019012929-4A patent/BR112019012929A2/pt active Search and Examination
- 2017-12-20 PE PE2019001295A patent/PE20191662A1/es unknown
- 2017-12-20 CN CN201780079923.2A patent/CN110267986B/zh active Active
- 2017-12-20 WO PCT/US2017/067475 patent/WO2018119016A1/en not_active Ceased
- 2017-12-20 US US15/848,090 patent/US11111292B2/en active Active
- 2017-12-20 CA CA3048186A patent/CA3048186A1/en active Pending
- 2017-12-20 JP JP2019534656A patent/JP7060906B2/ja active Active
- 2017-12-20 ES ES17829503T patent/ES2984636T3/es active Active
- 2017-12-20 KR KR1020197021088A patent/KR102651290B1/ko active Active
- 2017-12-20 AR ARP170103611A patent/AR110564A1/es not_active Application Discontinuation
- 2017-12-20 EP EP17829503.6A patent/EP3559030B1/en active Active
- 2017-12-20 MX MX2019007642A patent/MX2019007642A/es unknown
- 2017-12-20 RU RU2019123112A patent/RU2758008C2/ru active
- 2017-12-20 AU AU2017379853A patent/AU2017379853B2/en active Active
- 2017-12-20 IL IL267271A patent/IL267271B2/en unknown
- 2017-12-20 NZ NZ754606A patent/NZ754606A/en unknown
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2019
- 2019-06-20 CL CL2019001730A patent/CL2019001730A1/es unknown
- 2019-06-21 PH PH12019501452A patent/PH12019501452A1/en unknown
- 2019-06-24 ZA ZA2019/04097A patent/ZA201904097B/en unknown
-
2021
- 2021-07-26 US US17/385,532 patent/US12577298B2/en active Active