MX2019007642A - Anticuerpos anti-il-5. - Google Patents
Anticuerpos anti-il-5.Info
- Publication number
- MX2019007642A MX2019007642A MX2019007642A MX2019007642A MX2019007642A MX 2019007642 A MX2019007642 A MX 2019007642A MX 2019007642 A MX2019007642 A MX 2019007642A MX 2019007642 A MX2019007642 A MX 2019007642A MX 2019007642 A MX2019007642 A MX 2019007642A
- Authority
- MX
- Mexico
- Prior art keywords
- human
- antibody molecules
- antibodies
- bind
- disclosed
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
En el presente documento se describen moléculas de anticuerpos completamente humanos que se unen inmunoespecíficamente a IL-5 humana. Las moléculas de anticuerpo pueden unirse a IL-5 humana con una constante de afinidad de equilibrio (KD) de al menos aproximadamente 40 pM según lo determinado por la resonancia de plasmón de superficie.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662438502P | 2016-12-23 | 2016-12-23 | |
PCT/US2017/067475 WO2018119016A1 (en) | 2016-12-23 | 2017-12-20 | Anti-il-5 antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019007642A true MX2019007642A (es) | 2019-09-09 |
Family
ID=60972458
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019007642A MX2019007642A (es) | 2016-12-23 | 2017-12-20 | Anticuerpos anti-il-5. |
Country Status (19)
Country | Link |
---|---|
US (2) | US11111292B2 (es) |
EP (1) | EP3559030B1 (es) |
JP (1) | JP7060906B2 (es) |
KR (1) | KR102651290B1 (es) |
CN (1) | CN110267986B (es) |
AR (1) | AR110564A1 (es) |
AU (1) | AU2017379853A1 (es) |
BR (1) | BR112019012929A2 (es) |
CA (1) | CA3048186A1 (es) |
CL (1) | CL2019001730A1 (es) |
EA (1) | EA201991552A1 (es) |
IL (1) | IL267271A (es) |
MX (1) | MX2019007642A (es) |
NZ (1) | NZ754606A (es) |
PE (1) | PE20191662A1 (es) |
PH (1) | PH12019501452A1 (es) |
RU (1) | RU2758008C2 (es) |
WO (1) | WO2018119016A1 (es) |
ZA (1) | ZA201904097B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3630824A1 (en) | 2017-05-26 | 2020-04-08 | GlaxoSmithKline Intellectual Property Development Ltd | Biopharmaceutical compositions and related methods |
EP3896085A4 (en) * | 2018-12-12 | 2022-11-30 | Shanghai Pharmaexplorer Co., Ltd. | MONOCLONAL ANTIBODY TO HUMAN INTERLEUKIN 5 (IL-5) AND ITS USE |
KR20210145187A (ko) | 2019-03-29 | 2021-12-01 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | Il-5에 대한 항체를 함유하는 약학적 조성물 및 이의 용도 |
CN112745389B (zh) * | 2019-10-29 | 2022-11-25 | 瑞阳(苏州)生物科技有限公司 | 结合人il-5的单克隆抗体及其应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE87659T1 (de) | 1986-09-02 | 1993-04-15 | Enzon Lab Inc | Bindungsmolekuele mit einzelpolypeptidkette. |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
DE69329974T2 (de) | 1992-12-04 | 2001-07-19 | Medical Research Council, London | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
US6056957A (en) * | 1994-08-04 | 2000-05-02 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-5 |
US5693323A (en) * | 1994-12-23 | 1997-12-02 | Smithkline Beecham Corporation | Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders |
US6129913A (en) | 1994-12-23 | 2000-10-10 | Smithkline Beecham Corporation | Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders |
AUPO591797A0 (en) | 1997-03-27 | 1997-04-24 | Commonwealth Scientific And Industrial Research Organisation | High avidity polyvalent and polyspecific reagents |
DK1527100T3 (da) * | 2002-03-29 | 2009-09-07 | Schering Corp | Humane monoklonale antistoffer mod interleukin-5 og fremgangsm der og sammens tninger omfattende samme |
EP2231904B1 (en) | 2007-12-19 | 2016-01-13 | Janssen Biotech, Inc. | Design and generation of human de novo pix phage display libraries via fusion to pix or pvii, vectors, antibodies and methods |
TWI750133B (zh) | 2015-08-24 | 2021-12-21 | 美商葛蘭素史密斯克萊有限責任公司 | 生藥組成物 |
-
2017
- 2017-12-20 EP EP17829503.6A patent/EP3559030B1/en active Active
- 2017-12-20 MX MX2019007642A patent/MX2019007642A/es unknown
- 2017-12-20 JP JP2019534656A patent/JP7060906B2/ja active Active
- 2017-12-20 CN CN201780079923.2A patent/CN110267986B/zh active Active
- 2017-12-20 US US15/848,090 patent/US11111292B2/en active Active
- 2017-12-20 KR KR1020197021088A patent/KR102651290B1/ko active IP Right Grant
- 2017-12-20 BR BR112019012929A patent/BR112019012929A2/pt unknown
- 2017-12-20 NZ NZ754606A patent/NZ754606A/en unknown
- 2017-12-20 PE PE2019001295A patent/PE20191662A1/es unknown
- 2017-12-20 AR ARP170103611A patent/AR110564A1/es unknown
- 2017-12-20 WO PCT/US2017/067475 patent/WO2018119016A1/en unknown
- 2017-12-20 EA EA201991552A patent/EA201991552A1/ru unknown
- 2017-12-20 CA CA3048186A patent/CA3048186A1/en active Pending
- 2017-12-20 RU RU2019123112A patent/RU2758008C2/ru active
- 2017-12-20 AU AU2017379853A patent/AU2017379853A1/en active Pending
-
2019
- 2019-06-12 IL IL267271A patent/IL267271A/en unknown
- 2019-06-20 CL CL2019001730A patent/CL2019001730A1/es unknown
- 2019-06-21 PH PH12019501452A patent/PH12019501452A1/en unknown
- 2019-06-24 ZA ZA2019/04097A patent/ZA201904097B/en unknown
-
2021
- 2021-07-26 US US17/385,532 patent/US20210355205A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN110267986B (zh) | 2023-05-09 |
JP2020513761A (ja) | 2020-05-21 |
RU2019123112A (ru) | 2021-01-26 |
BR112019012929A2 (pt) | 2019-12-10 |
CL2019001730A1 (es) | 2019-09-27 |
EP3559030A1 (en) | 2019-10-30 |
ZA201904097B (en) | 2023-12-20 |
EP3559030B1 (en) | 2024-04-03 |
EP3559030C0 (en) | 2024-04-03 |
EA201991552A1 (ru) | 2020-01-09 |
WO2018119016A1 (en) | 2018-06-28 |
CN110267986A (zh) | 2019-09-20 |
JP7060906B2 (ja) | 2022-04-27 |
KR20190126769A (ko) | 2019-11-12 |
RU2019123112A3 (es) | 2021-04-05 |
RU2758008C2 (ru) | 2021-10-25 |
PE20191662A1 (es) | 2019-11-11 |
KR102651290B1 (ko) | 2024-03-25 |
NZ754606A (en) | 2023-06-30 |
AU2017379853A1 (en) | 2019-07-04 |
US20210355205A1 (en) | 2021-11-18 |
AR110564A1 (es) | 2019-04-10 |
CA3048186A1 (en) | 2018-06-28 |
US11111292B2 (en) | 2021-09-07 |
IL267271A (en) | 2019-08-29 |
US20180186873A1 (en) | 2018-07-05 |
PH12019501452A1 (en) | 2020-06-15 |
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