JP2020509069A5 - - Google Patents
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- Publication number
- JP2020509069A5 JP2020509069A5 JP2019548605A JP2019548605A JP2020509069A5 JP 2020509069 A5 JP2020509069 A5 JP 2020509069A5 JP 2019548605 A JP2019548605 A JP 2019548605A JP 2019548605 A JP2019548605 A JP 2019548605A JP 2020509069 A5 JP2020509069 A5 JP 2020509069A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formulation
- moiety
- compatible solute
- physiologically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 238000009472 formulation Methods 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 12
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 108010016626 Dipeptides Chemical group 0.000 claims 4
- 229910019142 PO4 Inorganic materials 0.000 claims 4
- 150000001413 amino acids Chemical group 0.000 claims 4
- 229960003237 betaine Drugs 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 4
- 239000010452 phosphate Substances 0.000 claims 4
- 239000011148 porous material Substances 0.000 claims 4
- 210000003491 skin Anatomy 0.000 claims 4
- 210000004243 sweat Anatomy 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 3
- -1 β-mannosyl glutamine Chemical compound 0.000 claims 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 2
- XLJMOXZZXDLZJX-YTCAKZPVSA-N 2,3-dihydroxy-n-[(2r,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]propanamide Chemical compound OCC(O)C(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O XLJMOXZZXDLZJX-YTCAKZPVSA-N 0.000 claims 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 238000005282 brightening Methods 0.000 claims 2
- WQXNXVUDBPYKBA-YFKPBYRVSA-N ectoine Chemical group CC1=[NH+][C@H](C([O-])=O)CCN1 WQXNXVUDBPYKBA-YFKPBYRVSA-N 0.000 claims 2
- 229960000367 inositol Drugs 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims 2
- 125000000647 trehalose group Chemical group 0.000 claims 2
- GUYHPGUANSLONG-SNAWJCMRSA-N (E)-4-(trimethylammonio)but-2-enoate Chemical compound C[N+](C)(C)C\C=C\C([O-])=O GUYHPGUANSLONG-SNAWJCMRSA-N 0.000 claims 1
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims 1
- SZRXFTWNSKAXPG-UHFFFAOYSA-N 2-methyl-2-sulfobutanoic acid Chemical compound CCC(C)(C(O)=O)S(O)(=O)=O SZRXFTWNSKAXPG-UHFFFAOYSA-N 0.000 claims 1
- VVEXENALPNQOAS-UHFFFAOYSA-N 5-hydroxy-2-methylpyrimidine-4-carboxylic acid Chemical group CC1=NC=C(O)C(C(O)=O)=N1 VVEXENALPNQOAS-UHFFFAOYSA-N 0.000 claims 1
- SPTHHTGLGVZZRH-UHFFFAOYSA-N Arsenobetaine Chemical compound C[As+](C)(C)CC([O-])=O SPTHHTGLGVZZRH-UHFFFAOYSA-N 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- CMUNUTVVOOHQPW-LURJTMIESA-N L-proline betaine Chemical compound C[N+]1(C)CCC[C@H]1C([O-])=O CMUNUTVVOOHQPW-LURJTMIESA-N 0.000 claims 1
- VEYYWZRYIYDQJM-ZETCQYMHSA-N N(2)-acetyl-L-lysine Chemical compound CC(=O)N[C@H](C([O-])=O)CCCC[NH3+] VEYYWZRYIYDQJM-ZETCQYMHSA-N 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- 206010040829 Skin discolouration Diseases 0.000 claims 1
- 239000004904 UV filter Substances 0.000 claims 1
- 238000009825 accumulation Methods 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 108091006003 carbonylated proteins Proteins 0.000 claims 1
- 230000006315 carbonylation Effects 0.000 claims 1
- 238000005810 carbonylation reaction Methods 0.000 claims 1
- 229960004203 carnitine Drugs 0.000 claims 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims 1
- 229960001231 choline Drugs 0.000 claims 1
- WXCQAWGXWVRCGP-UHFFFAOYSA-N choline sulfate Chemical compound C[N+](C)(C)CCOS([O-])(=O)=O WXCQAWGXWVRCGP-UHFFFAOYSA-N 0.000 claims 1
- PZJOIILIPTVGFU-UWTATZPHSA-N cyclic 2,3-bisphospho-D-glyceric acid Chemical compound OC(=O)[C@H]1COP(O)(=O)OP(O)(=O)O1 PZJOIILIPTVGFU-UWTATZPHSA-N 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 210000000434 stratum corneum Anatomy 0.000 claims 1
- 229960003080 taurine Drugs 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- UYPYRKYUKCHHIB-UHFFFAOYSA-N trimethylamine N-oxide Chemical compound C[N+](C)(C)[O-] UYPYRKYUKCHHIB-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17159311 | 2017-03-06 | ||
| EP17159311.4 | 2017-03-06 | ||
| PCT/EP2018/055251 WO2018162368A1 (en) | 2017-03-06 | 2018-03-05 | Use of compatible solutes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020509069A JP2020509069A (ja) | 2020-03-26 |
| JP2020509069A5 true JP2020509069A5 (https=) | 2021-04-15 |
| JP7132935B2 JP7132935B2 (ja) | 2022-09-07 |
Family
ID=58231498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019548605A Active JP7132935B2 (ja) | 2017-03-06 | 2018-03-05 | 適合溶質の使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20200030214A1 (https=) |
| EP (1) | EP3592329B1 (https=) |
| JP (1) | JP7132935B2 (https=) |
| CN (1) | CN110381917B (https=) |
| WO (1) | WO2018162368A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3104973B1 (fr) * | 2019-12-20 | 2022-07-22 | Sederma Sa | Composition cosmétique ou dermatologique agissant notamment sur les effets de la lumière bleue sur la peau et ses phanères, et utilisations associées |
| EP4322913A1 (en) * | 2021-04-16 | 2024-02-21 | DSM IP Assets B.V. | Retinol formulation (iii) |
| JP7821470B2 (ja) * | 2022-03-02 | 2026-02-27 | 日本メナード化粧品株式会社 | カルボニル化抑制剤 |
| CN115159671B (zh) * | 2022-06-30 | 2023-06-23 | 苏州博净源环境科技有限公司 | 一种基于高盐废水好氧处理的调渗剂及其制备方法与应用 |
| NL2035477B1 (en) * | 2023-02-20 | 2024-09-03 | Coty Inc | Eye cream formulation |
| FR3163566A1 (fr) * | 2024-06-21 | 2025-12-26 | L'oreal | Composition cosmétique comprenant un composé aminé, un agent séquestrant, du tocophérol, un corps gras et un agent antioxydant (poly)phénolique. |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2544180C2 (de) | 1975-10-03 | 1984-02-23 | Merck Patent Gmbh, 6100 Darmstadt | Lichtschutzmittel für kosmetische Zwecke |
| NL190101C (nl) | 1978-11-13 | 1993-11-01 | Givaudan & Cie Sa | Dibenzoylmethaanverbinding en tegen licht beschermend preparaat. |
| DE3302123A1 (de) | 1983-01-22 | 1984-07-26 | Haarmann & Reimer Gmbh | Neue dibenzol-methan-derivate, verfahren zu ihrer herstellung und ihre verwendung |
| TW197375B (https=) | 1990-11-19 | 1993-01-01 | Hayashibara Biochem Lab | |
| FR2680683B1 (fr) | 1991-08-29 | 1993-11-12 | Oreal | Composition cosmetique filtrante contenant un polymere filtre a structure hydrocarbonee et une silicone filtre. |
| DE4244580A1 (de) | 1992-12-31 | 1994-07-07 | Galinski Erwin A | Verfahren zur in vivo Gewinnung von Inhaltsstoffen aus Zellen |
| DE4342560A1 (de) | 1993-12-14 | 1995-06-22 | Marbert Gmbh | Ectoin und Ectoinderivate als Feuchtigkeitsspender in Kosmetikprodukten |
| DE19933461A1 (de) | 1998-07-10 | 2000-01-13 | Beiersdorf Ag | Verwendung von Ectoinen und UV-Filtern |
| DE19834818A1 (de) * | 1998-08-01 | 2000-02-03 | Merck Patent Gmbh | Kosmetische Formulierung |
| US20030157040A1 (en) * | 1998-08-01 | 2003-08-21 | Merck Patent Gmbh | Use of ectoine or ectoine derivatives in cosmetic formulations |
| DE19834816A1 (de) | 1998-08-01 | 2000-02-03 | Merck Patent Gmbh | Verwendung von Ectoin oder Ectoin-Derivaten in kosmetischen Formulierungen |
| AU750027B2 (en) | 1998-08-01 | 2002-07-11 | Merck Patent Gmbh | Use of ectoine or ectoine derivatives in cosmetic formulations |
| DE10002725A1 (de) | 2000-01-11 | 2001-07-12 | Beiersdorf Ag | Wirkstoffe und Zubereitungen für die Hautaufhellung und zur Verhinderung der Hautbräunung (skin whitening) |
| US20030147937A1 (en) * | 2000-04-12 | 2003-08-07 | Thomas Schwarz | Use of compatible solutes as substances having free radical scavenging properties |
| DE10114189B4 (de) | 2001-03-23 | 2013-01-03 | bitop Aktiengesellschaft für biotechnische Optimierung | Verfahren zur Gewinnung von Wertstoffen aus Organismen durch Beeinflussung/Beeinträchtigung der zelleigenen Transportsysteme für diese Wertstoffe bzw. durch Verwendung von Produktionsstämmen, denen besagte Transportsysteme fehlen |
| DE10214257A1 (de) * | 2002-03-28 | 2003-10-16 | Merck Patent Gmbh | Verwendung von kompatiblen Soluten zur Inhibierung der Freisetzung von Ceramiden |
| US20040253332A1 (en) * | 2002-04-11 | 2004-12-16 | Chaudhuri Ratan K. | Method for regulating the appearance of skin containing combination of skin care actives |
| DE10226990A1 (de) * | 2002-06-18 | 2004-03-18 | Sanguibiotech Ag | Topisch applizierbare Mikro-Emulsionen mit binärer Phasen- und Wirkstoffdifferenzierbarkeit, deren Herstellung und deren Verwendung, insbesondere zur Versorgung der Haut mit bioverfügbarem Sauerstoff |
| DE10324567A1 (de) | 2003-05-30 | 2004-12-23 | Symrise Gmbh & Co. Kg | Verwendung von Diphenylmethan-Derivaten als antimikrobielle Wirkstoffe |
| DE10337863A1 (de) | 2003-08-18 | 2005-03-17 | Merck Patent Gmbh | Verwendung von Chromen-4-on-Derivaten |
| WO2006111233A1 (de) | 2005-04-19 | 2006-10-26 | Merck Patent Gmbh | Antioxidantien |
| JP3914244B2 (ja) * | 2005-10-03 | 2007-05-16 | 株式会社ファンケル | 異常タンパク質除去用組成物 |
| US20080305059A1 (en) * | 2007-06-06 | 2008-12-11 | Chaudhuri Ratan K | Skin lightening compositions and methods |
| FR2926980A1 (fr) | 2008-02-06 | 2009-08-07 | Oreal | Composition cosmetique contenant un derive de dibenzoylmethane et un derive ester d'aminioacide neutre n-acyle particulier ; procede de photostabilisation du derive de dibenzoylmethane |
| WO2010017885A2 (en) | 2008-08-12 | 2010-02-18 | Merck Patent Gmbh | Use of 5-(7-methoxy-3,3-dimethyl-2,3-dihydro-1-benzoxepin-5-yl)-3-methyl- penta-2,4-dienoic acid as a cosmetic |
| GR1006881B (el) * | 2009-04-27 | 2010-07-13 | Κορρες Α.Ε. Φυσικα Προϊοντα, | Αντιγηραντικες ιδιοτητες της κερκετινης, του 18(α) - γλυκυρετινικου οξεος της χεδεραγενινης και των παραγωγων τους |
| JP2011148715A (ja) * | 2010-01-19 | 2011-08-04 | Maruzen Pharmaceut Co Ltd | タンパク質のカルボニル化抑制剤及び肌の透明感向上剤 |
| US20120114576A1 (en) * | 2010-07-30 | 2012-05-10 | Shiseido Company, Ltd. | Method for preventing or treating yellowish discoloration of skin |
| JP2012031106A (ja) * | 2010-07-30 | 2012-02-16 | Shiseido Co Ltd | カルボニル化抑制剤 |
| DE102011009112A1 (de) | 2011-01-21 | 2012-07-26 | Merck Patent Gmbh | Chromen-4-on-Derivate |
| FR2980362B1 (fr) * | 2011-09-27 | 2013-10-04 | Sederma Sa | Nouvelle utilisation cosmetique d'un extrait d'albizia julibrissin et composition topique correspondante |
| WO2013091775A2 (de) | 2011-12-21 | 2013-06-27 | Merck Patent Gmbh | Verwendung von cyclohexanolderivaten als antimikrobielle wirkstoffe |
| RU2014147075A (ru) * | 2012-04-25 | 2016-06-10 | Мерк Патент Гмбх | Применение производных дициклогексилметанола с антимикробными свойствами |
| RU2014149076A (ru) * | 2012-05-08 | 2016-06-27 | Мерк Патент Гмбх | Применение простых эфиров циклогексанола, обладающих антимикробными свойствами |
| DE102014113781A1 (de) * | 2014-09-23 | 2016-03-24 | Bitop Ag | Solut und Solutgemisch sowie eine Zusammensetzung enthaltend mindestens ein Solut zur Verwendung bei der Prävention oder Behandlung von durch Schwebstaub verursachter kosmetischer oder pathologischer Effloreszenzen |
| EP3215495A4 (en) * | 2014-11-03 | 2018-05-02 | Stella & Dot LLC | Skincare formulations and regimens |
| CN106137782A (zh) * | 2015-04-22 | 2016-11-23 | 捷通国际有限公司 | 包含青藤碱的局部组合物及用于抑制蛋白羰基化的方法 |
| CN106265113A (zh) * | 2015-05-14 | 2017-01-04 | 捷通国际有限公司 | 包含黄柏酮的组合物及在皮肤抗老化应用中使用该组合物的方法 |
-
2018
- 2018-03-05 JP JP2019548605A patent/JP7132935B2/ja active Active
- 2018-03-05 WO PCT/EP2018/055251 patent/WO2018162368A1/en not_active Ceased
- 2018-03-05 EP EP18708416.5A patent/EP3592329B1/en active Active
- 2018-03-05 US US16/491,447 patent/US20200030214A1/en not_active Abandoned
- 2018-03-05 CN CN201880014120.3A patent/CN110381917B/zh active Active
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