CN110381917B - 相容性溶质的用途 - Google Patents
相容性溶质的用途 Download PDFInfo
- Publication number
- CN110381917B CN110381917B CN201880014120.3A CN201880014120A CN110381917B CN 110381917 B CN110381917 B CN 110381917B CN 201880014120 A CN201880014120 A CN 201880014120A CN 110381917 B CN110381917 B CN 110381917B
- Authority
- CN
- China
- Prior art keywords
- acid
- skin
- compounds
- derivatives
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000011148 porous material Substances 0.000 claims abstract description 31
- 150000003839 salts Chemical class 0.000 claims abstract description 25
- 230000001603 reducing effect Effects 0.000 claims abstract description 17
- WQXNXVUDBPYKBA-YFKPBYRVSA-N ectoine Chemical compound CC1=[NH+][C@H](C([O-])=O)CCN1 WQXNXVUDBPYKBA-YFKPBYRVSA-N 0.000 claims description 23
- KIIBBJKLKFTNQO-WHFBIAKZSA-N 5-hydroxyectoine Chemical compound CC1=N[C@H](C(O)=O)[C@@H](O)CN1 KIIBBJKLKFTNQO-WHFBIAKZSA-N 0.000 claims description 6
- 239000000203 mixture Substances 0.000 abstract description 98
- 210000003491 skin Anatomy 0.000 abstract description 79
- 238000009472 formulation Methods 0.000 abstract description 61
- 102000004169 proteins and genes Human genes 0.000 abstract description 25
- 108090000623 proteins and genes Proteins 0.000 abstract description 25
- 108091006003 carbonylated proteins Proteins 0.000 abstract description 23
- 230000006315 carbonylation Effects 0.000 abstract description 16
- 238000005810 carbonylation reaction Methods 0.000 abstract description 16
- 238000000034 method Methods 0.000 abstract description 15
- 238000009825 accumulation Methods 0.000 abstract description 13
- 210000000434 stratum corneum Anatomy 0.000 abstract description 12
- 230000002401 inhibitory effect Effects 0.000 abstract description 11
- 150000001875 compounds Chemical class 0.000 description 89
- -1 aldehyde compounds Chemical class 0.000 description 70
- 229920001223 polyethylene glycol Polymers 0.000 description 49
- 239000002202 Polyethylene glycol Substances 0.000 description 47
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 42
- 239000000126 substance Substances 0.000 description 33
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 27
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 27
- 235000014113 dietary fatty acids Nutrition 0.000 description 27
- 229930195729 fatty acid Natural products 0.000 description 27
- 239000000194 fatty acid Substances 0.000 description 27
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 24
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 24
- 239000002537 cosmetic Substances 0.000 description 23
- 235000019441 ethanol Nutrition 0.000 description 23
- 239000000047 product Substances 0.000 description 23
- 235000018102 proteins Nutrition 0.000 description 23
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 22
- 239000004904 UV filter Substances 0.000 description 21
- 239000003921 oil Substances 0.000 description 21
- 235000019198 oils Nutrition 0.000 description 19
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 18
- 210000004027 cell Anatomy 0.000 description 17
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 17
- 239000003981 vehicle Substances 0.000 description 16
- 150000004665 fatty acids Chemical class 0.000 description 15
- 235000011187 glycerol Nutrition 0.000 description 15
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 14
- 238000003756 stirring Methods 0.000 description 14
- 239000004408 titanium dioxide Substances 0.000 description 14
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 13
- 239000001993 wax Substances 0.000 description 13
- 125000000217 alkyl group Chemical group 0.000 description 12
- 239000003963 antioxidant agent Substances 0.000 description 12
- 235000006708 antioxidants Nutrition 0.000 description 12
- 239000003995 emulsifying agent Substances 0.000 description 12
- 239000000839 emulsion Substances 0.000 description 12
- 239000000284 extract Substances 0.000 description 12
- 238000011282 treatment Methods 0.000 description 12
- 150000001413 amino acids Chemical class 0.000 description 11
- 125000004429 atom Chemical group 0.000 description 11
- 239000006071 cream Substances 0.000 description 11
- 238000002360 preparation method Methods 0.000 description 11
- 239000002904 solvent Substances 0.000 description 11
- 239000011787 zinc oxide Substances 0.000 description 11
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 10
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 10
- 239000002253 acid Substances 0.000 description 10
- 150000001298 alcohols Chemical class 0.000 description 10
- 229940024606 amino acid Drugs 0.000 description 10
- 235000001014 amino acid Nutrition 0.000 description 10
- 239000000499 gel Substances 0.000 description 10
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 10
- 229940049964 oleate Drugs 0.000 description 10
- 239000012071 phase Substances 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 9
- 239000000049 pigment Substances 0.000 description 9
- 229960004063 propylene glycol Drugs 0.000 description 9
- 235000013772 propylene glycol Nutrition 0.000 description 9
- 239000000377 silicon dioxide Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 8
- 235000015165 citric acid Nutrition 0.000 description 8
- 239000013256 coordination polymer Substances 0.000 description 8
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 8
- 210000002510 keratinocyte Anatomy 0.000 description 8
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 8
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 8
- 229920006395 saturated elastomer Polymers 0.000 description 8
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 7
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 7
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 7
- FMRHJJZUHUTGKE-UHFFFAOYSA-N Ethylhexyl salicylate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1O FMRHJJZUHUTGKE-UHFFFAOYSA-N 0.000 description 7
- 239000005642 Oleic acid Substances 0.000 description 7
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 7
- 206010040829 Skin discolouration Diseases 0.000 description 7
- 150000007513 acids Chemical class 0.000 description 7
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
- 150000002148 esters Chemical class 0.000 description 7
- 150000002191 fatty alcohols Chemical class 0.000 description 7
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 7
- 229920001296 polysiloxane Polymers 0.000 description 7
- 230000004224 protection Effects 0.000 description 7
- 230000001681 protective effect Effects 0.000 description 7
- 229940088594 vitamin Drugs 0.000 description 7
- 229930003231 vitamin Natural products 0.000 description 7
- 235000013343 vitamin Nutrition 0.000 description 7
- 239000011782 vitamin Substances 0.000 description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 6
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 6
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 6
- 239000004166 Lanolin Substances 0.000 description 6
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 6
- 229930003270 Vitamin B Natural products 0.000 description 6
- 239000002671 adjuvant Substances 0.000 description 6
- 230000003712 anti-aging effect Effects 0.000 description 6
- 230000003078 antioxidant effect Effects 0.000 description 6
- 229960003237 betaine Drugs 0.000 description 6
- 125000004432 carbon atom Chemical group C* 0.000 description 6
- 230000003834 intracellular effect Effects 0.000 description 6
- 235000019388 lanolin Nutrition 0.000 description 6
- 229940039717 lanolin Drugs 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 description 6
- 229920005862 polyol Polymers 0.000 description 6
- 150000003077 polyols Chemical class 0.000 description 6
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 6
- 229910052708 sodium Inorganic materials 0.000 description 6
- 239000011734 sodium Substances 0.000 description 6
- 125000005555 sulfoximide group Chemical group 0.000 description 6
- 239000004094 surface-active agent Substances 0.000 description 6
- 235000019156 vitamin B Nutrition 0.000 description 6
- 239000011720 vitamin B Substances 0.000 description 6
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 6
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 5
- DDXCFDOPXBPUJC-MTXRGOKVSA-N 2-(beta-D-mannosyl)-D-glyceric acid Chemical compound OC[C@H](C(O)=O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O DDXCFDOPXBPUJC-MTXRGOKVSA-N 0.000 description 5
- 208000035484 Cellulite Diseases 0.000 description 5
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 5
- 229910019142 PO4 Inorganic materials 0.000 description 5
- 206010049752 Peau d'orange Diseases 0.000 description 5
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 5
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 5
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 5
- 239000006185 dispersion Substances 0.000 description 5
- 235000014655 lactic acid Nutrition 0.000 description 5
- 239000004310 lactic acid Substances 0.000 description 5
- 229960000448 lactic acid Drugs 0.000 description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 5
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 5
- 235000021317 phosphate Nutrition 0.000 description 5
- 230000019612 pigmentation Effects 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 235000005875 quercetin Nutrition 0.000 description 5
- ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 5
- 150000003254 radicals Chemical class 0.000 description 5
- 230000009467 reduction Effects 0.000 description 5
- 239000011732 tocopherol Substances 0.000 description 5
- 229930003799 tocopherol Natural products 0.000 description 5
- 230000000699 topical effect Effects 0.000 description 5
- 150000003626 triacylglycerols Chemical class 0.000 description 5
- 229940045997 vitamin a Drugs 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 4
- ASKIVFGGGGIGKH-UHFFFAOYSA-N 2,3-dihydroxypropyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(O)CO ASKIVFGGGGIGKH-UHFFFAOYSA-N 0.000 description 4
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 4
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical class NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 240000000560 Citrus x paradisi Species 0.000 description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 4
- 108010016626 Dipeptides Chemical group 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- 239000004471 Glycine Substances 0.000 description 4
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 4
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 4
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 4
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 4
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 4
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- HEAHZSUCFKFERC-IWGRKNQJSA-N [(2e)-2-[[4-[(e)-[7,7-dimethyl-3-oxo-4-(sulfomethyl)-2-bicyclo[2.2.1]heptanylidene]methyl]phenyl]methylidene]-7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl]methanesulfonic acid Chemical group CC1(C)C2CCC1(CS(O)(=O)=O)C(=O)\C2=C\C(C=C1)=CC=C1\C=C/1C(=O)C2(CS(O)(=O)=O)CCC\1C2(C)C HEAHZSUCFKFERC-IWGRKNQJSA-N 0.000 description 4
- 229960004308 acetylcysteine Drugs 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 150000001299 aldehydes Chemical class 0.000 description 4
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 4
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 description 4
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 229910000420 cerium oxide Inorganic materials 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- PZJOIILIPTVGFU-UWTATZPHSA-N cyclic 2,3-bisphospho-D-glyceric acid Chemical compound OC(=O)[C@H]1COP(O)(=O)OP(O)(=O)O1 PZJOIILIPTVGFU-UWTATZPHSA-N 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 4
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 4
- 235000004554 glutamine Nutrition 0.000 description 4
- 229940074046 glyceryl laurate Drugs 0.000 description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 4
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- KQPYUDDGWXQXHS-UHFFFAOYSA-N juglone Chemical compound O=C1C=CC(=O)C2=C1C=CC=C2O KQPYUDDGWXQXHS-UHFFFAOYSA-N 0.000 description 4
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 4
- 150000002632 lipids Chemical class 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000006210 lotion Substances 0.000 description 4
- BMMGVYCKOGBVEV-UHFFFAOYSA-N oxo(oxoceriooxy)cerium Chemical compound [Ce]=O.O=[Ce]=O BMMGVYCKOGBVEV-UHFFFAOYSA-N 0.000 description 4
- 239000013500 performance material Substances 0.000 description 4
- 239000010452 phosphate Substances 0.000 description 4
- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical class NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 description 4
- 229960001285 quercetin Drugs 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 229920002545 silicone oil Polymers 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 229960000984 tocofersolan Drugs 0.000 description 4
- 150000003722 vitamin derivatives Chemical class 0.000 description 4
- HEOCBCNFKCOKBX-RELGSGGGSA-N (1s,2e,4r)-4,7,7-trimethyl-2-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-3-one Chemical compound C1=CC(C)=CC=C1\C=C/1C(=O)[C@]2(C)CC[C@H]\1C2(C)C HEOCBCNFKCOKBX-RELGSGGGSA-N 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 3
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 description 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 3
- JGUMTYWKIBJSTN-UHFFFAOYSA-N 2-ethylhexyl 4-[[4,6-bis[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 JGUMTYWKIBJSTN-UHFFFAOYSA-N 0.000 description 3
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 3
- WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 description 3
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 description 3
- QHYWQIVTVQAKQF-UHFFFAOYSA-N 3,5-dihydroxy-2-phenylchromen-4-one Chemical class OC=1C(=O)C=2C(O)=CC=CC=2OC=1C1=CC=CC=C1 QHYWQIVTVQAKQF-UHFFFAOYSA-N 0.000 description 3
- FJKROLUGYXJWQN-UHFFFAOYSA-M 4-hydroxybenzoate Chemical compound OC1=CC=C(C([O-])=O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-M 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 3
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 3
- 239000011627 DL-alpha-tocopherol Substances 0.000 description 3
- 235000001815 DL-alpha-tocopherol Nutrition 0.000 description 3
- 206010013786 Dry skin Diseases 0.000 description 3
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 description 3
- ATJXMQHAMYVHRX-CPCISQLKSA-N Ellagic acid Natural products OC1=C(O)[C@H]2OC(=O)c3cc(O)c(O)c4OC(=O)C(=C1)[C@H]2c34 ATJXMQHAMYVHRX-CPCISQLKSA-N 0.000 description 3
- 229920002079 Ellagic acid Polymers 0.000 description 3
- 235000015489 Emblica officinalis Nutrition 0.000 description 3
- 244000119298 Emblica officinalis Species 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- OVSQVDMCBVZWGM-IDRAQACASA-N Hirsutrin Natural products O([C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1)C1=C(c2cc(O)c(O)cc2)Oc2c(c(O)cc(O)c2)C1=O OVSQVDMCBVZWGM-IDRAQACASA-N 0.000 description 3
- FVQOMEDMFUMIMO-UHFFFAOYSA-N Hyperosid Natural products OC1C(O)C(O)C(CO)OC1OC1C(=O)C2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 FVQOMEDMFUMIMO-UHFFFAOYSA-N 0.000 description 3
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 3
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 3
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 description 3
- 206010051246 Photodermatosis Diseases 0.000 description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
- VYGQUTWHTHXGQB-UHFFFAOYSA-N Retinol hexadecanoate Natural products CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-UHFFFAOYSA-N 0.000 description 3
- 229920002125 Sokalan® Polymers 0.000 description 3
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 3
- 229930003268 Vitamin C Natural products 0.000 description 3
- NCHJGQKLPRTMAO-XWVZOOPGSA-N [(2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NCHJGQKLPRTMAO-XWVZOOPGSA-N 0.000 description 3
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 239000000443 aerosol Substances 0.000 description 3
- 238000013019 agitation Methods 0.000 description 3
- 235000004279 alanine Nutrition 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000003255 anti-acne Effects 0.000 description 3
- 230000000845 anti-microbial effect Effects 0.000 description 3
- 229960002255 azelaic acid Drugs 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 150000004777 chromones Chemical class 0.000 description 3
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- WSDISUOETYTPRL-UHFFFAOYSA-N dmdm hydantoin Chemical compound CC1(C)N(CO)C(=O)N(CO)C1=O WSDISUOETYTPRL-UHFFFAOYSA-N 0.000 description 3
- 230000037336 dry skin Effects 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 229960002852 ellagic acid Drugs 0.000 description 3
- 235000004132 ellagic acid Nutrition 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- UVCJGUGAGLDPAA-UHFFFAOYSA-N ensulizole Chemical compound N1C2=CC(S(=O)(=O)O)=CC=C2N=C1C1=CC=CC=C1 UVCJGUGAGLDPAA-UHFFFAOYSA-N 0.000 description 3
- 229960000655 ensulizole Drugs 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 239000003925 fat Substances 0.000 description 3
- 235000019197 fats Nutrition 0.000 description 3
- 239000012091 fetal bovine serum Substances 0.000 description 3
- OQLKNTOKMBVBKV-UHFFFAOYSA-N hexamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCCOC1=CC=C(C(N)=N)C=C1 OQLKNTOKMBVBKV-UHFFFAOYSA-N 0.000 description 3
- 229960001915 hexamidine Drugs 0.000 description 3
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 description 3
- 229940091173 hydantoin Drugs 0.000 description 3
- 229960000367 inositol Drugs 0.000 description 3
- OVSQVDMCBVZWGM-QCKGUQPXSA-N isoquercetin Natural products OC[C@@H]1O[C@@H](OC2=C(Oc3cc(O)cc(O)c3C2=O)c4ccc(O)c(O)c4)[C@H](O)[C@@H](O)[C@@H]1O OVSQVDMCBVZWGM-QCKGUQPXSA-N 0.000 description 3
- 239000000787 lecithin Substances 0.000 description 3
- 229940067606 lecithin Drugs 0.000 description 3
- 235000010445 lecithin Nutrition 0.000 description 3
- 229940069445 licorice extract Drugs 0.000 description 3
- 210000002752 melanocyte Anatomy 0.000 description 3
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 description 3
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 3
- 229960003512 nicotinic acid Drugs 0.000 description 3
- 235000001968 nicotinic acid Nutrition 0.000 description 3
- 239000011664 nicotinic acid Substances 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical group CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- 230000036542 oxidative stress Effects 0.000 description 3
- 229960001173 oxybenzone Drugs 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000006072 paste Substances 0.000 description 3
- 230000008845 photoaging Effects 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 239000003380 propellant Substances 0.000 description 3
- 125000001453 quaternary ammonium group Chemical class 0.000 description 3
- OVSQVDMCBVZWGM-QSOFNFLRSA-N quercetin 3-O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-QSOFNFLRSA-N 0.000 description 3
- LKUNXBRZDFMZOK-UHFFFAOYSA-N rac-1-monodecanoylglycerol Chemical compound CCCCCCCCCC(=O)OCC(O)CO LKUNXBRZDFMZOK-UHFFFAOYSA-N 0.000 description 3
- 235000020944 retinol Nutrition 0.000 description 3
- 239000011607 retinol Substances 0.000 description 3
- 229960003471 retinol Drugs 0.000 description 3
- 235000019172 retinyl palmitate Nutrition 0.000 description 3
- 239000011769 retinyl palmitate Substances 0.000 description 3
- 229940108325 retinyl palmitate Drugs 0.000 description 3
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 description 3
- 229960004889 salicylic acid Drugs 0.000 description 3
- 210000002374 sebum Anatomy 0.000 description 3
- 230000037307 sensitive skin Effects 0.000 description 3
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 3
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 3
- 235000019982 sodium hexametaphosphate Nutrition 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- 235000010356 sorbitol Nutrition 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 230000035882 stress Effects 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- 150000008163 sugars Chemical class 0.000 description 3
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- 229960001295 tocopherol Drugs 0.000 description 3
- 235000010384 tocopherol Nutrition 0.000 description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 3
- 229960003500 triclosan Drugs 0.000 description 3
- 229960004441 tyrosine Drugs 0.000 description 3
- 235000015112 vegetable and seed oil Nutrition 0.000 description 3
- 235000019154 vitamin C Nutrition 0.000 description 3
- 239000011718 vitamin C Substances 0.000 description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 2
- OIQXFRANQVWXJF-QBFSEMIESA-N (2z)-2-benzylidene-4,7,7-trimethylbicyclo[2.2.1]heptan-3-one Chemical class CC1(C)C2CCC1(C)C(=O)\C2=C/C1=CC=CC=C1 OIQXFRANQVWXJF-QBFSEMIESA-N 0.000 description 2
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- MEZZCSHVIGVWFI-UHFFFAOYSA-N 2,2'-Dihydroxy-4-methoxybenzophenone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1O MEZZCSHVIGVWFI-UHFFFAOYSA-N 0.000 description 2
- KXKQHJVZECGDCE-UHFFFAOYSA-N 2,2-diamino-5-oxohexanoic acid Chemical compound CC(=O)CCC(N)(N)C(O)=O KXKQHJVZECGDCE-UHFFFAOYSA-N 0.000 description 2
- ZXDDPOHVAMWLBH-UHFFFAOYSA-N 2,4-Dihydroxybenzophenone Chemical compound OC1=CC(O)=CC=C1C(=O)C1=CC=CC=C1 ZXDDPOHVAMWLBH-UHFFFAOYSA-N 0.000 description 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 2
- CIWBSHSKHKDKBQ-SZSCBOSDSA-N 2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one Chemical compound OC[C@H](O)C1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-SZSCBOSDSA-N 0.000 description 2
- HGTZHPGKDMHOLA-UHFFFAOYSA-N 2-acetyl-3,3-diaminobutanoic acid Chemical compound CC(=O)C(C(O)=O)C(C)(N)N HGTZHPGKDMHOLA-UHFFFAOYSA-N 0.000 description 2
- QTWJRLJHJPIABL-UHFFFAOYSA-N 2-methylphenol;3-methylphenol;4-methylphenol Chemical compound CC1=CC=C(O)C=C1.CC1=CC=CC(O)=C1.CC1=CC=CC=C1O QTWJRLJHJPIABL-UHFFFAOYSA-N 0.000 description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 2
- ISDGWTZFJKFKMO-UHFFFAOYSA-N 2-phenyl-1,3-dioxane-4,6-dione Chemical class O1C(=O)CC(=O)OC1C1=CC=CC=C1 ISDGWTZFJKFKMO-UHFFFAOYSA-N 0.000 description 2
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 description 2
- IJFXRHURBJZNAO-UHFFFAOYSA-N 3-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=CC(O)=C1 IJFXRHURBJZNAO-UHFFFAOYSA-N 0.000 description 2
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 description 2
- JVJFIQYAHPMBBX-UHFFFAOYSA-N 4-hydroxynonenal Chemical compound CCCCCC(O)C=CC=O JVJFIQYAHPMBBX-UHFFFAOYSA-N 0.000 description 2
- CSHZYWUPJWVTMQ-UHFFFAOYSA-N 4-n-Butylresorcinol Chemical compound CCCCC1=CC=C(O)C=C1O CSHZYWUPJWVTMQ-UHFFFAOYSA-N 0.000 description 2
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 2
- HGINCPLSRVDWNT-UHFFFAOYSA-N Acrolein Chemical compound C=CC=O HGINCPLSRVDWNT-UHFFFAOYSA-N 0.000 description 2
- HKIKAXXIWJHWLY-ZIIYPAMZSA-N Aloesin Chemical compound C=12OC(CC(=O)C)=CC(=O)C2=C(C)C=C(O)C=1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HKIKAXXIWJHWLY-ZIIYPAMZSA-N 0.000 description 2
- HKIKAXXIWJHWLY-QEVGBQTESA-N Aloesin Natural products O=C(CC=1Oc2c([C@H]3[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O3)c(O)cc(C)c2C(=O)C=1)C HKIKAXXIWJHWLY-QEVGBQTESA-N 0.000 description 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 2
- 241000416162 Astragalus gummifer Species 0.000 description 2
- 239000005711 Benzoic acid Substances 0.000 description 2
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 2
- LVDKZNITIUWNER-UHFFFAOYSA-N Bronopol Chemical compound OCC(Br)(CO)[N+]([O-])=O LVDKZNITIUWNER-UHFFFAOYSA-N 0.000 description 2
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- 108010087806 Carnosine Proteins 0.000 description 2
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 2
- WQXNXVUDBPYKBA-UHFFFAOYSA-N Ectoine Natural products CC1=NCCC(C(O)=O)N1 WQXNXVUDBPYKBA-UHFFFAOYSA-N 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- 102000002812 Heat-Shock Proteins Human genes 0.000 description 2
- 108010004889 Heat-Shock Proteins Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- XPJVKCRENWUEJH-UHFFFAOYSA-N Isobutylparaben Chemical compound CC(C)COC(=O)C1=CC=C(O)C=C1 XPJVKCRENWUEJH-UHFFFAOYSA-N 0.000 description 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 2
- 239000002211 L-ascorbic acid Substances 0.000 description 2
- 235000000069 L-ascorbic acid Nutrition 0.000 description 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 2
- 235000008708 Morus alba Nutrition 0.000 description 2
- 240000000249 Morus alba Species 0.000 description 2
- SRXKAYJJGAAOBP-UHFFFAOYSA-N N(5)-acetylornithine Chemical compound CC(=O)NCCCC(N)C(O)=O SRXKAYJJGAAOBP-UHFFFAOYSA-N 0.000 description 2
- DTERQYGMUDWYAZ-ZETCQYMHSA-N N(6)-acetyl-L-lysine Chemical compound CC(=O)NCCCC[C@H]([NH3+])C([O-])=O DTERQYGMUDWYAZ-ZETCQYMHSA-N 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 2
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 2
- WYWZRNAHINYAEF-UHFFFAOYSA-N Padimate O Chemical compound CCCCC(CC)COC(=O)C1=CC=C(N(C)C)C=C1 WYWZRNAHINYAEF-UHFFFAOYSA-N 0.000 description 2
- 235000019483 Peanut oil Nutrition 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 108010009736 Protein Hydrolysates Proteins 0.000 description 2
- RADKZDMFGJYCBB-UHFFFAOYSA-N Pyridoxal Chemical compound CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 2
- 239000004473 Threonine Substances 0.000 description 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
- 229920001615 Tragacanth Polymers 0.000 description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 2
- PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 description 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- 229930003316 Vitamin D Natural products 0.000 description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 229940022663 acetate Drugs 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 150000001335 aliphatic alkanes Chemical class 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- ANVAOWXLWRTKGA-XHGAXZNDSA-N all-trans-alpha-carotene Chemical compound CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1C(C)=CCCC1(C)C ANVAOWXLWRTKGA-XHGAXZNDSA-N 0.000 description 2
- 229940061720 alpha hydroxy acid Drugs 0.000 description 2
- 150000001280 alpha hydroxy acids Chemical class 0.000 description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- 229960000271 arbutin Drugs 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 235000009582 asparagine Nutrition 0.000 description 2
- 229960001230 asparagine Drugs 0.000 description 2
- 235000003704 aspartic acid Nutrition 0.000 description 2
- 235000012216 bentonite Nutrition 0.000 description 2
- 229960000686 benzalkonium chloride Drugs 0.000 description 2
- 235000010233 benzoic acid Nutrition 0.000 description 2
- ISAOCJYIOMOJEB-UHFFFAOYSA-N benzoin Chemical compound C=1C=CC=CC=1C(O)C(=O)C1=CC=CC=C1 ISAOCJYIOMOJEB-UHFFFAOYSA-N 0.000 description 2
- 229960002903 benzyl benzoate Drugs 0.000 description 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 2
- 229940000635 beta-alanine Drugs 0.000 description 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 2
- 229940093797 bioflavonoids Drugs 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- XSIFPSYPOVKYCO-UHFFFAOYSA-N butyl benzoate Chemical compound CCCCOC(=O)C1=CC=CC=C1 XSIFPSYPOVKYCO-UHFFFAOYSA-N 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 description 2
- 229940044199 carnosine Drugs 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 230000019522 cellular metabolic process Effects 0.000 description 2
- 229960000541 cetyl alcohol Drugs 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- VXIVSQZSERGHQP-UHFFFAOYSA-N chloroacetamide Chemical compound NC(=O)CCl VXIVSQZSERGHQP-UHFFFAOYSA-N 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 239000007957 coemulsifier Substances 0.000 description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 2
- 235000018417 cysteine Nutrition 0.000 description 2
- 229960002433 cysteine Drugs 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 125000000664 diazo group Chemical group [N-]=[N+]=[*] 0.000 description 2
- NZZIMKJIVMHWJC-UHFFFAOYSA-N dibenzoylmethane Chemical class C=1C=CC=CC=1C(=O)CC(=O)C1=CC=CC=C1 NZZIMKJIVMHWJC-UHFFFAOYSA-N 0.000 description 2
- FDATWRLUYRHCJE-UHFFFAOYSA-N diethylamino hydroxybenzoyl hexyl benzoate Chemical compound CCCCCCOC(=O)C1=CC=CC=C1C(=O)C1=CC=C(N(CC)CC)C=C1O FDATWRLUYRHCJE-UHFFFAOYSA-N 0.000 description 2
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Chemical class CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000003974 emollient agent Substances 0.000 description 2
- 229960004697 enzacamene Drugs 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- UQPHVQVXLPRNCX-UHFFFAOYSA-N erythrulose Chemical compound OCC(O)C(=O)CO UQPHVQVXLPRNCX-UHFFFAOYSA-N 0.000 description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- 229940068171 ethyl hexyl salicylate Drugs 0.000 description 2
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 2
- 229940114124 ferulic acid Drugs 0.000 description 2
- 235000001785 ferulic acid Nutrition 0.000 description 2
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 239000001530 fumaric acid Substances 0.000 description 2
- 229960002598 fumaric acid Drugs 0.000 description 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 2
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 2
- 235000013922 glutamic acid Nutrition 0.000 description 2
- 239000004220 glutamic acid Substances 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 229940080812 glyceryl caprate Drugs 0.000 description 2
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 229960002163 hydrogen peroxide Drugs 0.000 description 2
- 229960004337 hydroquinone Drugs 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- BTFJIXJJCSYFAL-UHFFFAOYSA-N icosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 2
- 150000002460 imidazoles Chemical class 0.000 description 2
- 125000001841 imino group Chemical group [H]N=* 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 2
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 2
- 229960004705 kojic acid Drugs 0.000 description 2
- CSFWPUWCSPOLJW-UHFFFAOYSA-N lawsone Chemical compound C1=CC=C2C(=O)C(O)=CC(=O)C2=C1 CSFWPUWCSPOLJW-UHFFFAOYSA-N 0.000 description 2
- 230000003859 lipid peroxidation Effects 0.000 description 2
- 235000019136 lipoic acid Nutrition 0.000 description 2
- 239000004973 liquid crystal related substance Substances 0.000 description 2
- RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 description 2
- 229940078752 magnesium ascorbyl phosphate Drugs 0.000 description 2
- 239000001630 malic acid Substances 0.000 description 2
- 235000011090 malic acid Nutrition 0.000 description 2
- HCZKYJDFEPMADG-TXEJJXNPSA-N masoprocol Chemical compound C([C@H](C)[C@H](C)CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-TXEJJXNPSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 230000003061 melanogenesis Effects 0.000 description 2
- 229910044991 metal oxide Inorganic materials 0.000 description 2
- 150000004706 metal oxides Chemical class 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- NCUJRUDLFCGVOE-UHFFFAOYSA-N noreugenin Chemical compound C1=C(O)C=C2OC(C)=CC(=O)C2=C1O NCUJRUDLFCGVOE-UHFFFAOYSA-N 0.000 description 2
- AZTPTPPLNRTTGQ-UHFFFAOYSA-N noreugenin Natural products OC1=CC(O)=C2C(=O)C(C)=COC2=C1 AZTPTPPLNRTTGQ-UHFFFAOYSA-N 0.000 description 2
- QWVGKYWNOKOFNN-UHFFFAOYSA-N o-cresol Chemical compound CC1=CC=CC=C1O QWVGKYWNOKOFNN-UHFFFAOYSA-N 0.000 description 2
- QUAMTGJKVDWJEQ-UHFFFAOYSA-N octabenzone Chemical compound OC1=CC(OCCCCCCCC)=CC=C1C(=O)C1=CC=CC=C1 QUAMTGJKVDWJEQ-UHFFFAOYSA-N 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 229960001679 octinoxate Drugs 0.000 description 2
- 239000004006 olive oil Substances 0.000 description 2
- 235000008390 olive oil Nutrition 0.000 description 2
- 235000010292 orthophenyl phenol Nutrition 0.000 description 2
- IWDCLRJOBJJRNH-UHFFFAOYSA-N p-cresol Chemical compound CC1=CC=C(O)C=C1 IWDCLRJOBJJRNH-UHFFFAOYSA-N 0.000 description 2
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 2
- 229940055726 pantothenic acid Drugs 0.000 description 2
- 235000019161 pantothenic acid Nutrition 0.000 description 2
- 239000011713 pantothenic acid Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000312 peanut oil Substances 0.000 description 2
- 229960005323 phenoxyethanol Drugs 0.000 description 2
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 2
- 239000000419 plant extract Substances 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 229920000058 polyacrylate Polymers 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 235000010241 potassium sorbate Nutrition 0.000 description 2
- 239000004302 potassium sorbate Substances 0.000 description 2
- 229940069338 potassium sorbate Drugs 0.000 description 2
- DKGFIVSGQRBSOG-UHFFFAOYSA-M potassium;4-hydroxybenzoate Chemical compound [K+].OC1=CC=C(C([O-])=O)C=C1 DKGFIVSGQRBSOG-UHFFFAOYSA-M 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 229960002429 proline Drugs 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 239000003531 protein hydrolysate Substances 0.000 description 2
- NHZMQXZHNVQTQA-UHFFFAOYSA-N pyridoxamine Chemical compound CC1=NC=C(CO)C(CN)=C1O NHZMQXZHNVQTQA-UHFFFAOYSA-N 0.000 description 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000001331 rosmarinus officinalis leaf Substances 0.000 description 2
- 229910052711 selenium Inorganic materials 0.000 description 2
- 239000011669 selenium Substances 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- IRHWMYKYLWNHTL-UHFFFAOYSA-M sodium 2-(N-morpholino)ethanesulfonate Chemical compound [Na+].[O-]S(=O)(=O)CCN1CCOCC1 IRHWMYKYLWNHTL-UHFFFAOYSA-M 0.000 description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 2
- 235000010234 sodium benzoate Nutrition 0.000 description 2
- 239000004299 sodium benzoate Substances 0.000 description 2
- 235000010230 sodium propyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004404 sodium propyl p-hydroxybenzoate Substances 0.000 description 2
- IXMINYBUNCWGER-UHFFFAOYSA-M sodium;4-propoxycarbonylphenolate Chemical compound [Na+].CCCOC(=O)C1=CC=C([O-])C=C1 IXMINYBUNCWGER-UHFFFAOYSA-M 0.000 description 2
- KJCLYACXIWMFCC-UHFFFAOYSA-M sodium;5-benzoyl-4-hydroxy-2-methoxybenzenesulfonate Chemical compound [Na+].C1=C(S([O-])(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 KJCLYACXIWMFCC-UHFFFAOYSA-M 0.000 description 2
- 235000010199 sorbic acid Nutrition 0.000 description 2
- 239000004334 sorbic acid Substances 0.000 description 2
- 229940075582 sorbic acid Drugs 0.000 description 2
- 229940035044 sorbitan monolaurate Drugs 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 description 2
- 229960000368 sulisobenzone Drugs 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 150000003573 thiols Chemical class 0.000 description 2
- 125000002640 tocopherol group Chemical class 0.000 description 2
- 235000019149 tocopherols Nutrition 0.000 description 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
- 235000010487 tragacanth Nutrition 0.000 description 2
- 239000000196 tragacanth Substances 0.000 description 2
- 229940116362 tragacanth Drugs 0.000 description 2
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 2
- 230000014616 translation Effects 0.000 description 2
- 150000003918 triazines Chemical class 0.000 description 2
- HTJNEBVCZXHBNJ-XCTPRCOBSA-H trimagnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;diphosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O HTJNEBVCZXHBNJ-XCTPRCOBSA-H 0.000 description 2
- UEVAMYPIMMOEFW-UHFFFAOYSA-N trolamine salicylate Chemical compound OCCN(CCO)CCO.OC(=O)C1=CC=CC=C1O UEVAMYPIMMOEFW-UHFFFAOYSA-N 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- WEYVVCKOOFYHRW-UHFFFAOYSA-N usnic acid Chemical compound CC12C(=O)C(C(=O)C)=C(O)C=C1OC1=C2C(O)=C(C)C(O)=C1C(C)=O WEYVVCKOOFYHRW-UHFFFAOYSA-N 0.000 description 2
- 239000004474 valine Substances 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- 235000019166 vitamin D Nutrition 0.000 description 2
- 239000011710 vitamin D Substances 0.000 description 2
- 150000003710 vitamin D derivatives Chemical class 0.000 description 2
- 229940046008 vitamin d Drugs 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 229940043810 zinc pyrithione Drugs 0.000 description 2
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 description 1
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 description 1
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- YSRSBDQINUMTIF-SNVBAGLBSA-N (2r)-decane-1,2-diol Chemical compound CCCCCCCC[C@@H](O)CO YSRSBDQINUMTIF-SNVBAGLBSA-N 0.000 description 1
- OBENDWOJIFFDLZ-UHFFFAOYSA-N (3,5-dimethylpyrazol-1-yl)methanol Chemical compound CC=1C=C(C)N(CO)N=1 OBENDWOJIFFDLZ-UHFFFAOYSA-N 0.000 description 1
- LDVVMCZRFWMZSG-OLQVQODUSA-N (3ar,7as)-2-(trichloromethylsulfanyl)-3a,4,7,7a-tetrahydroisoindole-1,3-dione Chemical compound C1C=CC[C@H]2C(=O)N(SC(Cl)(Cl)Cl)C(=O)[C@H]21 LDVVMCZRFWMZSG-OLQVQODUSA-N 0.000 description 1
- RUHCWQAFCGVQJX-RVWHZBQESA-N (3s,8s,9s,10r,13r,14s,17r)-3-hydroxy-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-1-one Chemical compound C1C=C2C[C@H](O)CC(=O)[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 RUHCWQAFCGVQJX-RVWHZBQESA-N 0.000 description 1
- GESOQMRLBPSMDF-UHFFFAOYSA-N (5-hydroxy-2-methyl-4-oxochromen-7-yl) hexadecanoate Chemical compound O1C(C)=CC(=O)C=2C1=CC(OC(=O)CCCCCCCCCCCCCCC)=CC=2O GESOQMRLBPSMDF-UHFFFAOYSA-N 0.000 description 1
- TXYBTICNEXWGOC-UHFFFAOYSA-N (6,6-dimethyl-1-phenylhepta-1,3-dienyl)benzene Chemical compound C=1C=CC=CC=1C(=CC=CCC(C)(C)C)C1=CC=CC=C1 TXYBTICNEXWGOC-UHFFFAOYSA-N 0.000 description 1
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- GUYHPGUANSLONG-SNAWJCMRSA-N (E)-4-(trimethylammonio)but-2-enoate Chemical compound C[N+](C)(C)C\C=C\C([O-])=O GUYHPGUANSLONG-SNAWJCMRSA-N 0.000 description 1
- WSWCOQWTEOXDQX-MQQKCMAXSA-M (E,E)-sorbate Chemical compound C\C=C\C=C\C([O-])=O WSWCOQWTEOXDQX-MQQKCMAXSA-M 0.000 description 1
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical class C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 description 1
- IZFHEQBZOYJLPK-SSDOTTSWSA-N (R)-dihydrolipoic acid Chemical compound OC(=O)CCCC[C@@H](S)CCS IZFHEQBZOYJLPK-SSDOTTSWSA-N 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical class C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 description 1
- DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 description 1
- RRFBTKHQZRCRSS-UHFFFAOYSA-N 1,3-bis(methoxymethyl)-5,5-diphenyl-1,3-diazinane-2,4,6-trione Chemical compound O=C1N(COC)C(=O)N(COC)C(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 RRFBTKHQZRCRSS-UHFFFAOYSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- NWGAAWUUGRXXSC-UHFFFAOYSA-N 1-(2-hydroxypropoxy)propan-2-yl 2-hydroxybenzoate Chemical compound CC(O)COCC(C)OC(=O)C1=CC=CC=C1O NWGAAWUUGRXXSC-UHFFFAOYSA-N 0.000 description 1
- OWEGWHBOCFMBLP-UHFFFAOYSA-N 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one Chemical compound C1=CN=CN1C(C(=O)C(C)(C)C)OC1=CC=C(Cl)C=C1 OWEGWHBOCFMBLP-UHFFFAOYSA-N 0.000 description 1
- SIQZJFKTROUNPI-UHFFFAOYSA-N 1-(hydroxymethyl)-5,5-dimethylhydantoin Chemical compound CC1(C)N(CO)C(=O)NC1=O SIQZJFKTROUNPI-UHFFFAOYSA-N 0.000 description 1
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 1
- ARIWANIATODDMH-AWEZNQCLSA-N 1-lauroyl-sn-glycerol Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)CO ARIWANIATODDMH-AWEZNQCLSA-N 0.000 description 1
- HBXWUCXDUUJDRB-UHFFFAOYSA-N 1-octadecoxyoctadecane Chemical compound CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC HBXWUCXDUUJDRB-UHFFFAOYSA-N 0.000 description 1
- IBLKWZIFZMJLFL-UHFFFAOYSA-N 1-phenoxypropan-2-ol Chemical compound CC(O)COC1=CC=CC=C1 IBLKWZIFZMJLFL-UHFFFAOYSA-N 0.000 description 1
- LALVCWMSKLEQMK-UHFFFAOYSA-N 1-phenyl-3-(4-propan-2-ylphenyl)propane-1,3-dione Chemical compound C1=CC(C(C)C)=CC=C1C(=O)CC(=O)C1=CC=CC=C1 LALVCWMSKLEQMK-UHFFFAOYSA-N 0.000 description 1
- PRDFBSVERLRRMY-UHFFFAOYSA-N 2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole Chemical compound C1=CC(OCC)=CC=C1C1=NC2=CC=C(C=3NC4=CC(=CC=C4N=3)N3CCN(C)CC3)C=C2N1 PRDFBSVERLRRMY-UHFFFAOYSA-N 0.000 description 1
- VSHIRTNKIXRXMI-UHFFFAOYSA-N 2,2-dimethyl-1,3-oxazolidine Chemical compound CC1(C)NCCO1 VSHIRTNKIXRXMI-UHFFFAOYSA-N 0.000 description 1
- WHQOKFZWSDOTQP-UHFFFAOYSA-N 2,3-dihydroxypropyl 4-aminobenzoate Chemical compound NC1=CC=C(C(=O)OCC(O)CO)C=C1 WHQOKFZWSDOTQP-UHFFFAOYSA-N 0.000 description 1
- CENPSTJGQOQKKW-UHFFFAOYSA-N 2,4,6-tris(4-phenylphenyl)-1,3,5-triazine Chemical compound C1=CC=CC=C1C1=CC=C(C=2N=C(N=C(N=2)C=2C=CC(=CC=2)C=2C=CC=CC=2)C=2C=CC(=CC=2)C=2C=CC=CC=2)C=C1 CENPSTJGQOQKKW-UHFFFAOYSA-N 0.000 description 1
- OVSKIKFHRZPJSS-UHFFFAOYSA-N 2,4-D Chemical compound OC(=O)COC1=CC=C(Cl)C=C1Cl OVSKIKFHRZPJSS-UHFFFAOYSA-N 0.000 description 1
- SBASXUCJHJRPEV-UHFFFAOYSA-N 2-(2-methoxyethoxy)ethanol Chemical group COCCOCCO SBASXUCJHJRPEV-UHFFFAOYSA-N 0.000 description 1
- CIOBGEWECUNDRU-UHFFFAOYSA-N 2-(3-methylpentan-3-yl)octanamide Chemical compound C(C)C(C(C(=O)N)CCCCCC)(C)CC CIOBGEWECUNDRU-UHFFFAOYSA-N 0.000 description 1
- FLPJVCMIKUWSDR-UHFFFAOYSA-N 2-(4-formylphenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(C=O)C=C1 FLPJVCMIKUWSDR-UHFFFAOYSA-N 0.000 description 1
- JINMBYCYQHBMPQ-UHFFFAOYSA-N 2-(4-hydroxy-3,5-dimethoxyphenyl)-1,3-dioxane-4,6-dione Chemical compound COC1=C(O)C(OC)=CC(C2OC(=O)CC(=O)O2)=C1 JINMBYCYQHBMPQ-UHFFFAOYSA-N 0.000 description 1
- ALBXRBNFWICCSC-UHFFFAOYSA-N 2-(5,5-dimethyl-1,1-diphenylhex-1-en-3-ylidene)propanedioic acid Chemical compound C=1C=CC=CC=1C(=CC(CC(C)(C)C)=C(C(O)=O)C(O)=O)C1=CC=CC=C1 ALBXRBNFWICCSC-UHFFFAOYSA-N 0.000 description 1
- USPWZHPEKZNJMB-UHFFFAOYSA-N 2-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]propanedioic acid Chemical compound COC1=CC(C=C(C(O)=O)C(O)=O)=CC(OC)=C1O USPWZHPEKZNJMB-UHFFFAOYSA-N 0.000 description 1
- TYRYZLMVZZMQDR-UHFFFAOYSA-N 2-[1,1-bis(2H-benzotriazol-4-yl)-2-methylidenebutyl]-3,4,5,6-tetramethylphenol Chemical compound C=C(C(C1=C(C(=C(C(=C1C)C)C)C)O)(C1=CC=CC=2NN=NC=21)C1=CC=CC=2NN=NC=21)CC TYRYZLMVZZMQDR-UHFFFAOYSA-N 0.000 description 1
- GIOMCCKTXLHGSZ-UHFFFAOYSA-N 2-[3-(2-dodecanoyloxyethyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]ethyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCN1C(=O)N(CCOC(=O)CCCCCCCCCCC)C(C)(C)C1=O GIOMCCKTXLHGSZ-UHFFFAOYSA-N 0.000 description 1
- NTRKEYLXTPNPIY-UHFFFAOYSA-N 2-[4-(diethylamino)phenyl]-3-hydroxychromen-4-one Chemical compound C1=CC(N(CC)CC)=CC=C1C1=C(O)C(=O)C2=CC=CC=C2O1 NTRKEYLXTPNPIY-UHFFFAOYSA-N 0.000 description 1
- KWIPUXXIFQQMKN-UHFFFAOYSA-N 2-azaniumyl-3-(4-cyanophenyl)propanoate Chemical compound OC(=O)C(N)CC1=CC=C(C#N)C=C1 KWIPUXXIFQQMKN-UHFFFAOYSA-N 0.000 description 1
- LSHGMOIQPURPAK-UHFFFAOYSA-N 2-benzylidene-1,4,7,7-tetramethylbicyclo[2.2.1]heptan-3-one Chemical compound CC1(C)C(C2=O)(C)CCC1(C)C2=CC1=CC=CC=C1 LSHGMOIQPURPAK-UHFFFAOYSA-N 0.000 description 1
- DHVLDKHFGIVEIP-UHFFFAOYSA-N 2-bromo-2-(bromomethyl)pentanedinitrile Chemical compound BrCC(Br)(C#N)CCC#N DHVLDKHFGIVEIP-UHFFFAOYSA-N 0.000 description 1
- YYOPMKVMFODPPR-UHFFFAOYSA-N 2-bromo-2-methylpentanedinitrile Chemical compound N#CC(Br)(C)CCC#N YYOPMKVMFODPPR-UHFFFAOYSA-N 0.000 description 1
- TYYHDKOVFSVWON-UHFFFAOYSA-N 2-butyl-2-methoxy-1,3-diphenylpropane-1,3-dione Chemical compound C=1C=CC=CC=1C(=O)C(OC)(CCCC)C(=O)C1=CC=CC=C1 TYYHDKOVFSVWON-UHFFFAOYSA-N 0.000 description 1
- WGPVWXXJNUNBNB-UHFFFAOYSA-N 2-carboxyphenolate;2-hydroxyethylazanium Chemical compound NCCO.OC(=O)C1=CC=CC=C1O WGPVWXXJNUNBNB-UHFFFAOYSA-N 0.000 description 1
- ISPYQTSUDJAMAB-UHFFFAOYSA-N 2-chlorophenol Chemical compound OC1=CC=CC=C1Cl ISPYQTSUDJAMAB-UHFFFAOYSA-N 0.000 description 1
- LWLRMRFJCCMNML-UHFFFAOYSA-N 2-ethylhexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC(CC)CCCC LWLRMRFJCCMNML-UHFFFAOYSA-N 0.000 description 1
- SFAAOBGYWOUHLU-UHFFFAOYSA-N 2-ethylhexyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(CC)CCCC SFAAOBGYWOUHLU-UHFFFAOYSA-N 0.000 description 1
- BHIZVZJETFVJMJ-UHFFFAOYSA-N 2-hydroxypropyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC(C)O BHIZVZJETFVJMJ-UHFFFAOYSA-N 0.000 description 1
- GHHURQMJLARIDK-UHFFFAOYSA-N 2-hydroxypropyl octanoate Chemical compound CCCCCCCC(=O)OCC(C)O GHHURQMJLARIDK-UHFFFAOYSA-N 0.000 description 1
- RUDXBXPTJPNTSO-UHFFFAOYSA-N 2-octyldodecyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(CCCCCCCC)CCCCCCCCCC RUDXBXPTJPNTSO-UHFFFAOYSA-N 0.000 description 1
- GGPOVLCFVFOVDF-UHFFFAOYSA-N 2-phenoxyethyl 4-hydroxybenzoate Chemical compound C1=CC(O)=CC=C1C(=O)OCCOC1=CC=CC=C1 GGPOVLCFVFOVDF-UHFFFAOYSA-N 0.000 description 1
- DWYHDSLIWMUSOO-UHFFFAOYSA-N 2-phenyl-1h-benzimidazole Chemical class C1=CC=CC=C1C1=NC2=CC=CC=C2N1 DWYHDSLIWMUSOO-UHFFFAOYSA-N 0.000 description 1
- WMJBVALTYVXGHW-UHFFFAOYSA-N 3,3-diphenylprop-2-enoic acid Chemical class C=1C=CC=CC=1C(=CC(=O)O)C1=CC=CC=C1 WMJBVALTYVXGHW-UHFFFAOYSA-N 0.000 description 1
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 description 1
- ODJQKYXPKWQWNK-UHFFFAOYSA-L 3-(2-carboxylatoethylsulfanyl)propanoate Chemical compound [O-]C(=O)CCSCCC([O-])=O ODJQKYXPKWQWNK-UHFFFAOYSA-L 0.000 description 1
- 229940099451 3-iodo-2-propynylbutylcarbamate Drugs 0.000 description 1
- WYVVKGNFXHOCQV-UHFFFAOYSA-N 3-iodoprop-2-yn-1-yl butylcarbamate Chemical compound CCCCNC(=O)OCC#CI WYVVKGNFXHOCQV-UHFFFAOYSA-N 0.000 description 1
- QJZYHAIUNVAGQP-UHFFFAOYSA-N 3-nitrobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid Chemical compound C1C2C=CC1C(C(=O)O)C2(C(O)=O)[N+]([O-])=O QJZYHAIUNVAGQP-UHFFFAOYSA-N 0.000 description 1
- TZZGHGKTHXIOMN-UHFFFAOYSA-N 3-trimethoxysilyl-n-(3-trimethoxysilylpropyl)propan-1-amine Chemical compound CO[Si](OC)(OC)CCCNCCC[Si](OC)(OC)OC TZZGHGKTHXIOMN-UHFFFAOYSA-N 0.000 description 1
- GGUFVZFOCZNPEG-UHFFFAOYSA-N 4,5,6-triphenyltriazine Chemical compound C1=CC=CC=C1C1=NN=NC(C=2C=CC=CC=2)=C1C1=CC=CC=C1 GGUFVZFOCZNPEG-UHFFFAOYSA-N 0.000 description 1
- PFHLGILELJGQSJ-UHFFFAOYSA-N 4-(2h-benzotriazol-4-ylmethyl)-2h-benzotriazole;2-butyl-3,4,5,6-tetramethylphenol Chemical compound CCCCC1=C(C)C(C)=C(C)C(C)=C1O.C=1C=CC=2NN=NC=2C=1CC1=CC=CC2=C1N=NN2 PFHLGILELJGQSJ-UHFFFAOYSA-N 0.000 description 1
- KKJKXQYVUVWWJP-JLHYYAGUSA-N 4-[(e)-(4,7,7-trimethyl-3-oxo-2-bicyclo[2.2.1]heptanylidene)methyl]benzenesulfonic acid Chemical compound CC1(C)C2CCC1(C)C(=O)\C2=C\C1=CC=C(S(O)(=O)=O)C=C1 KKJKXQYVUVWWJP-JLHYYAGUSA-N 0.000 description 1
- OSDLLIBGSJNGJE-UHFFFAOYSA-N 4-chloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=CC(C)=C1Cl OSDLLIBGSJNGJE-UHFFFAOYSA-N 0.000 description 1
- OFDWUEGFWVLDMP-UHFFFAOYSA-N 4-chloro-5-methyl-5H-1,3-thiazol-2-one Chemical compound CC1C(=NC(S1)=O)Cl OFDWUEGFWVLDMP-UHFFFAOYSA-N 0.000 description 1
- CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 description 1
- WXNZTHHGJRFXKQ-UHFFFAOYSA-N 4-chlorophenol Chemical compound OC1=CC=C(Cl)C=C1 WXNZTHHGJRFXKQ-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- ZEYHEAKUIGZSGI-UHFFFAOYSA-N 4-methoxybenzoic acid Chemical compound COC1=CC=C(C(O)=O)C=C1 ZEYHEAKUIGZSGI-UHFFFAOYSA-N 0.000 description 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 description 1
- BVNWQSXXRMNYKH-UHFFFAOYSA-N 4-phenyl-2h-benzotriazole Chemical class C1=CC=CC=C1C1=CC=CC2=C1NN=N2 BVNWQSXXRMNYKH-UHFFFAOYSA-N 0.000 description 1
- 229940046305 5-bromo-5-nitro-1,3-dioxane Drugs 0.000 description 1
- 229940100484 5-chloro-2-methyl-4-isothiazolin-3-one Drugs 0.000 description 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
- SJIDAAGFCNIAJP-UHFFFAOYSA-N 6-methylheptyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCC(C)C SJIDAAGFCNIAJP-UHFFFAOYSA-N 0.000 description 1
- ZRCMGIXRGFOXNT-UHFFFAOYSA-N 7a-ethyl-1,3,5,7-tetrahydro-[1,3]oxazolo[3,4-c][1,3]oxazole Chemical compound C1OCN2COCC21CC ZRCMGIXRGFOXNT-UHFFFAOYSA-N 0.000 description 1
- ZYQIUVQBZWVFRE-UHFFFAOYSA-N 8-methylnonyl 4-hydroxybenzoate Chemical compound CC(C)CCCCCCCOC(=O)C1=CC=C(O)C=C1 ZYQIUVQBZWVFRE-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- QQKKFVXSQXUHPI-NBVRZTHBSA-N Acidissiminol epoxide Chemical compound O1C(C)(C)C1CC(O)C(/C)=C/COC(C=C1)=CC=C1CCNC(=O)C1=CC=CC=C1 QQKKFVXSQXUHPI-NBVRZTHBSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 235000019489 Almond oil Nutrition 0.000 description 1
- 108010085443 Anserine Proteins 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 240000005343 Azadirachta indica Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- GWZYPXHJIZCRAJ-UHFFFAOYSA-N Biliverdin Natural products CC1=C(C=C)C(=C/C2=NC(=Cc3[nH]c(C=C/4NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)C(=C2C)CCC(=O)O)NC1=O GWZYPXHJIZCRAJ-UHFFFAOYSA-N 0.000 description 1
- RCNSAJSGRJSBKK-NSQVQWHSSA-N Biliverdin IX Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(\C=C/2C(=C(C)C(=C/C=3C(=C(C=C)C(=O)N=3)C)/N\2)CCC(O)=O)N1 RCNSAJSGRJSBKK-NSQVQWHSSA-N 0.000 description 1
- 238000009010 Bradford assay Methods 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 1
- GEIANPQDKUPTJD-UHFFFAOYSA-N C(C=C)(=O)O.C(CCCCCCC)C=1C(=C(C=CC1)C1=CC=CC=C1)C#N Chemical compound C(C=C)(=O)O.C(CCCCCCC)C=1C(=C(C=CC1)C1=CC=CC=C1)C#N GEIANPQDKUPTJD-UHFFFAOYSA-N 0.000 description 1
- BIQUJLSTLXZGTO-UHFFFAOYSA-N C(CC)(=O)O.C(C)C=1C(=C(C(=C2N(C(C(N2)=O)=O)CCCCCC)OC)C=CC1)OC Chemical compound C(CC)(=O)O.C(C)C=1C(=C(C(=C2N(C(C(N2)=O)=O)CCCCCC)OC)C=CC1)OC BIQUJLSTLXZGTO-UHFFFAOYSA-N 0.000 description 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 1
- SHESFHIAOWKQPJ-UHFFFAOYSA-N C1=NC=NC=N1.C1=CC=CC=C1C1=CC=CC=C1 Chemical compound C1=NC=NC=N1.C1=CC=CC=C1C1=CC=CC=C1 SHESFHIAOWKQPJ-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- BCZXFFBUYPCTSJ-UHFFFAOYSA-L Calcium propionate Chemical compound [Ca+2].CCC([O-])=O.CCC([O-])=O BCZXFFBUYPCTSJ-UHFFFAOYSA-L 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- 101100507655 Canis lupus familiaris HSPA1 gene Proteins 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- LKUNXBRZDFMZOK-GFCCVEGCSA-N Capric acid monoglyceride Natural products CCCCCCCCCC(=O)OC[C@H](O)CO LKUNXBRZDFMZOK-GFCCVEGCSA-N 0.000 description 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 1
- 239000005745 Captan Substances 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 1
- 235000009024 Ceanothus sanguineus Nutrition 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- WJLVQTJZDCGNJN-UHFFFAOYSA-N Chlorhexidine hydrochloride Chemical compound Cl.Cl.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WJLVQTJZDCGNJN-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 206010008583 Chloroma Diseases 0.000 description 1
- 244000276331 Citrus maxima Species 0.000 description 1
- 235000001759 Citrus maxima Nutrition 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- LAAPRQODJPXAHC-UHFFFAOYSA-N Coniferyl benzoate Natural products C1=C(O)C(OC)=CC(C=CCOC(=O)C=2C=CC=CC=2)=C1 LAAPRQODJPXAHC-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 description 1
- 108010069514 Cyclic Peptides Proteins 0.000 description 1
- 102000001189 Cyclic Peptides Human genes 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- MNQZXJOMYWMBOU-VKHMYHEASA-N D-glyceraldehyde Chemical compound OC[C@@H](O)C=O MNQZXJOMYWMBOU-VKHMYHEASA-N 0.000 description 1
- RBNPOMFGQQGHHO-UWTATZPHSA-N D-glyceric acid Chemical compound OC[C@@H](O)C(O)=O RBNPOMFGQQGHHO-UWTATZPHSA-N 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- 239000004287 Dehydroacetic acid Substances 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- GHKOFFNLGXMVNJ-UHFFFAOYSA-N Didodecyl thiobispropanoate Chemical compound CCCCCCCCCCCCOC(=O)CCSCCC(=O)OCCCCCCCCCCCC GHKOFFNLGXMVNJ-UHFFFAOYSA-N 0.000 description 1
- 239000003508 Dilauryl thiodipropionate Substances 0.000 description 1
- 239000002656 Distearyl thiodipropionate Substances 0.000 description 1
- OJIYIVCMRYCWSE-UHFFFAOYSA-M Domiphen bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CCOC1=CC=CC=C1 OJIYIVCMRYCWSE-UHFFFAOYSA-M 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- CTKXFMQHOOWWEB-UHFFFAOYSA-N Ethylene oxide/propylene oxide copolymer Chemical compound CCCOC(C)COCCO CTKXFMQHOOWWEB-UHFFFAOYSA-N 0.000 description 1
- 241000565391 Fraxinus mandshurica Species 0.000 description 1
- 241000206672 Gelidium Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- CMBYOWLFQAFZCP-UHFFFAOYSA-N Hexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCC CMBYOWLFQAFZCP-UHFFFAOYSA-N 0.000 description 1
- SHBUUTHKGIVMJT-UHFFFAOYSA-N Hydroxystearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OO SHBUUTHKGIVMJT-UHFFFAOYSA-N 0.000 description 1
- 241001562081 Ikeda Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- CMHMMKSPYOOVGI-UHFFFAOYSA-N Isopropylparaben Chemical compound CC(C)OC(=O)C1=CC=C(O)C=C1 CMHMMKSPYOOVGI-UHFFFAOYSA-N 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 150000008575 L-amino acids Chemical class 0.000 description 1
- SLRNWACWRVGMKD-UHFFFAOYSA-N L-anserine Natural products CN1C=NC(CC(NC(=O)CCN)C(O)=O)=C1 SLRNWACWRVGMKD-UHFFFAOYSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 240000003553 Leptospermum scoparium Species 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
- YEJCDKJIEMIWRQ-UHFFFAOYSA-N Linopirdine Chemical compound O=C1N(C=2C=CC=CC=2)C2=CC=CC=C2C1(CC=1C=CN=CC=1)CC1=CC=NC=C1 YEJCDKJIEMIWRQ-UHFFFAOYSA-N 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- MQHWFIOJQSCFNM-UHFFFAOYSA-L Magnesium salicylate Chemical compound [Mg+2].OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O MQHWFIOJQSCFNM-UHFFFAOYSA-L 0.000 description 1
- 102400000740 Melanocyte-stimulating hormone alpha Human genes 0.000 description 1
- 101710200814 Melanotropin alpha Proteins 0.000 description 1
- 235000013500 Melia azadirachta Nutrition 0.000 description 1
- ABSPRNADVQNDOU-UHFFFAOYSA-N Menaquinone 1 Natural products C1=CC=C2C(=O)C(CC=C(C)C)=C(C)C(=O)C2=C1 ABSPRNADVQNDOU-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 238000006845 Michael addition reaction Methods 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- VEYYWZRYIYDQJM-ZETCQYMHSA-N N(2)-acetyl-L-lysine Chemical compound CC(=O)N[C@H](C([O-])=O)CCCC[NH3+] VEYYWZRYIYDQJM-ZETCQYMHSA-N 0.000 description 1
- LFYLEOHOBYQMJR-UHFFFAOYSA-N N-(3-ethyloctan-3-yl)butanamide Chemical compound C(CCC)(=O)NC(CCCCC)(CC)CC LFYLEOHOBYQMJR-UHFFFAOYSA-N 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 125000003047 N-acetyl group Chemical group 0.000 description 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 1
- GIONKTHZOBWJSA-UHFFFAOYSA-N NC(=S)N.OC(O)C=C Chemical compound NC(=S)N.OC(O)C=C GIONKTHZOBWJSA-UHFFFAOYSA-N 0.000 description 1
- NVNLLIYOARQCIX-MSHCCFNRSA-N Nisin Chemical compound N1C(=O)[C@@H](CC(C)C)NC(=O)C(=C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](NC(=O)C(=C/C)/NC(=O)[C@H](N)[C@H](C)CC)CSC[C@@H]1C(=O)N[C@@H]1C(=O)N2CCC[C@@H]2C(=O)NCC(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(NCC(=O)N[C@H](C)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)NCC(=O)N[C@H](CS[C@@H]2C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CCSC)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(N[C@H](C)C(=O)N[C@@H]3C(=O)N[C@@H](C(N[C@H](CC=4NC=NC=4)C(=O)N[C@H](CS[C@@H]3C)C(=O)N[C@H](CO)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](CC=3NC=NC=3)C(=O)N[C@H](C(C)C)C(=O)NC(=C)C(=O)N[C@H](CCCCN)C(O)=O)=O)CS[C@@H]2C)=O)=O)CS[C@@H]1C NVNLLIYOARQCIX-MSHCCFNRSA-N 0.000 description 1
- 108010053775 Nisin Proteins 0.000 description 1
- MKYFYXQCGMHXJU-UHFFFAOYSA-N OCC1(OOCCCCC1)C1CCCCCCC1 Chemical compound OCC1(OOCCCCC1)C1CCCCCCC1 MKYFYXQCGMHXJU-UHFFFAOYSA-N 0.000 description 1
- 241000219925 Oenothera Species 0.000 description 1
- 235000004496 Oenothera biennis Nutrition 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 229920001090 Polyaminopropyl biguanide Polymers 0.000 description 1
- 239000004698 Polyethylene Chemical class 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 241000210053 Potentilla elegans Species 0.000 description 1
- KNAHARQHSZJURB-UHFFFAOYSA-N Propylthiouracile Chemical compound CCCC1=CC(=O)NC(=S)N1 KNAHARQHSZJURB-UHFFFAOYSA-N 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- ARCJQKUWGAZPFX-KBPBESRZSA-N S-trans-stilbene oxide Chemical compound C1([C@H]2[C@@H](O2)C=2C=CC=CC=2)=CC=CC=C1 ARCJQKUWGAZPFX-KBPBESRZSA-N 0.000 description 1
- RJFAYQIBOAGBLC-BYPYZUCNSA-N Selenium-L-methionine Chemical compound C[Se]CC[C@H](N)C(O)=O RJFAYQIBOAGBLC-BYPYZUCNSA-N 0.000 description 1
- RJFAYQIBOAGBLC-UHFFFAOYSA-N Selenomethionine Natural products C[Se]CCC(N)C(O)=O RJFAYQIBOAGBLC-UHFFFAOYSA-N 0.000 description 1
- FCHAMFUEENBIDH-UHFFFAOYSA-N Severin Natural products CC1CCC2C(C)C3CCC4(O)C(CC5C4CC(O)C6CC(CCC56C)OC(=O)C)C3CN2C1 FCHAMFUEENBIDH-UHFFFAOYSA-N 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 239000004288 Sodium dehydroacetate Substances 0.000 description 1
- 239000004280 Sodium formate Substances 0.000 description 1
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 description 1
- 239000004283 Sodium sorbate Substances 0.000 description 1
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 description 1
- 244000028419 Styrax benzoin Species 0.000 description 1
- 235000000126 Styrax benzoin Nutrition 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- 235000008411 Sumatra benzointree Nutrition 0.000 description 1
- 235000019486 Sunflower oil Nutrition 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 235000006468 Thea sinensis Nutrition 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 102000002933 Thioredoxin Human genes 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 235000010724 Wisteria floribunda Nutrition 0.000 description 1
- SFRPDSKECHTFQA-ONOWFSFQSA-N [(2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] propanoate Chemical compound CCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SFRPDSKECHTFQA-ONOWFSFQSA-N 0.000 description 1
- FOLJTMYCYXSPFQ-CJKAUBRRSA-N [(2r,3s,4s,5r,6r)-6-[(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-(octadecanoyloxymethyl)oxolan-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl octadecanoate Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](COC(=O)CCCCCCCCCCCCCCCCC)O[C@@H]1O[C@@]1(COC(=O)CCCCCCCCCCCCCCCCC)[C@@H](O)[C@H](O)[C@@H](CO)O1 FOLJTMYCYXSPFQ-CJKAUBRRSA-N 0.000 description 1
- TXZRBCSUYLEATA-GALHSAGASA-N [(z)-docos-13-enyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC TXZRBCSUYLEATA-GALHSAGASA-N 0.000 description 1
- IFZBEQXVUMQXAM-UHFFFAOYSA-N [Hg].BrC1=CC=CC=C1 Chemical compound [Hg].BrC1=CC=CC=C1 IFZBEQXVUMQXAM-UHFFFAOYSA-N 0.000 description 1
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
- NBVZMBLJRHUOJR-UHFFFAOYSA-N [amino-[4-[6-[4-[amino(azaniumylidene)methyl]phenoxy]hexoxy]phenyl]methylidene]azanium;2-hydroxyethanesulfonate Chemical compound OCCS(O)(=O)=O.OCCS(O)(=O)=O.C1=CC(C(=N)N)=CC=C1OCCCCCCOC1=CC=C(C(N)=N)C=C1 NBVZMBLJRHUOJR-UHFFFAOYSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 239000003570 air Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
- 239000008168 almond oil Substances 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- 239000011795 alpha-carotene Substances 0.000 description 1
- 235000003903 alpha-carotene Nutrition 0.000 description 1
- ANVAOWXLWRTKGA-HLLMEWEMSA-N alpha-carotene Natural products C(=C\C=C\C=C(/C=C/C=C(\C=C\C=1C(C)(C)CCCC=1C)/C)\C)(\C=C\C=C(/C=C/[C@H]1C(C)=CCCC1(C)C)\C)/C ANVAOWXLWRTKGA-HLLMEWEMSA-N 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 1
- UAYUMUJFJMGOAL-UHFFFAOYSA-H aluminum;magnesium;silver;diphosphate Chemical compound [Mg+2].[Al+3].[Ag+].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O UAYUMUJFJMGOAL-UHFFFAOYSA-H 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000003862 amino acid derivatives Chemical class 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 229940090948 ammonium benzoate Drugs 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- MYYIAHXIVFADCU-QMMMGPOBSA-N anserine Chemical compound CN1C=NC=C1C[C@H](NC(=O)CC[NH3+])C([O-])=O MYYIAHXIVFADCU-QMMMGPOBSA-N 0.000 description 1
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 235000009697 arginine Nutrition 0.000 description 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- XNEFYCZVKIDDMS-UHFFFAOYSA-N avobenzone Chemical compound C1=CC(OC)=CC=C1C(=O)CC(=O)C1=CC=C(C(C)(C)C)C=C1 XNEFYCZVKIDDMS-UHFFFAOYSA-N 0.000 description 1
- 229960005193 avobenzone Drugs 0.000 description 1
- XJMWHXZUIGHOBA-UHFFFAOYSA-N azane;propanoic acid Chemical compound N.CCC(O)=O XJMWHXZUIGHOBA-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- XVAMCHGMPYWHNL-UHFFFAOYSA-N bemotrizinol Chemical compound OC1=CC(OCC(CC)CCCC)=CC=C1C1=NC(C=2C=CC(OC)=CC=2)=NC(C=2C(=CC(OCC(CC)CCCC)=CC=2)O)=N1 XVAMCHGMPYWHNL-UHFFFAOYSA-N 0.000 description 1
- 229960004101 bemotrizinol Drugs 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- DMSMPAJRVJJAGA-UHFFFAOYSA-N benzo[d]isothiazol-3-one Chemical compound C1=CC=C2C(=O)NSC2=C1 DMSMPAJRVJJAGA-UHFFFAOYSA-N 0.000 description 1
- 229940050390 benzoate Drugs 0.000 description 1
- UDEWPOVQBGFNGE-UHFFFAOYSA-N benzoic acid n-propyl ester Chemical class CCCOC(=O)C1=CC=CC=C1 UDEWPOVQBGFNGE-UHFFFAOYSA-N 0.000 description 1
- 229960002130 benzoin Drugs 0.000 description 1
- 229940111759 benzophenone-2 Drugs 0.000 description 1
- 229940079894 benzophenone-9 Drugs 0.000 description 1
- 150000008366 benzophenones Chemical class 0.000 description 1
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 1
- 239000012964 benzotriazole Substances 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- VYTBDSUNRJYVHL-UHFFFAOYSA-N beta-Hydrojuglone Natural products O=C1CCC(=O)C2=C1C=CC=C2O VYTBDSUNRJYVHL-UHFFFAOYSA-N 0.000 description 1
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 229930003642 bicyclic monoterpene Natural products 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- QBUVFDKTZJNUPP-UHFFFAOYSA-N biliverdin-IXalpha Natural products N1C(=O)C(C)=C(C=C)C1=CC1=C(C)C(CCC(O)=O)=C(C=C2C(=C(C)C(C=C3C(=C(C=C)C(=O)N3)C)=N2)CCC(O)=O)N1 QBUVFDKTZJNUPP-UHFFFAOYSA-N 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- WXNRYSGJLQFHBR-UHFFFAOYSA-N bis(2,4-dihydroxyphenyl)methanone Chemical compound OC1=CC(O)=CC=C1C(=O)C1=CC=C(O)C=C1O WXNRYSGJLQFHBR-UHFFFAOYSA-N 0.000 description 1
- SODJJEXAWOSSON-UHFFFAOYSA-N bis(2-hydroxy-4-methoxyphenyl)methanone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=C(OC)C=C1O SODJJEXAWOSSON-UHFFFAOYSA-N 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 229960002645 boric acid Drugs 0.000 description 1
- GEHJBWKLJVFKPS-UHFFFAOYSA-N bromochloroacetic acid Chemical compound OC(=O)C(Cl)Br GEHJBWKLJVFKPS-UHFFFAOYSA-N 0.000 description 1
- XVBRCOKDZVQYAY-UHFFFAOYSA-N bronidox Chemical compound [O-][N+](=O)C1(Br)COCOC1 XVBRCOKDZVQYAY-UHFFFAOYSA-N 0.000 description 1
- 229960003168 bronopol Drugs 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- GWEWFXLOKRTOOW-UHFFFAOYSA-N butyl 4-hydroxycyclohexane-1-carboxylate Chemical compound CCCCOC(=O)C1CCC(O)CC1 GWEWFXLOKRTOOW-UHFFFAOYSA-N 0.000 description 1
- ULBTUVJTXULMLP-UHFFFAOYSA-N butyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCC ULBTUVJTXULMLP-UHFFFAOYSA-N 0.000 description 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 235000010237 calcium benzoate Nutrition 0.000 description 1
- 239000004301 calcium benzoate Substances 0.000 description 1
- 235000010331 calcium propionate Nutrition 0.000 description 1
- 239000004330 calcium propionate Substances 0.000 description 1
- 239000000378 calcium silicate Substances 0.000 description 1
- 229910052918 calcium silicate Inorganic materials 0.000 description 1
- MCFVRESNTICQSJ-RJNTXXOISA-L calcium sorbate Chemical compound [Ca+2].C\C=C\C=C\C([O-])=O.C\C=C\C=C\C([O-])=O MCFVRESNTICQSJ-RJNTXXOISA-L 0.000 description 1
- 235000010244 calcium sorbate Nutrition 0.000 description 1
- 239000004303 calcium sorbate Substances 0.000 description 1
- AVVIDTZRJBSXML-UHFFFAOYSA-L calcium;2-carboxyphenolate;dihydrate Chemical compound O.O.[Ca+2].OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O AVVIDTZRJBSXML-UHFFFAOYSA-L 0.000 description 1
- HZQXCUSDXIKLGS-UHFFFAOYSA-L calcium;dibenzoate;trihydrate Chemical compound O.O.O.[Ca+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 HZQXCUSDXIKLGS-UHFFFAOYSA-L 0.000 description 1
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 description 1
- 229940117949 captan Drugs 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 229960004203 carnitine Drugs 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 1
- 229940074979 cetyl palmitate Drugs 0.000 description 1
- NEUSVAOJNUQRTM-UHFFFAOYSA-N cetylpyridinium Chemical class CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 NEUSVAOJNUQRTM-UHFFFAOYSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 208000016252 change in skin color Diseases 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- WDRFFJWBUDTUCA-UHFFFAOYSA-N chlorhexidine acetate Chemical compound CC(O)=O.CC(O)=O.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WDRFFJWBUDTUCA-UHFFFAOYSA-N 0.000 description 1
- 229960001884 chlorhexidine diacetate Drugs 0.000 description 1
- 229960004504 chlorhexidine hydrochloride Drugs 0.000 description 1
- NVPYLTFYILJMRD-UHFFFAOYSA-N chlorobenzene;mercury Chemical compound [Hg].ClC1=CC=CC=C1 NVPYLTFYILJMRD-UHFFFAOYSA-N 0.000 description 1
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 1
- 150000005827 chlorofluoro hydrocarbons Chemical class 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- DHNRXBZYEKSXIM-UHFFFAOYSA-N chloromethylisothiazolinone Chemical compound CN1SC(Cl)=CC1=O DHNRXBZYEKSXIM-UHFFFAOYSA-N 0.000 description 1
- 229960005443 chloroxylenol Drugs 0.000 description 1
- 150000001841 cholesterols Chemical class 0.000 description 1
- WXCQAWGXWVRCGP-UHFFFAOYSA-N choline sulfate Chemical compound C[N+](C)(C)CCOS([O-])(=O)=O WXCQAWGXWVRCGP-UHFFFAOYSA-N 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 150000001851 cinnamic acid derivatives Chemical class 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229960003344 climbazole Drugs 0.000 description 1
- ASARMUCNOOHMLO-WLORSUFZSA-L cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2s)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O ASARMUCNOOHMLO-WLORSUFZSA-L 0.000 description 1
- 229940071160 cocoate Drugs 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- LAAPRQODJPXAHC-AATRIKPKSA-N coniferyl benzoate Chemical compound C1=C(O)C(OC)=CC(\C=C\COC(=O)C=2C=CC=CC=2)=C1 LAAPRQODJPXAHC-AATRIKPKSA-N 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 210000000736 corneocyte Anatomy 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 229930003836 cresol Natural products 0.000 description 1
- 125000000853 cresyl group Chemical group C1(=CC=C(C=C1)C)* 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 229940097362 cyclodextrins Drugs 0.000 description 1
- 229940086555 cyclomethicone Drugs 0.000 description 1
- OOTFVKOQINZBBF-UHFFFAOYSA-N cystamine Chemical compound CCSSCCN OOTFVKOQINZBBF-UHFFFAOYSA-N 0.000 description 1
- 229940099500 cystamine Drugs 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- YSRSBDQINUMTIF-UHFFFAOYSA-N decane-1,2-diol Chemical compound CCCCCCCCC(O)CO YSRSBDQINUMTIF-UHFFFAOYSA-N 0.000 description 1
- SASYSVUEVMOWPL-NXVVXOECSA-N decyl oleate Chemical compound CCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC SASYSVUEVMOWPL-NXVVXOECSA-N 0.000 description 1
- 229940097037 decylene glycol Drugs 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 235000019258 dehydroacetic acid Nutrition 0.000 description 1
- 229940061632 dehydroacetic acid Drugs 0.000 description 1
- JEQRBTDTEKWZBW-UHFFFAOYSA-N dehydroacetic acid Chemical compound CC(=O)C1=C(O)OC(C)=CC1=O JEQRBTDTEKWZBW-UHFFFAOYSA-N 0.000 description 1
- PGRHXDWITVMQBC-UHFFFAOYSA-N dehydroacetic acid Natural products CC(=O)C1C(=O)OC(C)=CC1=O PGRHXDWITVMQBC-UHFFFAOYSA-N 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 230000035618 desquamation Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 150000001983 dialkylethers Chemical class 0.000 description 1
- 229960004698 dichlorobenzyl alcohol Drugs 0.000 description 1
- 238000002349 difference gel electrophoresis Methods 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- 235000019304 dilauryl thiodipropionate Nutrition 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- WTUSOGAWFILRSJ-UHFFFAOYSA-N dioxido(phenoxy)borane;mercury(2+) Chemical compound [Hg+2].[O-]B([O-])OC1=CC=CC=C1 WTUSOGAWFILRSJ-UHFFFAOYSA-N 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- GLCJMPWWQKKJQZ-UHFFFAOYSA-L disodium;2-[4-(4,6-disulfonato-1h-benzimidazol-2-yl)phenyl]-1h-benzimidazole-4,6-disulfonate;hydron Chemical compound [Na+].[Na+].C1=C(S(O)(=O)=O)C=C2NC(C3=CC=C(C=C3)C3=NC4=C(C=C(C=C4N3)S(=O)(=O)O)S([O-])(=O)=O)=NC2=C1S([O-])(=O)=O GLCJMPWWQKKJQZ-UHFFFAOYSA-L 0.000 description 1
- QDCHWIWENYCPIL-UHFFFAOYSA-L disodium;4-hydroxy-5-(2-hydroxy-4-methoxy-5-sulfonatobenzoyl)-2-methoxybenzenesulfonate Chemical compound [Na+].[Na+].C1=C(S([O-])(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC(S([O-])(=O)=O)=C(OC)C=C1O QDCHWIWENYCPIL-UHFFFAOYSA-L 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- PWWSSIYVTQUJQQ-UHFFFAOYSA-N distearyl thiodipropionate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CCSCCC(=O)OCCCCCCCCCCCCCCCCCC PWWSSIYVTQUJQQ-UHFFFAOYSA-N 0.000 description 1
- 235000019305 distearyl thiodipropionate Nutrition 0.000 description 1
- 229960000735 docosanol Drugs 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229960001859 domiphen bromide Drugs 0.000 description 1
- HUVYTMDMDZRHBN-UHFFFAOYSA-N drometrizole trisiloxane Chemical compound C[Si](C)(C)O[Si](C)(O[Si](C)(C)C)CC(C)CC1=CC(C)=CC(N2N=C3C=CC=CC3=N2)=C1O HUVYTMDMDZRHBN-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- HEAHZSUCFKFERC-UHFFFAOYSA-N ecamsule Chemical compound CC1(C)C2CCC1(CS(O)(=O)=O)C(=O)C2=CC(C=C1)=CC=C1C=C1C(=O)C2(CS(O)(=O)=O)CCC1C2(C)C HEAHZSUCFKFERC-UHFFFAOYSA-N 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 229960002061 ergocalciferol Drugs 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
- HCZKYJDFEPMADG-UHFFFAOYSA-N erythro-nordihydroguaiaretic acid Natural products C=1C=C(O)C(O)=CC=1CC(C)C(C)CC1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-UHFFFAOYSA-N 0.000 description 1
- WSEQXVZVJXJVFP-FQEVSTJZSA-N escitalopram Chemical compound C1([C@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-FQEVSTJZSA-N 0.000 description 1
- 229960004341 escitalopram Drugs 0.000 description 1
- 239000010696 ester oil Substances 0.000 description 1
- 229960004756 ethanol Drugs 0.000 description 1
- ATJVZXXHKSYELS-FNORWQNLSA-N ethyl (e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate Chemical compound CCOC(=O)\C=C\C1=CC=C(O)C(OC)=C1 ATJVZXXHKSYELS-FNORWQNLSA-N 0.000 description 1
- IAJNXBNRYMEYAZ-UHFFFAOYSA-N ethyl 2-cyano-3,3-diphenylprop-2-enoate Chemical compound C=1C=CC=CC=1C(=C(C#N)C(=O)OCC)C1=CC=CC=C1 IAJNXBNRYMEYAZ-UHFFFAOYSA-N 0.000 description 1
- CBZHHQOZZQEZNJ-UHFFFAOYSA-N ethyl 4-[bis(2-hydroxypropyl)amino]benzoate Chemical compound CCOC(=O)C1=CC=C(N(CC(C)O)CC(C)O)C=C1 CBZHHQOZZQEZNJ-UHFFFAOYSA-N 0.000 description 1
- 229940093499 ethyl acetate Drugs 0.000 description 1
- 229940027504 ethyl ferulate Drugs 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- 229940043351 ethyl-p-hydroxybenzoate Drugs 0.000 description 1
- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 1
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 229940043259 farnesol Drugs 0.000 description 1
- 229930002886 farnesol Natural products 0.000 description 1
- ATJVZXXHKSYELS-UHFFFAOYSA-N ferulic acid ethyl ester Natural products CCOC(=O)C=CC1=CC=C(O)C(OC)=C1 ATJVZXXHKSYELS-UHFFFAOYSA-N 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- HVQAJTFOCKOKIN-UHFFFAOYSA-N flavonol Chemical class O1C2=CC=CC=C2C(=O)C(O)=C1C1=CC=CC=C1 HVQAJTFOCKOKIN-UHFFFAOYSA-N 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 229940049906 glutamate Drugs 0.000 description 1
- 229960000587 glutaral Drugs 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000036252 glycation Effects 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
- RZRNAYUHWVFMIP-HXUWFJFHSA-N glycerol monolinoleate Natural products CCCCCCCCC=CCCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-HXUWFJFHSA-N 0.000 description 1
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
- 125000005908 glyceryl ester group Chemical group 0.000 description 1
- 229940074052 glyceryl isostearate Drugs 0.000 description 1
- 229960004275 glycolic acid Drugs 0.000 description 1
- 125000003147 glycosyl group Chemical group 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 229940015043 glyoxal Drugs 0.000 description 1
- 235000002532 grape seed extract Nutrition 0.000 description 1
- 229940087603 grape seed extract Drugs 0.000 description 1
- 235000019382 gum benzoic Nutrition 0.000 description 1
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- PXDJXZJSCPSGGI-UHFFFAOYSA-N hexadecanoic acid hexadecyl ester Natural products CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC PXDJXZJSCPSGGI-UHFFFAOYSA-N 0.000 description 1
- 229960001715 hexamidine isethionate Drugs 0.000 description 1
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 description 1
- 229960004867 hexetidine Drugs 0.000 description 1
- 229960004881 homosalate Drugs 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 239000004021 humic acid Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- JLPAWRLRMTZCSF-UHFFFAOYSA-N hydroxypyruvaldehyde Chemical compound OCC(=O)C=O JLPAWRLRMTZCSF-UHFFFAOYSA-N 0.000 description 1
- 229940072106 hydroxystearate Drugs 0.000 description 1
- HWLFYOMFUTXMIT-UHFFFAOYSA-N imidazolidine-2,4-dione;octadecanoic acid Chemical compound O=C1CNC(=O)N1.CCCCCCCCCCCCCCCCCC(O)=O HWLFYOMFUTXMIT-UHFFFAOYSA-N 0.000 description 1
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical class C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 description 1
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- FRVCGRDGKAINSV-UHFFFAOYSA-L iron(2+);octadecanoate Chemical compound [Fe+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O FRVCGRDGKAINSV-UHFFFAOYSA-L 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 229940100554 isononyl isononanoate Drugs 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 229940089456 isopropyl stearate Drugs 0.000 description 1
- MGIYRDNGCNKGJU-UHFFFAOYSA-N isothiazolinone Chemical compound O=C1C=CSN1 MGIYRDNGCNKGJU-UHFFFAOYSA-N 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 229960004125 ketoconazole Drugs 0.000 description 1
- 150000002576 ketones Chemical group 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229940070765 laurate Drugs 0.000 description 1
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 235000012661 lycopene Nutrition 0.000 description 1
- 229960004999 lycopene Drugs 0.000 description 1
- 239000001751 lycopene Substances 0.000 description 1
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 1
- PJJZFXPJNUVBMR-UHFFFAOYSA-L magnesium benzoate Chemical compound [Mg+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 PJJZFXPJNUVBMR-UHFFFAOYSA-L 0.000 description 1
- CQQJGTPWCKCEOQ-UHFFFAOYSA-L magnesium dipropionate Chemical compound [Mg+2].CCC([O-])=O.CCC([O-])=O CQQJGTPWCKCEOQ-UHFFFAOYSA-L 0.000 description 1
- 229940072082 magnesium salicylate Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229960003951 masoprocol Drugs 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- SOXAGEOHPCXXIO-DVOMOZLQSA-N menthyl anthranilate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)C1=CC=CC=C1N SOXAGEOHPCXXIO-DVOMOZLQSA-N 0.000 description 1
- SOXAGEOHPCXXIO-UHFFFAOYSA-N meradimate Chemical compound CC(C)C1CCC(C)CC1OC(=O)C1=CC=CC=C1N SOXAGEOHPCXXIO-UHFFFAOYSA-N 0.000 description 1
- 229960002248 meradimate Drugs 0.000 description 1
- QRBYEQHPFPUAPM-UHFFFAOYSA-N mercury phenyl benzoate Chemical compound [Hg].C=1C=CC=CC=1C(=O)OC1=CC=CC=C1 QRBYEQHPFPUAPM-UHFFFAOYSA-N 0.000 description 1
- QFRWWTBTWUSSDA-UHFFFAOYSA-M mercury(1+);2-phenylacetate Chemical compound [Hg+].[O-]C(=O)CC1=CC=CC=C1 QFRWWTBTWUSSDA-UHFFFAOYSA-M 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- NTIBMIIYTKPBNR-UHFFFAOYSA-N methoxymethyl 2-hydroxybenzoate Chemical compound COCOC(=O)C1=CC=CC=C1O NTIBMIIYTKPBNR-UHFFFAOYSA-N 0.000 description 1
- XKZFMXOKCQATDH-QVBJCFTNSA-N methyl (2r)-2-[(5-methyl-2-propan-2-ylcyclohexanecarbonyl)amino]propanoate Chemical compound COC(=O)[C@@H](C)NC(=O)C1CC(C)CCC1C(C)C XKZFMXOKCQATDH-QVBJCFTNSA-N 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- OLXYLDUSSBULGU-UHFFFAOYSA-N methyl pyridine-4-carboxylate Chemical class COC(=O)C1=CC=NC=C1 OLXYLDUSSBULGU-UHFFFAOYSA-N 0.000 description 1
- JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000013048 microbiological method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 239000012184 mineral wax Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 description 1
- 108700019599 monomethylolglycine Proteins 0.000 description 1
- NALMPLUMOWIVJC-UHFFFAOYSA-N n,n,4-trimethylbenzeneamine oxide Chemical compound CC1=CC=C([N+](C)(C)[O-])C=C1 NALMPLUMOWIVJC-UHFFFAOYSA-N 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 235000010297 nisin Nutrition 0.000 description 1
- 239000004309 nisin Substances 0.000 description 1
- 239000001272 nitrous oxide Substances 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 125000003835 nucleoside group Chemical group 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- BARWIPMJPCRCTP-UHFFFAOYSA-N oleic acid oleyl ester Natural products CCCCCCCCC=CCCCCCCCCOC(=O)CCCCCCCC=CCCCCCCCC BARWIPMJPCRCTP-UHFFFAOYSA-N 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000010525 oxidative degradation reaction Methods 0.000 description 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000003346 palm kernel oil Substances 0.000 description 1
- 235000019865 palm kernel oil Nutrition 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000010690 paraffinic oil Substances 0.000 description 1
- QPTMDBQLCWRDCK-UHFFFAOYSA-I pentasodium;[2-[bis[[hydroxy(oxido)phosphoryl]methyl]amino]ethyl-(phosphonatomethyl)amino]methyl-hydroxyphosphinate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].OP([O-])(=O)CN(CP(O)([O-])=O)CCN(CP(O)([O-])=O)CP([O-])([O-])=O QPTMDBQLCWRDCK-UHFFFAOYSA-I 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 229940038597 peroxide anti-acne preparations for topical use Drugs 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 229940106026 phenoxyisopropanol Drugs 0.000 description 1
- FCJSHPDYVMKCHI-UHFFFAOYSA-N phenyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OC1=CC=CC=C1 FCJSHPDYVMKCHI-UHFFFAOYSA-N 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 235000019175 phylloquinone Nutrition 0.000 description 1
- 239000011772 phylloquinone Substances 0.000 description 1
- 239000000467 phytic acid Substances 0.000 description 1
- 229940068041 phytic acid Drugs 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 229960001898 phytomenadione Drugs 0.000 description 1
- 229940106587 pine bark extract Drugs 0.000 description 1
- 235000020741 pine bark extract Nutrition 0.000 description 1
- 150000004885 piperazines Chemical class 0.000 description 1
- 229940081510 piroctone olamine Drugs 0.000 description 1
- 229920001993 poloxamer 188 Polymers 0.000 description 1
- 229940044519 poloxamer 188 Drugs 0.000 description 1
- 229920003217 poly(methylsilsesquioxane) Polymers 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229940093424 polyaminopropyl biguanide Drugs 0.000 description 1
- 229920000573 polyethylene Chemical class 0.000 description 1
- 229920001843 polymethylhydrosiloxane Polymers 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 235000010235 potassium benzoate Nutrition 0.000 description 1
- 239000004300 potassium benzoate Substances 0.000 description 1
- 229940103091 potassium benzoate Drugs 0.000 description 1
- 229960003191 potassium methylparaben Drugs 0.000 description 1
- BWILYWWHXDGKQA-UHFFFAOYSA-M potassium propanoate Chemical compound [K+].CCC([O-])=O BWILYWWHXDGKQA-UHFFFAOYSA-M 0.000 description 1
- 235000010332 potassium propionate Nutrition 0.000 description 1
- 239000004331 potassium propionate Substances 0.000 description 1
- FRMWBRPWYBNAFB-UHFFFAOYSA-M potassium salicylate Chemical compound [K+].OC1=CC=CC=C1C([O-])=O FRMWBRPWYBNAFB-UHFFFAOYSA-M 0.000 description 1
- 229960003629 potassium salicylate Drugs 0.000 description 1
- HSDKCIYHTPCVAU-UHFFFAOYSA-M potassium;2-phenylphenolate Chemical compound [K+].[O-]C1=CC=CC=C1C1=CC=CC=C1 HSDKCIYHTPCVAU-UHFFFAOYSA-M 0.000 description 1
- MOCBTMXJPWSHOD-UHFFFAOYSA-M potassium;4-methoxycarbonylphenolate Chemical compound [K+].COC(=O)C1=CC=C([O-])C=C1 MOCBTMXJPWSHOD-UHFFFAOYSA-M 0.000 description 1
- ZGJADVGJIVEEGF-UHFFFAOYSA-M potassium;phenoxide Chemical compound [K+].[O-]C1=CC=CC=C1 ZGJADVGJIVEEGF-UHFFFAOYSA-M 0.000 description 1
- ZWJJGCJSVPNPIK-UHFFFAOYSA-N potassium;propyl 4-hydroxybenzoate Chemical compound [K].CCCOC(=O)C1=CC=C(O)C=C1 ZWJJGCJSVPNPIK-UHFFFAOYSA-N 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- PERLTXCUPZSJTA-YTXTXJHMSA-N propan-2-yl (2e,4e)-hexa-2,4-dienoate Chemical compound C\C=C\C=C\C(=O)OC(C)C PERLTXCUPZSJTA-YTXTXJHMSA-N 0.000 description 1
- PZQSQRCNMZGWFT-QXMHVHEDSA-N propan-2-yl (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC(C)C PZQSQRCNMZGWFT-QXMHVHEDSA-N 0.000 description 1
- ZPWFUIUNWDIYCJ-UHFFFAOYSA-N propan-2-yl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)C ZPWFUIUNWDIYCJ-UHFFFAOYSA-N 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229940026235 propylene glycol monolaurate Drugs 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 229960002662 propylthiouracil Drugs 0.000 description 1
- 229960003581 pyridoxal Drugs 0.000 description 1
- 235000008164 pyridoxal Nutrition 0.000 description 1
- 239000011674 pyridoxal Substances 0.000 description 1
- 235000008151 pyridoxamine Nutrition 0.000 description 1
- 239000011699 pyridoxamine Substances 0.000 description 1
- 235000008160 pyridoxine Nutrition 0.000 description 1
- 239000011677 pyridoxine Substances 0.000 description 1
- ZFCHNZDUMIOWFV-UHFFFAOYSA-N pyrimidine-2-carboxylic acid Chemical class OC(=O)C1=NC=CC=N1 ZFCHNZDUMIOWFV-UHFFFAOYSA-N 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical class O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- DCBSHORRWZKAKO-UHFFFAOYSA-N rac-1-monomyristoylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OCC(O)CO DCBSHORRWZKAKO-UHFFFAOYSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 230000011506 response to oxidative stress Effects 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
- 229960000342 retinol acetate Drugs 0.000 description 1
- 235000019173 retinyl acetate Nutrition 0.000 description 1
- 239000011770 retinyl acetate Substances 0.000 description 1
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- 229940058287 salicylic acid derivative anticestodals Drugs 0.000 description 1
- 150000003872 salicylic acid derivatives Chemical class 0.000 description 1
- 229910000338 selenium disulfide Inorganic materials 0.000 description 1
- JNMWHTHYDQTDQZ-UHFFFAOYSA-N selenium sulfide Chemical compound S=[Se]=S JNMWHTHYDQTDQZ-UHFFFAOYSA-N 0.000 description 1
- VIDTVPHHDGRGAF-UHFFFAOYSA-N selenium sulfide Chemical compound [Se]=S VIDTVPHHDGRGAF-UHFFFAOYSA-N 0.000 description 1
- 229960005265 selenium sulfide Drugs 0.000 description 1
- 229960002718 selenomethionine Drugs 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 150000003378 silver Chemical class 0.000 description 1
- 229940009188 silver Drugs 0.000 description 1
- 229940071575 silver citrate Drugs 0.000 description 1
- LMEWRZSPCQHBOB-UHFFFAOYSA-M silver;2-hydroxypropanoate Chemical compound [Ag+].CC(O)C([O-])=O LMEWRZSPCQHBOB-UHFFFAOYSA-M 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 235000019259 sodium dehydroacetate Nutrition 0.000 description 1
- 229940079839 sodium dehydroacetate Drugs 0.000 description 1
- 235000010226 sodium ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004402 sodium ethyl p-hydroxybenzoate Substances 0.000 description 1
- HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 1
- 235000019254 sodium formate Nutrition 0.000 description 1
- 229940101011 sodium hydroxymethylglycinate Drugs 0.000 description 1
- 239000011697 sodium iodate Substances 0.000 description 1
- 235000015281 sodium iodate Nutrition 0.000 description 1
- 229940032753 sodium iodate Drugs 0.000 description 1
- 235000010268 sodium methyl p-hydroxybenzoate Nutrition 0.000 description 1
- BYKRNSHANADUFY-UHFFFAOYSA-M sodium octanoate Chemical compound [Na+].CCCCCCCC([O-])=O BYKRNSHANADUFY-UHFFFAOYSA-M 0.000 description 1
- 235000010294 sodium orthophenyl phenol Nutrition 0.000 description 1
- NESLWCLHZZISNB-UHFFFAOYSA-M sodium phenolate Chemical compound [Na+].[O-]C1=CC=CC=C1 NESLWCLHZZISNB-UHFFFAOYSA-M 0.000 description 1
- 229940087596 sodium phenolsulfonate Drugs 0.000 description 1
- JXKPEJDQGNYQSM-UHFFFAOYSA-M sodium propionate Chemical compound [Na+].CCC([O-])=O JXKPEJDQGNYQSM-UHFFFAOYSA-M 0.000 description 1
- 235000010334 sodium propionate Nutrition 0.000 description 1
- 239000004324 sodium propionate Substances 0.000 description 1
- 229960003212 sodium propionate Drugs 0.000 description 1
- 229960004025 sodium salicylate Drugs 0.000 description 1
- LROWVYNUWKVTCU-STWYSWDKSA-M sodium sorbate Chemical compound [Na+].C\C=C\C=C\C([O-])=O LROWVYNUWKVTCU-STWYSWDKSA-M 0.000 description 1
- 235000019250 sodium sorbate Nutrition 0.000 description 1
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 1
- XNRNJIIJLOFJEK-UHFFFAOYSA-N sodium;1-oxidopyridine-2-thione Chemical compound [Na+].[O-]N1C=CC=CC1=S XNRNJIIJLOFJEK-UHFFFAOYSA-N 0.000 description 1
- CITBNDNUEPMTFC-UHFFFAOYSA-M sodium;2-(hydroxymethylamino)acetate Chemical compound [Na+].OCNCC([O-])=O CITBNDNUEPMTFC-UHFFFAOYSA-M 0.000 description 1
- BLXAGSNYHSQSRC-UHFFFAOYSA-M sodium;2-hydroxybenzenesulfonate Chemical compound [Na+].OC1=CC=CC=C1S([O-])(=O)=O BLXAGSNYHSQSRC-UHFFFAOYSA-M 0.000 description 1
- KSQXVLVXUFHGJQ-UHFFFAOYSA-N sodium;2-phenylphenol Chemical compound [Na+].OC1=CC=CC=C1C1=CC=CC=C1 KSQXVLVXUFHGJQ-UHFFFAOYSA-N 0.000 description 1
- OGBHACNFHJJTQT-UHFFFAOYSA-M sodium;4-butoxycarbonylphenolate Chemical compound [Na+].CCCCOC(=O)C1=CC=C([O-])C=C1 OGBHACNFHJJTQT-UHFFFAOYSA-M 0.000 description 1
- QYNMSPKSYXPZHG-UHFFFAOYSA-M sodium;4-ethoxycarbonylphenolate Chemical compound [Na+].CCOC(=O)C1=CC=C([O-])C=C1 QYNMSPKSYXPZHG-UHFFFAOYSA-M 0.000 description 1
- PESXGULMKCKJCC-UHFFFAOYSA-M sodium;4-methoxycarbonylphenolate Chemical compound [Na+].COC(=O)C1=CC=C([O-])C=C1 PESXGULMKCKJCC-UHFFFAOYSA-M 0.000 description 1
- UOULCEYHQNCFFH-UHFFFAOYSA-M sodium;hydroxymethanesulfonate Chemical compound [Na+].OCS([O-])(=O)=O UOULCEYHQNCFFH-UHFFFAOYSA-M 0.000 description 1
- 229940075554 sorbate Drugs 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000001570 sorbitan monopalmitate Substances 0.000 description 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 description 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 1
- ARCJQKUWGAZPFX-UHFFFAOYSA-N stilbene oxide Chemical compound O1C(C=2C=CC=CC=2)C1C1=CC=CC=C1 ARCJQKUWGAZPFX-UHFFFAOYSA-N 0.000 description 1
- 235000021286 stilbenes Nutrition 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-M succinate(1-) Chemical compound OC(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-M 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 230000037072 sun protection Effects 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 239000010677 tea tree oil Substances 0.000 description 1
- 229940111630 tea tree oil Drugs 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 235000019190 thiamine hydrochloride Nutrition 0.000 description 1
- 239000011747 thiamine hydrochloride Substances 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 229960000344 thiamine hydrochloride Drugs 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- 229940094937 thioredoxin Drugs 0.000 description 1
- 108060008226 thioredoxin Proteins 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229940055360 titanium dioxide / zinc oxide Drugs 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- LOIYMIARKYCTBW-OWOJBTEDSA-N trans-urocanic acid Chemical compound OC(=O)\C=C\C1=CNC=N1 LOIYMIARKYCTBW-OWOJBTEDSA-N 0.000 description 1
- LOIYMIARKYCTBW-UHFFFAOYSA-N trans-urocanic acid Natural products OC(=O)C=CC1=CNC=N1 LOIYMIARKYCTBW-UHFFFAOYSA-N 0.000 description 1
- 230000007723 transport mechanism Effects 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 229960001325 triclocarban Drugs 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- NMEPHPOFYLLFTK-UHFFFAOYSA-N trimethoxy(octyl)silane Chemical compound CCCCCCCC[Si](OC)(OC)OC NMEPHPOFYLLFTK-UHFFFAOYSA-N 0.000 description 1
- UYPYRKYUKCHHIB-UHFFFAOYSA-N trimethylamine N-oxide Chemical compound C[N+](C)(C)[O-] UYPYRKYUKCHHIB-UHFFFAOYSA-N 0.000 description 1
- QUTYHQJYVDNJJA-UHFFFAOYSA-K trisilver;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Ag+].[Ag+].[Ag+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QUTYHQJYVDNJJA-UHFFFAOYSA-K 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 229940004858 usnic acid Drugs 0.000 description 1
- ICTZCAHDGHPRQR-UHFFFAOYSA-N usnic acid Natural products OC1=C(C)C(O)=C(C(C)=O)C2=C1C1(C)C(O)=C(C(=O)C)C(=O)C=C1O2 ICTZCAHDGHPRQR-UHFFFAOYSA-N 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 239000001717 vitis vinifera seed extract Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 229960001296 zinc oxide Drugs 0.000 description 1
- 229940118827 zinc phenolsulfonate Drugs 0.000 description 1
- BOVNWDGXGNVNQD-UHFFFAOYSA-L zinc;2-hydroxybenzenesulfonate Chemical compound [Zn+2].OC1=CC=CC=C1S([O-])(=O)=O.OC1=CC=CC=C1S([O-])(=O)=O BOVNWDGXGNVNQD-UHFFFAOYSA-L 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
- WHNFPRLDDSXQCL-UAZQEYIDSA-N α-msh Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(N)=O)NC(=O)[C@H](CO)NC(C)=O)C1=CC=C(O)C=C1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明涉及至少一种相容性溶质和/或其生理学上可接受的盐用于抵抗与年龄相关的皮肤颜色变化或用于抑制和/或减少蛋白质羰基化和/或用于抑制和/或减少羰基化蛋白质在角质层中的累积的用途。本发明还涉及包含至少一种相容性溶质和/或其生理学上可接受的盐和至少一种另外的皮肤毛孔淡化活性物质的制剂,以及用于制备这种制剂的方法。
Description
本发明涉及至少一种相容性溶质和/或其生理学上可接受的盐用于抵抗与年龄相关的皮肤颜色变化或用于抑制和/或减少蛋白质羰基化和/或用于抑制和/或减少羰基化蛋白质在角质层中的累积的用途。本发明还涉及包含至少一种相容性溶质和/或其生理学上可接受的盐和至少一种另外的皮肤毛孔淡化活性物质的制剂,以及用于制备这种制剂的方法。
皮肤颜色是决定我们对皮肤的审美感受的主要因素之一。众所周知,随着年龄的增长,皮肤颜色可能变为黄黑色并变得不均匀。已经提出了导致皮肤颜色变化的一些潜在原因。在这方面,氧化的蛋白质如晚期糖基化(advanced glycation)终产物和羰基化蛋白质(其是脂质过氧化的终产物)可能导致老年人皮肤颜色变为黄黑色(Ogura等人2011,Journal of Dermatological Science 64,45-52)。最近,发现皮肤毛孔的增大也可能与皮肤颜色的不均匀有关。皮肤的显微镜观察显示皮肤毛孔周围的黑暗,这与毛囊性栓不同。这种较深色的区域也可能导致皮肤颜色不均匀。据报道,皮肤毛孔周围的变黑不是由黑色素引起的,而是由于皮肤毛孔周围角质层中羰基化蛋白质的累积(Akane Sasaki,August2016,“The accumulation of carbonylated proteins causes darkness around skinpores”,The 17th Annual Meeting of the Society for Photoaging Research)。
因此,本发明的目的是提供抵抗与年龄相关的皮肤颜色变化过程的活性物质。
令人惊讶的是,现在发现相容性溶质能够解决这个问题。
用于各种化妆品和药物目的的相容性溶质的用途是已知的。
例如,WO 94/15923描述了(S)-1,4,5,6-四氢-2-甲基-4-嘧啶羧酸或(S,S)-1,4,5,6-四氢-5-羟基-2-甲基-4-嘧啶羧酸可用于制备化妆品组合物或药物,例如用于治疗皮肤病。
此外,DE4342560描述了依克多因(ectoin)和依克多因衍生物作为化妆品中的润肤剂的用途。这些产品适用于例如老化、干燥或受刺激的皮肤的护理。
此外,DE19933466描述了依克多因和衍生物,例如羟基依克多因,可用作化妆品和皮肤病学组合物中的自由基清除剂。该组合物可用于治疗和/或预防由氧化应激和炎症反应引起的皮肤老化。
例如,在WO 00/07558、WO 00/07559、WO 00/07560和US 7981899中描述了依克多因和依克多因衍生物在化妆品制剂中的进一步应用,例如,干燥和/和干裂(flaky)皮肤的护理和预防,保护人体皮肤避免干燥和/或高盐浓度,保护人体皮肤的细胞、蛋白质和/或生物膜,保护人体皮肤的微生物区系,稳定皮肤屏障,以及保护和稳定人皮肤细胞的核酸。
然而,迄今为止还不知道选自相容性溶质的化合物(例如式Ia和Ib的化合物,式Ia和Ib的化合物的生理学上可耐受的盐和式Ia和Ib的化合物的立体异构形式)有利地适用于抵抗与年龄相关的皮肤颜色变化并抑制和/或减少角质层中(特别是在皮肤毛孔周围)的蛋白质羰基化。
因此,在第一个实施方案中,本发明涉及至少一种相容性溶质和/或其生理学上可接受的盐用于抵抗与年龄相关的皮肤颜色变化的用途。
通常,这种与年龄相关的皮肤颜色变化是向淡黄色或较深的皮肤或皮肤区域的变化。
蛋白质羰基化发生在全身(包括皮肤),并且可以由反应性醛化合物触发。这可以是外源的反应性醛或内源性形成的醛,例如由多不饱和脂肪酸(其在体内普遍存在)的氧化降解产生。得到的醛是例如丙烯醛和4-羟基壬烯醛。这种醛可以例如在皮肤表面皮脂的降解中形成。因此,可以在角质层中(特别是在暴露于阳光的区域的上部)发现羰基化蛋白质。已知在真皮上层产生的羰基化蛋白质而非黑色素沉着主要导致与光老化相关的淡黄色皮肤颜色改变的发展(Ogura等人2011,Journal of Dermatological Science 64,45-52)。由于羰基化蛋白质倾向于在毛孔周围积聚的事实,皮肤颜色变为淡黄色或较深色的这种变化经常发生在毛孔周围(Akane Sasaki,August 2016,“The accumulation of carbonylatedproteins causes darkness around skin pores”,The 17th Annual Meeting of theSociety for Photoaging Research)。
在这方面,发现相容性溶质能够淡化皮肤毛孔。
在一个优选的实施方案中,它用于淡化皮肤毛孔和/或减少人体皮肤中黄色或深色皮肤毛孔的数量。
在另一个优选的实施方案中,它用于使皮肤颜色均匀和/或用于减少皮肤颜色的不均匀性。
皮肤毛孔是皮肤表面存在的小开口。一般来说,它们被认为会排出体内存在的有毒和废弃的物质。在这样的概念中,它们对应于汗腺器官的口。然而,术语毛孔也适用于皮肤表面的可见微形貌(microtopographic)特征,其对应于毛皮脂腺囊的扩大的开口。它们看起来像空的漏斗状结构,或者相反,作为对应于粉刺的角质化圆柱形塞子。
已知相容性溶质能够最小化由于热休克蛋白的形成和其他保护性质而在皮肤内产生的氧化应激。进一步发现,相容性溶质能够减少角质层内羰基化蛋白质的形成。
在另一个实施方案中,本发明因此涉及至少一种相容性溶质和/或其生理学上可接受的盐用于抑制和/或减少蛋白质羰基化和/或用于抑制和/或减少羰基化蛋白质在角质层中,特别是在皮肤毛孔周围的累积的用途。
术语“抑制和/或减少蛋白质羰基化”涉及基于根据本发明的特定化合物的作用的蛋白质羰基化活性的任何降低。术语“抑制和/或减少角质层中羰基化蛋白质的累积”涉及基于根据本发明的特定化合物的作用的羰基化蛋白质的的累积的任何减少。
角质层是表皮的最外层,由死细胞(角质细胞(corneocyte))组成。该层由15至20层没有细胞核和细胞器的扁平细胞组成。它们的细胞质显示出丝状角蛋白。这些角质细胞嵌入由神经酰胺、胆固醇和脂肪酸组成的脂质基质中。
角质层起到形成屏障的作用,以保护下面的组织免受感染、脱水、化学物质和机械应力的影响。脱屑是细胞从角质层表面脱落的过程,其平衡在基底层中形成的增殖性角质形成细胞。这些细胞在大约14天的旅程中通过表皮向表面迁移。
化合物的上述用途可以在体外或体内模型中进行。特定细胞对式(I)的化合物的处理的敏感性可通过体外测试确定。为了体外测试,可以使用来自活组织检查样品的经培养的细胞。所述用途特别地对患有年龄引起的皮肤颜色变化的人类物种的样品体外进行。
多种特定化合物的测试使得能够选择看起来最适合于处理的活性化合物。
如上定义的相容性溶质的用途通常是局部的,并且优选是非治疗性或美容用途。它优选是化妆品用途,特别优选非治疗性化妆品用途。
根据通用的定义,相容性溶质是来自极端嗜盐和耐盐的真细菌的应激保护物质,所述真细菌通过生物合成或有效的运输机制大量累积它们。这些渗透活性物质阻止液体流出进入介质(变干燥),并且它们的名字来源于它们不会损害细胞代谢的事实(即使在高细胞质浓度下),即与代谢相容(根据:E.A.Galinski,M.Stein,B.Amendt,M.KinderComp.Biochem.Physiol.,117(3)(1997)357-365)。
根据本发明优选的相容性溶质选自糖和多元醇以及氨基酸和氨基酸衍生物。
根据本发明,至少一种相容性溶质优选选自:海藻糖,甘油,糖基甘油,β-甘露糖基甘油酸酯(firoin),β-甘露糖基甘油酸酰胺(firoinA),二-myo-肌醇磷酸酯(di-myo-inositol phosphate)(DIP),环状2,3-二磷酸甘油酸酯(cDPG),1,1-二甘油磷酸酯(DGP),二甘露糖基二肌醇磷酸酯(DMIP),甜菜碱,甘氨酸甜菜碱,脯氨酸甜菜碱,谷氨酸甜菜碱,丙氨酸,脯氨酸,谷氨酰胺,N-乙酰基赖氨酸,谷氨酰胺1-酰胺,牛磺酸,胆碱,胆碱O-硫酸盐,肉碱,砷-甜菜碱,巴豆甜菜碱,二甲基磺基乙酸酯,二甲基磺基丙酸酯,高甜菜碱,三甲胺N-氧化物,和选自根据式Ia和Ib的化合物的化合物
和/或其生理学上可接受的盐和/或立体异构体,
其中,
R1是H或烷基,
R2是H、COOH、COO-烷基或CO-NH-R5,
R3是H或OH,
R4是H或OH,
n是1、2或3,
R5是H、烷基、氨基酸部分、二肽部分或三肽部分
烷基是具有1至4个C原子的烷基。
更优选地,所述至少一种相容性溶质选自:海藻糖,β-甘露糖基甘油酸酯(firoin),β-甘露糖基甘油酸酰胺(firoin A),二-myo-肌醇磷酸酯(DIP),环状2,3-二磷酸甘油酸酯(cDPG),1,1-二甘油磷酸酯(DGP),二甘露糖基二肌醇磷酸酯(DMIP),甜菜碱,和选自如上定义的式Ia和Ib的化合物的化合物。
在更优选的实施方案中,所述至少一种相容性溶质选自如上定义的式Ia和Ib的化合物。
为了本发明的目的,以上和以下的选自式Ia和Ib的化合物、式Ia和Ib的化合物的生理学上可耐受的盐、以及式Ia和Ib的化合物的立体异构形式的所有化合物被称为“依克多因或依克多因衍生物”。
依克多因和依克多因衍生物是低分子量的环状氨基酸衍生物,其可以从各种嗜盐微生物中分离或合成制备。依克多因和羟基依克多因都具有不与细胞代谢反应的优点。
选自式Ia和Ib的化合物、式Ia和Ib的化合物的生理学上可耐受的盐和式Ia和Ib的化合物的立体异构形式的化合物可以以光学异构体、非对映异构体、外消旋体、两性离子、阳离子或其混合物的形式存在于组合物中。在选自式Ia和Ib的化合物、式Ia和Ib的化合物的生理学上可耐受的盐和式Ia和Ib的化合物的立体异构形式的化合物中,优选其中R1是H或CH3、R2是H或COOH、R3和R4彼此独立地是H或OH并且n是2的化合物。
特别优选地,所述至少一种相容性溶质选自(S)-1,4,5,6-四氢-2-甲基-4-嘧啶羧酸(依克多因)和(S,S)-1,4,5,6-四氢-5-羟基-2-甲基-4-嘧啶羧酸(羟基依克多因)。
最优选的是,所述至少一种相容性溶质是(S)-1,4,5,6-四氢-2-甲基-4-嘧啶羧酸(依克多因)。
式Ia和Ib的化合物的基团R5下提到的氨基酸残基衍生自相应的氨基酸。术语“氨基酸”是指以下化合物的立体异构形式,例如D和L形式:丙氨酸,β-丙氨酸,精氨酸,天冬酰胺,天冬氨酸,半胱氨酸,谷氨酰胺,谷氨酸,甘氨酸,组氨酸,异亮氨酸,亮氨酸,赖氨酸,甲硫氨酸,苯丙氨酸,丝氨酸,苏氨酸,色氨酸,酪氨酸,缬氨酸,γ-氨基丁酸,Nε-乙酰基-赖氨酸,Nδ-乙酰基鸟氨酸,Nγ-乙酰基二氨基丁酸和Nα-乙酰基二氨基丁酸。L-氨基酸是优选的。下列氨基酸的残基是优选的:丙氨酸,β-丙氨酸,天冬酰胺,天冬氨酸,谷氨酰胺,谷氨酸,甘氨酸,丝氨酸,苏氨酸,缬氨酸,γ-氨基丁酸,Nε-乙酰基-赖氨酸,Nδ-乙酰基鸟氨酸,Nγ-乙酰基二氨基丁酸和Nα-乙酰基二氨基丁酸。
在式Ia和Ib的化合物的基团R5下提到的二肽和三肽基团就其化学性质而言是酰胺(acid amide),并且在水解时分解得到2或3个氨基酸。二肽和三肽基团中的氨基酸通过酰胺键彼此键合。优选的二肽和三肽基团由优选的氨基酸构成。
在式Ia和Ib的化合物中,基团R1、R2和R5下提到的烷基包括甲基CH3,乙基C2H5,丙基CH2CH2CH3和CH(CH3)2和丁基CH2CH2CH2CH3,H3CCHCH2CH3,CH2CH(CH3)2和C(CH3)3。优选的烷基是甲基。
式Ia和Ib的化合物的优选的生理学上可耐受的盐是,例如,碱金属、碱土金属或铵盐,如Na、K、Mg或Ca盐,和衍生自有机碱三乙胺或三(2-羟基乙基)胺的盐。式Ia和Ib的化合物的进一步优选的生理学上可耐受的盐通过与无机酸如盐酸、硫酸和磷酸,或与有机羧酸或磺酸如乙酸、柠檬酸、苯甲酸、马来酸、富马酸、酒石酸和对甲苯磺酸反应而产生。
其中碱性和酸性基团(例如羧基或氨基)以相同的数量存在的式Ia和Ib的化合物形成内盐。
式Ia和Ib的化合物的制备描述于文献(DE4342560)中。(S)-1,4,5,6-四氢-2-甲基-4-嘧啶羧酸或(S,S)-1,4,5,6-四氢-5-羟基-2-甲基-4-嘧啶羧酸也可通过微生物学方法获得(Severin等人,J.Gen.Microb.138(1992)1629-1638或EP1409707A)。
已知相容性溶质能够最小化由于热休克蛋白的形成和其他保护性质而在皮肤内引起的氧化应激。然而,未知的是并且在本发明中首先描述了的是相容性溶质还能够减少羰基化蛋白质的形成。由于羰基化蛋白质倾向于在皮肤毛孔周围累积并且是这些区域中皮肤颜色变为黄色/棕色的原因,因此羰基化蛋白质形成的减少导致更均匀的皮肤颜色和皮肤中更少的深色或黄色毛孔。甚至皮肤颜色也可以恢复。
出于本发明的目的,术语“试剂”、“组合物”或“配制剂”也与术语“制剂”同义使用。
这里的制剂通常是可以局部施用的制剂,例如化妆品或皮肤病学制剂或医药产品。在本发明的意义上“可以局部施用”是指制剂在外部和局部施用,即制剂必须适合于例如能够施用于皮肤。在这种情况下,制剂包含化妆品、药物或皮肤病学上合适的媒介物(vehicle),以及根据所需的性质特征,任选其他的合适成分。局部制剂优选用作化妆品或皮肤病学制剂,特别优选用作化妆品制剂。合适的媒介物和助剂或填充剂在以下部分中详细描述。
制剂可包括或包含上文和/或下文提到的必要或任选的组分、基本上由其组成或由其组成。可用于制剂中的所有化合物或组分是已知的和可商购的或可通过已知方法合成。在权利要求中公开了进一步优选的实施方案组合。
如上所述并且也如优选所述的相容性溶质在本发明的制剂中通常以0.001至50重量%(基于制剂的总重量)的量存在,优选0.01至10重量%,和特别优选0.1至10重量%,基于组合物整体计。所述化合物在组合物中的比例非常特别优选为0.1至5重量%,基于组合物整体计。本领域技术人员在根据制剂的预期效果适当地选择量时绝对没有困难。
除相容性溶质外,组合物还可包含其他化妆品、皮肤病学或药学活性成分。
在一个实施方案中,本发明涉及包含至少一种相容性溶质和/或其生理学上可接受的盐和至少一种另外的皮肤毛孔淡化活性物质的制剂。
如上所述定义至少一种相容性溶质的优选实施方案。在一个特别优选的实施方案中,制剂中的至少一种相容性溶质选自如上定义的式Ia和Ib的化合物。
另外的皮肤毛孔淡化活性物质是本领域技术人员已知的,并且可以例如选自α-羟基酸(AHA),例如柠檬酸、乳酸或苹果酸,以及水杨酸、维生素C和其衍生物和余甘子(emblica)。
所述另外的活性化合物优选选自UV过滤剂、毛孔细化剂、抗氧化剂、维生素、皮肤增亮(skin-lightening)活性化合物、抗衰老活性化合物、抗炎活性化合物、抗微生物活性化合物、用于改善皮肤水分含量的活性化合物(皮肤水分调节剂)、抗脂肪团活性化合物、抗皱活性化合物、去头屑活性化合物、抗痤疮活性化合物、除臭剂、颜料和自晒黑物质;特别优选选自UV过滤剂、毛孔细化剂、抗氧化剂、维生素、皮肤增亮活性化合物、自晒黑物质、抗衰老活性化合物和抗脂肪团活性化合物。
在一个优选的实施方案中,制剂还包含UV过滤剂。原则上,所有UV过滤剂都适合于在根据本发明的制剂中组合。特别优选已经证明其生理学上的可接受性的UV过滤剂。对于UVA和UVB过滤剂从专业文献中已知有许多已证实的物质。以下列表中显示的化合物仅应视为示例。当然也可以使用其他UV过滤剂。
优选的制剂可包括有机UV过滤剂,所谓的亲水或亲脂防晒过滤剂,其在UVA区域和/或UVB区域和/或IR和/或VIS区域(吸收剂)中有效。这些物质尤其可以选自二苯甲酰甲烷衍生物、对氨基苯甲酸衍生物、水杨酸衍生物、β,β-二苯基丙烯酸酯衍生物、樟脑衍生物、三嗪衍生物、肉桂酸衍生物和聚合物过滤剂和硅酮过滤剂,其在申请WO 93/04665中进行了描述。有机过滤剂的其他实例在专利申请EP-A0 487 404中指出。所述UV过滤剂通常根据INCI命名法在下面命名。
特别适合的组合有:
二苯甲酰甲烷衍生物:4-异丙基-二苯甲酰基-甲烷和4,4'-甲氧基-叔丁基-二苯甲酰基甲烷描述于FR-A-2326405、FR-A-2440933和EP-A-0114607中。4,4'-甲氧基-叔丁基-二苯甲酰甲烷例如由Merck以“Eusolex 9020”的名称销售。
对氨基苯甲酸及其衍生物:PABA,乙基PABA,乙基二羟丙基PABA,乙基己基二甲基PABA,例如由ISP以名称“Escalol 507”、Glyceryl PABA、PEG-25PABA销售,例如由BASF以名称“UvinulP25”销售。
水杨酸盐/酯:由Merck以“Eusolex HMS”的名称销售的胡莫柳酯;水杨酸乙基己酯,例如由Symrise以“Neo Heliopan OS”的名称销售;二丙二醇水杨酸酯,例如由Scher以“Dipsal”的名称销售;TEA水杨酸盐/酯,例如由Symrise以“Neo Heliopan TS”的名称销售。
β,β-二苯基丙烯酸酯衍生物:氰双苯丙烯酸辛酯,例如由Merck以“OCR”的名称销售;来自巴斯夫的“Uvinul N539”;依托立林(Etocrylene),例如由BASF以“Uvinul N35”的名称销售。
二苯甲酮衍生物:二苯甲酮-1,例如以“Uvinul 400”的名称销售;二苯甲酮-2,例如以“Uvinul D50”的名称销售;二苯甲酮-3或氧苯酮,例如以“Uvinul M40”的名称销售;二苯甲酮-4,例如以“UvinulMS40”的名称销售;二苯甲酮-9,例如由BASF以“Uvinul DS-49”的名称销售;二苯甲酮-5、二苯甲酮-6,例如由Norquay以“Helisorb11”的名称销售;二苯甲酮-8,例如由American Cyanamid以“Spectra-Sorb UV-24”的名称销售;二苯甲酮-12n-己基2-(4-二乙基氨基-2-羟基苯甲酰基)苯甲酸酯或2-羟基-4-甲氧基二苯甲酮,由Merck,Darmstadt以4360的名称销售。
亚苄基樟脑衍生物:3-亚苄基樟脑,例如由Chimex以“MexorylSD”的名称销售;4-甲基亚苄基-樟脑,例如由Merck以“Eusolex 6300”的名称销售;亚苄基樟脑磺酸,例如由Chimex以“Mexoryl SL”的名称销售;樟脑苄烷铵甲基硫酸盐,例如由Chimex以“MexorylSO”的名称销售;对苯二亚甲基-二樟脑磺酸,例如由Chimex以“MexorylSX”的名称销售;由Chimex以“Mexoryl SW”的名称销售的聚丙烯酰胺甲基亚苄基樟脑。
苯基苯并咪唑衍生物:苯基苯并咪唑磺酸,例如由Merck以“Eusolex 232”的名称销售;苯基二苯并咪唑四磺酸二钠,例如由Symrise以“Neo Heliopan AP”的名称销售。
苯基苯并三唑衍生物:甲酚曲唑三硅氧烷,例如由Rhodia Chimie以“Silatrizole”的名称销售;固体形式的亚甲基双(苯并三唑基)四甲基丁基苯酚,例如由Fairmount Chemical以“MIXXIM BB/100”的名称销售,或以微粉化形式作为水分散体,例如由BASF以“TinosorbM”的名称销售。
三嗪衍生物:乙基己基三嗪酮,例如由BASF以“Uvinul T150”的名称销售;二乙基己基丁酰胺三嗪酮,例如由Sigma 3V以“UvasorbHEB”的名称销售;2,4,6-三-(二异丁基-4'-氨基亚苄基丙二酸酯)-s-三嗪或2,4,6-三(联苯基)-1,3,5-三嗪,由BASF作为TinosorbA2B销售;2,2’-[6-(4-甲氧基苯基)-1,3,5-三嗪-2,4-二基]双[5-(2-乙基己基)氧基]苯酚;由BASF作为Tinosorb S销售;N2,N4-双[4-[5-(1,1-二甲基丙基)-2-苯并噁唑基]苯基]-N6-(2-乙基己基)-1,3,5-三嗪-2,4,6-三胺,由Sigma3V作为Uvasorb K 2A销售,或三苯基三嗪,由BASF作为A2B销售。
邻氨基苯甲酸盐(Anthraniline)衍生物:邻氨基苯甲酸薄荷酯,例如由Symrise以“Neo Heliopan MA”的名称销售。
咪唑衍生物:乙基己基二甲氧基亚苄基二氧代咪唑啉丙酸酯。
亚苄基丙二酸酯衍生物:含有官能性亚苄基丙二酸酯基团的聚有机硅氧烷,例如聚硅氧烷-15,例如由Hoffmann LaRoche以“ParsolSLX”的名称销售。
4,4-二芳基丁二烯衍生物:1,1-二羧基(2,2'-二甲基丙基)-4,4-二苯基丁二烯。
苯并噁唑衍生物:2,4-双[5-(1-二甲基丙基)苯并噁唑-2-基(4-苯基)亚氨基]-6-(2-乙基己基)亚氨基-1,3,5-三嗪,例如由Sigma 3V以Uvasorb K2A的名称销售,以及包含该物质的混合物。
哌嗪衍生物,例如化合物
或以下结构的UV过滤剂
还可以使用基于聚硅氧烷共聚物的UV过滤剂,其具有根据下式的无规分布,其中,例如,a=1,2;b=58和c=2,8:
这个化合物列表代表了示例;当然也可以使用其他UV过滤剂。
合适的有机UV防护物质可以优选选自以下列表:水杨酸乙基己酯,苯基苯并咪唑磺酸,二苯甲酮-3,二苯甲酮-4,二苯甲酮-5,n-己基2-(4-二乙基氨基-2-羟基苯甲酰基)苯甲酸盐,4-甲基亚苄基樟脑,对苯二亚甲基二樟脑磺酸,苯基二苯并咪唑四磺酸二钠,亚甲基双(苯并三唑基)四甲基丁基苯酚,丁基甲氧基二苯甲酰甲烷,乙基己基三嗪酮,二乙基己基丁酰胺三嗪酮,甲酚曲唑三硅氧烷,聚硅氧烷-15,1,1-二羧基(2,2'-二甲基丙基)-4,4-二苯基丁二烯,2,4-双[5-1(二甲基丙基)苯并噁唑-2-基(4-苯基)亚氨基]-6-(2-乙基己基)亚氨基-1,3,5-三嗪及其混合物。
这些有机UV过滤剂通常以0.01至20重量%,优选1至10重量%的量掺入配制剂中。
制剂可包含其他无机UV过滤剂,即所谓的颗粒UV过滤剂。这些与颗粒UV过滤剂的组合既可以是粉末也可以是以下类型的分散体或糊剂。
这里优选的是来自以下的那些:二氧化钛,例如涂覆的二氧化钛(例如T-2000,/>T-AQUA,/>T-AVO,/>T-PRO,/>T-EASY),氧化锌(例如/>),氧化铁或氧化铈和/或氧化锆。
此外,与颜料二氧化钛或氧化锌的组合也是可能的,其中这些颜料的粒度大于或等于200nm,例如FG或/>FF-Pharma。
另外优选的可以是制剂包含已经通过常规方法进行后处理的无机UV过滤剂,例如在Cosmetics&Toiletries 1990,105,53中所述的。可以在这里选择一种或多种以下后处理组分:氨基酸,蜂蜡,脂肪酸,脂肪酸醇,阴离子表面活性剂,卵磷脂,磷脂,脂肪酸的钠、钾、锌、铁或铝盐,聚乙烯,硅酮,蛋白质(特别是胶原蛋白或弹性蛋白),烷醇胺,二氧化硅,氧化铝,其他金属氧化物,磷酸盐,如六偏磷酸钠,或甘油。
这里优选使用的颗粒UV过滤剂是:
-未处理的二氧化钛,例如来自Tayca的Microtita-nium Dioxide MT 500 B产品;来自Degussa的二氧化钛P25;
-经过后处理的微粉化二氧化钛,其使用氧化铝和二氧化硅后处理,例如来自Tayca的产品“Microtitanium Dioxide MT 100 SA,或来自Uniqema的产品”Tioveil Fin”;
-经过后处理的微粉化二氧化钛,其使用氧化铝和/或硬脂酸铝/月桂酸铝后处理,例如来自Tayca的Micro-titanium Dioxide MT 100T;来自Merck的Eusolex T-2000;
-经过后处理的微粉化二氧化钛,其使用氧化铁和/或硬脂酸铁后处理,例如来自Tayca的产品“Microtitanium Dioxide MT 100 F”;
-经过后处理的微粉化二氧化钛,其使用二氧化硅、氧化铝和硅酮后处理,例如来自Tayca的产品“Microtitanium Dioxide MT 100SAS”;
-用六偏磷酸钠后处理的微粉化二氧化钛,例如来自Tayca的产品“MicrotitaniumDioxide MT 150W”。
用于组合的经处理的微粉化二氧化钛也可以用以下进行后处理:
-辛基三甲氧基硅烷,例如来自Degussa的产品Tego Sun T 805;
-二氧化硅;例如,来自DSM的产品Parsol T-X;
-氧化铝和硬脂酸;例如,来自Sachtleben的产品UV-Titan M160;
-铝和甘油;例如,来自Sachtleben的产品UV-Titan,
-铝和硅油,例如来自Sachtleben的产品UV-Titan M262;
-六偏磷酸钠和聚乙烯吡咯烷酮,
-聚二甲基硅氧烷,例如来自Cardre的产品70250 Cardre UFTiO2SI3“;
-聚二甲基氢硅氧烷,例如来自Color Techniques的产品Microtitanium DioxideUSP Grade Hydrophobic。
与以下产品的组合也可以是有利的:
-未经处理的氧化锌,例如来自BASF(Sunsmart)的产品Z-Cote,来自Elementis的Nanox;
-经后处理的氧化锌,例如以下产品:
·来自Toshibi的“Zinc Oxide CS-5”(用聚甲基氢硅氧烷后处理的ZnO);
来自Nanophase Technologies的Nanogard Zinc Oxide FN;
·来自Shin-Etsu的“SPD-Z1”(用硅酮接枝的丙烯酸类聚合物后处理的ZnO,分散在环二甲基硅氧烷中);
·来自ISP的“Escalol Z100”(氧化铝后处理的ZnO,分散在甲氧基肉桂酸乙基己酯/PVP-十六碳烯/聚甲基硅氧烷共聚物混合物中);
·来自Fuji Pigment的“Fuji ZNO-SMS-10”(用二氧化硅和聚甲基硅倍半氧烷后处理的ZnO);
·未经处理的氧化铈微颜料(micropigment),例如来自RhonePoulenc的名称为“Colloidal Cerium Oxide”;
·未经处理和/或经过后处理的氧化铁,来自Arnaud的名称为Nanogar。
举例来说,还可以使用经过和没有经过后处理的各种金属氧化物的混合物,例如二氧化钛和氧化铈,例如来自Ikeda的产品Sunveil A。此外,还可以使用氧化铝、二氧化硅和硅酮后处理的二氧化钛/氧化锌混合物的混合物,例如来自Sachtleben的产品UV-TitanM261。
这些无机UV过滤剂通常以0.1至25重量%,优选2至10重量%的量加入制剂中。
通过组合一种或多种具有UV过滤作用的所述化合物,可以优化针对UV辐射的有害影响的保护作用。
所有所述UV过滤剂也可以以胶囊形式使用。特别是,采用胶囊形式的有机UV过滤剂是有利的。根据本发明使用的制剂中的胶囊优选以确保包封的UV过滤剂以上述重量百分比存在于制剂中的量存在。
根据本发明,制剂可优选进一步包含毛孔细化剂。毛孔细化剂是例如视黄醇(维生素A),5,7-二羟基-2-甲基色酮(以商品名 Luremine销售)、烟酰胺或异槲皮素。
在本发明的另一个优选实施方案中,所述制剂还包含至少一种皮肤增亮活性化合物(或同义的脱色活性化合物)或具有皮肤增亮活性的提取物。
皮肤增亮活性化合物原则上可以是本领域技术人员已知的所有活性化合物。适合于组合的是市售的黑素生成抑制剂,例如抗坏血酸及其衍生物,芦荟苦素,烟酰胺,余甘子,鞣花酸,甘草提取物,桑树提取物,曲酸,甘草提取物,噜忻喏(Rucinol),氢醌,壬二酸,熊果苷,抗坏血酸磷酸镁,乳酸,丁基苯基甲氧基苯基丙二醇(可从Merck以购买)等。具有皮肤增亮活性的化合物的优选实例是氢醌、烟酰胺、抗坏血酸及其生理上可接受的盐、曲酸,熊果苷、芦荟苦素、壬二酸、鞣花酸、乳酸、丁基苯基甲氧基苯基丙二醇或rucinol。具有皮肤增亮活性的提取物的优选实例是甘草提取物、桑树提取物或余甘子。
如上所述的制剂还可包含一种或多种自晒黑物质。这种类型的制剂通常具有对比度降低效果并且能够实现均匀的皮肤色调。本发明同样涉及如所述的相容性溶质与一种或多种自晒黑物质组合用于对比度降低和实现均匀皮肤色调的用途。因此,对比度降低剂是通过降低较强和较不强着色的皮肤区域之间的对比度来减少不均匀的皮肤着色的物质。这里通过不均匀的色素沉着和/或角质皮肤的不同分布可以产生这种不均匀的皮肤着色。不均匀的色素沉着在人群中绝不罕见,并且是基于黑素细胞产生的不同黑色素水平或皮肤中黑素细胞的不规则分布。
特别地通过其中进一步存在自晒黑物质的制剂可以实现对比度降低。这种自晒黑物质可以是基于美拉德反应或迈克尔加成与皮肤的氨基酸反应的自晒黑物质,或者可以是所谓的黑素生成促性物质或促沉着(propigmentation)物质,其促进皮肤的天然色素沉着。
优选的自晒黑物质是,例如:1,3-二羟基丙酮(DHA)和由其衍生的衍生物,甘油醛,羟甲基乙二醛,γ-二醛,赤藓酮糖,6-醛(aldo)-D-果糖,茚三酮,5-羟基-1,4-萘醌(胡桃醌)或2-羟基-1,4-萘醌(指甲草醌)或所述化合物的混合物。特别优选的是1,3-二羟基丙酮、赤藓酮糖及其混合物。
促沉着物质是本领域技术人员已知的。实例是甘草次酸(glycerrithinic acid),黑素细胞激活激素(α-MSH),肽类似物,胸苷二核苷酸,L-酪氨酸及其酯,双环单萜二醇(bicyclicmonoterpendiole)(描述于Brown等人,Photochemistry andPhotobiology B:Biology 63(2001)148-161)或7-酰氧基-色烯-4-酮衍生物(描述于WO2012/097857A1),特别是十六烷酸5-羟基-2-甲基-4-氧代-4H-色烯-7-基酯(可以 BronzylTM购自Merck KGaA,Darmstadt,Germany)。
优选地,自晒黑物质在组合物中的量为0.01至20重量%,更优选为0.5至15重量%,最优选为1至8重量%,与制剂的总重量相关。
在所述制剂中,还可以存在有色颜料,其中颜料的层结构不受限制。在使用0.5至5重量%时,有色颜料应优选为皮肤颜色或褐色。相应颜料的选择对于本领域技术人员来说是熟悉的。
在本发明的另一个优选实施方案中,该制剂包含一种或多种抗氧化剂和/或一种或多种维生素。抗氧化剂的使用能够通常实现针对氧化应激或自由基的作用的保护作用,本领域技术人员在选择适当快速或以延迟时间起作用的抗氧化剂方面绝对没有困难。从专题文献中已知有许多已证实可用作抗氧化剂的物质,例如氨基酸(例如甘氨酸,组氨酸,酪氨酸,色氨酸)及其衍生物,咪唑(例如尿刊酸)及其衍生物,肽,例如D,L-肌肽,D-肌肽,L-肌肽及其衍生物(例如鹅肌肽),类胡萝卜素,胡萝卜素(例如,α-胡萝卜素,β-胡萝卜素,番茄红素)和其衍生物,绿原酸及其衍生物,硫辛酸及其衍生物(例如二氢硫辛酸),葡糖硫金,丙基硫氧嘧啶和其他硫醇(例如硫氧还蛋白,谷胱甘肽,半胱氨酸,胱氨酸,胱胺和其糖基、N-乙酰基、甲基、乙基、丙基、戊基、丁基和月桂基、棕榈酰基、油烯基、γ-亚油基、胆固醇基和甘油基酯)及其盐,二月桂基硫代二丙酸酯,二硬脂基硫代二丙酸酯,硫代二丙酸及其衍生物(例如酯、醚、肽、脂质、核苷酸、核苷和盐)和亚砜亚胺化合物(例如丁硫氨酸亚砜亚胺,高半胱氨酸亚砜亚胺(homocystasulfoximine),丁硫氨酸砜,五、六-和七硫氨酸亚砜亚胺)(非常低耐受剂量(例如,pmol至μmol/kg)),以及(金属)螯合剂,(例如,α-羟基脂肪酸,棕榈酸,植酸,乳铁蛋白)),α-羟基酸(例如,柠檬酸,乳酸,苹果酸),腐殖酸,胆汁酸,胆汁提取物,胆红素,胆绿素,EDTA,EGTA,乙二胺四亚甲基膦酸五钠及其衍生物,不饱和脂肪酸及其衍生物,维生素C和衍生物(例如,抗坏血酸棕榈酸酯,抗坏血酸磷酸镁,抗坏血酸乙酸酯),生育酚和衍生物(例如维生素E乙酸酯),维生素A和衍生物(例如,维生素A棕榈酸酯),和安息香树脂的松柏醇苯甲酸酯,芸香亭酸及其衍生物,α-糖基芦丁,阿魏酸,亚糠基葡糖醇,肌肽,丁基羟基甲苯,丁基羟基茴香醚,去甲二氢愈创木酸,三羟基苯丁酮,槲皮素,尿酸及其衍生物,甘露糖和其衍生物,锌及其衍生物(例如ZnO,ZnSO4),硒及其衍生物(例如硒代甲硫氨酸),茋及其衍生物(例如二苯乙烯氧化物,反式二苯乙烯氧化物)。其他合适的抗氧化剂也描述于WO 2006/111233和WO 2006/111234中。
合适的抗氧化剂还是通式A或B的化合物
其中
R1表示-C(O)CH3、-CO2R3、-C(O)NH2和–C(O)N(R4)2,
X表示O或NH,
R2表示具有1至30个C原子的直链或支链烷基,
R3表示具有1至20个C原子的直链或支链烷基,
在每种情况下,R4彼此独立地表示H或具有1至8个C原子的直链或支链烷基,
R5表示H、具有1至8个C原子的直链或支链烷基或具有1至8个C原子的直链或支链烷氧基,和
R6表示具有1-8个C原子的直链或支链烷基。
优选2-(4-羟基-3,5-二甲氧基亚苄基)丙二酸和/或2-(4-羟基-3,5-二甲氧基苄基)丙二酸的衍生物,特别优选双(2-乙基己基)2-(4-羟基-3,5-二甲氧基亚苄基)丙二酸酯(例如ST Liquid)和/或双(2-乙基己基)2-(4-羟基-3,5-二甲氧基苄基)丙二酸酯(例如/>AP)。
抗氧化剂的混合物同样适用于根据本发明的制剂。已知和商用的混合物是例如包含作为活性成分的卵磷脂、L-(+)-抗坏血酸棕榈酸酯和柠檬酸、天然生育酚、L-(+)-抗坏血酸棕榈酸酯、L-(+)-抗坏血酸和柠檬酸(例如,K LIQUID)、天然来源的生育酚提取物、L-(+)-抗坏血酸棕榈酸酯、L-(+)-抗坏血酸和柠檬酸(例如,/>LLIQUID)、DL-α-生育酚、L-(+)-抗坏血酸棕榈酸酯、柠檬酸和卵磷脂(例如,/>LM)或丁基羟基甲苯(BHT)、L-(+)-抗坏血酸棕榈酸酯和柠檬酸(例如,/>2004)的混合物。这种类型的抗氧化剂与式(I)或其部分式的化合物通常以重量百分比计在1000:1至1:1000,优选以重量百分比计在100:1至1:100的范围用于这样的组合物中。
在具有抗氧化作用的酚中,多酚(其中一些是天然存在的)对于药物、化妆品或营养领域的应用特别有意义。例如,主要称为植物染料的类黄酮或生物类黄酮通常具有抗氧化潜力。Lemanska等人,Current Topics in Biophysics 2000,24(2),101-108涉及单和二羟基黄酮的取代模式的影响。其中观察到包含与酮官能团相邻的OH基团或在3'4'-或6,7-或7,8-位置具有OH基团的二羟基黄酮具有抗氧化性质,而在一些情况下其他单和二羟基黄酮没有抗氧化性质。
槲皮素(cyanidanol,cyanidenolon 1522,槲皮素(meletin),sophoretin,ericin,3,3',4',5,7-五羟基黄酮)经常被提及作为特别有效的抗氧化剂(例如Rice-Evans等人,Trends in Plant Science 1997,2(4),152-159)。Lemanska等人,Free RadicalBiology&Medicine 2001,31(7),869-881已经研究了羟基黄酮的抗氧化作用的pH依赖性。槲皮素在整个pH范围内在所研究的结构中表现出最高的活性。
根据本发明的制剂可包含维生素作为其他成分。根据本发明的制剂中优选存在维生素和维生素衍生物,其选自维生素A,维生素A丙酸酯,维生素A棕榈酸酯,维生素A醋酸酯,视黄醇,维生素B,盐酸氯化硫胺素(维生素B1),核黄素(维生素B2),烟酰胺,维生素C(抗坏血酸),维生素D,麦角钙化醇(维生素D2),维生素E,DL-α-生育酚,生育酚E乙酸酯,生育酚氢琥珀酸酯,维生素K1,秦皮甲素(维生素P活性化合物),硫胺素(维生素B1),烟酸(尼克酸),吡哆醇,吡哆醛,吡哆胺,(维生素B6),泛酸,生物素,叶酸和钴胺素(维生素B12),特别优选维生素A棕榈酸酯,维生素C及其衍生物,DL-α-生育酚,生育酚E乙酸酯,烟酸,泛酸和生物素。在化妆品应用的情况下,维生素通常以基于总重量的0.01至5重量%与制剂一起加入。营养-生理学应用面向各自推荐的维生素需求。
根据本发明的制剂还可包含至少一种用于维持和/或改善皮肤水分含量的物质。在不打算被视为限制的情况下,这些物质可以尤其是属于所谓的天然保湿因子的物质,例如,2-氧代吡咯烷5-羧酸。
根据本发明的制剂可另外包含抗衰老活性化合物、抗脂肪团活性化合物或常规皮肤保护或皮肤护理活性化合物。皮肤保护或皮肤护理活性化合物原则上可以是本领域技术人员已知的所有活性化合物。特别优选的抗衰老活性化合物是嘧啶羧酸、芳基肟、生物类黄酮、含生物类黄酮的提取物、色酮或类视黄醇。
另外,可以使用的抗衰老活性化合物是Merck的产品,例如5,7-二羟基-2-甲基色酮,以商品名 Luremine,/> Isoquercetin,/>Tilirosid或/> Cyclopeptide 5销售。
已知的抗衰老物质还是色酮,如例如EP 1508327中所述,或类视黄醇,例如视黄醇(维生素A),视黄酸,视黄醛或以及维生素A的合成修饰的化合物。色酮和所描述的类视黄醇同时也是有效的抗脂肪团活性化合物。同样已知的抗脂肪团活性化合物是咖啡因。
在上述配制剂中,相容性溶质可有利地与所有已知的防腐剂或抗微生物活性化合物组合,例如茴香酸,醇,苯甲酸铵,丙酸铵,苯甲酸,溴硝丙二醇,对羟基苯甲酸丁酯,苄索氯铵,苯扎氯铵,5-溴-5-硝基-1,3-二噁烷,苯甲醇,硼酸,苯并异噻唑啉酮,苯并三唑,苄基半甲酸酯,苯甲酸苄酯(benzylparaben),2-溴-2-硝基丙烷-1,3-二醇,苯甲酸丁酯,氯苯甘醚,辛癸酸甘油酯,辛乙二醇(caprylyl glycol),茶树叶提取物(Camellia Sinensis leafextract),假丝酵母菌/葡萄糖/甲基菜籽酸酯,氯二甲酚,氯乙酰胺,氯己定,三氯叔丁醇,苯甲酸钙,对羟基苯甲酸钙,丙酸钙,水杨酸钙,山梨酸钙,克菌丹,氯胺T,氯己定二乙酸盐,氯己定二葡萄糖酸盐,盐酸氯己定,氯乙酰胺(chloroacetamine),对氯间甲酚,氯苯酚,对氯苯酚,氯麝酚,柚(CitrusGrandis)(葡萄柚)果实提取物,柚(葡萄柚)种子提取物,间甲酚,邻甲酚,对甲酚,混合的甲酚,1,2-癸二醇(INCI亚癸基二醇),重氮烷基脲,二氯苄醇,二甲基噁唑烷,DMDM乙内酰脲,二甲基羟甲基吡唑,脱氢乙酸,重氮烷基脲,DEDM乙内酰脲,DEDM乙内酰脲二月桂酸酯,二溴丙脒二异硫代硫酸盐,二羟甲基乙烯硫脲,二硫代甲基苯甲酰胺,DMHF,度米芬,7-乙基双环噁唑烷,对羟基苯甲酸乙酯,乙基己基甘油,乙醇,阿魏酸乙酯,甲醛,阿魏酸,甘油基癸酸酯,戊二醛,甘油甲酸酯,乙二醛,己脒定二(羟乙基磺酸)盐,己二醇,海克替啶,己脒定,己脒定二对羟基苯甲酸酯,己脒定对羟基苯甲酸酯,4-羟基苯甲酸,羟基甲基二氧氮杂双环辛烷,咪唑烷基脲,咪唑烷基脲NF,对羟基苯甲酸异丁基酯,异噻唑啉酮,碘代丙炔基丁基氨基甲酸酯,对羟基苯甲酸异癸基酯,异丙基甲酚,对羟基苯甲酸异丙酯,山梨酸异丙酯,山梨酸钾NF FCC,地衣酸铜,苯甲酸钾,对羟基苯甲酸乙酯钾,对羟基苯甲酸甲酯钾,对羟基苯甲酸钾,苯酚钾,邻苯基苯酚钾,丙酸钾,丙基对羟基苯甲酸钾,水杨酸钾,山梨酸钾,对羟基苯甲酸甲酯,甲基异噻唑啉酮,甲苄索氯铵苯酚,甲基二溴戊二腈,六亚甲基四铵氯化物,甲基溴戊二腈,苯甲酸镁,丙酸镁,水杨酸镁,MDM乙内酰脲,苯甲酸MEA盐,邻苯基苯酚MEA盐,水杨酸MEA盐,甲基氯噻唑啉酮(methylchloristhiazolinone),苯甲酸钠NF FCC,辛酸钠,脱氢乙酸钠,脱氢乙酸钠FCC,羟基甲基甘氨酸钠,对羟基苯甲酸甲酯钠,对羟基苯甲酸丙酯钠,碘酸钠,印度楝树籽油,乳链球菌素,苯甲酸钠,对羟基苯甲酸丁酯钠,对氯间甲酚钠,对羟基苯甲酸乙酯钠,甲酸钠,羟基甲烷磺酸钠,对羟基苯甲酸异丁酯钠,对羟基苯甲酸钠,苯酚磺酸钠,苯酚钠,邻苯基苯酚钠,丙酸钠,对羟基苯甲酸丙酯钠,吡啶硫酮钠,水杨酸钠,山梨酸钠,邻苯基苯酚,苯氧乙醇,对羟基苯甲酸丙酯,聚甲氧基-双环噁唑烷,海岸松树皮提取物,泊洛沙姆188,PVP碘,对羟基苯甲酸酯,吡罗克酮乙醇胺盐(pircotone olamines),苯乙醇,聚氨基丙基双胍,聚季铵盐-42(polyquarternium-42),PEG-5DEDM乙内酰脲,PEG-15DEDM乙内酰脲,PEG-5乙内酰脲油酸酯,PEG-15DEDM乙内酰脲硬脂酸酯,苯乙醇,苯酚,对羟基苯甲酸苯氧乙酯,苯氧基异丙醇,苯甲酸苯酯,苯基乙酸汞,苯基苯甲酸汞,苯基硼酸汞,苯基溴化汞,苯基氯化汞,苯基对羟基苯甲酸酯,邻苯基苯酚,聚氨丙基双胍硬脂酸酯,丙酸,苯甲酸丙酯,季铵盐-15,季铵盐-8,季铵盐-14,迷迭香叶(Rosmarinus officinalis leaf)提取物,山梨酸NF FCC,二硫化硒(selenium disulfine),山梨酸,水杨酸,硼硅酸银,磷酸银镁铝,三氯生,二-α-生育酚,生育酚乙酸酯,thimersal,三氯卡班,TEA山梨酸盐,硫柳汞,松萝酸,十一碳烯酰基PEG-5对羟基苯甲酸酯,葡萄籽提取物,茶树油,过氧化氢,吡啶硫酮锌,氧化锌,苯酚磺酸锌或其组合。
在这方面,制剂可包含WO2013/091775A2、WO2013/159865A1或WO2013/167220A1中描述的抗微生物活性化合物,特别是4-羟基-环己烷羧酸丁酯(可作为SereneShield购自Merck KGaA,Darmstadt,Germany)。
制剂可进一步包含抗痤疮活性化合物,例如,在WO2009/098139第47页第2行至第48页第27行和DE10324567中是可想到的。示例性的进一步抗痤疮活性化合物是银颗粒和银盐,例如乳酸银和柠檬酸银,壬二酸,鞣花酸,乳酸,乙醇酸,水杨酸,甘草酸,三氯生,苯氧基乙醇,己脒定羟乙基磺酸盐,酮康唑,过氧化物例如过氧化氢或过氧化苯甲酰,3-羟基苯甲酸,4-羟基苯甲酸,植酸,花生四烯酸,辛乙二醇,乙基己基甘油,法呢醇,十六烷基吡啶鎓盐,6-三甲基戊基-2-吡啶酮(吡罗克酮乙醇胺盐(Piroctone Olamine))和脂羟酸(lipohydroxy acid)(LHA)。
去头屑活性化合物是例如吡啶硫酮锌,吡罗克酮乙醇胺盐,二硫化硒,氯咪巴唑,三氯生,对羟基苯甲酸丁酯,1,3-双(羟甲基)-5,5-二甲基咪唑啉-2,4-二酮(DMDM乙内酰脲),富马酸,甲基氯异噻唑啉酮或甲基异噻唑啉酮(MIT)。
例如,可以提及以下作为根据本发明的制剂的使用形式:溶液,悬浮液,乳液,PIT乳液,糊剂,软膏,凝胶,乳霜,洗剂,泡沫,面膜(mask),粉末,肥皂,含有表面活性剂的清洁制剂,油,气溶胶,硬膏剂(plaster),敷布,绷带和喷雾剂,特别是用于外用。其他应用形式是例如棒、洗发剂和淋浴。此外,典型的化妆品使用形式还有唇膏、唇部护理棒、粉末、乳液和蜡化妆品,以及防晒、晒前和晒后制剂。
根据本发明的化妆品和皮肤病制剂尤其可以是无水制剂、洗剂或乳液,例如乳霜或乳,或微乳液(在每种情况下为油包水(W/O)型或水包油(O/W)型),多层乳液,例如水包油包水(W/O/W)型或反之亦然(O/W/O),凝胶或溶液(特别是油-醇,油-水或水-醇凝胶或溶液),固体棒,软膏或气溶胶。对于应用,将本发明的化妆品和皮肤病学制剂以化妆品的通常方式中的足够的量施用于皮肤。
可以向制剂中加入任何所需的常规媒介物、助剂和如果需要的其他活性化合物。优选的助剂来源于防腐剂、稳定剂、增溶剂、着色剂即颜料、染料、乳化剂或气味改进剂。
软膏、糊剂、乳霜和凝胶可包含适用于局部施用的常规媒介物,例如动物和植物脂肪、蜡、石蜡、淀粉、黄蓍胶、纤维素衍生物、聚乙二醇、硅酮、膨润土、二氧化硅、滑石和二氧化钛,或这些物质的混合物。
粉末和喷雾剂可包含常规媒介物,例如乳糖、滑石、二氧化硅、氢氧化铝、硅酸钙和聚酰胺粉末,或这些物质的混合物。喷雾剂可以另外包含常规的易挥发的液化推进剂,例如含氯氟烃、丙烷/丁烷或二甲醚。也可以有利地使用压缩的空气。然而,空气也可用于无压计量装置,例如泵式喷雾器。
溶液和乳液可包含常规媒介物,例如溶剂、增溶剂和乳化剂,例如水、乙醇、异丙醇、碳酸乙酯、乙酸乙酯、苯甲醇、苯甲酸苄酯、丙二醇、1,3-丁二醇、油特别是棉籽油、花生油、小麦胚芽油、橄榄油、蓖麻油和芝麻油、甘油脂肪酸酯、聚乙二醇和脱水山梨糖醇的脂肪酸酯,或这些物质的混合物。
优选的增溶剂通常是2-异丙基-5-甲基环己烷-羰基-D-丙氨酸甲酯。
悬浮液可包括常规媒介物,例如液体稀释剂,例如水、乙醇或丙二醇、悬浮介质例如乙氧基化异硬脂醇、聚氧乙烯山梨糖醇酯和聚氧乙烯脱水山梨糖醇酯、微晶纤维素、偏氢氧化铝、膨润土、琼脂和黄蓍胶,或这些物质的混合物。
肥皂可包含常规媒介物,例如脂肪酸的碱金属盐,脂肪酸单酯的盐,脂肪酸蛋白水解物,异硫代硫酸盐(isothionate),羊毛脂,脂肪醇,植物油,植物提取物,甘油,糖或这些物质的混合物。
含表面活性剂的清洁产品可包含常规媒介物,例如脂肪醇硫酸盐,脂肪醇醚硫酸盐,磺基琥珀酸单酯,脂肪酸蛋白水解物,异硫代硫酸盐,咪唑啉鎓衍生物,甲基牛磺酸盐,肌氨酸盐,脂肪酸酰胺醚硫酸盐,烷基酰胺基甜菜碱,脂肪醇,脂肪酸甘油酯,脂肪酸二乙醇酰胺,植物油和合成油,羊毛脂衍生物,乙氧基化甘油脂肪酸酯,或这些物质的混合物。
面部和身体油可包含常规媒介物,例如合成油,例如脂肪酸酯,脂肪醇,硅油,天然油,例如植物油和油性植物提取物,石蜡油,羊毛脂油,或这些物质的混合物。
其他合适的媒介物是脂质体,环糊精或其他糖,例如山梨糖醇。
本发明的一个优选实施方案是乳液,其为乳霜或乳的形式,并且包含例如所述脂肪,油,蜡和其他脂肪物质,以及水或水相,例如具有溶剂或亲水性表面活性剂,和乳化剂,如通常用于这种类型的制剂的。
脂质相可以有利地选自以下物质组:
-矿物油,矿物蜡;
-油,例如癸酸或辛酸的甘油三酯,以及天然的油,例如蓖麻油;
-脂肪、蜡和其它天然和合成脂肪物质,优选脂肪酸与具有低碳数的醇(例如与异丙醇、丙二醇或甘油)的酯,或脂肪醇与具有低碳数的烷酸或与脂肪酸的酯;
-硅油,例如二甲基聚硅氧烷,二乙基聚硅氧烷,二苯基聚硅氧烷,及其混合形式。
出于本发明的目的,乳液、油凝胶或水分散体(hydrodispersion)或脂分散体(lipodispersion)的油相有利地选自链长为3至30个C原子的饱和和/或不饱和的支链和/或非支链的烷烃羧酸、链长为3至30个C原子的饱和和/或不饱和的支链和/或非支链的醇的酯,选自芳族羧酸和链长为3至30个C原子的饱和和/或不饱和的支链和/或非支链的醇的酯。这种类型的酯油可以有利地选自肉豆蔻酸异丙酯,棕榈酸异丙酯,硬脂酸异丙酯,油酸异丙酯,硬脂酸正丁酯,月桂酸正己酯,油酸正癸酯,硬脂酸异辛酯,硬脂酸异壬酯,异壬酸异壬酯,棕榈酸2-乙基己酯,月桂酸2-乙基己酯,硬脂酸2-十六烷基酯,棕榈酸2-辛基十二烷基酯,油酸油醇酯,瓢儿菜醇油酸酯,瓢儿菜醇芥酸酯油酸芥基酯,芥酸芥基酯,和这类酯的合成、半合成和天然混合物,例如,霍霍巴油。
此外,油相可有利地选自支链和非支链的烃和烃蜡、硅油、二烷基醚,选自饱和或不饱和的支链或非支链的醇和脂肪酸甘油三酯,特别是链长为8-24个C原子,特别是12-18个C原子的饱和和/或不饱和的支链和/或非支链的烷烃羧酸的三甘油酯。脂肪酸甘油三酯可以有利地选自,例如,合成、半合成和天然的油,例如橄榄油,向日葵油,大豆油,花生油,菜籽油,杏仁油,棕榈油,椰子油,棕榈仁油等。
这类油和蜡组分的任何所需的混合物也可有利地用于本发明的目的。使用蜡(例如十六烷基棕榈酸酯)作为油相的唯一脂质组分也可能是有利的。
根据本发明的制剂的水相可选地有利地包含具有低碳数的醇、二醇或多元醇,及其醚,优选乙醇,异丙醇,丙二醇,甘油,乙二醇,乙二醇单乙基或单丁基醚,丙二醇单甲基、单乙基或单丁基醚,二乙二醇单甲基或单乙基醚和类似产物,以及具有低碳数的醇,例如乙醇,异丙醇,1,2-丙二醇,甘油和特别地一种或多种增稠剂,其可以有利地选自二氧化硅、硅酸铝、多糖或其衍生物,例如透明质酸、黄原胶、羟丙基甲基纤维素,特别有利地选自聚丙烯酸酯,优选来自所谓的Carbopol的聚丙烯酸酯,例如Carbopol等级980、981、1382、2984、5984,在每种情况下其是单独的或组合的。特别是,使用上述溶剂的混合物。在醇溶剂的情况下,水可以是另一种成分。
在优选的实施方案中,根据本发明的制剂包含亲水性表面活性剂。亲水性表面活性剂优选选自烷基葡糖苷,酰基乳酸酯,甜菜碱和椰子两性乙酸盐。
可以使用的乳化剂是例如已知的W/O和O/W乳化剂。在根据本发明的优选O/W乳液中使用其他常规助乳化剂是有利的。
根据本发明选择的助乳化剂是有利的,例如,O/W乳化剂,主要选自HLB值为11-16(非常特别有利地具有14.5-15.5的HLB值)的物质,只要O/W乳化剂具有饱和基团R和R'。如果O/W乳化剂具有不饱和基团R和/或R',或者如果存在异烷基衍生物,则这种乳化剂的优选HLB值也可以更低或更高。
有利的是脂肪醇乙氧基化物选自乙氧基化硬脂醇、鲸蜡醇、十六烷基硬脂醇(鲸蜡硬脂醇)。
另外有利的是从以下组中选择脂肪酸乙氧基化物:
聚乙二醇(20)硬脂酸酯,聚乙二醇(21)硬脂酸酯,聚乙二醇(22)硬脂酸酯,聚乙二醇(23)硬脂酸酯,聚乙二醇(24)硬脂酸酯,聚乙二醇(25)硬脂酸酯,聚乙烯乙二醇(12)异硬脂酸酯,聚乙二醇(13)异硬脂酸酯,聚乙二醇(14)异硬脂酸酯,聚乙二醇(15)异硬脂酸酯,聚乙二醇(16)异硬脂酸酯,聚乙二醇(17)异硬脂酸酯,聚乙二醇(18)异硬脂酸酯,聚乙二醇(19)异硬脂酸酯,聚乙二醇(20)异硬脂酸酯,聚乙二醇(21)异硬脂酸酯,聚乙二醇(22)异硬脂酸酯,聚乙二醇(23)异硬脂酸酯,聚乙二醇(24)异硬脂酸酯,聚乙二醇(25)异硬脂酸酯,聚乙二醇(12)油酸酯,聚乙二醇(13)油酸酯,聚乙二醇(14)油酸酯,聚乙二醇(15)油酸,聚乙二醇(16)油酸酯,聚乙二醇(17)油酸酯,聚乙二醇(18)油酸酯,聚乙二醇(19)油酸酯,聚乙二醇(20)油酸酯。
可有利地使用的乙氧基化烷基醚羧酸或其盐是月桂醇聚醚--11羧酸钠。可以有利地使用的烷基醚硫酸盐是月桂醇聚醚1-4硫酸钠。可有利地使用的乙氧基化胆固醇衍生物是聚乙二醇(30)胆固醇醚。聚乙二醇(25)大豆甾醇也被证明是成功的。可有利地使用的乙氧基化甘油三酯是聚乙二醇(60)月见草甘油酯。
此外,有利的是从以下选择聚乙二醇甘油脂肪酸酯:聚乙二醇(20)甘油基月桂酸酯,聚乙二醇(21)甘油基月桂酸酯,聚乙二醇(22)甘油基月桂酸酯,聚乙二醇(23)甘油基月桂酸酯,聚乙二醇(6)甘油基癸酸酯/cprinate,聚乙二醇(20)甘油基油酸酯,聚乙二醇(20)甘油基异硬脂酸酯,聚乙二醇(18)甘油基油酸酯(椰油酸酯)。
同样有利的是从聚乙二醇(20)脱水山梨糖醇单月桂酸酯、聚乙二醇(20)脱水山梨糖醇单硬脂酸酯、聚乙二醇(20)脱水山梨糖醇单异硬脂酸酯、聚乙二醇(20)脱水山梨糖醇单棕榈酸酯和聚乙二醇(20)脱水山梨糖醇单油酸酯中选择脱水山梨糖醇酯。
以下可用作任选的W/O乳化剂,但是其根据本发明可能是有利的:
具有8-30个碳原子的脂肪醇,链长为8-24,特别是12-18个碳原子的饱和和/或不饱和的支链和/或非支链的烷烃羧酸的单甘油酯,链长为8-24,特别是12-18个碳原子的饱和和/或不饱和的支链和/或非支链的烷烃羧酸的二甘油酯,链长为8-24,特别是12-18个C原子的饱和和/或不饱和的支链和/或非支链的醇的单甘油醚,链长为8-24,特别是12-18个C原子的饱和和/或不饱和的支链和/或非支链的醇的双甘油醚,链长为8-24特别是12-18个碳原子的饱和和/或未饱和的支链和/或非支链的烷烃羧酸的丙二醇酯,链长为8-24,特别是12-18个C原子的饱和和/或不饱和的支链和/或非支链的烷烃羧酸的脱水山梨糖醇酯。
特别有利的W/O乳化剂是单硬脂酸甘油酯,单异硬脂酸甘油酯,单肉豆蔻酸甘油酯,单油酸甘油酯,单硬脂酸二甘油酯,单异硬脂酸二甘油酯,单硬脂酸丙二醇酯,单异硬脂酸丙二醇酯,单辛酸丙二醇酯,单月桂酸丙二醇酯,脱水山梨糖醇单异硬脂酸酯,脱水山梨糖醇单月桂酸酯,脱水山梨糖醇单辛酸酯,脱水山梨糖醇单异油酸酯,蔗糖二硬脂酸酯,鲸蜡醇,硬脂醇,花生醇,山萮醇,异山萮醇,沙油醇,鲛肝醇,聚乙二醇(2)十八烷基醚(硬脂醇聚氧乙烯醚-2),单月桂酸甘油酯,单癸酸甘油酯,单辛酸甘油酯或PEG-30二聚羟基硬脂酸酯。
制剂可包含通常用于此类制剂的化妆品佐剂,例如增稠剂,软化剂,润肤剂,表面活性剂,乳化剂,防腐剂,消泡剂,香料,蜡,羊毛脂,推进剂,染料和/或颜料(其使组合物本身或皮肤着色),以及化妆品中通常使用的其他成分。
所用的分散剂或增溶剂可以是油、蜡或其他脂肪物质、低级一元醇或低级多元醇或其混合物。特别优选的一元醇或多元醇包括乙醇、异丙醇、丙二醇、甘油和山梨糖醇。
进一步优选的实施方案是基于天然或合成油和蜡、羊毛脂、脂肪酸酯、特别是脂肪酸的甘油三酯的油性洗剂,或基于低级醇例如乙醇或甘油,例如丙二醇和/或多元醇,例如甘油以及油、蜡和脂肪酸酯例如脂肪酸的甘油三酯的油性醇洗剂。
根据本发明的制剂还可以是醇凝胶的形式,其包含一种或多种低级醇或多元醇(例如乙醇、丙二醇或甘油)和增稠剂,例如硅质土。油性醇凝胶还含有天然或合成的油或蜡。
固体棒优选由天然或合成的蜡和油、脂肪醇、脂肪酸、脂肪酸酯、羊毛脂和其他脂肪物质组成。
如果将制剂配制成气溶胶,则优选使用常用的推进剂,例如烷烃、空气、氮气、一氧化二氮,特别优选烷烃或空气。
本发明的另一个实施方案是如上所述的制剂,其特征在于存在适用于局部应用的媒介物和任选生理学上可接受的助剂和/或填充剂。这样的媒介物、助剂和填充剂如上文所述定义。
本发明的另一个实施方案涉及制备如上所述的制剂的方法,其特征在于将至少一种相容性溶质与至少一种另外的皮肤毛孔淡化活性物质和任选与其他成分混合。
这些化合物可以以通常的方式掺入化妆品或皮肤病学制剂中。
制备方法通常包括以下步骤:(a)将至少一种相容性溶质与至少一种另外的毛孔淡化活性化合物和至少一种适合局部应用的媒介物混合,并任选地与生理学上可接受的助剂和/或或填充剂混合,和任选地(b)相容性溶质的明显准备就绪(apparent making-ready)。可以借助于本领域技术人员熟知的技术制备本发明的制剂。如上文所述,混合可导致至少一种相容性溶质在媒介物中溶解、乳化或分散。本发明的与相容性溶质和制剂有关的先前教导及其实施方案是有效的,并且如果看起来合适,可以在不限制制剂的制备的情况下应用。
不言而喻的是,明显准备就绪是针对本发明意义上的用途,即用于抵抗与年龄相关的皮肤颜色变化,用于淡化毛孔和/或减少人体皮肤中的黄色或深色皮肤毛孔的数量,用于使皮肤颜色均匀和/或减少皮肤颜色的不均匀性,用于抑制和/或减少蛋白质羰基化和/或用于抑制和/或减少角质层中羰基化蛋白质的累积。例如,明显或适当的准备就绪可以在于:a)物质或事物的特定排列,即如果这些以这样的方式进行个性化以使得针对根据本专利的用途的适用性是明显的;b)出售使用说明附件(例如包装说明书);c)配制、装配、分配和即用包装;d)治疗计划、剂量建议;e)使用特定用途的商品名称(Schulte/Kühnen,GermanPatents Act,8th Edition,§14marginal note 101)。
将如上所述的组合物施用于皮肤。
即使没有进一步的评论,也假设本领域技术人员将能够在其最广泛的范围内利用以上描述。因此,优选实施方案应仅被视为描述性公开,其绝对不以任何方式进行限制。
以上和以下提及的所有申请和出版物的完整公开内容通过引用的方式并入本申请中。
以下实施例旨在举例说明本发明。但是,它们绝不应被视为是限制性的。
实施例
实施例1:具有细胞内累积的羰基化蛋白质的细胞的发育
蛋白质羰基化由通过脂质过氧化合成的活性醛化合物引发。由于皮肤毛孔总是被皮脂浸透,因此作为皮脂成分之一的油酸被用作细胞内合成反应性醛化合物的来源,以建立具有累积的羰基化蛋白质的细胞。
方法:
细胞培养:HaCaT角质形成细胞在补充有5%胎牛血清(FBS)(Thermofisher,Waltham,CA,USA)的Dulbeco改良Eagle培养基(DMEM)(Nissui,Tokyo,Japan)中于37℃下在5%CO2和95%空气中培养。
对于此实施例,将HaCaT角质形成细胞在含有几种浓度的油酸的DMEM中培养48小时。在用冷甲醇固定5分钟后,使细胞与0.1mol/L MES-Na缓冲液(pH5.5)中的20μmol/LFTSC(Sigma-Aldrich,St.Louis,MO,USA)在室温下反应1小时。使用荧光酶标仪TECAN SPARK10M(Switzerland)在Ex/Em 492nm/516nm处测量来源于CP的荧光强度。通过测量用Hoechst 33342-(Sigma-Aldrich(St.Louis,MO,USA))染色的细胞核的荧光强度测定细胞数。细胞内CP水平计算为FTSC的荧光强度/细胞核的荧光强度。
结果:
结果如图1所示:用油酸培养的HaCaT角质形成细胞显示出更高水平的细胞内CP。
实施例2:依克多因抑制细胞内羰基化蛋白质累积的影响
分析了依克多因对羰基化蛋白质累积的影响。
为了诱导Hsp70,将HaCaT角质形成细胞与100mM依克多因(Merck KGaA,Germany)一起培养24小时。将细胞与油酸一起培养另外48小时,并测定CP水平。在该检查中,使用200μM油酸来评估依克多因对细胞中CP累积的影响。
方法:
将HaCaT角质形成细胞在含有5%FBS和100mM依克多因的DMEM中培养24小时。用含有200μM油酸的DMEM进一步培养细胞48小时。用冷甲醇固定5分钟后,将细胞与0.1mol/LMES-Na缓冲液(pH5.5)中的20μmol/L FTSC在室温下反应1小时。来源于CP的荧光强度用荧光酶标仪TECAN SPARK 10M(Switzerland)在Ex/Em 492nm/516nm下测量。通过测量用Hoechst33342染色的细胞核的荧光强度来确定细胞数量。细胞内CP水平计算为FTSC的荧光强度/细胞核的荧光强度。
结果:
用依克多因预处理的细胞显示出抑制通过油酸的CP累积(图2)。
实施例3:依克多因对UVA和蓝光诱导的羰基化蛋白质形成的保护作用
评估了依克多因对UVA和蓝光诱导的羰基化蛋白质形成的保护活性。
方法:
将HaCaT角质形成细胞在具有10%SVF的无钙DMEM(Dulbecco改良的Eagle培养基)中在37℃和补充了5%CO2的潮湿的气氛中培养24小时。
在该初始时间段后,用各个活性化合物处理细胞培养物。未处理的样品用作参考。
以下活性化合物用于上述方法:
-溶于培养基中的0.5%w/v依克多因(Merck KGaA,Germany)
-溶于培养基中的0.3%w/v依克多因(Merck KGaA,Germany)
-作为内参的2.5mM N-乙酰半胱氨酸(NAC)(Sigma-Aldrich)
在24小时的时间段之后,通过用蓝光照射(460nm)或UVA照射(365nm)处理来在样品中诱导应激。另外,未经活性化合物处理的样品未进行照射以进行比较。
蓝光照射(460nm):
-来源:LED
-辐照度:53mW/cm2
-剂量:35J/cm2-(相当于计算机屏幕在8小时/天的过程中持续3天的发射量)
-照射时间:11分钟
UVA照射(365nm):
-来源:LED
-辐照度:50mW/cm2
-剂量:33J/cm2(即强度小于在欧洲中部阳光下在中午15分钟)
-照射时间:11分钟
在应激诱导后,立即将样品在-80℃下在液氮中快速冷冻用于分析。
为每种测试条件准备三个样品。
羰基化蛋白质的原位检测:在样品解冻后,使用OxiProteomics的验证方案从细胞中提取蛋白质。使用校准的BSA作为标准,通过Bradford方法(Bradford,1976,Anal.Biochem.,72,248)溶解和定量提取的蛋白质。将样品分成3份相等的量用于分析。
羰基化蛋白质用在蛋白质组学中常规使用的特异性功能化荧光探针(使用Cy3NHS(-羟基磺基琥珀酰亚胺))标记。然后通过高分辨率电泳分离(4-20%梯度SDS-PAGE;缓冲液trys-甘氨酸(Biorad))解析蛋白质。将蛋白质固定在凝胶上。用SyproRuby TM蛋白凝胶染剂对总蛋白质进行后染色。使用 DIGE成像仪(GE Healthcare)进行羰基化和总蛋白质的图像采集。使用ImageJ分析软件(Rasband,W.S.,ImageJ,U.S.National Instituteof Health,Bethesda,Maryland,USA,http://imagej.nih.gov/ij/,1997-B014)进行蛋白质带的密度计(Densitomertric)分析。从每个样品获得羰基化和总蛋白质的定量。
结果:
结果如图3至图6所示:
图3和5显示了在使用UVA照射的样品(图3)和使用蓝光照射的样品(图5)的SDS-PAGE之后获得的图像。图3和5中的左侧凝胶显示荧光标记的羰基化蛋白质;图3和图5中的右侧凝胶显示了染色后的总蛋白质。
图4(UVA照射)和6(蓝光照射)分别显示了根据图3和5的SDS-PAGE凝胶的定量分析。
样品代码:
CTRL=未经处理、未经辐照的对照
UVA=未经处理,用UVA照射
BL/蓝光=未经处理,用蓝光照射
NAC=N-乙酰半胱氨酸处理,用UVA或蓝光照射
依克多因0.3=用0.3%w/v的依克多因处理,用UVA或蓝光照射
依克多因0.5=用0.5%w/v的依克多因处理,用UVA或蓝光照射
图3和4显示,与对照相比,浓度为0.3%的依克多因针对UVA诱导的蛋白质羰基化具有显著的保护作用。由于测量数据的统计偏差太高而无法实现可靠解释,因此未观察到对照和浓度为0.5%的依克多因之间的显著比较。
图5和6显示,浓度为0.3%和0.5%的依克多因针对蓝光诱导的蛋白质羰基化具有显著的保护作用。两种使用水平的性能是相当的。
实施例4:用于敏感和脱水皮肤的水性面膜
程序:
混合水、甘油和A相的活性成分。搅拌至均匀。在低搅拌下喷洒Covacryl MV60,然后增加搅拌并搅拌至均匀。加入B并搅拌至均匀。加入C并搅拌至均匀。必要时调节至pH6.5。
备注:
外观:白色凝胶
pH:6.5
粘度:40 000cP(Fungilab Expert,Spindle PB,5rpm)
稳定性:室温、4℃和45℃下3个月
供应商:
(1)Merck KGaA,Darmstadt,Germany/EMD Performance Materials
(2)Sensient Cosmetic Technologies
实施例5:用于敏感和干燥皮肤的舒缓面膜
/>
/>
Carbopol Ultrez 21分散在水中并搅拌至均匀。加入与甘油预混合的黄原胶,搅拌至均匀。加入活性成分,搅拌至均匀。加入Montanov并加热A至80℃。
制备B相并将B加热至80℃。乳液:在高搅拌下将B倒入A中。用C中和并均化。
在T<60℃下加入D并搅拌至均匀。在温和搅拌下缓慢冷却乳霜。在T<35℃下加入E并搅拌至均匀。
备注:
外观:浓稠的白色乳霜
pH:6.3
粘度:370 000cP(Fungilab Expert,Spindle PD,3rpm)。2周后产品达到其粘度
稳定性:室温、4℃和45℃下3个月
供应商:
(1)Merck KGaA,Darmstadt,Germany/EMD Performance Materials
(2)Gattefossé
(3)Solvay
(4)Seppic
(5)BASF AG
(6)Greentech SA
(7)Croda
实施例6:用于敏感和干燥皮肤的日霜
/>
程序:
制备A相并在搅拌下混合直至均匀。制备B并将A和B加热至80℃。将C加入B中并搅拌至均匀。将D加入B+C中并搅拌至均匀。
乳液:在搅拌下将B+C+D倒入A中。均化。在温和搅拌下缓慢冷却乳霜。
在T<30℃时,添加预混合的E并搅拌至均匀。
备注:
外观:浓稠的白色乳霜
pH:6.3
粘度:120 000cP(Fungilab Expert,Spindle PC,5rpm)
稳定性:室温、4℃和45℃下3个月
供应商:
(1)Merck KGaA,Darmstadt,Germany/EMD Performance Materials
(2)Seppic
(3)BASF AG
(4)Brenntag Chemiepartner GmbH
实施例7:用于敏感和干燥皮肤的晚霜
/>
/>
程序:
在搅拌下将A相加热至85℃。在搅拌下将B1相加热至85℃。在搅拌下将B2相加热至85℃并检查 Isoquercetin的分散。然后将B2添加到B1。搅拌至均匀。乳液:在快速混合下将B缓慢倒入A中并保持快速混合约15分钟。
在乳液步骤之后缓慢加入C并搅拌至均匀。冷却并在T<40℃下在快速混合下缓慢加入D并搅拌至均匀。
备注:
外观:黄色乳霜
粘度:85 000cP(Fungilab Expert,Spindle PC,5rpm)
稳定性:室温、4℃和45℃下3个月
供应商:
(1)Merck KGaA,Darmstadt,Germany/EMD Performance Materials
(2)Gattefossé
(3)BASF AG
(4)Stearinerie Dubois Fils
Claims (2)
1.选自(S)-1,4,5,6-四氢-2-甲基-4-嘧啶羧酸和(S,S)-1,4,5,6-四氢-5-羟基-2-甲基-4-嘧啶羧酸的至少一种相容性溶质和/或其生理学上可接受的盐和/或立体异构体用于淡化皮肤毛孔或用于减少人体皮肤中黄色或深色皮肤毛孔的数量的用途。
2.根据权利要求1的用途,其特征在于所述至少一种相容性溶质是(S)-1,4,5,6-四氢-2-甲基-4-嘧啶羧酸。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17159311.4 | 2017-03-06 | ||
EP17159311 | 2017-03-06 | ||
PCT/EP2018/055251 WO2018162368A1 (en) | 2017-03-06 | 2018-03-05 | Use of compatible solutes |
Publications (2)
Publication Number | Publication Date |
---|---|
CN110381917A CN110381917A (zh) | 2019-10-25 |
CN110381917B true CN110381917B (zh) | 2023-10-31 |
Family
ID=58231498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201880014120.3A Active CN110381917B (zh) | 2017-03-06 | 2018-03-05 | 相容性溶质的用途 |
Country Status (5)
Country | Link |
---|---|
US (1) | US20200030214A1 (zh) |
EP (1) | EP3592329A1 (zh) |
JP (1) | JP7132935B2 (zh) |
CN (1) | CN110381917B (zh) |
WO (1) | WO2018162368A1 (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3104973B1 (fr) * | 2019-12-20 | 2022-07-22 | Sederma Sa | Composition cosmétique ou dermatologique agissant notamment sur les effets de la lumière bleue sur la peau et ses phanères, et utilisations associées |
US20240216252A1 (en) * | 2021-04-16 | 2024-07-04 | Dsm Ip Assets B.V. | Retinol formulation (iii) |
CN115159671B (zh) * | 2022-06-30 | 2023-06-23 | 苏州博净源环境科技有限公司 | 一种基于高盐废水好氧处理的调渗剂及其制备方法与应用 |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000007559A1 (de) * | 1998-08-01 | 2000-02-17 | Merck Patent Gmbh | Kosmetische formulierung enthaltend ectoinderivate, enzyme, vitamine und/oder vitamin-derivate |
DE10002725A1 (de) * | 2000-01-11 | 2001-07-12 | Beiersdorf Ag | Wirkstoffe und Zubereitungen für die Hautaufhellung und zur Verhinderung der Hautbräunung (skin whitening) |
EP2246037A2 (en) * | 2009-04-27 | 2010-11-03 | Korres S.A. Natural Products | Anti-aging and whitening properties of quercetin, 18a-glycyrrhetinic acid, hederagenin and its derivatives |
JP2011148715A (ja) * | 2010-01-19 | 2011-08-04 | Maruzen Pharmaceut Co Ltd | タンパク質のカルボニル化抑制剤及び肌の透明感向上剤 |
JP2011530546A (ja) * | 2008-08-12 | 2011-12-22 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 化粧品としての5−(7−メトキシ−3,3−ジメチル−2,3−ジヒドロ−1−ベンゾオキセピン−5−イル)−3−メチル−ペンタ−2,4−ジエン酸の使用 |
WO2012014901A1 (ja) * | 2010-07-30 | 2012-02-02 | 株式会社資生堂 | カルボニル化抑制剤 |
WO2016045714A1 (de) * | 2014-09-23 | 2016-03-31 | Bitop Ag | Solut und solutgemisch sowie eine zusammensetzung enthaltend mindestens ein solut zur verwendung bei der prävention oder behandlung von durch schwebstaub verursachter kosmetischer oder pathologischer effloreszenzen |
WO2016169373A1 (zh) * | 2015-04-22 | 2016-10-27 | 捷通国际有限公司 | 包含青藤碱的局部组合物及用于抑制蛋白羰基化的方法 |
WO2016183203A1 (en) * | 2015-05-14 | 2016-11-17 | Access Business Group International Llc | Compositions including obacunone and methods of using the same in skin anti-aging applications |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2544180C2 (de) | 1975-10-03 | 1984-02-23 | Merck Patent Gmbh, 6100 Darmstadt | Lichtschutzmittel für kosmetische Zwecke |
NL190101C (nl) | 1978-11-13 | 1993-11-01 | Givaudan & Cie Sa | Dibenzoylmethaanverbinding en tegen licht beschermend preparaat. |
DE3302123A1 (de) | 1983-01-22 | 1984-07-26 | Haarmann & Reimer Gmbh | Neue dibenzol-methan-derivate, verfahren zu ihrer herstellung und ihre verwendung |
TW197375B (zh) | 1990-11-19 | 1993-01-01 | Hayashibara Biochem Lab | |
FR2680683B1 (fr) | 1991-08-29 | 1993-11-12 | Oreal | Composition cosmetique filtrante contenant un polymere filtre a structure hydrocarbonee et une silicone filtre. |
DE4244580A1 (de) | 1992-12-31 | 1994-07-07 | Galinski Erwin A | Verfahren zur in vivo Gewinnung von Inhaltsstoffen aus Zellen |
DE4342560A1 (de) | 1993-12-14 | 1995-06-22 | Marbert Gmbh | Ectoin und Ectoinderivate als Feuchtigkeitsspender in Kosmetikprodukten |
DE19933464A1 (de) | 1998-07-10 | 2000-01-13 | Beiersdorf Ag | Emulgatorfreie, disperse topische Zubereitungen |
EP1100457B1 (de) | 1998-08-01 | 2004-10-06 | MERCK PATENT GmbH | Verwendung von ectoin oder ectoin-derivaten in kosmetischen formulierungen |
DE19834816A1 (de) | 1998-08-01 | 2000-02-03 | Merck Patent Gmbh | Verwendung von Ectoin oder Ectoin-Derivaten in kosmetischen Formulierungen |
US20030157040A1 (en) * | 1998-08-01 | 2003-08-21 | Merck Patent Gmbh | Use of ectoine or ectoine derivatives in cosmetic formulations |
US20030147937A1 (en) * | 2000-04-12 | 2003-08-07 | Thomas Schwarz | Use of compatible solutes as substances having free radical scavenging properties |
DE10114189B4 (de) | 2001-03-23 | 2013-01-03 | bitop Aktiengesellschaft für biotechnische Optimierung | Verfahren zur Gewinnung von Wertstoffen aus Organismen durch Beeinflussung/Beeinträchtigung der zelleigenen Transportsysteme für diese Wertstoffe bzw. durch Verwendung von Produktionsstämmen, denen besagte Transportsysteme fehlen |
DE10214257A1 (de) * | 2002-03-28 | 2003-10-16 | Merck Patent Gmbh | Verwendung von kompatiblen Soluten zur Inhibierung der Freisetzung von Ceramiden |
US20040253332A1 (en) * | 2002-04-11 | 2004-12-16 | Chaudhuri Ratan K. | Method for regulating the appearance of skin containing combination of skin care actives |
DE10226990A1 (de) * | 2002-06-18 | 2004-03-18 | Sanguibiotech Ag | Topisch applizierbare Mikro-Emulsionen mit binärer Phasen- und Wirkstoffdifferenzierbarkeit, deren Herstellung und deren Verwendung, insbesondere zur Versorgung der Haut mit bioverfügbarem Sauerstoff |
DE10324567A1 (de) | 2003-05-30 | 2004-12-23 | Symrise Gmbh & Co. Kg | Verwendung von Diphenylmethan-Derivaten als antimikrobielle Wirkstoffe |
DE10337863A1 (de) | 2003-08-18 | 2005-03-17 | Merck Patent Gmbh | Verwendung von Chromen-4-on-Derivaten |
ES2568516T3 (es) | 2005-04-19 | 2016-04-29 | Merck Patent Gmbh | Antioxidantes |
JP3914244B2 (ja) * | 2005-10-03 | 2007-05-16 | 株式会社ファンケル | 異常タンパク質除去用組成物 |
US20080305059A1 (en) * | 2007-06-06 | 2008-12-11 | Chaudhuri Ratan K | Skin lightening compositions and methods |
FR2926980A1 (fr) | 2008-02-06 | 2009-08-07 | Oreal | Composition cosmetique contenant un derive de dibenzoylmethane et un derive ester d'aminioacide neutre n-acyle particulier ; procede de photostabilisation du derive de dibenzoylmethane |
US20120114576A1 (en) * | 2010-07-30 | 2012-05-10 | Shiseido Company, Ltd. | Method for preventing or treating yellowish discoloration of skin |
DE102011009112A1 (de) | 2011-01-21 | 2012-07-26 | Merck Patent Gmbh | Chromen-4-on-Derivate |
FR2980362B1 (fr) * | 2011-09-27 | 2013-10-04 | Sederma Sa | Nouvelle utilisation cosmetique d'un extrait d'albizia julibrissin et composition topique correspondante |
USRE46698E1 (en) | 2011-12-21 | 2018-02-06 | Merck Patent Gmbh | Use of cyclohexanol derivatives as antimicrobial active compounds |
JP2015521161A (ja) | 2012-04-25 | 2015-07-27 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | 抗微生物特性を有するジシクロヘキシルメタノール誘導体の使用 |
WO2013167220A1 (de) | 2012-05-08 | 2013-11-14 | Merck Patent Gmbh | Verwendung von cyclohexanolethers mit antimikrobiellen eigenschaften |
AU2015343218A1 (en) * | 2014-11-03 | 2017-05-25 | Stella & Dot Llc | Skincare formulations and regimens |
-
2018
- 2018-03-05 CN CN201880014120.3A patent/CN110381917B/zh active Active
- 2018-03-05 JP JP2019548605A patent/JP7132935B2/ja active Active
- 2018-03-05 WO PCT/EP2018/055251 patent/WO2018162368A1/en unknown
- 2018-03-05 US US16/491,447 patent/US20200030214A1/en not_active Abandoned
- 2018-03-05 EP EP18708416.5A patent/EP3592329A1/en active Pending
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000007559A1 (de) * | 1998-08-01 | 2000-02-17 | Merck Patent Gmbh | Kosmetische formulierung enthaltend ectoinderivate, enzyme, vitamine und/oder vitamin-derivate |
DE10002725A1 (de) * | 2000-01-11 | 2001-07-12 | Beiersdorf Ag | Wirkstoffe und Zubereitungen für die Hautaufhellung und zur Verhinderung der Hautbräunung (skin whitening) |
JP2011530546A (ja) * | 2008-08-12 | 2011-12-22 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 化粧品としての5−(7−メトキシ−3,3−ジメチル−2,3−ジヒドロ−1−ベンゾオキセピン−5−イル)−3−メチル−ペンタ−2,4−ジエン酸の使用 |
EP2246037A2 (en) * | 2009-04-27 | 2010-11-03 | Korres S.A. Natural Products | Anti-aging and whitening properties of quercetin, 18a-glycyrrhetinic acid, hederagenin and its derivatives |
JP2011148715A (ja) * | 2010-01-19 | 2011-08-04 | Maruzen Pharmaceut Co Ltd | タンパク質のカルボニル化抑制剤及び肌の透明感向上剤 |
WO2012014901A1 (ja) * | 2010-07-30 | 2012-02-02 | 株式会社資生堂 | カルボニル化抑制剤 |
WO2016045714A1 (de) * | 2014-09-23 | 2016-03-31 | Bitop Ag | Solut und solutgemisch sowie eine zusammensetzung enthaltend mindestens ein solut zur verwendung bei der prävention oder behandlung von durch schwebstaub verursachter kosmetischer oder pathologischer effloreszenzen |
WO2016169373A1 (zh) * | 2015-04-22 | 2016-10-27 | 捷通国际有限公司 | 包含青藤碱的局部组合物及用于抑制蛋白羰基化的方法 |
WO2016183203A1 (en) * | 2015-05-14 | 2016-11-17 | Access Business Group International Llc | Compositions including obacunone and methods of using the same in skin anti-aging applications |
Also Published As
Publication number | Publication date |
---|---|
EP3592329A1 (en) | 2020-01-15 |
JP7132935B2 (ja) | 2022-09-07 |
JP2020509069A (ja) | 2020-03-26 |
WO2018162368A1 (en) | 2018-09-13 |
US20200030214A1 (en) | 2020-01-30 |
CN110381917A (zh) | 2019-10-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6553845B2 (ja) | スキン/ヘアライトニング組成物 | |
JP6449589B2 (ja) | 皮膚及び/又は毛髪ライトニングの混合物 | |
KR102667506B1 (ko) | 레조르시놀 유도체를 포함하는 약제 및 화장품 조성물 | |
US20070141014A1 (en) | Formulation assistants | |
JP5965915B2 (ja) | 2−ピロン | |
CN110381917B (zh) | 相容性溶质的用途 | |
EP2568953A2 (de) | Triazine als reaktionsbeschleuniger | |
ES2548042T3 (es) | Derivados de 7-aciloxi-cromen-4-ona y su uso como sustancias para autobronceado | |
US8613910B2 (en) | Flavonoids as synergists for enhancing the action of self-tanning substances | |
CN114206300A (zh) | 预防和减少角质化障碍及相关美容剂 | |
US10722441B2 (en) | Noreugenin glycoside derivatives | |
EP2470174A1 (en) | Use of faa and its derivatives in cosmetics and dermatology | |
KR20180122444A (ko) | 약제 | |
EP1909919B1 (de) | Flavonoide als synergisten zur verstärkung der wirkung von selbstbräunungssubstanzen | |
KR102657242B1 (ko) | 스크라레올라이드 (sclareolide) 를 포함하는 화장품 조성물 | |
JP2014515380A (ja) | ユーゲニア・ユニフローラからの抽出物 | |
EP2590619A2 (de) | Bräunungsverstärker und selbstbräunungssubstanzen | |
KR20190011764A (ko) | 생강 뿌리 co2 추출물을 포함하는 약제 | |
JP2012526058A (ja) | ケイ皮酸アスコルバート | |
WO2017008877A1 (de) | Zusammensetzungen von fluortensiden und antioxidantien | |
ES2518366T3 (es) | Flavonoides como sinérgicos para intensificar el efecto de sustancias autobronceadoras | |
US20170304168A1 (en) | Phenyl ketone derivatives as self-tanning agents | |
KR20130129221A (ko) | 디히드록시푸마르산 유도체 및 피부 미백을 위한 이의 용도 | |
US20150139922A1 (en) | Extracts of darlingtonia californica | |
US20140099274A1 (en) | Extracts of darlingtonia californica |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |