JP2020508984A5 - - Google Patents
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- JP2020508984A5 JP2020508984A5 JP2019543282A JP2019543282A JP2020508984A5 JP 2020508984 A5 JP2020508984 A5 JP 2020508984A5 JP 2019543282 A JP2019543282 A JP 2019543282A JP 2019543282 A JP2019543282 A JP 2019543282A JP 2020508984 A5 JP2020508984 A5 JP 2020508984A5
- Authority
- JP
- Japan
- Prior art keywords
- collagen
- seq
- binding
- polypeptide
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000008186 Collagen Human genes 0.000 claims description 54
- 229920001436 collagen Polymers 0.000 claims description 54
- 108010035532 Collagen Proteins 0.000 claims description 53
- 229920001184 polypeptide Polymers 0.000 claims description 39
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 39
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 39
- 239000011230 binding agent Substances 0.000 claims description 31
- 239000003814 drug Substances 0.000 claims description 26
- 229940124597 therapeutic agent Drugs 0.000 claims description 22
- 102000003982 Parathyroid hormone Human genes 0.000 claims description 16
- 108090000445 Parathyroid hormone Proteins 0.000 claims description 16
- 239000000199 parathyroid hormone Substances 0.000 claims description 16
- 229960001319 parathyroid hormone Drugs 0.000 claims description 16
- 150000001413 amino acids Chemical group 0.000 claims description 12
- 239000012634 fragment Substances 0.000 claims description 9
- 102000006461 Parathyroid Hormone Receptors Human genes 0.000 claims description 8
- 108010058828 Parathyroid Hormone Receptors Proteins 0.000 claims description 8
- 239000003102 growth factor Substances 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 239000000018 receptor agonist Substances 0.000 claims description 4
- 229940044601 receptor agonist Drugs 0.000 claims description 4
- 239000002464 receptor antagonist Substances 0.000 claims description 4
- 229940044551 receptor antagonist Drugs 0.000 claims description 4
- 208000024891 symptom Diseases 0.000 claims description 4
- 208000027932 Collagen disease Diseases 0.000 claims description 3
- 201000004384 Alopecia Diseases 0.000 claims description 2
- 208000024985 Alport syndrome Diseases 0.000 claims description 2
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims description 2
- 108010049951 Bone Morphogenetic Protein 3 Proteins 0.000 claims description 2
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims description 2
- 102100024504 Bone morphogenetic protein 3 Human genes 0.000 claims description 2
- 206010007710 Cartilage injury Diseases 0.000 claims description 2
- 108060005980 Collagenase Proteins 0.000 claims description 2
- 102000029816 Collagenase Human genes 0.000 claims description 2
- 108090000695 Cytokines Proteins 0.000 claims description 2
- 102000004127 Cytokines Human genes 0.000 claims description 2
- 102100028071 Fibroblast growth factor 7 Human genes 0.000 claims description 2
- 108090000385 Fibroblast growth factor 7 Proteins 0.000 claims description 2
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims description 2
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims description 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims description 2
- 102000018997 Growth Hormone Human genes 0.000 claims description 2
- 108010051696 Growth Hormone Proteins 0.000 claims description 2
- 201000002980 Hyperparathyroidism Diseases 0.000 claims description 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims description 2
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims description 2
- 208000033463 Ischaemic neuropathy Diseases 0.000 claims description 2
- 206010031243 Osteogenesis imperfecta Diseases 0.000 claims description 2
- 208000027077 Stickler syndrome Diseases 0.000 claims description 2
- 108091005735 TGF-beta receptors Proteins 0.000 claims description 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims description 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims description 2
- 102000016715 Transforming Growth Factor beta Receptors Human genes 0.000 claims description 2
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 claims description 2
- 101800004564 Transforming growth factor alpha Proteins 0.000 claims description 2
- 102400001320 Transforming growth factor alpha Human genes 0.000 claims description 2
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 claims description 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims description 2
- 206010052428 Wound Diseases 0.000 claims description 2
- 208000027418 Wounds and injury Diseases 0.000 claims description 2
- 210000000988 bone and bone Anatomy 0.000 claims description 2
- 210000004899 c-terminal region Anatomy 0.000 claims description 2
- 150000001720 carbohydrates Chemical class 0.000 claims description 2
- 235000014633 carbohydrates Nutrition 0.000 claims description 2
- 229960002424 collagenase Drugs 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 239000000122 growth hormone Substances 0.000 claims description 2
- 230000003779 hair growth Effects 0.000 claims description 2
- 208000024963 hair loss Diseases 0.000 claims description 2
- 230000003676 hair loss Effects 0.000 claims description 2
- 208000003215 hereditary nephritis Diseases 0.000 claims description 2
- 239000005556 hormone Substances 0.000 claims description 2
- 229940088597 hormone Drugs 0.000 claims description 2
- 150000002632 lipids Chemical class 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 208000031225 myocardial ischemia Diseases 0.000 claims description 2
- 102000040430 polynucleotide Human genes 0.000 claims description 2
- 108091033319 polynucleotide Proteins 0.000 claims description 2
- 239000002157 polynucleotide Substances 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 150000003384 small molecules Chemical class 0.000 claims description 2
- 208000020431 spinal cord injury Diseases 0.000 claims description 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims description 2
- 230000008467 tissue growth Effects 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims 2
- 108010059616 Activins Proteins 0.000 claims 1
- 208000002197 Ehlers-Danlos syndrome Diseases 0.000 claims 1
- 102100026818 Inhibin beta E chain Human genes 0.000 claims 1
- 239000000488 activin Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 6
- 241000124008 Mammalia Species 0.000 description 2
- 230000008468 bone growth Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023044982A JP7682503B2 (ja) | 2017-02-10 | 2023-03-22 | コラーゲン結合薬剤組成物およびその使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762457410P | 2017-02-10 | 2017-02-10 | |
| US62/457,410 | 2017-02-10 | ||
| PCT/US2018/017665 WO2018148573A1 (en) | 2017-02-10 | 2018-02-09 | Collagen-binding agent compositions and methods of using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023044982A Division JP7682503B2 (ja) | 2017-02-10 | 2023-03-22 | コラーゲン結合薬剤組成物およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020508984A JP2020508984A (ja) | 2020-03-26 |
| JP2020508984A5 true JP2020508984A5 (OSRAM) | 2021-03-25 |
| JP7397440B2 JP7397440B2 (ja) | 2023-12-13 |
Family
ID=63107889
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019543282A Active JP7397440B2 (ja) | 2017-02-10 | 2018-02-09 | コラーゲン結合薬剤組成物およびその使用方法 |
| JP2023044982A Active JP7682503B2 (ja) | 2017-02-10 | 2023-03-22 | コラーゲン結合薬剤組成物およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023044982A Active JP7682503B2 (ja) | 2017-02-10 | 2023-03-22 | コラーゲン結合薬剤組成物およびその使用方法 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US11624060B2 (OSRAM) |
| JP (2) | JP7397440B2 (OSRAM) |
| WO (1) | WO2018148573A1 (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2816009T3 (es) * | 2011-12-14 | 2021-03-31 | Univ Arkansas | Administración de agentes terapéuticos mediante una proteína de unión a colágeno |
| JP7397440B2 (ja) * | 2017-02-10 | 2023-12-13 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー | コラーゲン結合薬剤組成物およびその使用方法 |
| US12403179B2 (en) * | 2021-02-18 | 2025-09-02 | The Board Of Trustees Of The University Of Arkansas | Release of growth factors at wound healing stages |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8516421D0 (en) | 1985-06-28 | 1985-07-31 | Biotechnology Interface Ltd | Fibronectins |
| JP2950520B2 (ja) | 1993-04-02 | 1999-09-20 | アンティキャンサー インコーポレーテド | 毛胞に有益な配合物を送達する方法 |
| DE69734157T2 (de) | 1996-07-31 | 2006-07-13 | The General Hospital Corp., Boston | Parathyroidhormon-verwandthe peptidanaloge |
| US20100267012A1 (en) | 1997-11-04 | 2010-10-21 | Bergeron Michel G | Highly conserved genes and their use to generate probes and primers for detection of microorganisms |
| US6387663B1 (en) | 1998-07-31 | 2002-05-14 | University Of Southern California | Targeting pharmaceutical agents to injured tissues |
| US7601685B2 (en) | 1998-08-27 | 2009-10-13 | Eidgenossische Technische Hochschule Zurich | Growth factor modified protein matrices for tissue engineering |
| US20020102709A1 (en) | 1999-02-19 | 2002-08-01 | Tetsuya Ishikawa | Collagen-binding physiologically active polypeptide |
| EP1151116A1 (en) | 1999-02-19 | 2001-11-07 | Terumo Kabushiki Kaisha | Collagen-binding physiologically active polypeptide |
| US6908994B1 (en) | 1999-05-10 | 2005-06-21 | The Texas A&M University System | Collagen-binding proteins from enterococcal bacteria |
| US7396664B2 (en) | 1999-06-08 | 2008-07-08 | Regeneron Pharmaceuticals, Inc. | VEGF-binding fusion proteins and nucleic acids encoding the same |
| US20050124537A1 (en) | 2000-04-27 | 2005-06-09 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| US6756480B2 (en) | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| EP1314780A4 (en) | 2000-08-15 | 2004-07-28 | Terumo Corp | Collagen-binding hybrid polypeptides |
| JP2002058485A (ja) | 2000-08-16 | 2002-02-26 | Terumo Corp | コラーゲン結合性を有する骨形成促進融合蛋白質 |
| ES2301697T3 (es) | 2001-12-18 | 2008-07-01 | Eidgenossisch Technische Hochschule Zurich | Matrices de proteina modificada con factor de crecimiento para ingenieria de tejidos. |
| JP2003284553A (ja) * | 2002-03-28 | 2003-10-07 | Seikagaku Kogyo Co Ltd | 生理活性タンパク質 |
| AU2003256839B2 (en) | 2002-07-25 | 2009-10-29 | The General Hospital Corporation | Parathyroid hormone receptor activation and hematopoietic progenitor cell expansion |
| DE60307683T2 (de) | 2003-02-13 | 2008-05-15 | Synthes Gmbh | Injizierbare mischung zum ersatz von knochengewebe in situ |
| US20040220094A1 (en) | 2003-05-01 | 2004-11-04 | Skinner Keith K. | Inverse agonist and agonist peptides that stimulate/inhibit hair growth |
| US20050119183A1 (en) | 2003-11-12 | 2005-06-02 | Nps Allelix Corp. | Method for treating bone loss using parathyroid hormone |
| EP1557176A1 (en) | 2004-01-26 | 2005-07-27 | Ferring B.V. | Treatment of bone metastases by means of PTH receptor agonists |
| WO2005078085A1 (ja) | 2004-02-16 | 2005-08-25 | Techno Network Shikoku Co., Ltd. | コラーゲン様構造を有するポリペプチド |
| PL2348114T3 (pl) | 2004-04-21 | 2019-08-30 | Alexion Pharmaceuticals, Inc. | Koniugaty do dostarczania do kości i sposób ich wykorzystania do nakierowywania białek na kość |
| WO2006073711A2 (en) | 2005-01-06 | 2006-07-13 | Kuros Biosurgery Ag | Use of a matrix comprising a contrast agent in soft tissues |
| WO2007073661A1 (fr) | 2005-12-26 | 2007-07-05 | Yantai Zhenghai Bio-Technology Co., Ltd. | Matieres de squelette de collagene activees et leurs facteurs speciaux de restauration active fusionnee |
| CN103961686A (zh) | 2006-11-16 | 2014-08-06 | 凯制药公司 | 用于治疗甲状旁腺功能亢进和高钙血症的聚阳离子钙调节肽 |
| US8617543B2 (en) | 2007-02-14 | 2013-12-31 | Yolare Pharmaceuticals, LLC | Modified mutant collagenase and its use in fat melting and in scar reduction |
| ES2583002T3 (es) | 2007-04-09 | 2016-09-16 | The Board Of Trustees Of The University Of Arkansas | Proteínas de fusión de un dominio de enlazamiento a colágeno y hormona paratiroidea |
| WO2009014854A1 (en) | 2007-07-26 | 2009-01-29 | Allergan, Inc. | Methods of activiting clostridial toxins |
| US20100159564A1 (en) | 2007-11-30 | 2010-06-24 | Dwulet Francis E | Protease resistant recombinant bacterial collagenases |
| JP2010172247A (ja) | 2009-01-29 | 2010-08-12 | Kitasato Institute | 積層型高密度培養人工組織の製造方法及び積層型高密度培養人工組織 |
| WO2011060431A2 (en) | 2009-11-16 | 2011-05-19 | University Of Maryland Baltimore | Multivalent live vector vaccine against clostridium difficile-associated disease |
| WO2011142425A1 (ja) | 2010-05-12 | 2011-11-17 | 国立大学法人香川大学 | 上皮層含有組織の再生材および再生評価方法 |
| ES2385239B1 (es) | 2010-09-30 | 2013-06-19 | Proteos Biotech S.L.U. | Uso de colagenasa g recombinante, colagenasa h recombinante y pz-peptidasa recombinante para el tratamiento de enfermedades que cursan con alteraciones del colágeno. |
| DK2687847T3 (en) | 2011-03-16 | 2019-04-15 | Univ Tohoku | PROBE TO ANALYZE BIOLOGICAL Tissue AND PROCEDURE FOR USING SAME |
| WO2012157339A1 (ja) | 2011-05-13 | 2012-11-22 | 学校法人北里研究所 | 成長因子アンカーリング型骨移植材料、成長因子アンカーリング型骨移植材料の製造方法、成長因子アンカーリング型骨移植材料製造用キット、および骨形成方法 |
| ES2816009T3 (es) * | 2011-12-14 | 2021-03-31 | Univ Arkansas | Administración de agentes terapéuticos mediante una proteína de unión a colágeno |
| EP4276180A3 (en) | 2012-01-12 | 2024-01-10 | Endo Global Ventures | Clostridium histolyticum enzyme |
| US8915726B2 (en) | 2012-02-08 | 2014-12-23 | Shining Golden Yida Welding & Cutting Machinery Manufacture Ltd. | Rotary vane air motor with improved vanes and other improvements |
| US9526765B2 (en) * | 2012-02-09 | 2016-12-27 | The Kitasato Institute | Delivery of therapeutic agents by a collagen binding protein |
| WO2014098249A1 (ja) | 2012-12-21 | 2014-06-26 | 国立大学法人名古屋大学 | 組織修復活性組成物及びその利用 |
| US9878004B2 (en) | 2013-09-25 | 2018-01-30 | Axcella Health Inc. | Compositions and formulations for treatment of gastrointestinal tract malabsorption diseases and inflammatory conditions and methods of production and use thereof |
| US9539363B2 (en) | 2014-04-24 | 2017-01-10 | Warsaw Orthopedic, Inc. | Collagen matrix |
| WO2016060252A1 (ja) | 2014-10-16 | 2016-04-21 | 学校法人北里研究所 | 神経再生用移植材料、神経再生用移植材料の製造方法、及び神経再生用移植材料製造用キット |
| EP3112474A1 (en) | 2015-06-29 | 2017-01-04 | Evonik Degussa GmbH | Method of detecting avian necrotic enteritis |
| RS64440B1 (sr) | 2016-09-29 | 2023-09-29 | Ascendis Pharma Bone Diseases As | Režim doziranja za pth jedinjenje sa kontrolisanim oslobađanjem |
| JP7397440B2 (ja) * | 2017-02-10 | 2023-12-13 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー | コラーゲン結合薬剤組成物およびその使用方法 |
| US20190248881A1 (en) | 2017-12-04 | 2019-08-15 | Precithera, Inc. | TGF-ß RECEPTOR FUSION PROTEINS AND OTHER TGF-ß ANTAGONISTS FOR REDUCING TGF-ß SIGNALING |
| US10519236B2 (en) | 2018-01-23 | 2019-12-31 | New York University | Antibodies specific to delta 1 chain of T cell receptor |
| JP2021516966A (ja) | 2018-03-09 | 2021-07-15 | ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 組織への生物学的薬物の送達 |
-
2018
- 2018-02-09 JP JP2019543282A patent/JP7397440B2/ja active Active
- 2018-02-09 US US16/485,290 patent/US11624060B2/en active Active
- 2018-02-09 WO PCT/US2018/017665 patent/WO2018148573A1/en not_active Ceased
-
2023
- 2023-03-22 JP JP2023044982A patent/JP7682503B2/ja active Active
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