JP2015513312A5 - - Google Patents

Info

Publication number

JP2015513312A5

JP2015513312A5 JP2014547503A JP2014547503A JP2015513312A5 JP 2015513312 A5 JP2015513312 A5 JP 2015513312A5 JP 2014547503 A JP2014547503 A JP 2014547503A JP 2014547503 A JP2014547503 A JP 2014547503A JP 2015513312 A5 JP2015513312 A5 JP 2015513312A5

Authority

JP

Japan

Prior art keywords

pth

binding polypeptide

seq

collagen

polypeptide segment

Prior art date

2012-12-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 38
• 229920001184 polypeptide Polymers 0.000 claims 36
• 102000004196 processed proteins & peptides Human genes 0.000 claims 36
• 102000008186 Collagen Human genes 0.000 claims 29
• 108010035532 Collagen Proteins 0.000 claims 29
• 229920001436 collagen Polymers 0.000 claims 29
• 108090000445 Parathyroid hormone Proteins 0.000 claims 22
• 239000003814 drug Substances 0.000 claims 20
• 102000006461 Parathyroid Hormone Receptors Human genes 0.000 claims 19
• 108010058828 Parathyroid Hormone Receptors Proteins 0.000 claims 19
• 230000001580 bacterial effect Effects 0.000 claims 18
• 239000000018 receptor agonist Substances 0.000 claims 16
• 229940044601 receptor agonist Drugs 0.000 claims 16
• 229940124597 therapeutic agent Drugs 0.000 claims 14
• 239000000203 mixture Substances 0.000 claims 13
• 230000003779 hair growth Effects 0.000 claims 7
• 239000012634 fragment Substances 0.000 claims 6
• 208000025645 collagenopathy Diseases 0.000 claims 5
• 239000002464 receptor antagonist Substances 0.000 claims 5
• 229940044551 receptor antagonist Drugs 0.000 claims 5
• 150000001413 amino acids Chemical class 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• 201000002980 Hyperparathyroidism Diseases 0.000 claims 3
• 201000004384 Alopecia Diseases 0.000 claims 2
• 241000193830 Bacillus <bacterium> Species 0.000 claims 2
• 241000193403 Clostridium Species 0.000 claims 2
• 102000035195 Peptidases Human genes 0.000 claims 2
• 108091005804 Peptidases Proteins 0.000 claims 2
• 241000607598 Vibrio Species 0.000 claims 2
• 239000007864 aqueous solution Substances 0.000 claims 2
• 208000022605 chemotherapy-induced alopecia Diseases 0.000 claims 2
• 108020001507 fusion proteins Proteins 0.000 claims 2
• 102000037865 fusion proteins Human genes 0.000 claims 2
• 230000001737 promoting effect Effects 0.000 claims 2
• 235000019833 protease Nutrition 0.000 claims 2
• 208000024985 Alport syndrome Diseases 0.000 claims 1
• 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims 1
• 108010049951 Bone Morphogenetic Protein 3 Proteins 0.000 claims 1
• 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 1
• 102100024504 Bone morphogenetic protein 3 Human genes 0.000 claims 1
• 206010007710 Cartilage injury Diseases 0.000 claims 1
• 102000015225 Connective Tissue Growth Factor Human genes 0.000 claims 1
• 108010039419 Connective Tissue Growth Factor Proteins 0.000 claims 1
• 102000001301 EGF receptor Human genes 0.000 claims 1
• 108060006698 EGF receptor Proteins 0.000 claims 1
• 108090001047 Fibroblast growth factor 10 Proteins 0.000 claims 1
• 102100028412 Fibroblast growth factor 10 Human genes 0.000 claims 1
• 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 1
• 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 1
• 108090000381 Fibroblast growth factor 4 Proteins 0.000 claims 1
• 102100028072 Fibroblast growth factor 4 Human genes 0.000 claims 1
• 102000016355 Granulocyte-Macrophage Colony-Stimulating Factor Receptors Human genes 0.000 claims 1
• 108010092372 Granulocyte-Macrophage Colony-Stimulating Factor Receptors Proteins 0.000 claims 1
• 102000018997 Growth Hormone Human genes 0.000 claims 1
• 108010051696 Growth Hormone Proteins 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 1
• 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 1
• 206010031243 Osteogenesis imperfecta Diseases 0.000 claims 1
• 102000003982 Parathyroid hormone Human genes 0.000 claims 1
• 102000011653 Platelet-Derived Growth Factor Receptors Human genes 0.000 claims 1
• 108010076289 Platelet-Derived Growth Factor Receptors Proteins 0.000 claims 1
• 208000027077 Stickler syndrome Diseases 0.000 claims 1
• -1 TGF-b Proteins 0.000 claims 1
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
• 231100000360 alopecia Toxicity 0.000 claims 1
• 208000004631 alopecia areata Diseases 0.000 claims 1
• 230000008468 bone growth Effects 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 230000002708 enhancing effect Effects 0.000 claims 1
• 239000000122 growth hormone Substances 0.000 claims 1
• 208000003215 hereditary nephritis Diseases 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000000199 parathyroid hormone Substances 0.000 claims 1
• 201000010065 polycystic ovary syndrome Diseases 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 208000011580 syndromic disease Diseases 0.000 claims 1
• OGBMKVWORPGQRR-UMXFMPSGSA-N teriparatide Chemical compound C([C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CNC=N1 OGBMKVWORPGQRR-UMXFMPSGSA-N 0.000 claims 1