JP2020508063A5 - - Google Patents
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- Publication number
- JP2020508063A5 JP2020508063A5 JP2019545954A JP2019545954A JP2020508063A5 JP 2020508063 A5 JP2020508063 A5 JP 2020508063A5 JP 2019545954 A JP2019545954 A JP 2019545954A JP 2019545954 A JP2019545954 A JP 2019545954A JP 2020508063 A5 JP2020508063 A5 JP 2020508063A5
- Authority
- JP
- Japan
- Prior art keywords
- chimeric protein
- cells
- csf1r
- domain
- cd40l
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020001507 fusion proteins Proteins 0.000 claims description 112
- 102000037865 fusion proteins Human genes 0.000 claims description 112
- 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 claims description 47
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 claims description 47
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 34
- 108010029697 CD40 Ligand Proteins 0.000 claims description 31
- 102100032937 CD40 ligand Human genes 0.000 claims description 31
- 206010028980 Neoplasm Diseases 0.000 claims description 31
- 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 claims description 25
- 101150013553 CD40 gene Proteins 0.000 claims description 24
- 210000004027 cell Anatomy 0.000 claims description 20
- 108091011896 CSF1 Proteins 0.000 claims description 18
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 18
- 239000003446 ligand Substances 0.000 claims description 18
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 13
- 210000002540 macrophage Anatomy 0.000 claims description 13
- 230000000694 effects Effects 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- 101710165474 Tumor necrosis factor receptor superfamily member 5 Proteins 0.000 claims description 10
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 9
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims description 9
- 230000000259 anti-tumor effect Effects 0.000 claims description 9
- 210000003289 regulatory T cell Anatomy 0.000 claims description 9
- 230000008685 targeting Effects 0.000 claims description 9
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 8
- 208000027866 inflammatory disease Diseases 0.000 claims description 8
- 230000003993 interaction Effects 0.000 claims description 8
- 230000011664 signaling Effects 0.000 claims description 8
- 210000004881 tumor cell Anatomy 0.000 claims description 8
- 230000000903 blocking effect Effects 0.000 claims description 7
- 108020003175 receptors Proteins 0.000 claims description 7
- 230000001506 immunosuppresive effect Effects 0.000 claims description 6
- 230000002401 inhibitory effect Effects 0.000 claims description 6
- 230000002829 reductive effect Effects 0.000 claims description 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
- 229940123189 CD40 agonist Drugs 0.000 claims description 4
- 102000004127 Cytokines Human genes 0.000 claims description 4
- 108090000695 Cytokines Proteins 0.000 claims description 4
- 239000005557 antagonist Substances 0.000 claims description 4
- 210000004443 dendritic cell Anatomy 0.000 claims description 4
- 210000003162 effector t lymphocyte Anatomy 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 210000000225 synapse Anatomy 0.000 claims description 4
- 230000004913 activation Effects 0.000 claims description 3
- 230000003308 immunostimulating effect Effects 0.000 claims description 3
- 230000001965 increasing effect Effects 0.000 claims description 3
- 230000001988 toxicity Effects 0.000 claims description 3
- 231100000419 toxicity Toxicity 0.000 claims description 3
- 101100099884 Homo sapiens CD40 gene Proteins 0.000 claims description 2
- 101000916628 Homo sapiens Macrophage colony-stimulating factor 1 Proteins 0.000 claims description 2
- 108090000978 Interleukin-4 Proteins 0.000 claims description 2
- 210000004322 M2 macrophage Anatomy 0.000 claims description 2
- 230000037453 T cell priming Effects 0.000 claims description 2
- 230000006052 T cell proliferation Effects 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 2
- 210000001185 bone marrow Anatomy 0.000 claims description 2
- 210000002798 bone marrow cell Anatomy 0.000 claims description 2
- 210000004899 c-terminal region Anatomy 0.000 claims description 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 2
- 230000004069 differentiation Effects 0.000 claims description 2
- 239000012636 effector Substances 0.000 claims description 2
- 210000002443 helper t lymphocyte Anatomy 0.000 claims description 2
- 102000053925 human CSF1 Human genes 0.000 claims description 2
- 230000002519 immonomodulatory effect Effects 0.000 claims description 2
- 210000002865 immune cell Anatomy 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- 210000005008 immunosuppressive cell Anatomy 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 230000006698 induction Effects 0.000 claims description 2
- 230000002757 inflammatory effect Effects 0.000 claims description 2
- 230000004941 influx Effects 0.000 claims description 2
- 230000005764 inhibitory process Effects 0.000 claims description 2
- 230000002601 intratumoral effect Effects 0.000 claims description 2
- 210000001165 lymph node Anatomy 0.000 claims description 2
- 230000000873 masking effect Effects 0.000 claims description 2
- 230000035800 maturation Effects 0.000 claims description 2
- 210000000822 natural killer cell Anatomy 0.000 claims description 2
- 210000000440 neutrophil Anatomy 0.000 claims description 2
- 210000005259 peripheral blood Anatomy 0.000 claims description 2
- 239000011886 peripheral blood Substances 0.000 claims description 2
- 230000000770 proinflammatory effect Effects 0.000 claims description 2
- 230000004044 response Effects 0.000 claims description 2
- 230000003248 secreting effect Effects 0.000 claims description 2
- 230000019491 signal transduction Effects 0.000 claims description 2
- 231100000440 toxicity profile Toxicity 0.000 claims description 2
- 230000004614 tumor growth Effects 0.000 claims description 2
- 230000005909 tumor killing Effects 0.000 claims description 2
- 230000002045 lasting effect Effects 0.000 claims 2
- 230000003796 beauty Effects 0.000 claims 1
- 230000033228 biological regulation Effects 0.000 claims 1
- 210000003690 classically activated macrophage Anatomy 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 23
- 108010058398 Macrophage Colony-Stimulating Factor Receptor Proteins 0.000 description 7
- 108010082808 4-1BB Ligand Proteins 0.000 description 2
- 108010039471 Fas Ligand Protein Proteins 0.000 description 2
- 101100369992 Homo sapiens TNFSF10 gene Proteins 0.000 description 2
- 101100207070 Homo sapiens TNFSF8 gene Proteins 0.000 description 2
- -1 LIGHT Proteins 0.000 description 2
- 101100207071 Mus musculus Tnfsf8 gene Proteins 0.000 description 2
- 101000597780 Mus musculus Tumor necrosis factor ligand superfamily member 18 Proteins 0.000 description 2
- 108010042215 OX40 Ligand Proteins 0.000 description 2
- 102000046283 TNF-Related Apoptosis-Inducing Ligand Human genes 0.000 description 2
- 108700012411 TNFSF10 Proteins 0.000 description 2
- 102100024587 Tumor necrosis factor ligand superfamily member 15 Human genes 0.000 description 2
- 108090000138 Tumor necrosis factor ligand superfamily member 15 Proteins 0.000 description 2
- 102100035283 Tumor necrosis factor ligand superfamily member 18 Human genes 0.000 description 2
- 102100026890 Tumor necrosis factor ligand superfamily member 4 Human genes 0.000 description 2
- 102100031988 Tumor necrosis factor ligand superfamily member 6 Human genes 0.000 description 2
- 102100032100 Tumor necrosis factor ligand superfamily member 8 Human genes 0.000 description 2
- 102100032101 Tumor necrosis factor ligand superfamily member 9 Human genes 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- 239000000556 agonist Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000003259 immunoinhibitory effect Effects 0.000 description 1
- 238000001565 modulated differential scanning calorimetry Methods 0.000 description 1
- 210000004985 myeloid-derived suppressor cell Anatomy 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022125121A JP2022159393A (ja) | 2017-02-27 | 2022-08-04 | Ｃｓｆ１ｒベースのキメラタンパク質 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762463997P | 2017-02-27 | 2017-02-27 | |
| US62/463,997 | 2017-02-27 | ||
| PCT/US2018/020039 WO2018157164A1 (en) | 2017-02-27 | 2018-02-27 | Csf1r-based chimeric proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022125121A Division JP2022159393A (ja) | 2017-02-27 | 2022-08-04 | Ｃｓｆ１ｒベースのキメラタンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020508063A JP2020508063A (ja) | 2020-03-19 |
| JP2020508063A5 true JP2020508063A5 (https=) | 2021-04-08 |
| JP7121029B2 JP7121029B2 (ja) | 2022-08-17 |
Family
ID=63253352
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019545954A Active JP7121029B2 (ja) | 2017-02-27 | 2018-02-27 | Ｃｓｆ１ｒベースのキメラタンパク質 |
| JP2022125121A Pending JP2022159393A (ja) | 2017-02-27 | 2022-08-04 | Ｃｓｆ１ｒベースのキメラタンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022125121A Pending JP2022159393A (ja) | 2017-02-27 | 2022-08-04 | Ｃｓｆ１ｒベースのキメラタンパク質 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US11267856B2 (https=) |
| EP (1) | EP3585409A4 (https=) |
| JP (2) | JP7121029B2 (https=) |
| KR (1) | KR20190124247A (https=) |
| CN (1) | CN110381974A (https=) |
| AU (1) | AU2018223822A1 (https=) |
| BR (1) | BR112019017713A2 (https=) |
| CA (1) | CA3054132A1 (https=) |
| IL (1) | IL268197A (https=) |
| MX (1) | MX2019010173A (https=) |
| PH (1) | PH12019501534A1 (https=) |
| SA (1) | SA519402522B1 (https=) |
| SG (1) | SG11201906464UA (https=) |
| WO (1) | WO2018157164A1 (https=) |
| ZA (1) | ZA201906235B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11267856B2 (en) | 2017-02-27 | 2022-03-08 | Shattuck Labs, Inc. | CSF1R-CD40L chimeric proteins |
| EP3930851A4 (en) * | 2019-02-28 | 2023-03-29 | Shattuck Labs, Inc. | COMBINATION THERAPIES |
| US20220259281A1 (en) * | 2019-06-21 | 2022-08-18 | Shattuck Labs, Inc. | Chimeric protein expressing t-cells |
| CN111068054B (zh) * | 2019-11-06 | 2022-02-11 | 浙江大学医学院附属第一医院 | 以csf1r作为药物靶点治疗肿瘤的药剂及其制备方法 |
| CN113966230B (zh) * | 2019-12-24 | 2022-06-07 | 宝船生物医药科技(上海)有限公司 | 抗csf1r分子及其用途 |
| KR102671409B1 (ko) * | 2021-03-02 | 2024-05-31 | 진화섭 | Cd30을 발현하는 세포에 독성을 나타내는 재조합 단백질 및 이를 유효성분으로 포함하는 암의 치료용 약학적 조성물 |
| EP4305051A4 (en) * | 2021-03-08 | 2025-06-04 | Shattuck Labs, Inc. | CHIMERIC PROTEINS USEFUL IN AUTOIMMUNITY |
| KR20230012129A (ko) * | 2021-07-14 | 2023-01-26 | 주식회사 이뮤노로지컬디자이닝랩 | Cd30에 특이적으로 결합하는 키메릭 항원 수용체 및 이의 용도 |
| WO2024123812A1 (en) | 2022-12-05 | 2024-06-13 | Shattuck Labs, Inc. | Fusion proteins for the treatment of cardiometabolic diseases |
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-
2018
- 2018-02-27 US US16/484,853 patent/US11267856B2/en active Active
- 2018-02-27 CN CN201880014002.2A patent/CN110381974A/zh active Pending
- 2018-02-27 KR KR1020197027869A patent/KR20190124247A/ko not_active Ceased
- 2018-02-27 WO PCT/US2018/020039 patent/WO2018157164A1/en not_active Ceased
- 2018-02-27 JP JP2019545954A patent/JP7121029B2/ja active Active
- 2018-02-27 EP EP18756880.3A patent/EP3585409A4/en not_active Withdrawn
- 2018-02-27 MX MX2019010173A patent/MX2019010173A/es unknown
- 2018-02-27 CA CA3054132A patent/CA3054132A1/en active Pending
- 2018-02-27 AU AU2018223822A patent/AU2018223822A1/en not_active Abandoned
- 2018-02-27 SG SG11201906464UA patent/SG11201906464UA/en unknown
- 2018-02-27 BR BR112019017713A patent/BR112019017713A2/pt not_active Application Discontinuation
- 2018-12-18 US US16/223,332 patent/US10513548B2/en active Active
-
2019
- 2019-06-28 PH PH12019501534A patent/PH12019501534A1/en unknown
- 2019-07-21 IL IL268197A patent/IL268197A/en unknown
- 2019-08-25 SA SA519402522A patent/SA519402522B1/ar unknown
- 2019-09-20 ZA ZA2019/06235A patent/ZA201906235B/en unknown
- 2019-11-06 US US16/675,475 patent/US11267857B2/en active Active
-
2022
- 2022-01-28 US US17/587,447 patent/US20220144909A1/en not_active Abandoned
- 2022-08-04 JP JP2022125121A patent/JP2022159393A/ja active Pending
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