JP2020506919A5 - - Google Patents
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- Publication number
- JP2020506919A5 JP2020506919A5 JP2019540665A JP2019540665A JP2020506919A5 JP 2020506919 A5 JP2020506919 A5 JP 2020506919A5 JP 2019540665 A JP2019540665 A JP 2019540665A JP 2019540665 A JP2019540665 A JP 2019540665A JP 2020506919 A5 JP2020506919 A5 JP 2020506919A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkylene
- alkyl
- monomer
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000178 monomer Substances 0.000 claims description 46
- 229920000642 polymer Polymers 0.000 claims description 44
- 125000002947 alkylene group Chemical group 0.000 claims description 38
- 125000000217 alkyl group Chemical group 0.000 claims description 32
- 239000002775 capsule Substances 0.000 claims description 20
- 125000001424 substituent group Chemical group 0.000 claims description 16
- 125000003545 alkoxy group Chemical group 0.000 claims description 15
- 239000003814 drug Substances 0.000 claims description 15
- 238000002360 preparation method Methods 0.000 claims description 15
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 14
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 14
- 229910052736 halogen Inorganic materials 0.000 claims description 14
- 150000002367 halogens Chemical class 0.000 claims description 14
- 229940124597 therapeutic agent Drugs 0.000 claims description 14
- 239000000017 hydrogel Substances 0.000 claims description 13
- 125000000732 arylene group Chemical group 0.000 claims description 12
- 125000005549 heteroarylene group Chemical group 0.000 claims description 12
- 229910052799 carbon Inorganic materials 0.000 claims description 10
- 229910052760 oxygen Inorganic materials 0.000 claims description 10
- 125000002993 cycloalkylene group Chemical group 0.000 claims description 8
- 150000002402 hexoses Chemical class 0.000 claims description 8
- 150000002772 monosaccharides Chemical class 0.000 claims description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims description 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 7
- 150000001720 carbohydrates Chemical class 0.000 claims description 6
- 206010012601 diabetes mellitus Diseases 0.000 claims description 5
- IAJILQKETJEXLJ-KLVWXMOXSA-N (2s,3r,4r,5r)-2,3,4,5-tetrahydroxy-6-oxohexanoic acid Chemical compound O=C[C@H](O)[C@H](O)[C@@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-KLVWXMOXSA-N 0.000 claims description 4
- ZAQJHHRNXZUBTE-UHFFFAOYSA-N 1,3,4,5-tetrahydroxypentan-2-one Chemical compound OCC(O)C(O)C(=O)CO ZAQJHHRNXZUBTE-UHFFFAOYSA-N 0.000 claims description 4
- VQUZNVATTCZTQO-UHFFFAOYSA-N 2,3,4-trihydroxy-5-oxopentanoic acid Chemical compound O=CC(O)C(O)C(O)C(O)=O VQUZNVATTCZTQO-UHFFFAOYSA-N 0.000 claims description 4
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
- 150000001336 alkenes Chemical class 0.000 claims description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
- 150000002016 disaccharides Chemical class 0.000 claims description 4
- 125000001072 heteroaryl group Chemical group 0.000 claims description 4
- 125000005842 heteroatom Chemical group 0.000 claims description 4
- 125000000623 heterocyclic group Chemical group 0.000 claims description 4
- 125000005647 linker group Chemical group 0.000 claims description 4
- 229920001542 oligosaccharide Polymers 0.000 claims description 4
- 150000002482 oligosaccharides Chemical class 0.000 claims description 4
- 239000001301 oxygen Substances 0.000 claims description 4
- 150000002972 pentoses Chemical class 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 239000011593 sulfur Chemical group 0.000 claims description 4
- 125000006649 (C2-C20) alkynyl group Chemical group 0.000 claims description 3
- 102000004127 Cytokines Human genes 0.000 claims description 3
- 108090000695 Cytokines Proteins 0.000 claims description 3
- 239000002870 angiogenesis inducing agent Substances 0.000 claims description 3
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 3
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 3
- 239000012634 fragment Substances 0.000 claims description 3
- 239000003102 growth factor Substances 0.000 claims description 3
- 239000005556 hormone Substances 0.000 claims description 3
- 229940088597 hormone Drugs 0.000 claims description 3
- 102000039446 nucleic acids Human genes 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims description 3
- 150000007523 nucleic acids Chemical class 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 150000003384 small molecules Chemical class 0.000 claims description 3
- 230000001225 therapeutic effect Effects 0.000 claims description 3
- 125000003358 C2-C20 alkenyl group Chemical group 0.000 claims description 2
- 239000004971 Cross linker Substances 0.000 claims description 2
- 125000004450 alkenylene group Chemical group 0.000 claims description 2
- 125000005724 cycloalkenylene group Chemical group 0.000 claims description 2
- SWXVUIWOUIDPGS-UHFFFAOYSA-N diacetone alcohol Chemical compound CC(=O)CC(C)(C)O SWXVUIWOUIDPGS-UHFFFAOYSA-N 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 150000004043 trisaccharides Chemical class 0.000 claims description 2
- -1 C 3-12 cycloalkynyl Chemical group 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 6
- 0 CC(*)C(C)CCC(C)(C)NC(C(*=C)=C)=O Chemical compound CC(*)C(C)CCC(C)(C)NC(C(*=C)=C)=O 0.000 description 5
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 4
- 229920000615 alginic acid Polymers 0.000 description 4
- 235000010443 alginic acid Nutrition 0.000 description 4
- 229940072056 alginate Drugs 0.000 description 3
- 238000005538 encapsulation Methods 0.000 description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 2
- 206010016654 Fibrosis Diseases 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000000304 alkynyl group Chemical group 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762451629P | 2017-01-27 | 2017-01-27 | |
| US62/451,629 | 2017-01-27 | ||
| PCT/US2018/015613 WO2018140834A1 (en) | 2017-01-27 | 2018-01-27 | Zwitterionically modified polymers and hydrogels |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020506919A JP2020506919A (ja) | 2020-03-05 |
| JP2020506919A5 true JP2020506919A5 (https=) | 2021-03-11 |
| JP7198210B2 JP7198210B2 (ja) | 2022-12-28 |
Family
ID=62978825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019540665A Active JP7198210B2 (ja) | 2017-01-27 | 2018-01-27 | 両性イオン性改変ポリマーおよびヒドロゲル |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11634512B2 (https=) |
| EP (1) | EP3573624B1 (https=) |
| JP (1) | JP7198210B2 (https=) |
| KR (1) | KR102618302B1 (https=) |
| CN (2) | CN110381956B (https=) |
| AU (1) | AU2018212895B2 (https=) |
| BR (1) | BR112019015141A2 (https=) |
| CA (1) | CA3051142A1 (https=) |
| IL (1) | IL267991A (https=) |
| MX (1) | MX2019008388A (https=) |
| RU (1) | RU2019126801A (https=) |
| SG (1) | SG11201906804UA (https=) |
| WO (1) | WO2018140834A1 (https=) |
| ZA (1) | ZA201904624B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112019015141A2 (pt) | 2017-01-27 | 2020-03-24 | Cornell University | Polímeros e hidrogéis modificados com zwitteríon |
| US20220127421A1 (en) * | 2019-03-05 | 2022-04-28 | University Of Florida Research Foundation, Inc. | Polyurethane copolymers and blends, methods of manufacture thereof and articles containing the same |
| US12559867B2 (en) | 2019-04-30 | 2026-02-24 | Cornell University | Fibers of polymers that have a backbone including a positively charged component of a zwitterionic moiety, and their use in implantable therapeutic delivery systems |
| US20230173141A1 (en) * | 2020-04-02 | 2023-06-08 | Cornell University | Nanofiber-enabled encapsulation devices and uses thereof |
| JP2023527796A (ja) * | 2020-05-28 | 2023-06-30 | マックマスター、ユニバーシティー | インサイチュゲル化両性イオン性ヒドロゲル組成物、及びその使用方法 |
| KR102413336B1 (ko) * | 2020-07-10 | 2022-06-27 | 부경대학교 산학협력단 | 다공성 알지네이트 기반 하이드로겔, 이의 제조방법 및 이를 이용한 약물 전달체 |
| CN113563267B (zh) * | 2021-07-08 | 2023-05-30 | 深圳华源再生医学有限公司 | 一种磺酸甜菜碱的制备方法及应用 |
| CN113667141B (zh) * | 2021-07-09 | 2023-10-03 | 深圳华源再生医学有限公司 | 抗蛋白粘附的海藻酸盐水凝胶及其制备方法和应用 |
| WO2023023116A1 (en) * | 2021-08-18 | 2023-02-23 | Cornell University | Broad spectrum anti-microbial polymeric composition |
| JP7694952B2 (ja) * | 2021-11-17 | 2025-06-18 | 国立大学法人 奈良先端科学技術大学院大学 | ポリブチレンサクシネート系共重合体 |
| CN114702606A (zh) * | 2022-02-18 | 2022-07-05 | 深圳华源再生医学有限公司 | 一种两性离子修饰的多糖类聚合物及其制备方法与应用 |
| WO2023230524A1 (en) | 2022-05-25 | 2023-11-30 | Flagship Pioneering Innovations Vi, Llc | Compositions of secretory and/or catalytic cells and methods using the same |
| US20250213470A1 (en) | 2022-06-03 | 2025-07-03 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods |
| WO2026026907A1 (zh) * | 2024-07-31 | 2026-02-05 | 北京拓界生物医药科技有限公司 | 一种修饰的聚合物及其用途 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2744130A (en) | 1952-04-11 | 1956-05-01 | Du Pont | Quaternary ammonium monomers and polymers thereof |
| US4868121A (en) | 1985-02-07 | 1989-09-19 | Mcdonnell Douglas Corporation | Islet isolation process |
| US5821121A (en) | 1991-06-24 | 1998-10-13 | Pacific Biomedical Research, Inc. | Hormone-secreting cells maintained in long-term culture |
| JPH05148288A (ja) | 1991-11-29 | 1993-06-15 | Kao Corp | 新規ベタイン化糖化合物 |
| US5273904A (en) | 1992-03-18 | 1993-12-28 | Cobe Laboratories, Inc. | Apparatus for purifying islets of Langerhans |
| CA2266581C (en) | 1996-09-19 | 2007-03-13 | The Regents Of The University Of Michigan | Polymers containing polysaccharides such as alginates or modified alginates |
| CA2297025A1 (en) * | 1997-07-25 | 1999-02-04 | Sdg, Inc. | Polymer based pharmaceutical compositions for targeted delivery of biologically active agents |
| GB0119665D0 (en) * | 2001-08-10 | 2001-10-03 | Isis Innovation | Conjugates |
| AU2003210959A1 (en) | 2002-02-12 | 2003-09-04 | Cornell Research Foundation, Inc. | Identification and high-yield isolation of human pancreatic islet progenitor and stem cells |
| JP2009514807A (ja) | 2005-10-17 | 2009-04-09 | イサグロ リチェルカ ソシエタ ア レスポンサビリタ リミタータ | 植物病原体の制御のための化合物および関連する使用 |
| WO2011057219A2 (en) | 2009-11-06 | 2011-05-12 | University Of Washington Through Its Center For Commercialization | Crosslinked zwitterionic hydrogels |
| WO2011160066A1 (en) | 2010-06-17 | 2011-12-22 | Regents Of The University Of Minnesota | Production of insulin producing cells |
| JP5690671B2 (ja) | 2010-06-30 | 2015-03-25 | 富士フイルム株式会社 | 新規な重合性組成物及びそれに用いる重合性化合物、並びに新規な重合性組成物を用いた画像形成材料及び平版印刷版原版 |
| WO2012167223A1 (en) | 2011-06-02 | 2012-12-06 | Massachusetts Institute Of Technology | Modified alginates for cell encapsulation and cell therapy |
| CZ303879B6 (cs) | 2012-02-28 | 2013-06-05 | Contipro Biotech S.R.O. | Deriváty na bázi kyseliny hyaluronové schopné tvorit hydrogely, zpusob jejich prípravy, hydrogely na bázi techto derivátu, zpusob jejich prípravy a pouzití |
| WO2014194268A1 (en) | 2013-05-30 | 2014-12-04 | The University Of Akron | Switchable antimicrobial and antifouling carboxybetaine-based hydrogels |
| US20160251470A1 (en) | 2013-10-14 | 2016-09-01 | The University Of Akron | Zwitterionic polysaccharide polymers having antifouling, antimicrobial and optical transparency properties |
| CA2934700A1 (en) * | 2014-01-06 | 2015-07-09 | Rhizen Pharmaceuticals Sa | Glutaminase inhibitors |
| JP6723169B2 (ja) | 2014-08-01 | 2020-07-15 | マサチューセッツ インスティテュート オブ テクノロジー | 抗線維化材料のための修飾されたアルギネートおよび用途 |
| EP3261626A4 (en) * | 2015-02-27 | 2018-10-03 | Wayne State University | Methods and compositions relating to biocompatible implants |
| NZ742800A (en) | 2015-11-01 | 2019-03-29 | Massachusetts Inst Technology | Modified alginates for anti-fibrotic materials and applications |
| CN109563199A (zh) | 2016-06-13 | 2019-04-02 | 麻省理工学院 | 用于减少异物反应和纤维化的生物相容性两性离子聚合物涂层和水凝胶 |
| WO2017218207A1 (en) | 2016-06-16 | 2017-12-21 | Pioneer Hi-Bred International, Inc. | Compositions and methods to control insect pests |
| BR112019015141A2 (pt) | 2017-01-27 | 2020-03-24 | Cornell University | Polímeros e hidrogéis modificados com zwitteríon |
-
2018
- 2018-01-27 BR BR112019015141-9A patent/BR112019015141A2/pt not_active IP Right Cessation
- 2018-01-27 AU AU2018212895A patent/AU2018212895B2/en active Active
- 2018-01-27 CN CN201880017027.8A patent/CN110381956B/zh active Active
- 2018-01-27 KR KR1020197023740A patent/KR102618302B1/ko active Active
- 2018-01-27 CN CN202410053011.XA patent/CN118108677A/zh active Pending
- 2018-01-27 MX MX2019008388A patent/MX2019008388A/es unknown
- 2018-01-27 WO PCT/US2018/015613 patent/WO2018140834A1/en not_active Ceased
- 2018-01-27 CA CA3051142A patent/CA3051142A1/en active Pending
- 2018-01-27 RU RU2019126801A patent/RU2019126801A/ru unknown
- 2018-01-27 EP EP18744703.2A patent/EP3573624B1/en active Active
- 2018-01-27 JP JP2019540665A patent/JP7198210B2/ja active Active
- 2018-01-27 US US16/480,996 patent/US11634512B2/en active Active
- 2018-01-27 SG SG11201906804UA patent/SG11201906804UA/en unknown
-
2019
- 2019-07-11 IL IL267991A patent/IL267991A/en unknown
- 2019-07-15 ZA ZA2019/04624A patent/ZA201904624B/en unknown
-
2023
- 2023-03-16 US US18/122,416 patent/US12378329B2/en active Active
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