JP2020506878A5 - - Google Patents

Info

Publication number
JP2020506878A5
JP2020506878A5 JP2019530506A JP2019530506A JP2020506878A5 JP 2020506878 A5 JP2020506878 A5 JP 2020506878A5 JP 2019530506 A JP2019530506 A JP 2019530506A JP 2019530506 A JP2019530506 A JP 2019530506A JP 2020506878 A5 JP2020506878 A5 JP 2020506878A5
Authority
JP
Japan
Prior art keywords
alkyl
ring
trek
haloalkoxy
haloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019530506A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020506878A (ja
JP7120549B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/JP2017/044975 external-priority patent/WO2018110669A1/en
Publication of JP2020506878A publication Critical patent/JP2020506878A/ja
Publication of JP2020506878A5 publication Critical patent/JP2020506878A5/ja
Application granted granted Critical
Publication of JP7120549B2 publication Critical patent/JP7120549B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019530506A 2016-12-15 2017-12-14 Trek(twik関連kチャネル)チャネルのアクチベータ Active JP7120549B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662434524P 2016-12-15 2016-12-15
US62/434,524 2016-12-15
PCT/JP2017/044975 WO2018110669A1 (en) 2016-12-15 2017-12-14 Activator of trek (twik related k+ channels) channels

Publications (3)

Publication Number Publication Date
JP2020506878A JP2020506878A (ja) 2020-03-05
JP2020506878A5 true JP2020506878A5 (enExample) 2022-03-28
JP7120549B2 JP7120549B2 (ja) 2022-08-17

Family

ID=62558996

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019530506A Active JP7120549B2 (ja) 2016-12-15 2017-12-14 Trek(twik関連kチャネル)チャネルのアクチベータ

Country Status (4)

Country Link
US (2) US11046683B2 (enExample)
EP (1) EP3558992A4 (enExample)
JP (1) JP7120549B2 (enExample)
WO (1) WO2018110669A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX388871B (es) 2014-06-27 2025-03-20 Nogra Pharma Ltd Moduladores del receptor arilo y metodos para elaborar y usar los mismos.
WO2018232264A1 (en) * 2017-06-15 2018-12-20 The Board Of Regents Of The University Of Oklahoma Benzamide derivatives for inhibiting endoplasmic reticulum (er) stress
WO2021080013A1 (en) * 2019-10-24 2021-04-29 Ono Pharmaceutical Co., Ltd. Inhibitors of trek (twik related k+ channels) channel function
CN114031601B (zh) * 2022-01-12 2022-03-18 南京桦冠生物技术有限公司 一种盐酸兰地洛尔的制备方法
EP4482486A4 (en) * 2022-02-23 2026-04-15 Biohaven Therapeutics Ltd PYRAZOLYL COMPOUNDS USED AS KV7 CHANNEL ACTIVATORS
WO2023164538A1 (en) * 2022-02-23 2023-08-31 Biohaven Therapeutics Ltd. Pyrazolyl compounds as kv7 channel activators
JP2025507542A (ja) * 2022-02-23 2025-03-21 バイオヘイブン・セラピューティクス・リミテッド Kv7チャネル活性化剤としてのピラゾリル化合物
CN114805233A (zh) * 2022-03-30 2022-07-29 华南理工大学 苯基四氮唑类xor抑制剂及其制备方法与应用

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5783593A (en) * 1993-11-04 1998-07-21 Abbott Laboratories Inhibitors of squalene synthetase and protein farnesyltransferase
WO1999065897A1 (en) * 1998-06-19 1999-12-23 Chiron Corporation Inhibitors of glycogen synthase kinase 3
DE60023492T2 (de) 1999-05-17 2006-07-20 Novo Nordisk A/S Glucagon antagonisten/inverse agonisten
DE19929787A1 (de) * 1999-06-29 2001-01-04 Bayer Ag Neue 4-(2-Oxodihydrooxadiazinylphenyl)amide und ihre Verwendung
DE10060807A1 (de) * 2000-12-07 2002-06-20 Aventis Pharma Gmbh Ortho, ortho-substituierte stickstoffhaltige Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
WO2002100833A1 (en) 2001-06-12 2002-12-19 Sumitomo Pharmaceuticals Company, Limited Rho KINASE INHIBITORS
CA2460541A1 (en) * 2001-09-14 2003-04-03 Helle Birk Olsen Novel ligands for the hisb10 zn2+ sites of the r-state insulin hexamer
GB0124936D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
US7119120B2 (en) 2001-12-26 2006-10-10 Genzyme Corporation Phosphate transport inhibitors
DK1603570T5 (da) * 2003-02-26 2013-12-09 Sugen Inc Aminoheteroarylforbindelser som proteinkinaseinhibitorer
BRPI0408365B8 (pt) 2003-03-14 2021-05-25 Avidex Ltd compostos heterocíclicos de imunomodulação
WO2005000821A1 (en) * 2003-06-12 2005-01-06 Eli Lilly And Company Tachykinin receptor antagonists
JP5017103B2 (ja) 2004-06-17 2012-09-05 トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド 薬剤共結晶組成物および関連した使用方法
KR20070094754A (ko) 2004-12-01 2007-09-21 데브젠 엔브이 이온 채널, 특히 Kv 패밀리로부터의 이온 채널과상호작용하는 5-카복사미도 치환된 티아졸 유도체
EP1838690A2 (en) * 2004-12-21 2007-10-03 Devgen N.V. Compounds with kv4 ion channel activity
AU2006306542B2 (en) * 2005-10-21 2012-04-19 Merck Sharp & Dohme Corp. Potassium channel inhibitors
DE102006005861A1 (de) 2006-02-09 2007-08-23 Aicuris Gmbh & Co. Kg Substituierte Chinolone III
CA2637620A1 (en) * 2006-02-16 2007-08-30 Boehringer Ingelheim International Gmbh Substituted pyridineamide compounds useful as soluble epoxide hydrolase inhibitors
US7601716B2 (en) * 2006-05-01 2009-10-13 Cephalon, Inc. Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors
JP2009536657A (ja) * 2006-05-10 2009-10-15 レノビス, インコーポレイテッド イオンチャンネルリガンドとしてのアミド誘導体およびそれを用いる医薬組成物および方法
WO2007138112A2 (en) * 2006-06-01 2007-12-06 Devgen N.V. Compounds that interact with ion channels, in particular with ion channels from the kv family
WO2007138110A2 (en) * 2006-06-01 2007-12-06 Devgen N.V. Compounds that interact with ion channels, in particular with ion channels from the kv family
ATE520651T1 (de) * 2006-10-23 2011-09-15 Pfizer Substituierte phenylmethylbicyclocarbonsäureamidverbindungen
US7956216B2 (en) * 2006-12-21 2011-06-07 The Walter And Eliza Hall Institute Of Medical Research Alpha-helical mimetics
EP1995241B1 (en) * 2007-03-23 2010-03-17 ICAgen, Inc. Inhibitors of ion channels
WO2009017838A2 (en) 2007-08-01 2009-02-05 Exelixis, Inc. Combinations of jak-2 inhibitors and other agents
EP2020413A1 (de) 2007-08-02 2009-02-04 Bayer CropScience AG Oxaspirocyclische-spiro-substituierte Tetram- und Tetronsäure-Derivate
ES2400604T3 (es) 2007-08-17 2013-04-11 Icagen, Inc. Heterociclos como moduladores del canal de potasio
DE102007044277A1 (de) 2007-09-17 2009-03-19 Grünenthal GmbH Substituierte Nicotinamid-Verbindungen und deren Verwendung in Arzneimitteln
WO2009064449A1 (en) 2007-11-13 2009-05-22 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
WO2009117421A2 (en) * 2008-03-17 2009-09-24 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
TW201004939A (en) * 2008-04-17 2010-02-01 Glaxo Group Ltd Novel compounds
TW201000447A (en) * 2008-05-30 2010-01-01 Astrazeneca Ab New compounds useful in pain therapy
TW201000446A (en) * 2008-05-30 2010-01-01 Astrazeneca Ab New compounds useful in pain therapy
PE20100083A1 (es) * 2008-06-05 2010-02-17 Janssen Pharmaceutica Nv Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar
CA2751534A1 (en) * 2009-03-03 2010-09-10 Pfizer Inc. Novel phenyl imidazoles and phenyl triazoles as gamma-secretase modulators
TWI475020B (zh) 2009-03-12 2015-03-01 The substituted nicotine amide as a KCNQ2 / 3 modifier
TWI461197B (zh) * 2009-03-12 2014-11-21 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier
WO2011021645A1 (ja) * 2009-08-19 2011-02-24 大日本住友製薬株式会社 2環性ウレア誘導体、またはその薬学的に許容される塩
JP2013028538A (ja) * 2009-11-13 2013-02-07 Dainippon Sumitomo Pharma Co Ltd 新規アミド誘導体
CN103249721B (zh) * 2010-10-18 2016-10-12 拉夸里亚创药株式会社 作为ttx-s阻滞剂的芳胺衍生物
DE102011101446A1 (de) * 2011-05-10 2012-11-15 Aicuris Gmbh & Co. Kg Herstellung von "Dense Bodies" (DB)
JP6007417B2 (ja) * 2011-05-31 2016-10-12 レセプトス エルエルシー 新規glp−1受容体安定剤および調節剤
KR101476379B1 (ko) 2011-11-30 2014-12-29 한국과학기술연구원 페녹시프로판올 유도체 및 이를 함유하는 약학적 조성물
CA2860022A1 (fr) 2011-12-30 2013-07-04 Universite D'auvergne Clermont I Composes anti-douleur
WO2013156155A1 (en) 2012-04-18 2013-10-24 Grünenthal GmbH Substituted 4-aminobenzamides as kcnq2/3 modulators
AR094929A1 (es) * 2013-02-28 2015-09-09 Bristol Myers Squibb Co Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
JPWO2015012328A1 (ja) 2013-07-24 2017-03-02 武田薬品工業株式会社 複素環化合物
JP2017114765A (ja) 2014-04-25 2017-06-29 大正製薬株式会社 トリアゾリルで置換されたヘテロアリール化合物
CN106414429B (zh) 2014-06-03 2020-01-03 爱杜西亚药品有限公司 吡唑化合物及其作为t型钙通道阻断剂的用途
AU2015283850B2 (en) * 2014-07-03 2020-06-04 Board Of Regents, University Of Texas System GLS1 inhibitors for treating disease

Similar Documents

Publication Publication Date Title
JP2020506878A5 (enExample)
TWI730986B (zh) 抗真菌化合物方法
JP2010522709A5 (enExample)
JP2005536475A5 (enExample)
JP2009523760A5 (enExample)
JP2009542595A5 (enExample)
EA016687B8 (ru) Производные циклопропиламида
JP2015528471A5 (enExample)
JP2014502641A5 (enExample)
JP2017505790A (ja) mIDH1阻害剤としてのベンズイミダゾール−2−アミン
RU2010107892A (ru) Производные феноксипирролидина, их применение и фармацевтические композиции, содержащие их
JP2018534286A5 (enExample)
RU2009103307A (ru) ПРОИЗВОДНЫЕ ИМИДАЗО[1, 2-a]ПИРИДИН-2-КАРБОКСАМИДОВ, ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ В ТЕРАПИИ
JP2005506308A5 (enExample)
JP2017511339A5 (enExample)
JP2010522711A5 (enExample)
JP2015500223A5 (enExample)
JP2018505876A5 (enExample)
JP2019534310A5 (enExample)
WO2017079753A1 (en) Lysine-specific histone demethylase as a novel therapeutic target in myeloproliferative neoplasms
JP2017502063A5 (enExample)
JP2019529460A5 (enExample)
CN110325523B (zh) 作为缓激肽b1受体拮抗剂的羧酸芳族酰胺
JP2017525717A5 (enExample)
JP2016537432A5 (enExample)