JP2020506727A5 - - Google Patents
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- JP2020506727A5 JP2020506727A5 JP2019563679A JP2019563679A JP2020506727A5 JP 2020506727 A5 JP2020506727 A5 JP 2020506727A5 JP 2019563679 A JP2019563679 A JP 2019563679A JP 2019563679 A JP2019563679 A JP 2019563679A JP 2020506727 A5 JP2020506727 A5 JP 2020506727A5
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- Prior art keywords
- cancer
- chimeric protein
- receptor
- mutations
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022165861A JP7605800B2 (ja) | 2017-02-06 | 2022-10-14 | 標的化キメラタンパク質及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762454993P | 2017-02-06 | 2017-02-06 | |
| US62/454,993 | 2017-02-06 | ||
| PCT/EP2018/052814 WO2018141964A1 (en) | 2017-02-06 | 2018-02-05 | Targeted chimeric proteins and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022165861A Division JP7605800B2 (ja) | 2017-02-06 | 2022-10-14 | 標的化キメラタンパク質及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020506727A JP2020506727A (ja) | 2020-03-05 |
| JP2020506727A5 true JP2020506727A5 (enExample) | 2021-03-18 |
| JP7476467B2 JP7476467B2 (ja) | 2024-05-01 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019563679A Active JP7476467B2 (ja) | 2017-02-06 | 2018-02-05 | 標的化キメラタンパク質及びその使用 |
| JP2022165861A Active JP7605800B2 (ja) | 2017-02-06 | 2022-10-14 | 標的化キメラタンパク質及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022165861A Active JP7605800B2 (ja) | 2017-02-06 | 2022-10-14 | 標的化キメラタンパク質及びその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11384154B2 (enExample) |
| EP (1) | EP3577133A1 (enExample) |
| JP (2) | JP7476467B2 (enExample) |
| KR (1) | KR102642385B1 (enExample) |
| CN (1) | CN110546160A (enExample) |
| AU (1) | AU2018216032B2 (enExample) |
| CA (1) | CA3052523A1 (enExample) |
| IL (1) | IL268346B2 (enExample) |
| MX (1) | MX2019009255A (enExample) |
| WO (1) | WO2018141964A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3455245A2 (en) * | 2016-05-13 | 2019-03-20 | Orionis Biosciences NV | Therapeutic targeting of non-cellular structures |
| KR102642385B1 (ko) * | 2017-02-06 | 2024-03-04 | 오리오니스 바이오사이언시스 엔브이 | 표적화된 키메라 단백질 및 이의 용도 |
| EP3665201A4 (en) | 2017-08-09 | 2021-06-02 | Orionis Biosciences, Inc. | CD8 BINDERS |
| CN117924493A (zh) | 2017-08-09 | 2024-04-26 | 奥里尼斯生物科学有限公司 | Clec9a结合剂及其用途 |
| EP3664829A4 (en) | 2017-08-09 | 2021-05-05 | Orionis Biosciences, Inc. | LIAISON OFFICERS AT PD-1 AND PD-L1 |
| US12655186B2 (en) | 2018-01-26 | 2026-06-16 | Orionis Biosciences, Inc. | Chimeric protein comprising anti-XCR1 antibody and modified interferon alpha 2 |
| CA3090406A1 (en) | 2018-02-05 | 2019-08-08 | Orionis Biosciences, Inc. | Fibroblast binding agents and use thereof |
| EP3833391A4 (en) | 2018-08-08 | 2022-08-10 | Orionis Biosciences, Inc. | ANTI-SIRP1ALPHA CHIMERIC PROTEINS AND USES THEREOF |
| AU2019353367A1 (en) * | 2018-10-02 | 2021-02-18 | Mitsubishi Tanabe Pharma Corporation | Bi-specific binding agents targeting syndecan-1 and fibroblast growth factor receptor |
| GB2593632B8 (en) * | 2018-10-29 | 2026-07-08 | Umc Utrecht Holding Bv | IGA mediated killing of aberrant cells by CD47-Sirpalpha checkpoint inhibition of neutrophils |
| EP3890773A4 (en) * | 2018-11-08 | 2022-11-09 | Orionis Biosciences, Inc. | MODULATION OF DENDRITIC CELL LINES |
| BR112021009325A2 (pt) | 2018-11-14 | 2021-09-14 | Arch Oncology, Inc. | Anticorpo monoclonal, ou fragmento de ligação ao antígeno do mesmo; anticorpo biespecífico; método para prevenir ou tratar um câncer suscetível em um ser humano; método de ensaio de expressão de sirp¿ em células tumorais e/ou imunes; e; composição farmacêutica |
| WO2020198665A1 (en) | 2019-03-28 | 2020-10-01 | Orionis Biosciences, Inc. | Fibroblast activation protein binding agents and use thereof |
| CN113840833B (zh) | 2019-03-28 | 2025-06-17 | 奥里尼斯生物科学股份有限公司 | 基于clec9a的嵌合蛋白复合物 |
| JP7689079B2 (ja) | 2019-03-28 | 2025-06-05 | オリオニス バイオサイエンシズ，インコーポレイテッド | 治療用インターフェロンアルファ１タンパク質 |
| CN114072428B (zh) * | 2019-08-30 | 2024-02-13 | 正大天晴药业集团南京顺欣制药有限公司 | 一种靶向PD-L1和TGF-β的融合蛋白及其用途 |
| EP4034146A4 (en) * | 2019-09-26 | 2024-03-06 | Orionis Biosciences, Inc. | CONJUGATED CHIMERIC PROTEINS |
| EP4061951A4 (en) * | 2019-11-18 | 2024-03-13 | The Brigham & Women's Hospital, Inc. | CODON-OPTIMIZED NEW GENERATION OF REGULAtable FUSOGENIC ONCOLYTIC VIRUSES OF HERPES SIMPLEX VIRUS TYPE 1 AND METHOD OF USE |
| CA3163358A1 (en) | 2019-12-03 | 2021-06-10 | Evotec International Gmbh | Interferon-associated antigen binding proteins and uses thereof |
| CN113354738B (zh) * | 2020-03-05 | 2022-09-09 | 绍兴德方华生物技术有限公司 | 融合毒素VEGF165b/mGEL及其编码基因与应用 |
| CN116234572A (zh) * | 2020-04-30 | 2023-06-06 | 安驰肿瘤公司 | 治疗性SIRPα抗体 |
| WO2022002153A1 (zh) * | 2020-06-30 | 2022-01-06 | 正大天晴药业集团股份有限公司 | 用于治疗肿瘤的药物 |
| CN116194466A (zh) * | 2020-08-27 | 2023-05-30 | 联邦高等教育系统匹兹堡大学 | 编码重组转化生长因子(TGF)-β单体的溶瘤病毒及其用途 |
| AU2021341508A1 (en) | 2020-09-10 | 2023-05-25 | Precirix N.V. | Antibody fragment against fap |
| WO2022120286A1 (en) * | 2020-12-06 | 2022-06-09 | ALX Oncology Inc. | Multimers for reducing the interference of drugs that bind cd47 in serological assays |
| CN114349850A (zh) * | 2020-12-18 | 2022-04-15 | 蒋庆华 | 抗体及其制备方法和编码核酸以及工程细胞 |
| WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
| AU2023264245A1 (en) | 2022-05-02 | 2024-12-19 | Precirix N.V. | Pre-targeting |
| WO2024105180A1 (en) | 2022-11-16 | 2024-05-23 | Boehringer Ingelheim International Gmbh | Predictive efficacy biomarkers for anti-sirpa antibodies |
| CN116732012A (zh) * | 2023-03-13 | 2023-09-12 | 山东舜丰生物科技有限公司 | 碱基编辑器及其应用 |
| EP4480501A1 (en) * | 2023-06-21 | 2024-12-25 | Nmi Naturwissenschaftliches Und Medizinisches Institut An Der Universität Tübingen | Sirp nanobodies |
| EP4754149A1 (en) * | 2023-07-29 | 2026-06-10 | Shanghai Kaijin Biotechnology , Ltd | Modified type e multi-specific antibodies |
| CN117430716B (zh) * | 2023-10-16 | 2024-05-31 | 珠海臻谱基因科技有限公司 | 靶向保守的HIV gp41亚基近膜端外区的重组干扰素药物及其应用 |
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2018
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- 2018-02-05 AU AU2018216032A patent/AU2018216032B2/en active Active
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- 2018-02-05 CA CA3052523A patent/CA3052523A1/en active Pending
- 2018-02-05 CN CN201880023712.1A patent/CN110546160A/zh active Pending
- 2018-02-05 JP JP2019563679A patent/JP7476467B2/ja active Active
- 2018-02-05 WO PCT/EP2018/052814 patent/WO2018141964A1/en not_active Ceased
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2022
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