JP2020506693A5 - - Google Patents

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JP2020506693A5
JP2020506693A5 JP2019540076A JP2019540076A JP2020506693A5 JP 2020506693 A5 JP2020506693 A5 JP 2020506693A5 JP 2019540076 A JP2019540076 A JP 2019540076A JP 2019540076 A JP2019540076 A JP 2019540076A JP 2020506693 A5 JP2020506693 A5 JP 2020506693A5
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Japan
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ace2
variant
amino acid
acid sequence
fusion protein
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JP2019540076A
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Japanese (ja)
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JP7332157B2 (ja
JP2020506693A (ja
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Priority claimed from PCT/US2018/014991 external-priority patent/WO2018140456A1/en
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Priority to JP2023127196A priority Critical patent/JP2023133564A/ja
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JP2019540076A 2017-01-24 2018-01-24 アンジオテンシン変換酵素2(ace2)の活性な低分子量変異体 Active JP7332157B2 (ja)

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Application Number Priority Date Filing Date Title
JP2023127196A JP2023133564A (ja) 2017-01-24 2023-08-03 アンジオテンシン変換酵素2(ace2)の活性な低分子量変異体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762449857P 2017-01-24 2017-01-24
US62/449,857 2017-01-24
PCT/US2018/014991 WO2018140456A1 (en) 2017-01-24 2018-01-24 Active low molecular weight variants of angiotensin converting enzyme 2 (ace2)

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JP2023127196A Division JP2023133564A (ja) 2017-01-24 2023-08-03 アンジオテンシン変換酵素2(ace2)の活性な低分子量変異体

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JP2020506693A JP2020506693A (ja) 2020-03-05
JP2020506693A5 true JP2020506693A5 (https=) 2021-03-11
JP7332157B2 JP7332157B2 (ja) 2023-08-23

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JP2019540076A Active JP7332157B2 (ja) 2017-01-24 2018-01-24 アンジオテンシン変換酵素2(ace2)の活性な低分子量変異体
JP2023127196A Pending JP2023133564A (ja) 2017-01-24 2023-08-03 アンジオテンシン変換酵素2(ace2)の活性な低分子量変異体

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JP2023127196A Pending JP2023133564A (ja) 2017-01-24 2023-08-03 アンジオテンシン変換酵素2(ace2)の活性な低分子量変異体

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US (4) US10443049B2 (https=)
EP (1) EP3574094A4 (https=)
JP (2) JP7332157B2 (https=)
WO (1) WO2018140456A1 (https=)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018140456A1 (en) 2017-01-24 2018-08-02 Northwestern University Active low molecular weight variants of angiotensin converting enzyme 2 (ace2)
EP3717077A1 (en) 2017-11-29 2020-10-07 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Methods for modulating pigmentation by angiotensin-converting enzyme 2 modulation
JP7340372B2 (ja) 2019-07-11 2023-09-07 浜松ホトニクス株式会社 光活性化アデニル酸シクラーゼ
US11518788B2 (en) * 2020-07-10 2022-12-06 Avirus, Inc. Methods and compositions for treating and preventing viral infection
KR20220136369A (ko) * 2020-01-23 2022-10-07 에이바이러스 인코포레이티드 바이러스 감염의 치료 및 예방을 위한 방법 및 조성물
US20210236583A1 (en) * 2020-02-03 2021-08-05 Yuntao Wu Targeting the renin-angiotensin system for treatment of environment-and pathogen-induced lung injury
EP4073243A4 (en) * 2020-02-13 2024-08-07 Sichuan Baili Pharmaceutical Co. Ltd. RECOMBINANT ECA2-FC FUSION MOLECULES, METHODS OF PREPARATION AND USE THEREOF
TWI886211B (zh) * 2020-02-13 2025-06-11 美商西雅圖免疫公司 重組ace2-fc融合分子以及製造及使用彼等之方法
WO2021164723A1 (en) * 2020-02-20 2021-08-26 Lee Sheau Long Ginsenoside m1 as a modulator of angiotensin regulating enzymes and its use for treating diseases or conditions including symptoms caused by coronavirus
CN111474363A (zh) * 2020-02-22 2020-07-31 安徽华培生物科技有限公司 一种新型冠状病毒检测方法
US12123036B2 (en) 2020-02-26 2024-10-22 Northwestern University Soluble ACE2 variants and uses therefor
CA3173064A1 (en) * 2020-02-27 2021-09-02 Huahui Health Ltd. Soluble ace2 and fusion protein, and applications thereof
WO2021170113A1 (zh) * 2020-02-29 2021-09-02 南京金斯瑞生物科技有限公司 ACE-2-Fc融合蛋白治疗冠状病毒的方法
US11857620B2 (en) 2020-03-11 2024-01-02 Immunitybio, Inc. Method of inducing immunity against SARS-CoV-2 using spike (s) and nucleocapsid (N)-ETSD immunogens delivered by a replication-defective adenovirus
US20210284716A1 (en) 2020-03-11 2021-09-16 Immunitybio, Inc. ACE2-Fc Trap
US12285480B2 (en) 2020-03-11 2025-04-29 Nantcell, Inc. Method of inducing immunity against SARS-CoV-2 using spike and nucleocapsid-ETSD immunogens delivered by RNA and replication-defective adenoviruses
CN115244077B (zh) * 2020-03-11 2025-04-29 南特细胞公司 蛋白质治疗剂
CN116057176A (zh) * 2020-03-21 2023-05-02 赖瑞克斯生物科技公司 Ace2和补体途径的双特异性和三特异性功能分子及其用途
WO2021195009A1 (en) * 2020-03-23 2021-09-30 Sapience Therapeutics, Inc. Peptide antagonists of ace2-binding proteins
CN113444710A (zh) * 2020-03-25 2021-09-28 上海英脉德医疗科技有限公司 ACE2-Fc融合蛋白及其用途
WO2021202456A1 (en) * 2020-03-30 2021-10-07 The Wistar Institute Of Anatomy And Biology Synthetic soluble receptor mimics and methods of use for treatment of covid-19
WO2021197501A1 (zh) * 2020-04-02 2021-10-07 创观(苏州)生物科技有限公司 病毒不易感动物
EP4126009A4 (en) * 2020-04-03 2024-04-17 The University of North Carolina at Chapel Hill BINDING PROTEINS FOR USE AGAINST ACE2-TARGETED VIRUSES
US20230203466A1 (en) * 2020-04-03 2023-06-29 Medgenome Inc. Ace2 receptor polymorphisms and varying susceptibility to sars-cov-2, methods for diagnosis and treatment
US20230158125A1 (en) * 2020-04-20 2023-05-25 Sorrento Therapeutics, Inc. Pulmonary Administration of ACE2 Polypeptides
WO2021237239A1 (en) * 2020-05-18 2021-11-25 Northwestern University Active low molecular weight variant of angiotensin converting enzyme 2 (ace2) for the treatment of diseases and conditions of the eye
US11773385B2 (en) * 2020-05-19 2023-10-03 Children's Medical Center Corporation High-affinity human ACE2 construct for use in diagnosing and treating coronaviruses
WO2021247675A1 (en) * 2020-06-02 2021-12-09 Ngm Biopharmaceuticals, Inc. Coronavirus-binding agents and uses thereof
DE102020207224A1 (de) 2020-06-09 2021-12-09 Christoph Karle Protein oder Peptid, insbesondere zur Prophylaxe und/oder Behandlung einer durch Coronaviren, insbesondere SARS-CoV-2-Viren, hervorgerufenen Infektion oder Infektionskrankheit und/oder einer Folgekrankheit davon
CA3179834A1 (en) * 2020-06-25 2021-12-30 David S. Block Ace2-fc fusion proteins and methods of use
WO2022008642A1 (en) 2020-07-08 2022-01-13 Apeiron Biologics Ag Treatment of sars-cov-2 infection with a combination of targets
WO2022012688A1 (en) * 2020-07-17 2022-01-20 Shenzhen Bay Laboratory Ace2-ig fusion variants
KR102492081B1 (ko) 2020-07-28 2023-01-26 재단법인대구경북과학기술원 코로나바이러스 감염증 covid-19 치료용 펩타이드 및 이의 용도
KR20230065256A (ko) * 2020-08-06 2023-05-11 비온테크 에스이 코로나바이러스 s 단백질용 결합제
US20220041660A1 (en) * 2020-08-06 2022-02-10 University Of Delaware Compositions and methods for sequestering viral particles in respiratory tract
US20230303654A1 (en) * 2020-08-11 2023-09-28 City Of Hope Compositions and uses of sars-cov-2 targeted chimeric antigen receptor modified nk cells
WO2022072757A1 (en) * 2020-10-01 2022-04-07 Systimmune, Inc. Recombinant ace2-fc fusion molecules and methods of making and using thereof
WO2022075667A1 (ko) * 2020-10-05 2022-04-14 한양대학교 산학협력단 안정화된 ace2 변이체, 이를 이용한 ace2-fc 융합단백질 및 covid-19 예방 또는 치료용 약학 조성물
EP4228697A4 (en) * 2020-10-16 2025-01-01 Invisishield Technologies Ltd. Compositions for preventing or treating viral and other microbial infections
EP4249499A4 (en) * 2020-11-20 2025-01-01 Daegu Gyeongbuk Institute Of Science and Technology Coronavirus infectious disease covid-19 therapeutic proteins ctp alpha, ctp beta, ctp gamma, ctp delta, and uses thereof
CA3200885A1 (en) 2020-11-23 2022-05-27 Genentech, Inc. Methods for modulating host cell surface interactions with sars-cov-2
WO2022119380A1 (ko) * 2020-12-03 2022-06-09 주식회사 유틸렉스 신규한 ace2 변이체 및 그의 이용
EP4011387A1 (en) * 2020-12-11 2022-06-15 IMBA-Institut für Molekulare Biotechnologie GmbH Superior neutralization of sars-cov-2 by deglycosylated human angiotensin converting enzyme 2
US20220226489A1 (en) 2021-01-20 2022-07-21 Singh Biotechnology, Llc Therapeutics directed against coronavirus
CA3206022A1 (en) * 2021-01-26 2022-08-04 Traian Sulea Ace2-receptor ectodomain fusion molecules and uses thereof
WO2022165245A1 (en) * 2021-01-29 2022-08-04 The Trustees Of The University Of Pennsylvania Compositions and method of use of mutant ace2 decoy variants
CN115667506A (zh) * 2021-02-10 2023-01-31 西雅图免疫公司 重组ace2-fc融合分子及其制备和使用方法
WO2022207918A1 (en) 2021-04-02 2022-10-06 Apeiron Biologics Ag COVID-19 Therapy
US20240360181A1 (en) * 2021-05-20 2024-10-31 Achelois Biopharma, Inc. Compositions and methods for multivalent surface display on enveloped particles
CN113324933B (zh) * 2021-06-01 2022-07-26 浙江大学 一种检测血管紧张素转换酶的方法及其应用
WO2022271863A1 (en) * 2021-06-23 2022-12-29 Chan Zuckerberg Biohub, Inc. Coronavirus neutralizing compositions and associated methods
WO2023108040A2 (en) * 2021-12-09 2023-06-15 Gliknik Inc. Ace2-fc fusion proteins and methods of use
WO2023201306A1 (en) 2022-04-14 2023-10-19 Invisishield Technologies Ltd. Compositions for preventing or treating influenza infections
CA3256035A1 (en) 2022-04-14 2023-10-19 Invisishield Technologies Ltd. COMPOSITIONS FOR PREVENTING OR TREATMENT OF CORONAVIRUS INFECTIONS
EP4335870A1 (en) 2022-09-06 2024-03-13 NantCell, Inc. Peptide therapeutics against sars-cov-2 spike protein
CN116023509A (zh) * 2022-11-18 2023-04-28 中国药科大学 一种融合蛋白及其应用
DE202023100085U1 (de) 2023-01-09 2023-02-03 Sundararajan Gothandam Eine doppelte Blockade des Renin-Angiotensin-Systems zur Verringerung der frühen Veränderungen der diabetischen Retinopathie und Nephropathie
CN118085110A (zh) * 2024-04-02 2024-05-28 中国药科大学 一种靶向肿瘤的融合蛋白及其应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540930A (en) 1983-09-12 1985-09-10 Wisconsin Alumni Research Foundation Plywheel-powered mobile X-ray apparatus
US5124154A (en) 1990-06-12 1992-06-23 Insite Vision Incorporated Aminosteroids for ophthalmic use
US6610497B1 (en) 1997-12-11 2003-08-26 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therefor
US7396664B2 (en) 1999-06-08 2008-07-08 Regeneron Pharmaceuticals, Inc. VEGF-binding fusion proteins and nucleic acids encoding the same
WO2002061131A2 (en) 2000-12-04 2002-08-08 Bristol-Myers Squibb Company Human single nucleotide polymorphisms
AT506258A1 (de) 2007-12-18 2009-07-15 Apeiron Biolog Forschungs Und Behandlung inflammatorischer krankheiten
CN104147611A (zh) * 2009-09-30 2014-11-19 葛兰素集团有限公司 具有延长的半衰期的药物融合体和缀合物
AU2013216910A1 (en) * 2012-02-10 2014-08-28 Tarix Pharmaceuticals Ltd. Compositions and methods for treatment of peripheral vascular disease
CN104470944B (zh) 2012-05-25 2021-09-14 詹森生物科技公司 非天然共有白蛋白结合结构域
AU2014204769B2 (en) 2013-01-14 2016-08-11 Apeiron Biologics Ag Modified ACE2 polypeptides
WO2015058214A1 (en) 2013-10-18 2015-04-23 Trustees Of The University Of Pennsylvania Oral delivery of angiotensin converting enzyme 2 (ace2) or angiotensin-(1-7) bioencapsulated in plant cells
WO2018140456A1 (en) 2017-01-24 2018-08-02 Northwestern University Active low molecular weight variants of angiotensin converting enzyme 2 (ace2)
US12123036B2 (en) 2020-02-26 2024-10-22 Northwestern University Soluble ACE2 variants and uses therefor
WO2021237239A1 (en) 2020-05-18 2021-11-25 Northwestern University Active low molecular weight variant of angiotensin converting enzyme 2 (ace2) for the treatment of diseases and conditions of the eye

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