JP2020506693A5 - - Google Patents

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JP2020506693A5
JP2020506693A5 JP2019540076A JP2019540076A JP2020506693A5 JP 2020506693 A5 JP2020506693 A5 JP 2020506693A5 JP 2019540076 A JP2019540076 A JP 2019540076A JP 2019540076 A JP2019540076 A JP 2019540076A JP 2020506693 A5 JP2020506693 A5 JP 2020506693A5
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Japan
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ace2
variant
amino acid
acid sequence
fusion protein
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JP2019540076A
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Japanese (ja)
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JP7332157B2 (ja
JP2020506693A (ja
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Priority claimed from PCT/US2018/014991 external-priority patent/WO2018140456A1/en
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Priority to JP2023127196A priority Critical patent/JP2023133564A/ja
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JP2019540076A 2017-01-24 2018-01-24 アンジオテンシン変換酵素2(ace2)の活性な低分子量変異体 Active JP7332157B2 (ja)

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Application Number Priority Date Filing Date Title
JP2023127196A JP2023133564A (ja) 2017-01-24 2023-08-03 アンジオテンシン変換酵素2(ace2)の活性な低分子量変異体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762449857P 2017-01-24 2017-01-24
US62/449,857 2017-01-24
PCT/US2018/014991 WO2018140456A1 (en) 2017-01-24 2018-01-24 Active low molecular weight variants of angiotensin converting enzyme 2 (ace2)

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JP2023127196A Division JP2023133564A (ja) 2017-01-24 2023-08-03 アンジオテンシン変換酵素2(ace2)の活性な低分子量変異体

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JP2020506693A JP2020506693A (ja) 2020-03-05
JP2020506693A5 true JP2020506693A5 (https=) 2021-03-11
JP7332157B2 JP7332157B2 (ja) 2023-08-23

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JP2019540076A Active JP7332157B2 (ja) 2017-01-24 2018-01-24 アンジオテンシン変換酵素2(ace2)の活性な低分子量変異体
JP2023127196A Pending JP2023133564A (ja) 2017-01-24 2023-08-03 アンジオテンシン変換酵素2(ace2)の活性な低分子量変異体

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JP2023127196A Pending JP2023133564A (ja) 2017-01-24 2023-08-03 アンジオテンシン変換酵素2(ace2)の活性な低分子量変異体

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US (4) US10443049B2 (https=)
EP (1) EP3574094A4 (https=)
JP (2) JP7332157B2 (https=)
WO (1) WO2018140456A1 (https=)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018140456A1 (en) 2017-01-24 2018-08-02 Northwestern University Active low molecular weight variants of angiotensin converting enzyme 2 (ace2)
US11337909B2 (en) 2017-11-29 2022-05-24 Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmholtz-Gemeinschaft Methods for modulating pigmentation by angiotensin-converting enzyme 2 modulation
JP7340372B2 (ja) * 2019-07-11 2023-09-07 浜松ホトニクス株式会社 光活性化アデニル酸シクラーゼ
BR112022014552A2 (pt) * 2020-01-23 2022-10-25 Avirus Inc Polipeptídeo recombinante, composição farmacêutica, método de prevenção ou tratamento de uma infecção viral em um indivíduo que necessita do mesmo, molécula de rna, composição terapêutica, sistema de expressão, polipeptídeo recombinante para tratar infecção por sars-cov-2 e polinucleotídeo que codifica o polipeptídeo recombinante
US11518788B2 (en) * 2020-07-10 2022-12-06 Avirus, Inc. Methods and compositions for treating and preventing viral infection
US20210236583A1 (en) * 2020-02-03 2021-08-05 Yuntao Wu Targeting the renin-angiotensin system for treatment of environment-and pathogen-induced lung injury
US20230250410A1 (en) * 2020-02-13 2023-08-10 Systimmune, Inc. Recombinant ace2-fc fusion molecules and methods of making and using thereof
TWI886211B (zh) * 2020-02-13 2025-06-11 美商西雅圖免疫公司 重組ace2-fc融合分子以及製造及使用彼等之方法
US20230101022A1 (en) * 2020-02-20 2023-03-30 Sheau-Long Lee Ginsenoside m1 as a modulator of angiotensin regulating enzymes and its use for treating diseases or conditions including symptoms caused by coronavirus
CN111474363A (zh) * 2020-02-22 2020-07-31 安徽华培生物科技有限公司 一种新型冠状病毒检测方法
US12123036B2 (en) 2020-02-26 2024-10-22 Northwestern University Soluble ACE2 variants and uses therefor
JP7554837B2 (ja) * 2020-02-27 2024-09-20 華輝安健(北京)生物科技有限公司 可溶性ace2及び融合タンパク質、並びにその適用
WO2021170113A1 (zh) * 2020-02-29 2021-09-02 南京金斯瑞生物科技有限公司 ACE-2-Fc融合蛋白治疗冠状病毒的方法
US12285480B2 (en) 2020-03-11 2025-04-29 Nantcell, Inc. Method of inducing immunity against SARS-CoV-2 using spike and nucleocapsid-ETSD immunogens delivered by RNA and replication-defective adenoviruses
US20210284716A1 (en) 2020-03-11 2021-09-16 Immunitybio, Inc. ACE2-Fc Trap
CN120518773A (zh) 2020-03-11 2025-08-22 南特细胞公司 蛋白质治疗剂
US11857620B2 (en) 2020-03-11 2024-01-02 Immunitybio, Inc. Method of inducing immunity against SARS-CoV-2 using spike (s) and nucleocapsid (N)-ETSD immunogens delivered by a replication-defective adenovirus
CN116057176A (zh) * 2020-03-21 2023-05-02 赖瑞克斯生物科技公司 Ace2和补体途径的双特异性和三特异性功能分子及其用途
WO2021195009A1 (en) * 2020-03-23 2021-09-30 Sapience Therapeutics, Inc. Peptide antagonists of ace2-binding proteins
CN113444710A (zh) * 2020-03-25 2021-09-28 上海英脉德医疗科技有限公司 ACE2-Fc融合蛋白及其用途
US20230137756A1 (en) * 2020-03-30 2023-05-04 The Wistar Institute Of Anatomy And Biology Synthetic Soluble Receptor Mimics and Methods of Use for Treatment of COVID-19
WO2021197501A1 (zh) * 2020-04-02 2021-10-07 创观(苏州)生物科技有限公司 病毒不易感动物
US20230203466A1 (en) * 2020-04-03 2023-06-29 Medgenome Inc. Ace2 receptor polymorphisms and varying susceptibility to sars-cov-2, methods for diagnosis and treatment
WO2021203098A2 (en) * 2020-04-03 2021-10-07 The University Of North Carolina At Chapel Hill Binding proteins useful against ace2-targeted viruses
WO2021216547A1 (en) * 2020-04-20 2021-10-28 Sorrento Therapeutics, Inc. Pulmonary administration of ace2 polypeptides
US20210386837A1 (en) * 2020-05-18 2021-12-16 Northwestern University Active low molecular weight variants of angiotensin converting enzyme 2 (ace2) for the treatment of diseases and conditions of the eye
US11773385B2 (en) * 2020-05-19 2023-10-03 Children's Medical Center Corporation High-affinity human ACE2 construct for use in diagnosing and treating coronaviruses
WO2021247675A1 (en) * 2020-06-02 2021-12-09 Ngm Biopharmaceuticals, Inc. Coronavirus-binding agents and uses thereof
DE102020207224A1 (de) 2020-06-09 2021-12-09 Christoph Karle Protein oder Peptid, insbesondere zur Prophylaxe und/oder Behandlung einer durch Coronaviren, insbesondere SARS-CoV-2-Viren, hervorgerufenen Infektion oder Infektionskrankheit und/oder einer Folgekrankheit davon
EP4171603A4 (en) * 2020-06-25 2024-06-26 Gliknik Inc. ACE2-FC FUSION PROTEINS AND METHODS OF USE
WO2022008642A1 (en) 2020-07-08 2022-01-13 Apeiron Biologics Ag Treatment of sars-cov-2 infection with a combination of targets
WO2022012688A1 (en) * 2020-07-17 2022-01-20 Shenzhen Bay Laboratory Ace2-ig fusion variants
KR102492081B1 (ko) * 2020-07-28 2023-01-26 재단법인대구경북과학기술원 코로나바이러스 감염증 covid-19 치료용 펩타이드 및 이의 용도
US20220041660A1 (en) * 2020-08-06 2022-02-10 University Of Delaware Compositions and methods for sequestering viral particles in respiratory tract
EP4192859A1 (en) * 2020-08-06 2023-06-14 BioNTech SE Binding agents for coronavirus s protein
WO2022035998A1 (en) * 2020-08-11 2022-02-17 City Of Hope Compositions and uses of sars-cov-2 targeted chimeric antigen receptor modified nk cells
US20230365956A1 (en) * 2020-10-01 2023-11-16 Systimmune, Inc. Recombinant ace2-fc fusion molecules and methods of making and using thereof
WO2022075667A1 (ko) * 2020-10-05 2022-04-14 한양대학교 산학협력단 안정화된 ace2 변이체, 이를 이용한 ace2-fc 융합단백질 및 covid-19 예방 또는 치료용 약학 조성물
US11440952B2 (en) 2020-10-16 2022-09-13 Invisishield Technologies Ltd. Compositions for preventing or treating viral and other microbial infections
EP4249499A4 (en) * 2020-11-20 2025-01-01 Daegu Gyeongbuk Institute Of Science and Technology Coronavirus infectious disease covid-19 therapeutic proteins ctp alpha, ctp beta, ctp gamma, ctp delta, and uses thereof
BR112023009875A2 (pt) 2020-11-23 2024-02-06 Genentech Inc Métodos para tratar um indivíduo com uma infecção por sars-cov-2, para reduzir a ligação de sars-cov-2 a uma célula, para diminuir a infecção por sars-cov-2 e para identificar um modulador, métodos de profilaxia, moduladores isolados, usos e antagonistas
WO2022119380A1 (ko) * 2020-12-03 2022-06-09 주식회사 유틸렉스 신규한 ace2 변이체 및 그의 이용
EP4011387A1 (en) * 2020-12-11 2022-06-15 IMBA-Institut für Molekulare Biotechnologie GmbH Superior neutralization of sars-cov-2 by deglycosylated human angiotensin converting enzyme 2
WO2022159433A1 (en) 2021-01-20 2022-07-28 Singh Biotechnology, Llc Therapeutics directed against coronavirus
JP2024505203A (ja) * 2021-01-26 2024-02-05 ナショナル リサーチ カウンシル オブ カナダ Ace2受容体エクトドメイン融合分子及びその使用
WO2022165246A1 (en) * 2021-01-29 2022-08-04 The Trustees Of The University Of Pennsylvania Compositions and method of use of mutant ace2 decoy variants
JP7539479B2 (ja) * 2021-02-10 2024-08-23 シーチュアン バイリ ファーマスーティカル シーオー. エルティーディー. 組換えace2-fc融合分子、その製造方法及びその使用
WO2022207918A1 (en) 2021-04-02 2022-10-06 Apeiron Biologics Ag COVID-19 Therapy
US20240360181A1 (en) * 2021-05-20 2024-10-31 Achelois Biopharma, Inc. Compositions and methods for multivalent surface display on enveloped particles
CN113324933B (zh) * 2021-06-01 2022-07-26 浙江大学 一种检测血管紧张素转换酶的方法及其应用
US20240270797A1 (en) * 2021-06-23 2024-08-15 Cz Biohub Sf, Llc Coronavirus neutralizing compositions and associated methods
EP4444344A2 (en) * 2021-12-09 2024-10-16 Gliknik Inc. Ace2-fc fusion proteins and methods of use
CA3256035A1 (en) 2022-04-14 2023-10-19 Invisishield Technologies Ltd. COMPOSITIONS FOR PREVENTING OR TREATMENT OF CORONAVIRUS INFECTIONS
WO2023201306A1 (en) 2022-04-14 2023-10-19 Invisishield Technologies Ltd. Compositions for preventing or treating influenza infections
EP4335870A1 (en) 2022-09-06 2024-03-13 NantCell, Inc. Peptide therapeutics against sars-cov-2 spike protein
CN116023509A (zh) * 2022-11-18 2023-04-28 中国药科大学 一种融合蛋白及其应用
DE202023100085U1 (de) 2023-01-09 2023-02-03 Sundararajan Gothandam Eine doppelte Blockade des Renin-Angiotensin-Systems zur Verringerung der frühen Veränderungen der diabetischen Retinopathie und Nephropathie
CN118085110A (zh) * 2024-04-02 2024-05-28 中国药科大学 一种靶向肿瘤的融合蛋白及其应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540930A (en) 1983-09-12 1985-09-10 Wisconsin Alumni Research Foundation Plywheel-powered mobile X-ray apparatus
US5124154A (en) 1990-06-12 1992-06-23 Insite Vision Incorporated Aminosteroids for ophthalmic use
US6610497B1 (en) 1997-12-11 2003-08-26 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therefor
US7396664B2 (en) 1999-06-08 2008-07-08 Regeneron Pharmaceuticals, Inc. VEGF-binding fusion proteins and nucleic acids encoding the same
WO2002061131A2 (en) 2000-12-04 2002-08-08 Bristol-Myers Squibb Company Human single nucleotide polymorphisms
AT506258A1 (de) 2007-12-18 2009-07-15 Apeiron Biolog Forschungs Und Behandlung inflammatorischer krankheiten
MX2012003939A (es) * 2009-09-30 2012-07-30 Glaxo Group Ltd Fusiones y conjugados de farmaco.
KR20140140546A (ko) 2012-02-10 2014-12-09 타릭스 파마슈티컬스 엘티디. 말초 혈관 질환의 치료를 위한 조성물 및 방법
MX355041B (es) 2012-05-25 2018-03-28 Janssen Biotech Inc Dominios de union a albumina consenso no naturales.
KR20150110607A (ko) 2013-01-14 2015-10-02 아페이론 바이오로직스 아게 변형된 ace2 폴리펩티드
CA2957211C (en) 2013-10-18 2022-07-05 Trustees Of The University Of Pennsylvania Oral delivery of angiotensin converting enzyme 2 (ace2) or angiotensin-(1-7) bioencapsulated in plant cells
WO2018140456A1 (en) 2017-01-24 2018-08-02 Northwestern University Active low molecular weight variants of angiotensin converting enzyme 2 (ace2)
US12123036B2 (en) 2020-02-26 2024-10-22 Northwestern University Soluble ACE2 variants and uses therefor
US20210386837A1 (en) 2020-05-18 2021-12-16 Northwestern University Active low molecular weight variants of angiotensin converting enzyme 2 (ace2) for the treatment of diseases and conditions of the eye

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