JP2020505461A5 - - Google Patents
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- JP2020505461A5 JP2020505461A5 JP2019560456A JP2019560456A JP2020505461A5 JP 2020505461 A5 JP2020505461 A5 JP 2020505461A5 JP 2019560456 A JP2019560456 A JP 2019560456A JP 2019560456 A JP2019560456 A JP 2019560456A JP 2020505461 A5 JP2020505461 A5 JP 2020505461A5
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- JP
- Japan
- Prior art keywords
- roller
- press
- temperature
- layered
- hydrophilic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 37
- 239000000463 material Substances 0.000 claims description 33
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical class OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 230000002209 hydrophobic effect Effects 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical class CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 claims description 4
- 238000002844 melting Methods 0.000 claims description 4
- 230000008018 melting Effects 0.000 claims description 4
- 239000004014 plasticizer Substances 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Chemical class OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical class OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical class CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 2
- 239000004359 castor oil Substances 0.000 claims description 2
- 235000019438 castor oil Nutrition 0.000 claims description 2
- 229920002678 cellulose Chemical class 0.000 claims description 2
- 239000001913 cellulose Chemical class 0.000 claims description 2
- -1 citrate ester Chemical class 0.000 claims description 2
- 229940088679 drug related substance Drugs 0.000 claims description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 2
- 150000002314 glycerols Chemical class 0.000 claims description 2
- 150000002334 glycols Chemical class 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 239000000600 sorbitol Chemical class 0.000 claims description 2
- 239000001856 Ethyl cellulose Substances 0.000 claims 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical group CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 3
- 239000000227 bioadhesive Substances 0.000 claims 3
- 235000019325 ethyl cellulose Nutrition 0.000 claims 3
- 229920001249 ethyl cellulose Polymers 0.000 claims 3
- 229920001477 hydrophilic polymer Polymers 0.000 claims 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 2
- 229920002307 Dextran Polymers 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 2
- 230000003352 fibrogenic effect Effects 0.000 claims 2
- 229920001600 hydrophobic polymer Polymers 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical class OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 claims 1
- 241000416162 Astragalus gummifer Species 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- 244000007835 Cyamopsis tetragonoloba Species 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229920002148 Gellan gum Polymers 0.000 claims 1
- 102000004856 Lectins Human genes 0.000 claims 1
- 108090001090 Lectins Proteins 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 229920002807 Thiomer Polymers 0.000 claims 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims 1
- 229920006243 acrylic copolymer Polymers 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 239000000783 alginic acid Substances 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 229960001126 alginic acid Drugs 0.000 claims 1
- 150000004781 alginic acids Chemical class 0.000 claims 1
- 150000001447 alkali salts Chemical class 0.000 claims 1
- 235000010418 carrageenan Nutrition 0.000 claims 1
- 239000000679 carrageenan Substances 0.000 claims 1
- 229920001525 carrageenan Polymers 0.000 claims 1
- 229940113118 carrageenan Drugs 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 239000002523 lectin Substances 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 229920001277 pectin Polymers 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 claims 1
- 229920001610 polycaprolactone Polymers 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229920001285 xanthan gum Polymers 0.000 claims 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000000835 fiber Substances 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 description 2
- UYXTWWCETRIEDR-UHFFFAOYSA-N Tributyrin Chemical compound CCCC(=O)OCC(OC(=O)CCC)COC(=O)CCC UYXTWWCETRIEDR-UHFFFAOYSA-N 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical class COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 1
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 229940099371 diacetylated monoglycerides Drugs 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- WEAPVABOECTMGR-UHFFFAOYSA-N triethyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)(OC(C)=O)CC(=O)OCC WEAPVABOECTMGR-UHFFFAOYSA-N 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201770042 | 2017-01-23 | ||
| DKPA201770042 | 2017-01-23 | ||
| PCT/DK2018/050009 WO2018133909A1 (en) | 2017-01-23 | 2018-01-22 | Method for fabrication of a two-layered product based on electrospun fibres |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020505461A JP2020505461A (ja) | 2020-02-20 |
| JP2020505461A5 true JP2020505461A5 (cg-RX-API-DMAC7.html) | 2021-03-04 |
| JP7162014B2 JP7162014B2 (ja) | 2022-10-27 |
Family
ID=58536694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019560456A Active JP7162014B2 (ja) | 2017-01-23 | 2018-01-22 | 電界紡糸繊維に基づく２層生成物の製作方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11801671B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3570821B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7162014B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102592782B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN110248647A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2018209591B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112019014236A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3050027A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK3570821T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2887977T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL267916B (cg-RX-API-DMAC7.html) |
| MX (1) | MX382197B (cg-RX-API-DMAC7.html) |
| RU (1) | RU2019125715A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018133909A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112107559B (zh) * | 2019-06-20 | 2023-09-08 | 普济生物科技（台州）有限公司 | 口腔透粘膜药物剂型 |
| WO2021069952A1 (en) * | 2019-10-07 | 2021-04-15 | The Stellenbosch Nanofiber Company (Pty) Ltd | Method of preparing a cosmetic component |
| WO2021072113A1 (en) | 2019-10-08 | 2021-04-15 | Afyx Therapeutics A/S | Compositions for the delivery of proteins |
| DE102020129363A1 (de) | 2020-11-06 | 2022-05-12 | Selina Jakumeit | Schutzvorrichtung als temporäre Versiegelung während sexueller Aktivitäten zur Vermeidung von Harnwegs- und Blasenentzündungen |
| CN112516368B (zh) * | 2020-11-27 | 2022-05-03 | 佛山仙湖实验室 | 一种复合纤维膜及其制备方法和应用 |
| TWI823151B (zh) * | 2021-10-01 | 2023-11-21 | 南亞塑膠工業股份有限公司 | 雙層醫用膜及其製法 |
| EP4436544A1 (en) | 2021-11-23 | 2024-10-02 | Afyx Development A/S | Mucosal patches and methods of use thereof |
| WO2025051337A1 (en) | 2023-09-06 | 2025-03-13 | Afyx Development A/S | Compositions and methods for treating and preventing oral cancer |
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| GB201614100D0 (en) | 2016-08-17 | 2016-09-28 | Globalacorn Ltd | Carriers |
| JP7353980B2 (ja) | 2017-01-23 | 2023-10-02 | アフリックス セラピューティクス アー／エス | 高含量の生体接着物質を有する電界紡糸繊維を調製する方法 |
-
2018
- 2018-01-22 BR BR112019014236-3A patent/BR112019014236A2/pt not_active Application Discontinuation
- 2018-01-22 US US16/479,493 patent/US11801671B2/en active Active
- 2018-01-22 CA CA3050027A patent/CA3050027A1/en active Pending
- 2018-01-22 EP EP18702051.6A patent/EP3570821B1/en active Active
- 2018-01-22 JP JP2019560456A patent/JP7162014B2/ja active Active
- 2018-01-22 DK DK18702051.6T patent/DK3570821T3/da active
- 2018-01-22 KR KR1020197023235A patent/KR102592782B1/ko active Active
- 2018-01-22 AU AU2018209591A patent/AU2018209591B2/en active Active
- 2018-01-22 RU RU2019125715A patent/RU2019125715A/ru unknown
- 2018-01-22 CN CN201880007754.6A patent/CN110248647A/zh active Pending
- 2018-01-22 ES ES18702051T patent/ES2887977T3/es active Active
- 2018-01-22 WO PCT/DK2018/050009 patent/WO2018133909A1/en not_active Ceased
- 2018-01-22 MX MX2019008258A patent/MX382197B/es unknown
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2019
- 2019-07-08 IL IL267916A patent/IL267916B/en unknown
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