JP2020505025A5 - - Google Patents

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JP2020505025A5
JP2020505025A5 JP2019538202A JP2019538202A JP2020505025A5 JP 2020505025 A5 JP2020505025 A5 JP 2020505025A5 JP 2019538202 A JP2019538202 A JP 2019538202A JP 2019538202 A JP2019538202 A JP 2019538202A JP 2020505025 A5 JP2020505025 A5 JP 2020505025A5
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cell according
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gene
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JP2019538202A
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JP2020505025A (ja
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Priority claimed from PCT/US2018/013688 external-priority patent/WO2018132783A1/en
Publication of JP2020505025A publication Critical patent/JP2020505025A/ja
Publication of JP2020505025A5 publication Critical patent/JP2020505025A5/ja
Priority to JP2022208126A priority Critical patent/JP2023052079A/ja
Priority to JP2025003516A priority patent/JP2025069169A/ja
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JP2019538202A 2017-01-13 2018-01-14 免疫工学的な改変をした多能性細胞 Pending JP2020505025A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022208126A JP2023052079A (ja) 2017-01-13 2022-12-26 免疫工学的な改変をした多能性細胞
JP2025003516A JP2025069169A (ja) 2017-01-13 2025-01-09 免疫工学的な改変をした多能性細胞

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762445969P 2017-01-13 2017-01-13
US62/445,969 2017-01-13
PCT/US2018/013688 WO2018132783A1 (en) 2017-01-13 2018-01-14 Immunoengineered pluripotent cells

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JP2022208126A Division JP2023052079A (ja) 2017-01-13 2022-12-26 免疫工学的な改変をした多能性細胞

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JP2020505025A JP2020505025A (ja) 2020-02-20
JP2020505025A5 true JP2020505025A5 (enExample) 2021-02-25

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JP2019538202A Pending JP2020505025A (ja) 2017-01-13 2018-01-14 免疫工学的な改変をした多能性細胞
JP2022208126A Pending JP2023052079A (ja) 2017-01-13 2022-12-26 免疫工学的な改変をした多能性細胞
JP2025003516A Pending JP2025069169A (ja) 2017-01-13 2025-01-09 免疫工学的な改変をした多能性細胞

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JP2022208126A Pending JP2023052079A (ja) 2017-01-13 2022-12-26 免疫工学的な改変をした多能性細胞
JP2025003516A Pending JP2025069169A (ja) 2017-01-13 2025-01-09 免疫工学的な改変をした多能性細胞

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US (2) US20190376045A1 (enExample)
EP (1) EP3568464A1 (enExample)
JP (3) JP2020505025A (enExample)
KR (2) KR20240095477A (enExample)
CN (1) CN110177869A (enExample)
AU (2) AU2018207649B2 (enExample)
BR (1) BR112019014257A2 (enExample)
CA (1) CA3049766A1 (enExample)
EA (1) EA201991692A1 (enExample)
IL (1) IL267616A (enExample)
MX (1) MX2019008413A (enExample)
WO (1) WO2018132783A1 (enExample)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016094679A1 (en) 2014-12-10 2016-06-16 Regents Of The University Of Minnesota Genetically modified cells, tissues, and organs for treating disease
EP3294342A4 (en) 2015-05-08 2018-11-07 President and Fellows of Harvard College Universal donor stem cells and related methods
WO2017093969A1 (en) 2015-12-04 2017-06-08 Novartis Ag Compositions and methods for immunooncology
KR20240095477A (ko) * 2017-01-13 2024-06-25 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 면역조작된 만능 세포
EP3601528A4 (en) * 2017-03-20 2021-05-05 Washington University Cells and methods of uses and making the same
KR20190130608A (ko) 2017-03-22 2019-11-22 노파르티스 아게 면역종양학을 위한 조성물 및 방법
CN110869494B (zh) 2017-06-12 2025-02-18 西奈卫生系统公司 无需全身性免疫遏制的同种异体移植物耐受
EP3652312A1 (en) 2017-07-14 2020-05-20 Editas Medicine, Inc. Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
AU2019305585A1 (en) * 2018-07-17 2021-01-28 The Regents Of The University Of California Cells differentiated from immunoengineered pluripotent cells
EP3824075A4 (en) * 2018-07-17 2022-04-20 The Regents of The University of California CHIMERA ANTIGEN RECEPTOR T-CELLS DERIVED FROM IMMUNOMANIPULATED PLURIPOTENTS STEM CELLS
US12378572B2 (en) 2018-09-07 2025-08-05 Crispr Therapeutics Ag Universal donor cells
CN113195724A (zh) * 2018-09-26 2021-07-30 新加坡国立大学 低免疫原性的工程化人类间充质基质细胞,制备方法和试剂盒
UY38427A (es) * 2018-10-26 2020-05-29 Novartis Ag Métodos y composiciones para terapia con células oculares
CA3123102A1 (en) 2018-12-13 2020-06-18 Sinai Health System Immunomodulatory cells and uses thereof
CN111424016A (zh) * 2019-01-09 2020-07-17 复旦大学 降低细胞免疫原性的诱导型多能干细胞系及建立方法
SG11202108891QA (en) * 2019-02-15 2021-09-29 Harvard College Universal donor stem cells and related methods
US20220213434A1 (en) 2019-05-10 2022-07-07 The Regents Of The University Of California Modified pluripotent cells
US11162079B2 (en) 2019-05-10 2021-11-02 The Regents Of The University Of California Blood type O Rh-hypo-immunogenic pluripotent cells
US12391923B2 (en) 2019-06-26 2025-08-19 The Regents Of The University Of California SIRPα-silenced natural killer (NK) cells
TW202115245A (zh) * 2019-06-27 2021-04-16 丹麥商諾佛 儂迪克股份有限公司 安全免疫隱形細胞
US20220333082A1 (en) 2019-07-10 2022-10-20 Helmuth Heinrich Kunz Methods for deriving autologous and hypoimmunogenic hair follicle containing sheets in vitro
EP4007596A1 (en) * 2019-08-01 2022-06-08 Sana Biotechnology, Inc. Dux4 expressing cells and uses thereof
JP7728747B2 (ja) 2019-08-23 2025-08-25 サナ バイオテクノロジー,インコーポレイテッド Cd24発現細胞およびそれらの用途
US11116798B2 (en) 2019-09-05 2021-09-14 Crispr Therapeutics Ag Universal donor cells
US11104918B2 (en) 2019-09-05 2021-08-31 Crispr Therapeutics Ag Universal donor cells
US12551560B2 (en) 2019-09-09 2026-02-17 Scribe Therapeutics Inc. Compositions and methods for use in immunotherapy
WO2021055985A1 (en) * 2019-09-22 2021-03-25 Cellerant Therapeutics, Inc. Ipsc-derived, hypoimmunogenic, myeloid progenitor cells
EP4045648A4 (en) * 2019-10-15 2023-11-22 The Regents of The University of California Transplanted cell protection via fc sequestration
JP7853210B2 (ja) * 2020-01-13 2026-04-28 サナ バイオテクノロジー,インコーポレイテッド 血液型抗原の修飾
EP4585223A3 (en) 2020-01-15 2025-07-30 The Regents of the University of California Transplanted cell protection via inhibition of polymorphonuclear cells
EP4090747A1 (en) 2020-01-17 2022-11-23 Sana Biotechnology, Inc. Safety switches for regulation of gene expression
EP4125961A1 (en) * 2020-03-25 2023-02-08 Sana Biotechnology, Inc. Hypoimmunogenic neural cells for the treatment of neurological disorders and conditions
WO2021207121A1 (en) * 2020-04-06 2021-10-14 Rxcell Inc. Hypoimmunogenic cells and methods and compositions for their production
EP4138893A4 (en) * 2020-04-21 2024-06-12 Intima Bioscience, Inc. Cellular vaccine platform and methods of use
JP2023525579A (ja) * 2020-05-15 2023-06-16 アールエックスセル インコーポレーテッド 低免疫原性の細胞および免疫応答におけるそれらの使用
AU2021325941A1 (en) 2020-08-13 2023-03-09 Sana Biotechnology, Inc. Methods of treating sensitized patients with hypoimmunogenic cells, and associated methods and compositions
CN112342196A (zh) * 2020-08-18 2021-02-09 未来智人再生医学研究院(广州)有限公司 一种免疫兼容可逆的通用型多能干细胞及其应用
IL301972A (en) * 2020-10-09 2023-06-01 Sana Biotechnology Inc Methods for activating safe killing mechanisms using the CD47–SIRPα blocking factor
CA3196346A1 (en) * 2020-10-20 2022-04-28 Herman Waldmann Methods and compositions for cellular therapy
CN114525255A (zh) * 2020-10-30 2022-05-24 未来智人再生医学研究院(广州)有限公司 一种表达il-11的多能干细胞衍生物及其应用
CN114457021A (zh) * 2020-10-30 2022-05-10 未来智人再生医学研究院(广州)有限公司 一种表达cd47抗体的多能干细胞及其衍生物与应用
US11459372B2 (en) 2020-11-30 2022-10-04 Crispr Therapeutics Ag Gene-edited natural killer cells
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
IL303269A (en) 2020-12-03 2023-07-01 Century Therapeutics Inc Genetically engineered cells and uses thereof
CN114107211B (zh) * 2020-12-04 2025-09-30 未来智人再生医学研究院(广州)有限公司 一种多能干细胞及其衍生物
CN116829698A (zh) * 2020-12-07 2023-09-29 加利福尼亚大学董事会 通过SIRP-α衔接体的先天免疫细胞沉默
EP4271798A1 (en) 2020-12-30 2023-11-08 CRISPR Therapeutics AG Compositions and methods for differentiating stem cells into nk cells
US11965022B2 (en) 2020-12-31 2024-04-23 Sana Biotechnology, Inc. Methods and compositions for modulating CAR-T activity
US11566230B2 (en) 2020-12-31 2023-01-31 Crispr Therapeutics Ag Universal donor cells
CA3212370A1 (en) 2021-03-03 2022-09-09 Sana Biotechnology, Inc. Immunosuppressive therapies for use with cardiomyocyte cell therapies, and associated methods and compositions
WO2022191216A1 (ja) * 2021-03-09 2022-09-15 国立研究開発法人理化学研究所 低免疫原性網膜色素上皮細胞の製造方法
AU2022249039A1 (en) * 2021-03-30 2023-09-28 The Regents Of The University Of California Transplanted cell protection via modified fc receptors
EP4323501A1 (en) * 2021-04-16 2024-02-21 Beam Therapeutics Inc. Genetic modification of hepatocytes
CA3219830A1 (en) * 2021-05-24 2022-12-01 Lei Zhang Ciita targeting zinc finger nucleases
US20240226164A1 (en) 2021-05-27 2024-07-11 Sana Biotechnology, Inc. Hypoimmunogenic cells comprising engineered hla-e or hla-g
CA3225283A1 (en) 2021-07-14 2023-01-19 Sonja SCHREPFER Altered expression of y chromosome-linked antigens in hypoimmunogenic cells
KR102847814B1 (ko) * 2021-07-28 2025-08-21 의료법인 성광의료재단 B2m 유전자의 발현이 저해된 유전적으로 조작된 줄기세포 및 이의 이용방법
US20260053851A1 (en) 2021-08-11 2026-02-26 Sana Biotechnology, Inc. Inducible systems for altering gene expression in hypoimmunogenic cells
AU2022326565A1 (en) 2021-08-11 2024-02-08 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy
AU2022325231A1 (en) 2021-08-11 2024-02-08 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions
CA3227108A1 (en) 2021-08-11 2023-02-16 Xiaomeng HU Genetically modified primary cells for allogeneic cell therapy
AU2022325955A1 (en) 2021-08-11 2024-02-08 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy to reduce instant blood mediated inflammatory reactions
CN117904109A (zh) * 2021-08-27 2024-04-19 浙江大学 一种超级增强子核心序列调控b2m基因表达的效果及应用
US20250313861A1 (en) 2021-10-22 2025-10-09 Sana Biotechnology, Inc. Methods of engineering allogeneic t cells with a transgene in a tcr locus and associated compositions and methods
WO2023122337A1 (en) 2021-12-23 2023-06-29 Sana Biotechnology, Inc. Chimeric antigen receptor (car) t cells for treating autoimmune disease and associated methods
CA3246902A1 (en) * 2022-01-10 2023-07-13 Sana Biotechnology, Inc. DIFFERENTIATED HYPOIMMUNOUS BETA CELLS FROM PURIPOTENTIC STEM CELLS AND RELATED USES AND METHODS
EP4479084A1 (en) 2022-02-14 2024-12-25 Sana Biotechnology, Inc. Methods of treating patients exhibiting a prior failed therapy with hypoimmunogenic cells
WO2023158836A1 (en) 2022-02-17 2023-08-24 Sana Biotechnology, Inc. Engineered cd47 proteins and uses thereof
WO2023173123A1 (en) 2022-03-11 2023-09-14 Sana Biotechnology, Inc. Genetically modified cells and compositions and uses thereof
WO2023183313A1 (en) 2022-03-22 2023-09-28 Sana Biotechnology, Inc. Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods
CN114958768B (zh) * 2022-06-02 2023-03-24 健颐生物科技发展(山东)有限公司 Fgf10旁分泌通用型人成纤维细胞制剂的制备方法
CN117343962A (zh) * 2022-06-29 2024-01-05 中国科学院上海营养与健康研究所 免疫兼容型人多能干细胞、其制备方法及应用
EP4547825A1 (en) 2022-07-01 2025-05-07 Novo Nordisk A/S Enhancing neuronal differentiation of ventral midbrain neural progenitor cells
WO2024012420A1 (zh) * 2022-07-11 2024-01-18 士泽生物医药(苏州)有限公司 一种表达faslg的通用型细胞及其制备方法
CN117431217A (zh) * 2022-07-12 2024-01-23 上海驯鹿生物技术有限公司 表达靶向cd5的嵌合抗原受体(car)的细胞及其应用
GB202211117D0 (en) * 2022-07-29 2022-09-14 Replay Holdings Llc Compositions and methods for non-immunogenecity
GB202212144D0 (en) * 2022-08-19 2022-10-05 Resolution Therapeutics Ltd Cells for therapy
WO2024097313A1 (en) 2022-11-02 2024-05-10 Sana Biotechnology, Inc. Methods for producing t cell therapy products
EP4619015A1 (en) * 2022-11-15 2025-09-24 The Board of Trustees of the Leland Stanford Junior University Hypoallogenic-immunogenic pluripotent stem cells as anti-cancer vaccine
CN118147077B (zh) * 2022-12-07 2025-09-26 士泽生物医药(苏州)有限公司 一种表达gsn的通用型细胞及其制备方法
CN118207165B (zh) * 2022-12-07 2026-03-20 士泽生物医药(苏州)有限公司 一种表达stc1的通用型细胞及其制备方法
GB202218755D0 (en) * 2022-12-13 2023-01-25 Replay Holdings Llc Compositions and methods for non-immunogenicity
CN118207166A (zh) * 2022-12-16 2024-06-18 士泽生物医药(苏州)有限公司 一种通用型细胞及其制备方法
WO2024151541A1 (en) 2023-01-09 2024-07-18 Sana Biotechnology, Inc. Type-1 diabetes autoimmune mouse
WO2024169917A1 (zh) * 2023-02-16 2024-08-22 士泽生物医药(苏州)有限公司 通用型细胞及其制备方法
CN121843705A (zh) 2023-05-03 2026-04-10 萨那生物科技公司 工程化胰岛细胞的给药和施用方法
WO2024243236A2 (en) 2023-05-22 2024-11-28 Sana Biotechnology, Inc. Methods of delivery of islet cells and related methods
EP4735585A1 (en) 2023-06-30 2026-05-06 Novo Nordisk A/S Enhancing neuronal differentiation of neural progenitor cells
KR102740042B1 (ko) * 2023-07-12 2024-12-06 ㈜바이오솔빅스 인간 전분화능 줄기세포로 유래된 심장 오가노이드 제조방법, 효능 및 독성 평가 기술
WO2025043172A1 (en) 2023-08-23 2025-02-27 Sana Biotechnology, Inc. Modified cd47 proteins and their uses
WO2025054202A1 (en) 2023-09-05 2025-03-13 Sana Biotechnology, Inc. Method of screening a sample comprising a transgene with a unique barcode
CN119351338B (zh) * 2023-09-15 2026-01-23 士泽生物医药(苏州)有限公司 一种表达cd300ld的低免疫原性细胞及其制备方法
WO2025096757A1 (en) 2023-11-01 2025-05-08 Sana Biotechnology, Inc. Hypoimmunogenic cd22-targeted car t cells for the treatment of relapsed and/or refractory b cell lymphomas
AU2025208175A1 (en) 2024-01-12 2026-06-25 Sana Biotechnology, Inc. Safety switches to control in vitro and in vivo proliferation of cell therapy products
WO2025230947A1 (en) 2024-04-30 2025-11-06 Satellite Biosciences, Inc. Engineered hepatocytes for secreting polypeptides
WO2025230941A1 (en) 2024-04-30 2025-11-06 Satellite Biosciences, Inc. Hypoimmunogenic cell mixtures and methods of use thereof
CN121006322A (zh) * 2024-05-22 2025-11-25 上海苹谱医疗科技有限公司 一种通用型工程化细胞及其制备方法与应用
WO2025259640A1 (en) * 2024-06-14 2025-12-18 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for bioengineering hypoimmunogenic organs, tissues and cells
WO2026072871A1 (en) * 2024-09-26 2026-04-02 Sana Biotechnology, Inc. Alternative sources of tissue

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8724885D0 (en) 1987-10-23 1987-11-25 Binns M M Fowlpox virus promotors
DE19539493A1 (de) 1995-10-24 1997-04-30 Thomae Gmbh Dr K Starker homologer Promotor aus Hamster
US20040053836A1 (en) * 2002-04-22 2004-03-18 Philipp Mayer-Kuckuk Method for modulating the production of a selected protein in vivo
EP2342340A1 (en) 2008-09-22 2011-07-13 Rxi Pharmaceuticals Corporation Rna interference in skin indications
CN105925535A (zh) * 2009-06-05 2016-09-07 细胞动力国际有限公司 重编程t细胞和造血细胞的方法
US9089520B2 (en) 2010-05-21 2015-07-28 Baylor College Of Medicine Methods for inducing selective apoptosis
EP4253409A3 (en) * 2012-04-17 2023-12-06 University of Washington through its Center for Commercialization Hla class ii deficient cells, hla class i deficient cells capable of expressing hla class ii proteins, and uses thereof
EP3114217A4 (en) * 2014-03-07 2017-09-20 Bellicum Pharmaceuticals, Inc. Caspase polypeptides having modified activity and uses thereof
KR20160145186A (ko) * 2014-04-24 2016-12-19 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 입양 세포 요법 생성물을 생성하기 위한 유도 만능 줄기 세포의 응용
WO2016142532A1 (en) * 2015-03-11 2016-09-15 Cellectis Methods for engineering allogeneic t cell to increase their persistence and/or engraftment into patients
EP3294342A4 (en) * 2015-05-08 2018-11-07 President and Fellows of Harvard College Universal donor stem cells and related methods
US12642852B1 (en) * 2015-11-04 2026-06-02 Fate Therapeutics, Inc. Genomic engineering of pluripotent cells
KR20240095477A (ko) * 2017-01-13 2024-06-25 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 면역조작된 만능 세포
US20220213434A1 (en) * 2019-05-10 2022-07-07 The Regents Of The University Of California Modified pluripotent cells

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