JP2020500207A5 - - Google Patents

Download PDF

Info

Publication number
JP2020500207A5
JP2020500207A5 JP2019538096A JP2019538096A JP2020500207A5 JP 2020500207 A5 JP2020500207 A5 JP 2020500207A5 JP 2019538096 A JP2019538096 A JP 2019538096A JP 2019538096 A JP2019538096 A JP 2019538096A JP 2020500207 A5 JP2020500207 A5 JP 2020500207A5
Authority
JP
Japan
Prior art keywords
optionally substituted
nhc
group
compound
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2019538096A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020500207A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/053629 external-priority patent/WO2018064119A1/en
Publication of JP2020500207A publication Critical patent/JP2020500207A/ja
Publication of JP2020500207A5 publication Critical patent/JP2020500207A5/ja
Pending legal-status Critical Current

Links

JP2019538096A 2016-09-28 2017-09-27 カルパインモジュレーター及びそれらの治療上の使用 Pending JP2020500207A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662401093P 2016-09-28 2016-09-28
US62/401,093 2016-09-28
US201762459461P 2017-02-15 2017-02-15
US62/459,461 2017-02-15
US201762554939P 2017-09-06 2017-09-06
US62/554,939 2017-09-06
PCT/US2017/053629 WO2018064119A1 (en) 2016-09-28 2017-09-27 Calpain modulators and therapeutic uses thereof

Publications (2)

Publication Number Publication Date
JP2020500207A JP2020500207A (ja) 2020-01-09
JP2020500207A5 true JP2020500207A5 (OSRAM) 2020-11-12

Family

ID=61763018

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019538096A Pending JP2020500207A (ja) 2016-09-28 2017-09-27 カルパインモジュレーター及びそれらの治療上の使用

Country Status (18)

Country Link
US (3) US10934261B2 (OSRAM)
EP (1) EP3523294A4 (OSRAM)
JP (1) JP2020500207A (OSRAM)
KR (1) KR20190063473A (OSRAM)
CN (1) CN110023304A (OSRAM)
AU (1) AU2017336523B2 (OSRAM)
BR (1) BR112019006110A2 (OSRAM)
CA (1) CA3038331A1 (OSRAM)
CL (3) CL2019000793A1 (OSRAM)
CO (1) CO2019004113A2 (OSRAM)
EC (1) ECSP19029982A (OSRAM)
IL (1) IL265564A (OSRAM)
MX (2) MX2019003425A (OSRAM)
PE (1) PE20191153A1 (OSRAM)
PH (1) PH12019500637A1 (OSRAM)
SG (1) SG10201912574WA (OSRAM)
TW (1) TW201823213A (OSRAM)
WO (1) WO2018064119A1 (OSRAM)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017292646A1 (en) 2016-07-05 2019-02-07 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
PE20190473A1 (es) 2016-09-16 2019-04-04 Cortexyme Inc Inhibidores cetonicos de gingipain de lisina
WO2018064119A1 (en) 2016-09-28 2018-04-05 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
AU2018289434A1 (en) * 2017-06-23 2020-01-16 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
UY37806A (es) 2017-07-11 2020-01-31 Vertex Pharma Carboxamidas como moduladores de los canales de sodio
US20210009564A1 (en) * 2018-03-28 2021-01-14 Blade Therapertics, Inc. Calpain modulators and therapeutic uses thereof
CA3093749A1 (en) * 2018-03-28 2019-10-03 Blade Therapeutics, Inc. Method of treating fibrotic disease
DK3784661T3 (da) 2018-04-25 2024-02-12 Bayer Ag Hidtil ukendte heteroaryl-triazol- og heteroaryl-tetrazol-forbindelser som pesticider
CN112703188A (zh) * 2018-06-28 2021-04-23 布莱德治疗公司 用钙蛋白酶抑制剂治疗肝纤维化的方法
CN112996786B (zh) 2018-10-30 2024-08-20 吉利德科学公司 用于抑制α4β7整合素的化合物
WO2020092375A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Quinoline derivatives as alpha4beta7 integrin inhibitors
ES3013256T3 (en) 2018-10-30 2025-04-11 Gilead Sciences Inc Imidazo[1,2-a]pyridine derivatives as alpha4beta7 integrin inhibitors for the treatment of inflammatory diseases
US11179383B2 (en) 2018-10-30 2021-11-23 Gilead Sciences, Inc. Compounds for inhibition of α4β7 integrin
WO2020146612A1 (en) 2019-01-10 2020-07-16 Vertex Pharmaceuticals Incorporated Esters and carbamates as modulators of sodium channels
US12441703B2 (en) 2019-01-10 2025-10-14 Vertex Pharmaceuticals Incorporated Carboxamides as modulators of sodium channels
CN111825653A (zh) * 2019-04-19 2020-10-27 安道麦马克西姆有限公司 取代吡唑类化合物的制备及其作为邻氨基苯甲酰胺前体的用途
MX2022000951A (es) 2019-07-23 2022-02-14 Bayer Ag Novedosos compuestos de heteroaril-triazol como plaguicidas.
EP4003973B1 (en) 2019-07-23 2024-11-20 Bayer Aktiengesellschaft Novel heteroaryl-triazole compounds as pesticides
MX2022001155A (es) * 2019-07-31 2022-05-18 Blade Therapeutics Inc Inhibidores de calpaina y usos de los mismos para el tratamiento de trastornos neurologicos.
US11578069B2 (en) 2019-08-14 2023-02-14 Gilead Sciences, Inc. Compounds for inhibition of α4 β7 integrin
CN110604735B (zh) * 2019-09-18 2022-10-25 华东师范大学 一种治疗肝纤维化、硬皮病的化合物及其应用
HUE069128T2 (hu) 2019-12-06 2025-02-28 Vertex Pharma Szubsztituált tetrahidrofurán vegyületek mint nátriumcsatornák modulátorai
CA3162405A1 (en) 2019-12-26 2021-07-01 Xiangyang Chen Crystalline forms of (s) -1- (1-acryloylpyrrolidin-3-yl) -3- ( (3, 5-dimethoxyphenyl) ethynyl) -5- (methylamino) -1h-pyrazole-4-carboxamide
AU2021289665A1 (en) 2020-06-10 2022-12-15 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
WO2022017975A1 (en) 2020-07-18 2022-01-27 Syngenta Crop Protection Ag Pesticidally active heterocyclic derivatives with sulfur containing substituents
WO2022020242A1 (en) 2020-07-20 2022-01-27 Enanta Pharmaceuticals, Inc. Functionalized peptides as antiviral agents
CN111718326B (zh) * 2020-07-23 2023-04-07 河南中医药大学 一种含喹啉结构的nnn型嘧啶腙钴(ii)配合物及其制备方法和应用
WO2022109360A1 (en) 2020-11-23 2022-05-27 Enanta Pharmaceuticals, Inc. Novel spiropyrrolidine derived antiviral agents
US11352363B1 (en) 2020-11-23 2022-06-07 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
US11384090B2 (en) 2020-11-23 2022-07-12 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
WO2022235605A1 (en) 2021-05-04 2022-11-10 Enanta Pharmaceuticals, Inc. Novel macrocyclic antiviral agents
US11319325B1 (en) 2021-05-11 2022-05-03 Enanta Pharmaceuticals, Inc. Macrocyclic spiropyrrolidine derived antiviral agents
US12398147B2 (en) 2021-05-11 2025-08-26 Enanta Pharmaceuticals, Inc. Macrocyclic spiropyrrolidine derived antiviral agents
AU2022284886A1 (en) 2021-06-04 2023-11-30 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels
CA3224494A1 (en) 2021-07-09 2023-01-12 Koen Vandyck Anti-viral compounds
US11325916B1 (en) 2021-07-29 2022-05-10 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
US11339170B1 (en) 2021-07-23 2022-05-24 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
US12479854B2 (en) 2021-07-29 2025-11-25 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
CN113651762B (zh) * 2021-09-03 2023-12-26 上海晋鲁医药科技有限公司 一种1-甲基-1h-1,2,4-三氮唑-3-甲酸甲酯的制备方法
WO2023043816A1 (en) 2021-09-17 2023-03-23 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
US12145941B2 (en) 2021-12-08 2024-11-19 Enanta Pharmaceuticals, Inc. Heterocyclic antiviral agents
US11993600B2 (en) 2021-12-08 2024-05-28 Enanta Pharmaceuticals, Inc. Saturated spirocyclics as antiviral agents
WO2023118434A1 (en) * 2021-12-22 2023-06-29 Globachem Nv Pesticidally active amide compounds
US20250064789A1 (en) * 2022-03-01 2025-02-27 Westvac Biopharma Co., Ltd. Ketoamide derivatives and pharmaceutical uses thereof
TW202409000A (zh) * 2022-08-29 2024-03-01 美商富曼西公司 用於製備3-鹵代-4,5-二氫-1h-吡唑之高效新方法
KR102844743B1 (ko) * 2024-06-03 2025-08-12 주식회사 에이켐바이오 신규 피롤 또는 신규 이미다졸 유도체와 그것의 폐섬유화증 개선 용도

Family Cites Families (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
WO1984003506A1 (en) 1983-03-08 1984-09-13 Commw Serum Lab Commission Antigenically active amino acid sequences
US4708871A (en) 1983-03-08 1987-11-24 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
US4863940A (en) * 1984-07-26 1989-09-05 Rohm And Haas N-acetonyl-substituted amides and phytopathogenic fungicidal use thereof
NZ215865A (en) 1985-04-22 1988-10-28 Commw Serum Lab Commission Method of determining the active site of a receptor-binding analogue
US4783443A (en) 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
US5571689A (en) 1988-06-16 1996-11-05 Washington University Method of N-acylating peptide and proteins with diheteroatom substituted analogs of myristic acid
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5663143A (en) 1988-09-02 1997-09-02 Dyax Corp. Engineered human-derived kunitz domains that inhibit human neutrophil elastase
WO1990007329A1 (en) 1989-01-06 1990-07-12 The Regents Of The University Of California Selection method for pharmacologically active compounds
IE910847A1 (en) 1990-03-13 1991-09-25 Fisons Plc Immunosuppressive macrocyclic compounds
ATE176239T1 (de) 1990-11-21 1999-02-15 Iterex Pharma Lp Synthese äquimolarer mischungen vielzähliger oligomere, speziell oligopeptidmischungen
CA2095633C (en) 1990-12-03 2003-02-04 Lisa J. Garrard Enrichment method for variant proteins with altered binding properties
US5331573A (en) 1990-12-14 1994-07-19 Balaji Vitukudi N Method of design of compounds that mimic conformational features of selected peptides
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
WO1992013549A1 (en) 1991-02-07 1992-08-20 Research Corporation Technologies, Inc. Inhibition of cell proliferation by hydrophobic peptides
SE9102462D0 (sv) 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
EP0541946B1 (de) 1991-10-07 1996-07-17 Hoechst Aktiengesellschaft Verfahren zur diastereoselektiven reduktiven Pinakol-Kupplung von homochiralen alpha-Aminoaldehyden
US5644048A (en) 1992-01-10 1997-07-01 Isis Pharmaceuticals, Inc. Process for preparing phosphorothioate oligonucleotides
WO1994000095A2 (en) 1992-06-24 1994-01-06 Cortex Pharmaceuticals, Inc. Use of calpain inhibitors in the inhibition and treatment of medical conditions associated with increased calpain activity
US5658885A (en) 1993-04-27 1997-08-19 The Dupont Merck Pharmaceutical Company Amidino and guanidino substituted boronic acid inhibitors of trypsin-like enzymes
WO1995009859A1 (en) 1993-10-07 1995-04-13 The Du Pont Merck Pharmaceutical Company Boropeptide inhibitors of thrombin which contain a substituted pyrrolidine ring
ATE377006T1 (de) 1995-11-28 2007-11-15 Cephalon Inc Aus d-aminosäuren abgeleitete cystein- und serinproteasehemmer
DE19642591A1 (de) 1996-10-15 1998-04-16 Basf Ag Neue Piperidin-Ketocarbonsäure-Derivate, deren Herstellung und Anwendung
WO1998021186A1 (en) 1996-11-13 1998-05-22 Cephalon, Inc. Benzothiazo and related heterocyclic group-containing cysteine and serine protease inhibitors
DE19648793A1 (de) 1996-11-26 1998-05-28 Basf Ag Neue Benzamide und deren Anwendung
US5952322A (en) 1996-12-05 1999-09-14 Pfizer Inc. Method of reducing tissue damage associated with non-cardiac ischemia using glycogen phosphorylase inhibitors
DE19650975A1 (de) 1996-12-09 1998-06-10 Basf Ag Neue heterocyclisch substituierte Benzamide und deren Anwendung
PL334059A1 (en) 1996-12-11 2000-01-31 Basf Ag Ketone benzamides useful as calpain inhibitors
US6100267A (en) 1997-03-14 2000-08-08 Smithkline Beecham Corporation Quinoline- and naphthalenecarboxamides, pharmaceutical compositions and methods of inhibiting calpain
CA2284041C (en) 1997-03-14 2010-05-18 Smithkline Beecham Corporation Indolecarboxamides, pharmaceutical compositions and methods of inhibiting calpain
US6083944A (en) 1997-10-07 2000-07-04 Cephalon, Inc. Quinoline-containing α-ketoamide cysteine and serine protease inhibitors
US6150378A (en) 1997-10-07 2000-11-21 Cephalon, Inc. Peptidyl-containing α-ketoamide cysteine and serine protease inhibitors
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
AU2960599A (en) 1998-03-30 1999-10-18 Akira Karasawa Quinazoline derivatives
PL343495A1 (en) * 1998-04-20 2001-08-27 Basf Ag Heterocyclically substituted amides used as calpain inhibitors
DE19817459A1 (de) * 1998-04-20 1999-10-21 Basf Ag Neue heterozyklische substituierte Amide, Herstellung und Anwendung
DE19818614A1 (de) 1998-04-20 1999-10-21 Basf Ag Neue substituierte Amide, deren Herstellung und Anwendung
TR200003071T2 (tr) 1998-04-20 2001-04-20 Basf Aktiengesellschaft Sistein-proteazı önleyici etkiye sahip yeni heterosiklik ikame edilmiş amidler
DE19817461A1 (de) 1998-04-20 1999-10-21 Basf Ag Neue substituierte Benzamide, deren Herstellung und Anwendung
CN1306505A (zh) 1998-04-20 2001-08-01 Basf公司 新的取代酰胺、其制备以及应用
ATE524440T1 (de) 1998-05-25 2011-09-15 Abbott Gmbh & Co Kg Heterocyclische substituierte amide, deren herstellung und anwendung
US6335155B1 (en) 1998-06-26 2002-01-01 Sunesis Pharmaceuticals, Inc. Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
US6280946B2 (en) 1998-08-07 2001-08-28 Boston Probes, Inc. PNA probes, probe sets, methods and kits pertaining to the universal detection of bacteria and eucarya
EP1141708A1 (en) 1998-12-28 2001-10-10 Sunesis Pharmaceuticals Inc. Identifying small organic molecule ligands for binding
JP2002539190A (ja) 1999-03-15 2002-11-19 アクシス・ファーマシューティカルズ・インコーポレイテッド プロテアーゼ阻害剤としての新規化合物および組成物
HK1039108A1 (zh) * 1999-03-15 2002-04-12 Axys Pharmaceuticals, Inc. 以n-氰甲基酰胺作为蛋白酶抑制剂
EP1165490B1 (en) * 1999-03-16 2006-08-16 Cytovia, Inc. Substituted 2-aminobenzamide caspase inhibitors and the use thereof
NZ516348A (en) 1999-06-23 2003-06-30 Aventis Pharma Gmbh Substituted benzimidazole
US6900207B2 (en) 2000-01-26 2005-05-31 Ono Pharmaceutical Co., Ltd. N-containing five-membered ring compounds and pharmaceutical agents comprising the same as active ingredient
EP1283728A2 (en) 2000-05-23 2003-02-19 Amersham Health AS Contrast agents
US6582827B1 (en) 2000-11-27 2003-06-24 The Trustees Of Columbia University In The City Of New York Specialized substrates for use in sequential lateral solidification processing
DE10114762A1 (de) 2001-03-26 2002-10-02 Knoll Gmbh Verwendung von Cysteinprotease-Inhibitoren
CA2936534C (en) 2001-07-23 2021-01-26 The Board Of Trustees Of Leland Stanford Junior University Methods and compositions for rnai mediated inhibition of gene expression in mammals
US6878743B2 (en) 2001-09-18 2005-04-12 Sunesis Pharmaceuticals, Inc. Small molecule inhibitors of caspases
US20030167490A1 (en) 2001-11-26 2003-09-04 Hunter Craig P. Gene silencing by systemic RNA interference
TW200301698A (en) 2001-12-21 2003-07-16 Bristol Myers Squibb Co Acridone inhibitors of IMPDH enzyme
NZ534238A (en) 2002-01-31 2006-09-29 Morphochem Ag Komb Chemie Compounds that inhibit factor Xa activity
KR100838333B1 (ko) 2002-04-25 2008-06-13 오노 야꾸힝 고교 가부시키가이샤 디케토히드라진 유도체 화합물 및 그 화합물을 유효성분으로서 함유하는 약제
EP1546089A2 (en) 2002-08-09 2005-06-29 TransTech Pharma Inc. Aryl and heteroaryl compounds and methods to modulate coagulation
KR101076018B1 (ko) 2003-01-08 2011-10-21 유니버시티 오브 워싱톤 항균제
US20040242542A1 (en) 2003-03-25 2004-12-02 The Regents Of The University Of California Compositions and methods for inducing CD81 dependent antiproliferation and for treating hepatitis C and other disorders
WO2005000793A1 (ja) 2003-06-26 2005-01-06 Taisho Pharmaceutical Co., Ltd. 2位置換シクロアルキルカルボン酸誘導体
EP1493739A1 (fr) 2003-07-03 2005-01-05 Warner-Lambert Company LLC Dérivés thiophényliques d'aminoacides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
WO2005014006A1 (en) 2003-07-21 2005-02-17 Novartis Ag Combinations of a cathepsin k inhibitor and a bisphophonate in the treatment of bone metastasis, tumor growth and tumor-induced bone loss
US7459472B2 (en) 2003-08-08 2008-12-02 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
CA2535337A1 (en) 2003-08-14 2005-03-03 Merck & Co., Inc. Macrocyclic beta-secretase inhibitors for the treatment of alzheimer's disease
EP1741441A4 (en) 2004-04-26 2010-03-03 Ono Pharmaceutical Co BONE-ENHANCING AGENT CHARACTERIZED BY USING CATHEPSIN K INHIBITOR WITH PTH
JP2008519761A (ja) 2004-11-09 2008-06-12 スミスクライン ビーチャム コーポレーション グリコーゲンホスホリラーゼ阻害化合物およびその医薬組成物
WO2006078942A2 (en) 2005-01-21 2006-07-27 President And Fellows Of Harvard College Regulation of protein synthesis by inhibition of eif4e-eif4g interaction
US20080311036A1 (en) 2005-05-11 2008-12-18 University Of Florida Research Foundation, Inc. Imaging of Neural and Organ Injury or Damage
JP2009503084A (ja) 2005-08-01 2009-01-29 フェノミックス コーポレーション C型肝炎セリンプロテアーゼ阻害剤およびその使用
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
AR055395A1 (es) 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
JP2009521504A (ja) 2005-12-22 2009-06-04 スミスクライン・ビーチャム・コーポレイション Akt活性阻害剤
WO2007081530A2 (en) 2006-01-03 2007-07-19 Med Institute, Inc. Endoluminal medical device for local delivery of cathepsin inhibitors
WO2007089618A2 (en) 2006-01-27 2007-08-09 Phenomix Corporation Hepatitis c serine protease inhibitors and uses therefor
JP2009526854A (ja) 2006-02-16 2009-07-23 エスエムエイ ファンデーション 脊髄性筋萎縮症を治療するためのユビキチン/プロテアソーム阻害剤
EP2194039A1 (en) 2006-03-16 2010-06-09 Vertex Pharmceuticals Incorporated Process for preparing optically enriched compounds
US20080045521A1 (en) 2006-06-09 2008-02-21 Astrazeneca Ab Phenylalanine derivatives
US8710178B2 (en) 2006-10-18 2014-04-29 Lincoln University Macrocyclic cysteine protease inhibitors and compositions thereof
PT2439205E (pt) 2006-12-29 2015-07-16 Abbvie Deutschland Compostos de carboxamida e seus usos como inibidores de calpaína
CN101903392A (zh) 2007-02-27 2010-12-01 弗特克斯药品有限公司 丝氨酸蛋白酶的抑制剂
CA2691987C (en) 2007-06-12 2016-08-16 Achaogen, Inc. Antibacterial agents
EP2014657A1 (de) 2007-06-21 2009-01-14 Bayer Schering Pharma Aktiengesellschaft Diaminopyrimidine als Modulatoren des EP2-Rezeptors
TWI453019B (zh) 2007-12-28 2014-09-21 Abbvie Deutschland 甲醯胺化合物
TW201010700A (en) 2008-08-25 2010-03-16 Piramal Lifesciences Ltd Diacylglycerol acyltransferase inhibitors
US8629157B2 (en) 2009-01-05 2014-01-14 Boehringer Ingelheim International Gmbh Pyrrolidine compounds which modulate the CB2 receptor
GB2467561A (en) 2009-02-06 2010-08-11 Summit Corp Plc Dual calpain-ROS inhibitors
TWI519530B (zh) 2009-02-20 2016-02-01 艾伯維德國有限及兩合公司 羰醯胺化合物及其作為鈣蛋白酶(calpain)抑制劑之用途
US8236798B2 (en) 2009-05-07 2012-08-07 Abbott Gmbh & Co. Kg Carboxamide compounds and their use as calpain inhibitors
US9051304B2 (en) 2009-12-22 2015-06-09 AbbVie Deutschland GmbH & Co. KG Carboxamide compounds and their use as calpain inhibitors V
US8598211B2 (en) 2009-12-22 2013-12-03 Abbvie Inc. Carboxamide compounds and their use as calpain inhibitors IV
CN102812167A (zh) 2009-12-30 2012-12-05 阿维拉制药公司 蛋白的配体-介导的共价修饰
EP2560491A1 (en) 2010-04-21 2013-02-27 Signature Therapeutics, Inc. Peripheral opioid agonists and peripheral opioid antagonists
WO2011133871A2 (en) 2010-04-22 2011-10-27 Alnylam Pharmaceuticals, Inc. 5'-end derivatives
WO2011159781A2 (en) 2010-06-17 2011-12-22 Senomyx, Inc. Bitter taste modulators
US20120010235A1 (en) 2010-07-12 2012-01-12 Xin-Jie Chu N-substituted pyrrolidines
WO2012021788A2 (en) 2010-08-13 2012-02-16 Banyan Biomarkers Dipeptide calpain inhibitors
US9000025B2 (en) 2010-08-20 2015-04-07 Amira Pharmaceuticals, Inc. Autotaxin inhibitors and uses thereof
US20120095211A1 (en) 2010-09-22 2012-04-19 Intermune, Inc. Substituted proline inhibitors of hepatitis c virus replication
WO2012076639A1 (en) 2010-12-09 2012-06-14 Abbott Gmbh & Co. Kg Carboxamide compounds and their use as calpain inhibitors v
BR112013022946A2 (pt) 2011-03-09 2017-07-18 Signature Therapeutics Inc pró-fármacos de agentes ativos com ligantes heterocíclocos
US8685916B2 (en) 2011-03-09 2014-04-01 Signature Therapeutics, Inc. Opioid prodrugs with heterocyclic linkers
WO2012140500A1 (en) 2011-04-15 2012-10-18 New World Laboratories, Inc. Selective cysteine protease inhibitors and uses thereof
CN108383893A (zh) 2011-08-30 2018-08-10 塔夫茨大学信托人 用于治疗实体瘤的fap-活化的蛋白酶体抑制剂
KR20140102253A (ko) 2011-11-25 2014-08-21 에프. 호프만-라 로슈 아게 카텝신의 억제제로서의 피롤리딘 유도체
KR20140114827A (ko) 2012-01-11 2014-09-29 에프. 호프만-라 로슈 아게 프로테아제 억제제로서 매크로사이클릭 아미드
EP2834230A1 (en) 2012-04-03 2015-02-11 AbbVie Deutschland GmbH & Co KG Carboxamide compounds and their use as calpain inhibitors v
EP2844249A4 (en) 2012-05-02 2016-03-09 Univ Kansas State MACROCYCLIC AND PEPTIDOMIMETIC COMPOUNDS AS VIRUZIDES AGAINST 3C OR 3C LIKE PROTEASES OF PICORNIVERS, CALICIVIRES AND CORONA VIRUSES
WO2014075146A1 (en) 2012-11-16 2014-05-22 Adelaide Research & Innovation Pty Ltd Macrocyclic compounds and uses thereof
TW201506024A (zh) 2013-07-02 2015-02-16 必治妥美雅史谷比公司 作為有效rock抑制劑的三環甲醯胺衍生物
TW201605859A (zh) * 2013-11-14 2016-02-16 必治妥美雅史谷比公司 作為酪蛋白激酶1δ/ε抑制劑之新穎經取代之吡唑并-哌
EP3107952B1 (en) 2014-02-19 2018-09-26 ETH Zurich Method for the generation of chemical libraries
EP3119777A1 (de) 2014-03-21 2017-01-25 Bayer Pharma Aktiengesellschaft Cyano-substituierte imidazo[1,2-a]pyridincarboxamide und ihre verwendung
WO2015179441A2 (en) 2014-05-20 2015-11-26 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
WO2015196086A1 (en) 2014-06-20 2015-12-23 The University of Montana, Missoula, MT NOVEL INHIBITORS OF SYSTEM Xc(-)
WO2016027284A2 (en) 2014-08-22 2016-02-25 Alkem Laboratories Ltd. Piperidine ureas as cathepsin cysteine protease inhibitors
ES2714283T3 (es) 2014-09-04 2019-05-28 Bristol Myers Squibb Co Macrociclos de diamida que son inhibidores de FXIa
US11219670B2 (en) 2014-09-05 2022-01-11 The Johns Hopkins University Targeting CAPN9/CAPNS2 activity as a therapeutic strategy for the treatment of myofibroblast differentiation and associated pathologies
WO2016089648A1 (en) 2014-12-01 2016-06-09 Vtv Therapeutics Llc Bach 1 inhibitors in combination with nrf2 activators and pharmaceutical compositions thereof
ES2864839T3 (es) 2015-07-02 2021-10-14 Turning Point Therapeutics Inc Macrociclos de diarilo quirales como moduladores de proteína quinasas
US9938273B2 (en) 2015-12-07 2018-04-10 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
CN105669520B (zh) 2016-01-12 2018-10-30 山东大学 含有色氨酸基本骨架的邻苯二胺类选择性组蛋白去乙酰化酶抑制剂及其制备方法和应用
WO2017156074A1 (en) 2016-03-09 2017-09-14 Blade Therapeutics, Inc. Calpain modulators and methods of production and use thereof
WO2017156071A1 (en) 2016-03-09 2017-09-14 Blade Therapeutics, Inc. Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof
ES2965394T3 (es) 2016-06-29 2024-04-15 Univ California Compuestos y composiciones para el tratamiento del cáncer
AU2017292646A1 (en) 2016-07-05 2019-02-07 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
WO2018064119A1 (en) 2016-09-28 2018-04-05 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
AU2018289434A1 (en) 2017-06-23 2020-01-16 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
US20210009564A1 (en) 2018-03-28 2021-01-14 Blade Therapertics, Inc. Calpain modulators and therapeutic uses thereof
CA3093749A1 (en) 2018-03-28 2019-10-03 Blade Therapeutics, Inc. Method of treating fibrotic disease
WO2019217465A1 (en) 2018-05-09 2019-11-14 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof background
CN112703188A (zh) 2018-06-28 2021-04-23 布莱德治疗公司 用钙蛋白酶抑制剂治疗肝纤维化的方法
WO2020006177A1 (en) 2018-06-29 2020-01-02 Blade Therapeutics, Inc. Vascular adhesion protein-1 (vap-1) modulators and therapeutic uses thereof

Similar Documents

Publication Publication Date Title
JP2020500207A5 (OSRAM)
RU2011133825A (ru) Пирролопиридины, полезные в качестве ингибиторов протеинкиназы
JP2015522650A5 (OSRAM)
RU2017132433A (ru) Фторированные производные тетрагидронафтиридинилнонановой кислоты и их применение
CY1118721T1 (el) Παραγωγα 2,3 διϋδρο-1η-ινδεν-1-υλ-2,7-διαζασπειρο[3.6]εννεανιου και η χρηση αυτων ως ανταγωνιστες ή αντιστροφοι αγωνιστες του υποδοχεα γκρελινης
JP2017504642A5 (OSRAM)
JP2020500182A5 (OSRAM)
WO2009046834A3 (en) Use of t140 and optionally retrocyclin-1 as therapeutic agents for the treatment of m. tuberculosis infections
WO2009033756A3 (en) Use of oxyntomodulin alone or in combination with melanotropin potentiating factor as a therapeutic agent
JP2016500661A5 (OSRAM)
JP2014511891A5 (OSRAM)
WO2009033683A3 (en) Galanin message associated peptide alone or in combination with minigastrin as a therapeutic agent
JP2005528406A5 (OSRAM)
JP2015535832A5 (OSRAM)
WO2009040024A3 (en) Use of bim-23127 and optionally urodilatin as therapeutic agents eg for the treatment of m. tuberculosis infections
JP2009534405A5 (OSRAM)
WO2009043526A3 (en) Use of gip ( 6-30) alone or in combination with hgh as a therapeutic agent
WO2009040029A3 (en) Use of adrenomedullin as a therapeutic agent for the treatment of excessive angiogenesis
WO2012107706A8 (en) Phenothiazine diaminium salts and their use
WO2009046827A3 (en) Use of growth hormone-releasing factor and/or mage-3 antigen (271-279) as therapeutic agents
WO2009040028A3 (en) Use of casoxin c and optionally adrenomedullin as therapeutic agents for the treatment of excessive angiogenesis
JP2009502830A5 (OSRAM)
EA200800162A1 (ru) Новые фармацевтические композиции с замедленным высвобождением и способы их получения
WO2009039978A3 (en) Therapeutic use of neuropeptide ei and acth 7-38 and compositions thereof
JP2015507636A5 (OSRAM)