JP2020500005A5 - - Google Patents
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- JP2020500005A5 JP2020500005A5 JP2019518550A JP2019518550A JP2020500005A5 JP 2020500005 A5 JP2020500005 A5 JP 2020500005A5 JP 2019518550 A JP2019518550 A JP 2019518550A JP 2019518550 A JP2019518550 A JP 2019518550A JP 2020500005 A5 JP2020500005 A5 JP 2020500005A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- binding protein
- seq
- klebsiella
- pneumoniae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000025171 antigen binding proteins Human genes 0.000 claims description 210
- 108091000831 antigen binding proteins Proteins 0.000 claims description 210
- 241000588747 Klebsiella pneumoniae Species 0.000 claims description 86
- 238000000034 method Methods 0.000 claims description 62
- 239000000427 antigen Substances 0.000 claims description 60
- 102000036639 antigens Human genes 0.000 claims description 60
- 108091007433 antigens Proteins 0.000 claims description 60
- 241000588748 Klebsiella Species 0.000 claims description 52
- 210000004027 cell Anatomy 0.000 claims description 26
- 239000002158 endotoxin Substances 0.000 claims description 26
- 229920006008 lipopolysaccharide Polymers 0.000 claims description 26
- 230000003115 biocidal effect Effects 0.000 claims description 22
- 239000008194 pharmaceutical composition Substances 0.000 claims description 20
- 239000003242 anti bacterial agent Substances 0.000 claims description 19
- 230000000844 anti-bacterial effect Effects 0.000 claims description 14
- 210000002966 serum Anatomy 0.000 claims description 14
- 230000000295 complement effect Effects 0.000 claims description 13
- 238000003556 assay Methods 0.000 claims description 12
- 230000001419 dependent effect Effects 0.000 claims description 12
- 102000039446 nucleic acids Human genes 0.000 claims description 10
- 108020004707 nucleic acids Proteins 0.000 claims description 10
- 150000007523 nucleic acids Chemical class 0.000 claims description 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 9
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 8
- 206010061259 Klebsiella infection Diseases 0.000 claims description 8
- 229940088710 antibiotic agent Drugs 0.000 claims description 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 8
- 206010040047 Sepsis Diseases 0.000 claims description 6
- 241000191967 Staphylococcus aureus Species 0.000 claims description 6
- 239000012634 fragment Substances 0.000 claims description 6
- 238000002372 labelling Methods 0.000 claims description 6
- 230000004083 survival effect Effects 0.000 claims description 6
- 230000001225 therapeutic effect Effects 0.000 claims description 6
- 102000023732 binding proteins Human genes 0.000 claims description 5
- 108091008324 binding proteins Proteins 0.000 claims description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 4
- 108010043121 Green Fluorescent Proteins Proteins 0.000 claims description 4
- 102000004144 Green Fluorescent Proteins Human genes 0.000 claims description 4
- 101710154606 Hemagglutinin Proteins 0.000 claims description 4
- 108060003951 Immunoglobulin Proteins 0.000 claims description 4
- 241001534216 Klebsiella granulomatis Species 0.000 claims description 4
- 241000588749 Klebsiella oxytoca Species 0.000 claims description 4
- 201000009906 Meningitis Diseases 0.000 claims description 4
- 241000699666 Mus <mouse, genus> Species 0.000 claims description 4
- 241000699670 Mus sp. Species 0.000 claims description 4
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims description 4
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims description 4
- 101710176177 Protein A56 Proteins 0.000 claims description 4
- 108091005948 blue fluorescent proteins Proteins 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 239000012636 effector Substances 0.000 claims description 4
- 239000005090 green fluorescent protein Substances 0.000 claims description 4
- 239000000185 hemagglutinin Substances 0.000 claims description 4
- 210000004408 hybridoma Anatomy 0.000 claims description 4
- 102000018358 immunoglobulin Human genes 0.000 claims description 4
- 208000015181 infectious disease Diseases 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 231100000518 lethal Toxicity 0.000 claims description 4
- 230000001665 lethal effect Effects 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 241000588746 Raoultella planticola Species 0.000 claims description 3
- 108091006047 fluorescent proteins Proteins 0.000 claims description 3
- 102000034287 fluorescent proteins Human genes 0.000 claims description 3
- 101100476210 Caenorhabditis elegans rnt-1 gene Proteins 0.000 claims description 2
- 229930186147 Cephalosporin Natural products 0.000 claims description 2
- 208000003322 Coinfection Diseases 0.000 claims description 2
- 108010078777 Colistin Proteins 0.000 claims description 2
- 241000699802 Cricetulus griseus Species 0.000 claims description 2
- 206010011409 Cross infection Diseases 0.000 claims description 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims description 2
- 206010012735 Diarrhoea Diseases 0.000 claims description 2
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims description 2
- 206010024652 Liver abscess Diseases 0.000 claims description 2
- 208000006816 Neonatal Sepsis Diseases 0.000 claims description 2
- 206010029803 Nosocomial infection Diseases 0.000 claims description 2
- 108700022034 Opsonin Proteins Proteins 0.000 claims description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 2
- 206010035664 Pneumonia Diseases 0.000 claims description 2
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims description 2
- 206010062255 Soft tissue infection Diseases 0.000 claims description 2
- 208000006045 Spondylarthropathies Diseases 0.000 claims description 2
- 239000004098 Tetracycline Substances 0.000 claims description 2
- 206010048038 Wound infection Diseases 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- 239000002246 antineoplastic agent Substances 0.000 claims description 2
- 239000003963 antioxidant agent Substances 0.000 claims description 2
- 230000003078 antioxidant effect Effects 0.000 claims description 2
- 229960002685 biotin Drugs 0.000 claims description 2
- 235000020958 biotin Nutrition 0.000 claims description 2
- 239000011616 biotin Substances 0.000 claims description 2
- 229940041011 carbapenems Drugs 0.000 claims description 2
- 229940124587 cephalosporin Drugs 0.000 claims description 2
- 150000001780 cephalosporins Chemical class 0.000 claims description 2
- 229960005091 chloramphenicol Drugs 0.000 claims description 2
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 claims description 2
- 238000011260 co-administration Methods 0.000 claims description 2
- 229960003346 colistin Drugs 0.000 claims description 2
- 229940127089 cytotoxic agent Drugs 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 206010014801 endophthalmitis Diseases 0.000 claims description 2
- 238000000684 flow cytometry Methods 0.000 claims description 2
- 229940124307 fluoroquinolone Drugs 0.000 claims description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 2
- 239000010931 gold Substances 0.000 claims description 2
- 229910052737 gold Inorganic materials 0.000 claims description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 2
- 210000005260 human cell Anatomy 0.000 claims description 2
- 238000001948 isotopic labelling Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229960002260 meropenem Drugs 0.000 claims description 2
- DMJNNHOOLUXYBV-PQTSNVLCSA-N meropenem Chemical compound C=1([C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)S[C@@H]1CN[C@H](C(=O)N(C)C)C1 DMJNNHOOLUXYBV-PQTSNVLCSA-N 0.000 claims description 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 2
- JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 claims description 2
- 230000002956 necrotizing effect Effects 0.000 claims description 2
- 230000014207 opsonization Effects 0.000 claims description 2
- 230000003287 optical effect Effects 0.000 claims description 2
- 210000001672 ovary Anatomy 0.000 claims description 2
- XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 claims description 2
- KNIWPHSUTGNZST-UHFFFAOYSA-N polymyxin E2 Natural products CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O KNIWPHSUTGNZST-UHFFFAOYSA-N 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 230000002335 preservative effect Effects 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 150000007660 quinolones Chemical class 0.000 claims description 2
- 238000003127 radioimmunoassay Methods 0.000 claims description 2
- 230000001235 sensitizing effect Effects 0.000 claims description 2
- 230000011664 signaling Effects 0.000 claims description 2
- 201000005671 spondyloarthropathy Diseases 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- 229940124530 sulfonamide Drugs 0.000 claims description 2
- 150000003456 sulfonamides Chemical class 0.000 claims description 2
- 230000002195 synergetic effect Effects 0.000 claims description 2
- 235000019364 tetracycline Nutrition 0.000 claims description 2
- 229940040944 tetracyclines Drugs 0.000 claims description 2
- 150000003522 tetracyclines Chemical class 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 231100000419 toxicity Toxicity 0.000 claims description 2
- 230000001988 toxicity Effects 0.000 claims description 2
- 239000003053 toxin Substances 0.000 claims description 2
- 231100000765 toxin Toxicity 0.000 claims description 2
- 108700012359 toxins Proteins 0.000 claims description 2
- 229960001082 trimethoprim Drugs 0.000 claims description 2
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 claims description 2
- 208000019206 urinary tract infection Diseases 0.000 claims description 2
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 208000032376 Lung infection Diseases 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 108091005957 yellow fluorescent proteins Proteins 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 201000002661 Spondylitis Diseases 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662410005P | 2016-10-19 | 2016-10-19 | |
| US62/410,005 | 2016-10-19 | ||
| PCT/US2017/056725 WO2018075375A1 (en) | 2016-10-19 | 2017-10-16 | Anti-o1 antibodies and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020500005A JP2020500005A (ja) | 2020-01-09 |
| JP2020500005A5 true JP2020500005A5 (enExample) | 2020-11-19 |
| JP7160484B2 JP7160484B2 (ja) | 2022-10-25 |
Family
ID=62019658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019518550A Active JP7160484B2 (ja) | 2016-10-19 | 2017-10-16 | 抗ｏ１抗体およびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US11117956B2 (enExample) |
| EP (1) | EP3529273A4 (enExample) |
| JP (1) | JP7160484B2 (enExample) |
| KR (1) | KR20190064636A (enExample) |
| CN (1) | CN109843917B (enExample) |
| AU (1) | AU2017346488A1 (enExample) |
| BR (1) | BR112019007147A2 (enExample) |
| CA (1) | CA3039686A1 (enExample) |
| EA (1) | EA201990895A1 (enExample) |
| IL (1) | IL266049A (enExample) |
| SG (1) | SG11201903063UA (enExample) |
| WO (1) | WO2018075375A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201900027XA (en) | 2016-08-05 | 2019-02-27 | Medimmune Llc | Anti-o2 antibodies and uses thereof |
| WO2018075375A1 (en) | 2016-10-19 | 2018-04-26 | Medimmune, Llc | Anti-o1 antibodies and uses thereof |
| BR112021024197A2 (pt) * | 2019-06-06 | 2022-04-26 | Nomad Bioscience Gmbh | Klebicinas para o controle de klebsiella |
| WO2021186398A1 (en) | 2020-03-19 | 2021-09-23 | Medimmune Limited | Anti-klebsiella pneumoniae antibodies and uses thereof |
| CN116033922B (zh) * | 2021-08-25 | 2025-08-19 | 北京三诺佳邑生物技术有限责任公司 | 特异性识别肺炎克雷伯菌o1抗原的抗体及其应用 |
| US20250066458A1 (en) * | 2021-12-06 | 2025-02-27 | Beijing Solobio Genetechnology Co., Ltd. | Bispecific Antibodies Specifically Binding to Klebsiella Pneumoniae O2 Antigen and O1 Antigen and Compositions Thereof |
| IT202300000924U1 (it) * | 2023-01-23 | 2024-12-22 | Philomena Dove | Cucitura all-up leggins seamless |
| CN118620072A (zh) * | 2023-12-27 | 2024-09-10 | 上海博钒生物科技有限公司 | 一种肺炎克雷伯菌多糖单克隆抗体、其杂交瘤细胞株及其应用 |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4474893A (en) | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
| US4714681A (en) | 1981-07-01 | 1987-12-22 | The Board Of Reagents, The University Of Texas System Cancer Center | Quadroma cells and trioma cells and methods for the production of same |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5179018A (en) | 1983-10-14 | 1993-01-12 | Centocor, Inc. | Mamalian monoclonal antibodies against endotoxin of gram-negative bacteria |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| US4925648A (en) | 1988-07-29 | 1990-05-15 | Immunomedics, Inc. | Detection and treatment of infectious and inflammatory lesions |
| US5601819A (en) | 1988-08-11 | 1997-02-11 | The General Hospital Corporation | Bispecific antibodies for selective immune regulation and for selective immune cell binding |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| ATE144793T1 (de) | 1989-06-29 | 1996-11-15 | Medarex Inc | Bispezifische reagenzien für die aids-therapie |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| KR100272077B1 (ko) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물 |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| AU667460B2 (en) | 1990-10-05 | 1996-03-28 | Medarex, Inc. | Targeted immunostimulation with bispecific reagents |
| AU8727291A (en) | 1990-10-29 | 1992-06-11 | Cetus Oncology Corporation | Bispecific antibodies, method of production, and uses thereof |
| WO1992009690A2 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
| WO1992019973A1 (en) | 1991-04-26 | 1992-11-12 | Surface Active Limited | Novel antibodies, and methods for their use |
| AU3178993A (en) | 1991-11-25 | 1993-06-28 | Enzon, Inc. | Multivalent antigen-binding proteins |
| ATE408012T1 (de) | 1991-12-02 | 2008-09-15 | Medical Res Council | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
| CA2131528C (en) | 1992-03-05 | 2004-07-13 | Philip E. Thorpe | Methods and compositions for targeting the vasculature of solid tumors |
| CA2118508A1 (en) | 1992-04-24 | 1993-11-11 | Elizabeth S. Ward | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
| EP0672142B1 (en) | 1992-12-04 | 2001-02-28 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
| US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| US6180377B1 (en) | 1993-06-16 | 2001-01-30 | Celltech Therapeutics Limited | Humanized antibodies |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US7264963B1 (en) | 1995-08-18 | 2007-09-04 | Morphosys Ag | Protein(poly)peptide libraries |
| CA2229043C (en) | 1995-08-18 | 2016-06-07 | Morphosys Gesellschaft Fur Proteinoptimierung Mbh | Protein/(poly)peptide libraries |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| BR0008758A (pt) | 1999-01-15 | 2001-12-04 | Genentech Inc | Variantes de polipeptìdeos parentais com funçãoefetora alterada, polipeptìdeos, composição ácidonucleico isolado, vetor, célula hospedeira,método para produzir uma variante depolipeptìdeo, método para o tratamento de umadesordem em mamìferos e método para produziruma região fc variante |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US7183387B1 (en) | 1999-01-15 | 2007-02-27 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US6897044B1 (en) | 1999-01-28 | 2005-05-24 | Biogen Idec, Inc. | Production of tetravalent antibodies |
| US6360513B1 (en) | 1999-05-11 | 2002-03-26 | Sargento Foods Inc. | Resealable bag for filling with food product(s) and method |
| WO2001002588A2 (en) | 1999-07-02 | 2001-01-11 | Morphosys Ag | Generation of specific binding partners binding to (poly)peptides encoded by genomic dna fragments or ests |
| US7658921B2 (en) | 2000-12-12 | 2010-02-09 | Medimmune, Llc | Molecules with extended half-lives, compositions and uses thereof |
| PT1355919E (pt) | 2000-12-12 | 2011-03-02 | Medimmune Llc | Moléculas com semivida longa, composições que as contêm e suas utilizações |
| WO2002096948A2 (en) | 2001-01-29 | 2002-12-05 | Idec Pharmaceuticals Corporation | Engineered tetravalent antibodies and methods of use |
| US20030020733A1 (en) | 2001-07-24 | 2003-01-30 | Yin Memphis Zhihong | Computer display having selective area magnification |
| US20040002587A1 (en) | 2002-02-20 | 2004-01-01 | Watkins Jeffry D. | Fc region variants |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| EP1587540B1 (en) | 2003-01-09 | 2021-09-15 | MacroGenics, Inc. | IDENTIFICATION AND ENGINEERING OF ANTIBODIES WITH VARIANT Fc REGIONS AND METHODS OF USING SAME |
| EA013614B1 (ru) | 2003-07-15 | 2010-06-30 | Амджен Инк. | Изолированное антитело к фактору роста нервов (ngf) и способы его применения |
| DK1933871T3 (da) | 2005-09-07 | 2013-07-08 | Amgen Fremont Inc | Humane monoklonale antistoffer mod activin-receptor-lignende kinase-1 |
| EP2152731A2 (en) * | 2007-05-02 | 2010-02-17 | Intercell AG | Klebsiella antigens |
| EP2240203B1 (en) | 2008-02-05 | 2014-04-09 | Bristol-Myers Squibb Company | Alpha 5 - beta 1 antibodies and their uses |
| US8271784B2 (en) | 2009-10-15 | 2012-09-18 | International Business Machines Corporation | Communication between key manager and storage subsystem kernel via management console |
| MX353233B (es) | 2009-12-06 | 2018-01-08 | Bioverativ Therapeutics Inc | Polipéptidos híbridos y quiméricos del factor viii-fc, y métodos de uso de los mismos. |
| WO2012006635A1 (en) | 2010-07-09 | 2012-01-12 | Biogen Idec Hemophilia Inc. | Processable single chain molecules and polypeptides made using same |
| EA028433B1 (ru) | 2012-03-08 | 2017-11-30 | Янссен Вэксинс Энд Превеншн Б.В. | Антитело, связывающееся с вирусами гриппа b и его применение |
| WO2014027697A1 (en) * | 2012-08-13 | 2014-02-20 | Kyowa Hakko Kirin Co., Ltd. | Anti-pneumococcal surface protein (psp) monoclonal antibody |
| EA201500362A1 (ru) | 2012-10-05 | 2015-08-31 | Кадмон Корпорейшн, Ллк | Ингибиторы rho-киназы |
| WO2015175874A2 (en) | 2014-05-16 | 2015-11-19 | Medimmune, Llc | Molecules with altered neonate fc receptor binding having enhanced therapeutic and diagnostic properties |
| CA2973134A1 (en) | 2015-02-17 | 2016-08-25 | Arsanis Biosciences Gmbh | Antibodies targeting a galactan-based o-antigen of k. pneumoniae |
| MX2018001964A (es) | 2015-08-24 | 2018-06-19 | Medimmune Llc | Polipeptidos mrka, anticuerpos y usos de los mismos. |
| BR112018007483A2 (pt) | 2015-10-16 | 2018-10-23 | Arsanis Biosciences Gmbh | ?anticorpo monoclonal bactericida contra klebsiella pneumoniae, uma preparação farmacêutica para uso médico e diagnóstico; ácido nucleico codificante; e método de produção? |
| SG11201900027XA (en) | 2016-08-05 | 2019-02-27 | Medimmune Llc | Anti-o2 antibodies and uses thereof |
| WO2018075375A1 (en) | 2016-10-19 | 2018-04-26 | Medimmune, Llc | Anti-o1 antibodies and uses thereof |
-
2017
- 2017-10-16 WO PCT/US2017/056725 patent/WO2018075375A1/en not_active Ceased
- 2017-10-16 EP EP17861658.7A patent/EP3529273A4/en active Pending
- 2017-10-16 CN CN201780063662.5A patent/CN109843917B/zh active Active
- 2017-10-16 SG SG11201903063UA patent/SG11201903063UA/en unknown
- 2017-10-16 EA EA201990895A patent/EA201990895A1/ru unknown
- 2017-10-16 CA CA3039686A patent/CA3039686A1/en active Pending
- 2017-10-16 KR KR1020197013535A patent/KR20190064636A/ko not_active Withdrawn
- 2017-10-16 BR BR112019007147A patent/BR112019007147A2/pt not_active Application Discontinuation
- 2017-10-16 AU AU2017346488A patent/AU2017346488A1/en not_active Abandoned
- 2017-10-16 US US16/342,688 patent/US11117956B2/en active Active
- 2017-10-16 JP JP2019518550A patent/JP7160484B2/ja active Active
-
2019
- 2019-04-15 IL IL266049A patent/IL266049A/en unknown
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2021
- 2021-08-09 US US17/397,474 patent/US12018068B2/en active Active
-
2024
- 2024-05-24 US US18/673,848 patent/US20240383969A1/en active Pending
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