CA3039686A1 - Anti-o1 antibodies and uses thereof - Google Patents
Anti-o1 antibodies and uses thereof Download PDFInfo
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- CA3039686A1 CA3039686A1 CA3039686A CA3039686A CA3039686A1 CA 3039686 A1 CA3039686 A1 CA 3039686A1 CA 3039686 A CA3039686 A CA 3039686A CA 3039686 A CA3039686 A CA 3039686A CA 3039686 A1 CA3039686 A1 CA 3039686A1
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- binding protein
- antigen binding
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- klebsiella
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Classifications
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- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
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- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/24—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- G01N2333/26—Klebsiella (G)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
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Applications Claiming Priority (3)
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| US201662410005P | 2016-10-19 | 2016-10-19 | |
| US62/410,005 | 2016-10-19 | ||
| PCT/US2017/056725 WO2018075375A1 (en) | 2016-10-19 | 2017-10-16 | Anti-o1 antibodies and uses thereof |
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| CA3039686A1 true CA3039686A1 (en) | 2018-04-26 |
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| EP (1) | EP3529273A4 (enExample) |
| JP (1) | JP7160484B2 (enExample) |
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| CA (1) | CA3039686A1 (enExample) |
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| SG (1) | SG11201903063UA (enExample) |
| WO (1) | WO2018075375A1 (enExample) |
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| SG11201900027XA (en) | 2016-08-05 | 2019-02-27 | Medimmune Llc | Anti-o2 antibodies and uses thereof |
| WO2018075375A1 (en) | 2016-10-19 | 2018-04-26 | Medimmune, Llc | Anti-o1 antibodies and uses thereof |
| BR112021024197A2 (pt) * | 2019-06-06 | 2022-04-26 | Nomad Bioscience Gmbh | Klebicinas para o controle de klebsiella |
| WO2021186398A1 (en) | 2020-03-19 | 2021-09-23 | Medimmune Limited | Anti-klebsiella pneumoniae antibodies and uses thereof |
| CN116033922B (zh) * | 2021-08-25 | 2025-08-19 | 北京三诺佳邑生物技术有限责任公司 | 特异性识别肺炎克雷伯菌o1抗原的抗体及其应用 |
| US20250066458A1 (en) * | 2021-12-06 | 2025-02-27 | Beijing Solobio Genetechnology Co., Ltd. | Bispecific Antibodies Specifically Binding to Klebsiella Pneumoniae O2 Antigen and O1 Antigen and Compositions Thereof |
| IT202300000924U1 (it) * | 2023-01-23 | 2024-12-22 | Philomena Dove | Cucitura all-up leggins seamless |
| CN118620072A (zh) * | 2023-12-27 | 2024-09-10 | 上海博钒生物科技有限公司 | 一种肺炎克雷伯菌多糖单克隆抗体、其杂交瘤细胞株及其应用 |
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| US4474893A (en) | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
| US4714681A (en) | 1981-07-01 | 1987-12-22 | The Board Of Reagents, The University Of Texas System Cancer Center | Quadroma cells and trioma cells and methods for the production of same |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5179018A (en) | 1983-10-14 | 1993-01-12 | Centocor, Inc. | Mamalian monoclonal antibodies against endotoxin of gram-negative bacteria |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
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-
2017
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- 2017-10-16 EP EP17861658.7A patent/EP3529273A4/en active Pending
- 2017-10-16 CN CN201780063662.5A patent/CN109843917B/zh active Active
- 2017-10-16 SG SG11201903063UA patent/SG11201903063UA/en unknown
- 2017-10-16 EA EA201990895A patent/EA201990895A1/ru unknown
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- 2017-10-16 KR KR1020197013535A patent/KR20190064636A/ko not_active Withdrawn
- 2017-10-16 BR BR112019007147A patent/BR112019007147A2/pt not_active Application Discontinuation
- 2017-10-16 AU AU2017346488A patent/AU2017346488A1/en not_active Abandoned
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| Publication number | Publication date |
|---|---|
| JP2020500005A (ja) | 2020-01-09 |
| US20220056113A1 (en) | 2022-02-24 |
| US20200231660A1 (en) | 2020-07-23 |
| US12018068B2 (en) | 2024-06-25 |
| KR20190064636A (ko) | 2019-06-10 |
| AU2017346488A1 (en) | 2019-05-30 |
| EP3529273A4 (en) | 2020-07-01 |
| US20240383969A1 (en) | 2024-11-21 |
| CN109843917B (zh) | 2023-10-03 |
| EA201990895A1 (ru) | 2019-10-31 |
| SG11201903063UA (en) | 2019-05-30 |
| EP3529273A1 (en) | 2019-08-28 |
| CN109843917A (zh) | 2019-06-04 |
| JP7160484B2 (ja) | 2022-10-25 |
| WO2018075375A1 (en) | 2018-04-26 |
| IL266049A (en) | 2019-06-30 |
| BR112019007147A2 (pt) | 2019-06-25 |
| US11117956B2 (en) | 2021-09-14 |
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