JP2020189864A5 - - Google Patents
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- JP2020189864A5 JP2020189864A5 JP2020135560A JP2020135560A JP2020189864A5 JP 2020189864 A5 JP2020189864 A5 JP 2020189864A5 JP 2020135560 A JP2020135560 A JP 2020135560A JP 2020135560 A JP2020135560 A JP 2020135560A JP 2020189864 A5 JP2020189864 A5 JP 2020189864A5
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- JP
- Japan
- Prior art keywords
- compound
- use according
- pharmaceutically acceptable
- acceptable salt
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 21
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 208000018737 Parkinson disease Diseases 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 239000007864 aqueous solution Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000007935 neutral effect Effects 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- 239000000939 antiparkinson agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 0 C[C@](Cc1cc(O)c(*)cc1)(C(O*)=O)NN Chemical compound C[C@](Cc1cc(O)c(*)cc1)(C(O*)=O)NN 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021132161A JP2021183628A (ja) | 2014-10-21 | 2021-08-16 | カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法 |
| JP2023174083A JP7688087B2 (ja) | 2014-10-21 | 2023-10-06 | カルビドパおよびｌ－ドーパプロドラッグならびにそれらの使用方法 |
| JP2025084629A JP2025118978A (ja) | 2014-10-21 | 2025-05-21 | カルビドパおよびｌ－ドーパプロドラッグならびにそれらの使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462066771P | 2014-10-21 | 2014-10-21 | |
| US62/066,771 | 2014-10-21 | ||
| JP2019139442A JP6750076B2 (ja) | 2014-10-21 | 2019-07-30 | カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019139442A Division JP6750076B2 (ja) | 2014-10-21 | 2019-07-30 | カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021132161A Division JP2021183628A (ja) | 2014-10-21 | 2021-08-16 | カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020189864A JP2020189864A (ja) | 2020-11-26 |
| JP2020189864A5 true JP2020189864A5 (enExample) | 2021-05-06 |
| JP6932227B2 JP6932227B2 (ja) | 2021-09-08 |
Family
ID=54478240
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017521517A Active JP6567049B2 (ja) | 2014-10-21 | 2015-10-21 | カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法 |
| JP2019139442A Active JP6750076B2 (ja) | 2014-10-21 | 2019-07-30 | カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法 |
| JP2020135560A Active JP6932227B2 (ja) | 2014-10-21 | 2020-08-11 | カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法 |
| JP2021132161A Pending JP2021183628A (ja) | 2014-10-21 | 2021-08-16 | カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法 |
| JP2023174083A Active JP7688087B2 (ja) | 2014-10-21 | 2023-10-06 | カルビドパおよびｌ－ドーパプロドラッグならびにそれらの使用方法 |
| JP2025084629A Pending JP2025118978A (ja) | 2014-10-21 | 2025-05-21 | カルビドパおよびｌ－ドーパプロドラッグならびにそれらの使用方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017521517A Active JP6567049B2 (ja) | 2014-10-21 | 2015-10-21 | カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法 |
| JP2019139442A Active JP6750076B2 (ja) | 2014-10-21 | 2019-07-30 | カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021132161A Pending JP2021183628A (ja) | 2014-10-21 | 2021-08-16 | カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法 |
| JP2023174083A Active JP7688087B2 (ja) | 2014-10-21 | 2023-10-06 | カルビドパおよびｌ－ドーパプロドラッグならびにそれらの使用方法 |
| JP2025084629A Pending JP2025118978A (ja) | 2014-10-21 | 2025-05-21 | カルビドパおよびｌ－ドーパプロドラッグならびにそれらの使用方法 |
Country Status (37)
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US10258585B2 (en) | 2014-03-13 | 2019-04-16 | Neuroderm, Ltd. | DOPA decarboxylase inhibitor compositions |
| PL3777833T3 (pl) | 2014-03-13 | 2024-03-25 | Neuroderm Ltd. | Kompozycje inhibitorów dekarboksylazy dopa |
| ES2739536T3 (es) * | 2014-10-21 | 2020-01-31 | Abbvie Inc | Profármacos de carbidopa y L-dopa y su uso para tratar la enfermedad de Parkinson |
| US20190224220A1 (en) * | 2016-04-20 | 2019-07-25 | Abbvie Inc. | Carbidopa and L-Dopa Prodrugs and Methods of Use |
| US11148999B2 (en) | 2016-06-22 | 2021-10-19 | MedChem Partners, LLC | Nitric oxide donors |
| WO2018154447A1 (en) * | 2017-02-21 | 2018-08-30 | Neuroderm Ltd | Dopa decarboxylase inhibitor compositions |
| US20180311238A1 (en) * | 2017-04-28 | 2018-11-01 | Saniona A/S | Selective Agonist Of a6 Containing nAChRs |
| WO2019097120A1 (en) | 2017-11-16 | 2019-05-23 | Orion Corporation | New use and pharmaceutical dosage forms |
| PT3713933T (pt) | 2017-11-24 | 2026-05-19 | H Lundbeck As | Novos profrmacos de catecolamina para utilizao no tratamento de doena de parkinson |
| CN110294789A (zh) * | 2018-03-21 | 2019-10-01 | 海南大学 | 含多巴寡肽的合成方法及其在抗帕金森病前药方面的应用 |
| CN112770734B (zh) | 2018-09-13 | 2024-08-20 | 堪培拉大学 | 抑制方法 |
| TW202031265A (zh) * | 2018-11-15 | 2020-09-01 | 美商艾伯維有限公司 | 用於皮下投藥之醫藥調配物 |
| WO2020178810A1 (en) * | 2019-03-04 | 2020-09-10 | Neuroderm, Ltd. | Pharmaceutical compositions comprising levodopa amide derivatives and uses thereof |
| US11130775B2 (en) | 2019-05-20 | 2021-09-28 | H. Lundbeck A/S | Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11111263B2 (en) | 2019-05-20 | 2021-09-07 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11168056B2 (en) | 2019-05-20 | 2021-11-09 | H. Lundbeck A/S | Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol |
| US11104697B2 (en) | 2019-05-20 | 2021-08-31 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| JP7641234B2 (ja) | 2019-05-21 | 2025-03-06 | ハー・ルンドベック・アクチエゼルスカベット | パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ |
| US12391650B2 (en) | 2019-05-21 | 2025-08-19 | H. Lundbeck A/S | Catecholamine prodrugs for use in the treatment of Parkinson's disease |
| EP3972600B1 (en) | 2019-05-21 | 2026-02-18 | H. Lundbeck A/S | Catecholamine carbamate prodrugs for use in the treatment of parkinson s disease |
| WO2020234275A1 (en) | 2019-05-21 | 2020-11-26 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's diseases |
| US11213502B1 (en) | 2020-11-17 | 2022-01-04 | Neuroderm, Ltd. | Method for treatment of parkinson's disease |
| US11331293B1 (en) | 2020-11-17 | 2022-05-17 | Neuroderm, Ltd. | Method for treatment of Parkinson's disease |
| US11844754B2 (en) | 2020-11-17 | 2023-12-19 | Neuroderm, Ltd. | Methods for treatment of Parkinson's disease |
| MX2023010450A (es) * | 2021-03-10 | 2023-09-14 | Neuroderm Ltd | Composiciones liquidas estabilizadas que comprenden un conjugado de tirosina y levodopa, y usos de estas. |
| EP4223288B1 (en) | 2022-02-07 | 2024-03-06 | Berlirem GmbH | Novel kit of pharmaceutical preparations for the treatment of parkinson's disease |
| US12161612B2 (en) | 2023-04-14 | 2024-12-10 | Neuroderm, Ltd. | Methods and compositions for reducing symptoms of Parkinson's disease |
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2015
- 2015-10-21 ES ES15791424T patent/ES2739536T3/es active Active
- 2015-10-21 MX MX2017005236A patent/MX381069B/es unknown
- 2015-10-21 RU RU2017117413A patent/RU2743347C2/ru active
- 2015-10-21 TR TR2019/08296T patent/TR201908296T4/tr unknown
- 2015-10-21 TW TW110101738A patent/TWI755257B/zh active
- 2015-10-21 EP EP15791424.3A patent/EP3209302B1/en active Active
- 2015-10-21 CA CA2965379A patent/CA2965379A1/en not_active Abandoned
- 2015-10-21 KR KR1020177013734A patent/KR102537018B1/ko active Active
- 2015-10-21 DK DK15791424.3T patent/DK3209302T3/da active
- 2015-10-21 CN CN201580069519.8A patent/CN107206013A/zh active Pending
- 2015-10-21 SM SM20190376T patent/SMT201900376T1/it unknown
- 2015-10-21 SI SI201530761T patent/SI3209302T1/sl unknown
- 2015-10-21 HR HRP20191285TT patent/HRP20191285T1/hr unknown
- 2015-10-21 RU RU2021103000A patent/RU2021103000A/ru unknown
- 2015-10-21 KR KR1020237015051A patent/KR20230066484A/ko not_active Ceased
- 2015-10-21 RS RS20190854A patent/RS58972B1/sr unknown
- 2015-10-21 AU AU2015335941A patent/AU2015335941B2/en active Active
- 2015-10-21 KR KR1020247023761A patent/KR20240113982A/ko active Pending
- 2015-10-21 MX MX2021003840A patent/MX393568B/es unknown
- 2015-10-21 EP EP19164151.3A patent/EP3569587A1/en not_active Withdrawn
- 2015-10-21 AR ARP150103412A patent/AR102389A1/es unknown
- 2015-10-21 CN CN202010250040.7A patent/CN111494395B/zh active Active
- 2015-10-21 CN CN202010250046.4A patent/CN111454290B/zh active Active
- 2015-10-21 UA UAA201704815A patent/UA120437C2/uk unknown
- 2015-10-21 MY MYPI2017701367A patent/MY189519A/en unknown
- 2015-10-21 US US14/919,418 patent/US9446059B2/en active Active
- 2015-10-21 PT PT15791424T patent/PT3209302T/pt unknown
- 2015-10-21 BR BR112017008198-9A patent/BR112017008198B1/pt active IP Right Grant
- 2015-10-21 CN CN202010123543.8A patent/CN111362980B/zh active Active
- 2015-10-21 SG SG11201703170RA patent/SG11201703170RA/en unknown
- 2015-10-21 JP JP2017521517A patent/JP6567049B2/ja active Active
- 2015-10-21 PL PL15791424T patent/PL3209302T3/pl unknown
- 2015-10-21 LT LTEP15791424.3T patent/LT3209302T/lt unknown
- 2015-10-21 TW TW104134601A patent/TWI718999B/zh active
- 2015-10-21 EP EP22204022.2A patent/EP4186510A1/en active Pending
- 2015-10-21 HU HUE15791424 patent/HUE044115T2/hu unknown
- 2015-10-21 WO PCT/US2015/056686 patent/WO2016065019A1/en not_active Ceased
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2016
- 2016-07-21 US US15/216,009 patent/US20160362431A1/en not_active Abandoned
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2017
- 2017-04-19 ZA ZA2017/02760A patent/ZA201702760B/en unknown
- 2017-04-20 IL IL251829A patent/IL251829B/en active IP Right Grant
- 2017-04-20 SA SA521421115A patent/SA521421115B1/ar unknown
- 2017-04-21 PH PH12017500746A patent/PH12017500746B1/en unknown
- 2017-09-26 US US15/715,245 patent/US10174061B2/en active Active
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2018
- 2018-12-05 US US16/210,996 patent/US10730895B2/en active Active
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2019
- 2019-07-19 CY CY20191100771T patent/CY1121826T1/el unknown
- 2019-07-30 JP JP2019139442A patent/JP6750076B2/ja active Active
- 2019-08-23 IL IL268885A patent/IL268885B/en active IP Right Grant
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2020
- 2020-05-04 US US16/866,400 patent/US11091507B2/en not_active Expired - Fee Related
- 2020-08-04 IL IL276493A patent/IL276493A/en unknown
- 2020-08-11 JP JP2020135560A patent/JP6932227B2/ja active Active
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2021
- 2021-03-04 AU AU2021201414A patent/AU2021201414B2/en active Active
- 2021-07-16 US US17/378,321 patent/US20220153765A1/en not_active Abandoned
- 2021-08-16 JP JP2021132161A patent/JP2021183628A/ja active Pending
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2022
- 2022-10-24 US US17/971,836 patent/US20230106081A1/en not_active Abandoned
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2023
- 2023-02-20 HU HUS2300009C patent/HUS2300009I1/hu unknown
- 2023-03-07 CY CY2023010C patent/CY2023010I1/el unknown
- 2023-03-20 NO NO2023013C patent/NO2023013I1/no unknown
- 2023-03-24 NL NL301224C patent/NL301224I2/nl unknown
- 2023-03-31 FI FIC20230014C patent/FIC20230014I1/fi unknown
- 2023-04-03 LU LU00304C patent/LUC00304I2/fr unknown
- 2023-06-08 LT LTPA2023519C patent/LTC3209302I2/lt unknown
- 2023-08-04 AU AU2023210650A patent/AU2023210650A1/en not_active Abandoned
- 2023-09-29 FR FR23C1035C patent/FR23C1035I2/fr active Active
- 2023-10-06 JP JP2023174083A patent/JP7688087B2/ja active Active
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2025
- 2025-05-21 JP JP2025084629A patent/JP2025118978A/ja active Pending
- 2025-09-25 AU AU2025238004A patent/AU2025238004A1/en active Pending
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