JP6567049B2 - カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法 - Google Patents

カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法 Download PDF

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Publication number
JP6567049B2
JP6567049B2 JP2017521517A JP2017521517A JP6567049B2 JP 6567049 B2 JP6567049 B2 JP 6567049B2 JP 2017521517 A JP2017521517 A JP 2017521517A JP 2017521517 A JP2017521517 A JP 2017521517A JP 6567049 B2 JP6567049 B2 JP 6567049B2
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Japan
Prior art keywords
compound
formula
another embodiment
pharmaceutically acceptable
dopa
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JP2017521517A
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Japanese (ja)
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JP2017537066A5 (enExample
JP2017537066A (ja
Inventor
カーディナル−デイビッド，ベノイト
チャン，ビンセント・エス
デンパー，カッシブラ・イー
エンライト，ブライアン・ピー
ヘンリー，ロジャー・エフ
ホー，レイモンド
ホワン，イエ
ハターズ，アレクサンダー・ディー
クリックス，ラッセル・シー
クラッベ，スコット・ダブリュ
キム，フィリップ・アール
ラオ，イエンビン
ロウ，シャオチュン
マッキー，シーン・イー
マツレンコ，マーク・エイ
メイヤー，ピーター・ティー
ミラー，クリストファー・ピー
スタンブリ，ジェームズ
ボイト，エリック・エイ
ワン，ジー
ジャン，ジェフ・ジー
ステラ，バレンティノ・ジェイ
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AbbVie Inc
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AbbVie Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/094—Esters of phosphoric acids with arylalkanols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/02—Compounds containing any of the groups, e.g. carbazates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2017521517A 2014-10-21 2015-10-21 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法 Active JP6567049B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462066771P 2014-10-21 2014-10-21
US62/066,771 2014-10-21
PCT/US2015/056686 WO2016065019A1 (en) 2014-10-21 2015-10-21 Carbidopa and l-dopa prodrugs and their use to treat parkinson's disease

Related Child Applications (1)

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JP2019139442A Division JP6750076B2 (ja) 2014-10-21 2019-07-30 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法

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JP2017537066A JP2017537066A (ja) 2017-12-14
JP2017537066A5 JP2017537066A5 (enExample) 2019-07-11
JP6567049B2 true JP6567049B2 (ja) 2019-08-28

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JP2017521517A Active JP6567049B2 (ja) 2014-10-21 2015-10-21 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法
JP2019139442A Active JP6750076B2 (ja) 2014-10-21 2019-07-30 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法
JP2020135560A Active JP6932227B2 (ja) 2014-10-21 2020-08-11 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法
JP2021132161A Pending JP2021183628A (ja) 2014-10-21 2021-08-16 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法
JP2023174083A Active JP7688087B2 (ja) 2014-10-21 2023-10-06 カルビドパおよびｌ－ドーパプロドラッグならびにそれらの使用方法
JP2025084629A Pending JP2025118978A (ja) 2014-10-21 2025-05-21 カルビドパおよびｌ－ドーパプロドラッグならびにそれらの使用方法

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JP2019139442A Active JP6750076B2 (ja) 2014-10-21 2019-07-30 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法
JP2020135560A Active JP6932227B2 (ja) 2014-10-21 2020-08-11 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法
JP2021132161A Pending JP2021183628A (ja) 2014-10-21 2021-08-16 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法
JP2023174083A Active JP7688087B2 (ja) 2014-10-21 2023-10-06 カルビドパおよびｌ－ドーパプロドラッグならびにそれらの使用方法
JP2025084629A Pending JP2025118978A (ja) 2014-10-21 2025-05-21 カルビドパおよびｌ－ドーパプロドラッグならびにそれらの使用方法

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US (7) US9446059B2 (enExample)
EP (3) EP3209302B1 (enExample)
JP (6) JP6567049B2 (enExample)
KR (3) KR20230066484A (enExample)
CN (4) CN111454290B (enExample)
AR (1) AR102389A1 (enExample)
AU (4) AU2015335941B2 (enExample)
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PH (1) PH12017500746B1 (enExample)
PL (1) PL3209302T3 (enExample)
PT (1) PT3209302T (enExample)
RS (1) RS58972B1 (enExample)
RU (2) RU2021103000A (enExample)
SA (1) SA521421115B1 (enExample)
SG (1) SG11201703170RA (enExample)
SI (1) SI3209302T1 (enExample)
SM (1) SMT201900376T1 (enExample)
TR (1) TR201908296T4 (enExample)
TW (2) TWI718999B (enExample)
UA (1) UA120437C2 (enExample)
WO (1) WO2016065019A1 (enExample)
ZA (1) ZA201702760B (enExample)

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JP7562562B2 (ja) 2019-05-21 2024-10-07 ハー・ルンドベック・アクチエゼルスカベット パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ
JP7641234B2 (ja) 2019-05-21 2025-03-06 ハー・ルンドベック・アクチエゼルスカベット パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ
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