JP6567049B2 - カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法 - Google Patents

カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法 Download PDF

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JP6567049B2
JP6567049B2 JP2017521517A JP2017521517A JP6567049B2 JP 6567049 B2 JP6567049 B2 JP 6567049B2 JP 2017521517 A JP2017521517 A JP 2017521517A JP 2017521517 A JP2017521517 A JP 2017521517A JP 6567049 B2 JP6567049 B2 JP 6567049B2
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compound
formula
another embodiment
pharmaceutically acceptable
dopa
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JP2017537066A (ja
JP2017537066A5 (enExample
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カーディナル−デイビッド，ベノイト
チャン，ビンセント・エス
デンパー，カッシブラ・イー
エンライト，ブライアン・ピー
ヘンリー，ロジャー・エフ
ホー，レイモンド
ホワン，イエ
ハターズ，アレクサンダー・ディー
クリックス，ラッセル・シー
クラッベ，スコット・ダブリュ
キム，フィリップ・アール
ラオ，イエンビン
ロウ，シャオチュン
マッキー，シーン・イー
マツレンコ，マーク・エイ
メイヤー，ピーター・ティー
ミラー，クリストファー・ピー
スタンブリ，ジェームズ
ボイト，エリック・エイ
ワン，ジー
ジャン，ジェフ・ジー
ステラ，バレンティノ・ジェイ
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アッヴィ・インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/094—Esters of phosphoric acids with arylalkanols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/02—Compounds containing any of the groups, e.g. carbazates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2017521517A 2014-10-21 2015-10-21 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法 Active JP6567049B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462066771P 2014-10-21 2014-10-21
US62/066,771 2014-10-21
PCT/US2015/056686 WO2016065019A1 (en) 2014-10-21 2015-10-21 Carbidopa and l-dopa prodrugs and their use to treat parkinson's disease

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JP2017537066A JP2017537066A (ja) 2017-12-14
JP2017537066A5 JP2017537066A5 (enExample) 2019-07-11
JP6567049B2 true JP6567049B2 (ja) 2019-08-28

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JP2017521517A Active JP6567049B2 (ja) 2014-10-21 2015-10-21 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法
JP2019139442A Active JP6750076B2 (ja) 2014-10-21 2019-07-30 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法
JP2020135560A Active JP6932227B2 (ja) 2014-10-21 2020-08-11 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法
JP2021132161A Pending JP2021183628A (ja) 2014-10-21 2021-08-16 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法
JP2023174083A Active JP7688087B2 (ja) 2014-10-21 2023-10-06 カルビドパおよびｌ－ドーパプロドラッグならびにそれらの使用方法
JP2025084629A Pending JP2025118978A (ja) 2014-10-21 2025-05-21 カルビドパおよびｌ－ドーパプロドラッグならびにそれらの使用方法

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JP2020135560A Active JP6932227B2 (ja) 2014-10-21 2020-08-11 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法
JP2021132161A Pending JP2021183628A (ja) 2014-10-21 2021-08-16 カルビドパおよびｌ−ドーパプロドラッグならびにそれらの使用方法
JP2023174083A Active JP7688087B2 (ja) 2014-10-21 2023-10-06 カルビドパおよびｌ－ドーパプロドラッグならびにそれらの使用方法
JP2025084629A Pending JP2025118978A (ja) 2014-10-21 2025-05-21 カルビドパおよびｌ－ドーパプロドラッグならびにそれらの使用方法

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EP (3) EP3209302B1 (enExample)
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KR (3) KR20240113982A (enExample)
CN (4) CN111362980B (enExample)
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SA (1) SA521421115B1 (enExample)
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SI (1) SI3209302T1 (enExample)
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TW (2) TWI755257B (enExample)
UA (1) UA120437C2 (enExample)
WO (1) WO2016065019A1 (enExample)
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