JP2020073494A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020073494A5 JP2020073494A5 JP2019224873A JP2019224873A JP2020073494A5 JP 2020073494 A5 JP2020073494 A5 JP 2020073494A5 JP 2019224873 A JP2019224873 A JP 2019224873A JP 2019224873 A JP2019224873 A JP 2019224873A JP 2020073494 A5 JP2020073494 A5 JP 2020073494A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- aqueous pharmaceutical
- composition according
- pirfenidone
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 239000007788 liquid Substances 0.000 claims 11
- 230000008685 targeting Effects 0.000 claims 8
- 239000000443 aerosol Substances 0.000 claims 7
- ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical compound C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 claims 7
- 229960003073 pirfenidone Drugs 0.000 claims 7
- 239000003446 ligand Substances 0.000 claims 6
- 239000006199 nebulizer Substances 0.000 claims 6
- 150000003384 small molecules Chemical class 0.000 claims 5
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 210000004072 lung Anatomy 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 2
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims 2
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 2
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 229940126864 fibroblast growth factor Drugs 0.000 claims 2
- LVWZTYCIRDMTEY-UHFFFAOYSA-N metamizole Chemical compound O=C1C(N(CS(O)(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 LVWZTYCIRDMTEY-UHFFFAOYSA-N 0.000 claims 2
- 239000006186 oral dosage form Substances 0.000 claims 2
- 230000003204 osmotic effect Effects 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 claims 2
- BLUGYPPOFIHFJS-UUFHNPECSA-N (2s)-n-[(2s)-1-[[(3r,4s,5s)-3-methoxy-1-[(2s)-2-[(1r,2r)-1-methoxy-2-methyl-3-oxo-3-[[(1s)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamid Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 BLUGYPPOFIHFJS-UUFHNPECSA-N 0.000 claims 1
- 208000007934 ACTH-independent macronodular adrenal hyperplasia Diseases 0.000 claims 1
- 102100031168 CCN family member 2 Human genes 0.000 claims 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims 1
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims 1
- 102100031706 Fibroblast growth factor 1 Human genes 0.000 claims 1
- 101000777550 Homo sapiens CCN family member 2 Proteins 0.000 claims 1
- 101000950669 Homo sapiens Mitogen-activated protein kinase 9 Proteins 0.000 claims 1
- 101001092910 Homo sapiens Serum amyloid P-component Proteins 0.000 claims 1
- -1 IW001 Proteins 0.000 claims 1
- 108010005716 Interferon beta-1a Proteins 0.000 claims 1
- 102000008070 Interferon-gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 1
- 102100037809 Mitogen-activated protein kinase 9 Human genes 0.000 claims 1
- 108010089484 PRM-151 Proteins 0.000 claims 1
- 102100036202 Serum amyloid P-component Human genes 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 229910001622 calcium bromide Inorganic materials 0.000 claims 1
- 239000001110 calcium chloride Substances 0.000 claims 1
- 229910001628 calcium chloride Inorganic materials 0.000 claims 1
- WGEFECGEFUFIQW-UHFFFAOYSA-L calcium dibromide Chemical compound [Ca+2].[Br-].[Br-] WGEFECGEFUFIQW-UHFFFAOYSA-L 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 239000006184 cosolvent Substances 0.000 claims 1
- 230000008021 deposition Effects 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 229960004461 interferon beta-1a Drugs 0.000 claims 1
- 229960003130 interferon gamma Drugs 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- OTCKOJUMXQWKQG-UHFFFAOYSA-L magnesium bromide Chemical compound [Mg+2].[Br-].[Br-] OTCKOJUMXQWKQG-UHFFFAOYSA-L 0.000 claims 1
- 229910001623 magnesium bromide Inorganic materials 0.000 claims 1
- 229910001629 magnesium chloride Inorganic materials 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- XZXHXSATPCNXJR-ZIADKAODSA-N nintedanib Chemical compound O=C1NC2=CC(C(=O)OC)=CC=C2\C1=C(C=1C=CC=CC=1)\NC(C=C1)=CC=C1N(C)C(=O)CN1CCN(C)CC1 XZXHXSATPCNXJR-ZIADKAODSA-N 0.000 claims 1
- 229960004378 nintedanib Drugs 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- 239000006068 taste-masking agent Substances 0.000 claims 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000001256 tonic effect Effects 0.000 claims 1
- 239000000080 wetting agent Substances 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022024945A JP2022078126A (ja) | 2012-07-24 | 2022-02-21 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
| JP2024040308A JP2024095678A (ja) | 2012-07-24 | 2024-03-14 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261675286P | 2012-07-24 | 2012-07-24 | |
| US61/675,286 | 2012-07-24 | ||
| US201361756983P | 2013-01-25 | 2013-01-25 | |
| US61/756,983 | 2013-01-25 | ||
| US201361824818P | 2013-05-17 | 2013-05-17 | |
| US61/824,818 | 2013-05-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018116525A Division JP2018172402A (ja) | 2012-07-24 | 2018-06-19 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022024945A Division JP2022078126A (ja) | 2012-07-24 | 2022-02-21 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020073494A JP2020073494A (ja) | 2020-05-14 |
| JP2020073494A5 true JP2020073494A5 (enExample) | 2020-11-26 |
| JP7120984B2 JP7120984B2 (ja) | 2022-08-17 |
Family
ID=49997965
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015524425A Active JP6501264B2 (ja) | 2012-07-24 | 2013-07-24 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
| JP2018116525A Pending JP2018172402A (ja) | 2012-07-24 | 2018-06-19 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
| JP2019224873A Active JP7120984B2 (ja) | 2012-07-24 | 2019-12-12 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
| JP2022024945A Pending JP2022078126A (ja) | 2012-07-24 | 2022-02-21 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
| JP2024040308A Pending JP2024095678A (ja) | 2012-07-24 | 2024-03-14 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015524425A Active JP6501264B2 (ja) | 2012-07-24 | 2013-07-24 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
| JP2018116525A Pending JP2018172402A (ja) | 2012-07-24 | 2018-06-19 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022024945A Pending JP2022078126A (ja) | 2012-07-24 | 2022-02-21 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
| JP2024040308A Pending JP2024095678A (ja) | 2012-07-24 | 2024-03-14 | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2877164B1 (enExample) |
| JP (5) | JP6501264B2 (enExample) |
| AU (5) | AU2013295800A1 (enExample) |
| CA (1) | CA2880011C (enExample) |
| ES (1) | ES2959198T3 (enExample) |
| HU (1) | HUE063581T2 (enExample) |
| NZ (1) | NZ705260A (enExample) |
| WO (1) | WO2014018668A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10105356B2 (en) | 2011-01-31 | 2018-10-23 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| HUE058753T2 (hu) | 2011-01-31 | 2022-09-28 | Avalyn Pharma Inc | Aeroszol formájú pirfenidon- és piridon-analóg vegyületek és alkalmazásaik |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| CA3280124A1 (en) | 2013-07-31 | 2025-10-31 | Avalyn Pharma Inc. | Aerosol imatinib compounds and uses thereof |
| JP7066321B2 (ja) | 2014-01-10 | 2022-05-13 | アヴァリン ファーマ インク． | エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 |
| RU2692485C2 (ru) | 2014-04-02 | 2019-06-25 | Интермьюн, Инк. | Противофиброзные пиридиноны |
| IL295472B2 (en) * | 2016-03-28 | 2024-10-01 | Presage Biosciences Inc | Pharmaceutical combinations for the treatment of cancer |
| US10238821B2 (en) * | 2016-10-11 | 2019-03-26 | Microdose Therapeutx, Inc. | Inhaler and methods of use thereof |
| WO2018234527A1 (en) * | 2017-06-22 | 2018-12-27 | Softhale Nv | PIRFENIDONE AEROSOL ADMINISTRATION |
| US12048801B2 (en) | 2017-06-22 | 2024-07-30 | Invox Belgium Nv | Aerosol delivery of pirfenidone |
| GB201807050D0 (en) * | 2018-04-30 | 2018-06-13 | Cellprotect Nordic Pharmaceuticals Ab | Medical uses |
| WO2020219168A1 (en) | 2019-04-24 | 2020-10-29 | Convergene, Llc | Small molecule bromodomain inhibitors and uses thereof |
| KR102847500B1 (ko) * | 2019-05-27 | 2025-08-20 | 디에스엠 아이피 어셋츠 비.브이. | 인 화합물 및 유기 황 화합물의 존재 하에서의 알킨의 알켄으로의 선택적 수소화 |
| JP7490813B2 (ja) * | 2020-04-22 | 2024-05-27 | ユンジン ファーム．カンパニー、リミテッド | 安全性と安定性が改善されたピルフェニドンを含む腸溶性製剤およびその製造方法 |
| AU2021396535A1 (en) * | 2020-12-07 | 2023-06-22 | Mannkind Corporation | Method and composition for treating pulmonary fibrosis |
| US12508228B2 (en) * | 2022-03-30 | 2025-12-30 | The Chinese University Of Hong Kong | PFD loaded microspheres and method for preparing injectable composite microsphere hydrogel solution from same |
| CN115970069B (zh) * | 2022-12-13 | 2024-09-24 | 南通大学附属医院 | 载吡非尼酮纳米粒子复合涂层输尿管支架管的制备方法 |
| CN119548479A (zh) * | 2024-12-31 | 2025-03-04 | 延边大学 | 一种吸入用吡非尼酮溶液及其使用方法 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3826255A (en) | 1972-06-22 | 1974-07-30 | Hudson Oxygen Therapy Sales Co | Intermittent positive pressure breathing manifold |
| YU41046B (en) | 1974-08-22 | 1986-10-31 | Schering Ag | Medicine inholating device |
| ZA757570B (en) | 1974-12-09 | 1977-07-27 | Affiliated Med Res | A useful n-substituted pyridone |
| US4268460A (en) | 1977-12-12 | 1981-05-19 | Warner-Lambert Company | Nebulizer |
| US4253468A (en) | 1978-08-14 | 1981-03-03 | Steven Lehmbeck | Nebulizer attachment |
| US4263907A (en) | 1979-05-14 | 1981-04-28 | Lindsey Joseph W | Respirator nebulizer |
| US4510929A (en) | 1982-04-30 | 1985-04-16 | Bordoni Maurice E | Disposable radioactive aerosol inhalation apparatus |
| US4649911A (en) | 1983-09-08 | 1987-03-17 | Baylor College Of Medicine | Small particle aerosol generator for treatment of respiratory disease including the lungs |
| US4624251A (en) | 1984-09-13 | 1986-11-25 | Riker Laboratories, Inc. | Apparatus for administering a nebulized substance |
| US5152456A (en) | 1989-12-12 | 1992-10-06 | Bespak, Plc | Dispensing apparatus having a perforate outlet member and a vibrating device |
| US5164740A (en) | 1991-04-24 | 1992-11-17 | Yehuda Ivri | High frequency printing mechanism |
| DE59108798D1 (de) | 1991-11-07 | 1997-08-28 | Ritzau Pari Werk Gmbh Paul | Vernebler insbesondere zur Anwendung in Geräten für die Inhalationstherapie |
| EP0615470B1 (en) | 1991-12-04 | 1995-12-13 | The Technology Partnership Public Limited Company | Fluid droplet production apparatus and method |
| US5558085A (en) | 1993-01-29 | 1996-09-24 | Aradigm Corporation | Intrapulmonary delivery of peptide drugs |
| US5934272A (en) | 1993-01-29 | 1999-08-10 | Aradigm Corporation | Device and method of creating aerosolized mist of respiratory drug |
| US5709202A (en) | 1993-05-21 | 1998-01-20 | Aradigm Corporation | Intrapulmonary delivery of aerosolized formulations |
| AU4990696A (en) | 1995-02-24 | 1996-09-11 | Nanosystems L.L.C. | Aerosols containing nanoparticle dispersions |
| US5586550A (en) | 1995-08-31 | 1996-12-24 | Fluid Propulsion Technologies, Inc. | Apparatus and methods for the delivery of therapeutic liquids to the respiratory system |
| US6427682B1 (en) | 1995-04-05 | 2002-08-06 | Aerogen, Inc. | Methods and apparatus for aerosolizing a substance |
| US5758637A (en) | 1995-08-31 | 1998-06-02 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
| US5823179A (en) | 1996-02-13 | 1998-10-20 | 1263152 Ontario Inc. | Nebulizer apparatus and method |
| US6083922A (en) | 1996-04-02 | 2000-07-04 | Pathogenesis, Corp. | Method and a tobramycin aerosol formulation for treatment prevention and containment of tuberculosis |
| US5906202A (en) | 1996-11-21 | 1999-05-25 | Aradigm Corporation | Device and method for directing aerosolized mist to a specific area of the respiratory tract |
| US6349719B2 (en) | 1997-02-24 | 2002-02-26 | Aradigm Corporation | Formulation and devices for monitoring the efficacy of the delivery of aerosols |
| DE19713636A1 (de) | 1997-04-02 | 1998-10-08 | Pari Gmbh | Atemzugsimulator |
| US5855564A (en) | 1997-08-20 | 1999-01-05 | Aradigm Corporation | Aerosol extrusion mechanism |
| JP2001518494A (ja) | 1997-10-08 | 2001-10-16 | セプレイサー インコーポレイテッド | エアゾル投与用の投薬形態 |
| DK1129741T3 (da) | 1997-11-19 | 2006-08-07 | Microflow Eng Sa | Forstövningsindretning til inhalator |
| US6192876B1 (en) | 1997-12-12 | 2001-02-27 | Astra Aktiebolag | Inhalation apparatus and method |
| WO2000016775A1 (en) | 1998-09-18 | 2000-03-30 | Mepha Ag | Topical formulation of alkyl-, phenyl-pyridone |
| GB2343122B (en) | 1998-10-26 | 2003-01-08 | Medic Aid Ltd | Improvements in and relating to nebulisers |
| US6070575A (en) | 1998-11-16 | 2000-06-06 | Aradigm Corporation | Aerosol-forming porous membrane with certain pore structure |
| US6584971B1 (en) | 1999-01-04 | 2003-07-01 | Medic-Aid Limited | Drug delivery apparatus |
| US6338443B1 (en) | 1999-06-18 | 2002-01-15 | Mercury Enterprises, Inc. | High efficiency medical nebulizer |
| US6962151B1 (en) | 1999-11-05 | 2005-11-08 | Pari GmbH Spezialisten für effektive Inhalation | Inhalation nebulizer |
| CA2826724C (en) | 2000-04-11 | 2016-02-02 | Trudell Medical International | Aerosol delivery apparatus with positive expiratory pressure capacity |
| US6601581B1 (en) | 2000-11-01 | 2003-08-05 | Advanced Medical Applications, Inc. | Method and device for ultrasound drug delivery |
| DE10102846B4 (de) | 2001-01-23 | 2012-04-12 | Pari Pharma Gmbh | Aerosolgenerator |
| ATE298600T1 (de) | 2001-10-18 | 2005-07-15 | Pari Gmbh | Inhalationstherapievorrichtung |
| ATE269735T1 (de) | 2001-10-18 | 2004-07-15 | Pari Gmbh | Inhalationstherapievorrichtung |
| JP2005508220A (ja) | 2001-10-24 | 2005-03-31 | パーリ・ゲーエムベーハー | 薬用組成物調製用具 |
| US7550133B2 (en) * | 2002-11-26 | 2009-06-23 | Alexza Pharmaceuticals, Inc. | Respiratory drug condensation aerosols and methods of making and using them |
| JP4542743B2 (ja) | 2002-12-26 | 2010-09-15 | Ｋｄｌ株式会社 | ピリドン誘導体の溶液状医薬組成物 |
| US7838532B2 (en) | 2005-05-18 | 2010-11-23 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
| CA2693771A1 (en) * | 2007-07-13 | 2009-01-22 | Abbott Biotechnology Ltd. | Methods and compositions for pulmonary administration of a tnf.alpha. inhibitor |
| US20090196930A1 (en) * | 2007-12-27 | 2009-08-06 | Aires Pharmaceuticals, Inc. | Aerosolized nitrite and nitric oxide -donating compounds and uses thereof |
| AU2009302478B2 (en) * | 2008-10-07 | 2015-09-03 | Horizon Orphan Llc | Aerosol fluoroquinolone formulations for improved pharmacokinetics |
| AU2010302420B2 (en) * | 2009-10-02 | 2013-07-04 | Astrazeneca Ab | 2-pyridone compounds used as inhibitors of neutrophil elastase |
| JP6239054B2 (ja) * | 2010-11-26 | 2017-11-29 | 東芝メディカルシステムズ株式会社 | 磁気共鳴診断装置 |
| HUE058753T2 (hu) * | 2011-01-31 | 2022-09-28 | Avalyn Pharma Inc | Aeroszol formájú pirfenidon- és piridon-analóg vegyületek és alkalmazásaik |
-
2013
- 2013-07-24 JP JP2015524425A patent/JP6501264B2/ja active Active
- 2013-07-24 EP EP13822166.8A patent/EP2877164B1/en active Active
- 2013-07-24 ES ES13822166T patent/ES2959198T3/es active Active
- 2013-07-24 WO PCT/US2013/051880 patent/WO2014018668A2/en not_active Ceased
- 2013-07-24 AU AU2013295800A patent/AU2013295800A1/en not_active Abandoned
- 2013-07-24 NZ NZ705260A patent/NZ705260A/en unknown
- 2013-07-24 HU HUE13822166A patent/HUE063581T2/hu unknown
- 2013-07-24 CA CA2880011A patent/CA2880011C/en active Active
-
2018
- 2018-06-19 JP JP2018116525A patent/JP2018172402A/ja active Pending
- 2018-07-23 AU AU2018206852A patent/AU2018206852A1/en not_active Abandoned
-
2019
- 2019-12-12 JP JP2019224873A patent/JP7120984B2/ja active Active
-
2020
- 2020-03-03 AU AU2020201557A patent/AU2020201557B2/en active Active
-
2022
- 2022-02-21 JP JP2022024945A patent/JP2022078126A/ja active Pending
- 2022-11-16 AU AU2022271417A patent/AU2022271417A1/en not_active Abandoned
-
2024
- 2024-03-14 JP JP2024040308A patent/JP2024095678A/ja active Pending
- 2024-11-29 AU AU2024267029A patent/AU2024267029A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024095678A5 (enExample) | ||
| JP2018199688A5 (enExample) | ||
| JP2015523395A5 (enExample) | ||
| JP2019031514A5 (enExample) | ||
| JP2017502064A5 (enExample) | ||
| NZ760541A (en) | Aerosol pirfenidone and pyridone analog compounds and uses thereof | |
| JP6066350B2 (ja) | エアロゾルボーラスとしてのイロプロストの投与 | |
| JP2017505348A (ja) | 肺疾患治療のための肥満細胞安定剤 | |
| JP2023542629A (ja) | 改良されたエアロゾルパラメータのための噴霧器デバイスの最適化及びその使用 | |
| HRP20221185T1 (hr) | Beta-ukosnica peptidomimetik s inhibitorskom aktivnošću elastase i njegovi oblici doziranja aerosolom | |
| US20230158259A1 (en) | Products of manufacture and methods for treating, ameliorating or preventing microbial infections | |
| US20250228779A1 (en) | Method and composition for treating pulmonary fibrosis | |
| CN104853744B (zh) | 气溶胶化伊洛前列素的给药 | |
| Hsu et al. | Iloprost inhalation solution for the treatment of pulmonary arterial hypertension | |
| Standaert et al. | The choice of compressor effects the aerosol parameters and the delivery of tobramycin from a single model nebulizer | |
| US20180325908A1 (en) | Methods and compositions for treating pulmonary hypertension | |
| MX2013004030A (es) | Composicion farmaceutica a base de denufosol para tratar fibrosis quistica. | |
| AU2020103517A4 (en) | Ibp- nebulizer: intelligent nebulizer for bronchitis patients | |
| CN118984697A (zh) | 曲前列尼尔-伊洛前列素联合疗法 | |
| KR20240136408A (ko) | 폐 고혈압을 치료하기 위한 트레프로스티닐 | |
| CZ2007598A3 (cs) | Prostredek pro rozprašovace | |
| WO2010009288A1 (en) | Compositions and uses of antiviral active pharmaceutical agents | |
| KR20230035518A (ko) | 선천적 면역 반응을 생성하기 위한 퀴닌과 그의 용도 | |
| US20250352530A1 (en) | Method and composition for treating lung diseases | |
| US20240424229A1 (en) | Aerosol delivery of pirfenidone |