JP2019535836A5 - - Google Patents
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- Publication number
- JP2019535836A5 JP2019535836A5 JP2019548534A JP2019548534A JP2019535836A5 JP 2019535836 A5 JP2019535836 A5 JP 2019535836A5 JP 2019548534 A JP2019548534 A JP 2019548534A JP 2019548534 A JP2019548534 A JP 2019548534A JP 2019535836 A5 JP2019535836 A5 JP 2019535836A5
- Authority
- JP
- Japan
- Prior art keywords
- sepiapterin
- free base
- crystal form
- ray diffraction
- deficiency
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022151886A JP2023002532A (ja) | 2016-11-29 | 2022-09-22 | セピプテリン及びその塩の多形 |
| JP2024087740A JP2024123011A (ja) | 2016-11-29 | 2024-05-30 | セピプテリン及びその塩の多形 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662427686P | 2016-11-29 | 2016-11-29 | |
| US62/427,686 | 2016-11-29 | ||
| US201762546390P | 2017-08-16 | 2017-08-16 | |
| US62/546,390 | 2017-08-16 | ||
| PCT/US2017/063517 WO2018102315A1 (en) | 2016-11-29 | 2017-11-28 | Polymoprhs of sepiapterin and salts thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022151886A Division JP2023002532A (ja) | 2016-11-29 | 2022-09-22 | セピプテリン及びその塩の多形 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019535836A JP2019535836A (ja) | 2019-12-12 |
| JP2019535836A5 true JP2019535836A5 (https=) | 2021-01-14 |
| JP7148533B2 JP7148533B2 (ja) | 2022-10-05 |
Family
ID=62241930
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019548534A Active JP7148533B2 (ja) | 2016-11-29 | 2017-11-28 | セピプテリン及びその塩の多形 |
| JP2022151886A Pending JP2023002532A (ja) | 2016-11-29 | 2022-09-22 | セピプテリン及びその塩の多形 |
| JP2024087740A Pending JP2024123011A (ja) | 2016-11-29 | 2024-05-30 | セピプテリン及びその塩の多形 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022151886A Pending JP2023002532A (ja) | 2016-11-29 | 2022-09-22 | セピプテリン及びその塩の多形 |
| JP2024087740A Pending JP2024123011A (ja) | 2016-11-29 | 2024-05-30 | セピプテリン及びその塩の多形 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US11072614B2 (https=) |
| EP (1) | EP3548497A4 (https=) |
| JP (3) | JP7148533B2 (https=) |
| KR (3) | KR102561697B1 (https=) |
| CN (2) | CN116903624A (https=) |
| AU (3) | AU2017366879C1 (https=) |
| BR (1) | BR122021026889A8 (https=) |
| CA (1) | CA3043502A1 (https=) |
| CO (1) | CO2019006018A2 (https=) |
| IL (2) | IL266955B2 (https=) |
| MA (1) | MA46973A (https=) |
| MX (3) | MX386520B (https=) |
| WO (1) | WO2018102315A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2562176B1 (en) | 2010-04-22 | 2018-08-15 | Nihon University | Medicinal agent and beverage/food for preventing cerebral dysfunction and improving same |
| MA46973A (fr) | 2016-11-29 | 2019-10-09 | Censa Pharmaceuticals Inc | Polymorphes de sépiaptérine et leurs sels |
| MA46972A (fr) | 2016-11-29 | 2019-10-09 | Censa Pharmaceuticals Inc | Forme polymorphe de sépiaptérine |
| JP7811085B2 (ja) * | 2017-09-01 | 2026-02-04 | ピーティーシー セラピューティクス エムピー，インコーポレイテッド | セピアプテリンを含む医薬組成物及びその使用 |
| FI3801536T3 (fi) | 2018-05-30 | 2024-08-29 | Ptc Therapeutics Mp Inc | Sepiapteriinin antaminen ilman ruokaa käytettäväksi menetelmässä sepiapteriinin plasma-altistuksen lisäämiseksi |
| EP3801534B1 (en) | 2018-05-30 | 2026-02-18 | PTC Therapeutics MP, Inc. | Treatment of phenylketonuria with sepiapterin |
| AU2019277372B2 (en) | 2018-05-30 | 2024-12-19 | Ptc Therapeutics Mp, Inc. | Pharmaceutically acceptable salts of sepiapterin |
| IL290321B1 (en) | 2019-08-05 | 2026-04-01 | Ptc Therapeutics Inc | Use of spiapterin and its metabolites for radiation exposure treatment |
| IL291565B1 (en) * | 2019-09-25 | 2026-04-01 | Ptc Therapeutics Inc | Method for treating phenylalanine irregularity |
| EP4093405A1 (en) | 2020-01-24 | 2022-11-30 | PTC Therapeutics MP, Inc. | Methods for treating parkinson's disease with sepiapterin |
| WO2022173823A1 (en) | 2021-02-09 | 2022-08-18 | Ptc Therapeutics Mp, Inc. | Methods for treating covid-19 with sepiapterin |
| IL305037A (en) | 2021-02-09 | 2023-10-01 | Ptc Therapeutics Mp Inc | Methods of treating glioblastomas with spiafatrin |
| PE20241579A1 (es) | 2021-09-29 | 2024-08-01 | Ptc Therapeutics Inc | Composicion farmaceutica de sepiapterina |
| WO2024249602A2 (en) * | 2023-05-30 | 2024-12-05 | The Board Of Trustees Of The Leland Stanford Junior University | Restless leg syndrome (rls) and periodic leg movements (plms) during sleep: biomarker and drug target |
| CN117205164B (zh) * | 2023-09-30 | 2024-07-26 | 山东新时代药业有限公司 | 一种盐酸沙丙蝶呤片剂及其制备方法 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5925323A (ja) | 1982-03-03 | 1984-02-09 | 鐘淵化学工業株式会社 | プテリン誘導体からなる脳内神経伝達物質の関わる疾病の治療剤 |
| EP0722731B1 (en) | 1994-08-05 | 2002-06-05 | Suntory Limited | Remedy for spinocerebellar degeneration |
| JP2002515965A (ja) | 1995-08-18 | 2002-05-28 | ダブリュー． ランドリ，ドナルド | 抗体触媒反応の調節による有機化合物の検出 |
| US8188043B2 (en) | 1999-07-28 | 2012-05-29 | The Board Of Trustees Of The Leland Stanford Jr. University | Nicotine in therapeutic angiogenesis and vasculogenesis |
| FR2859996B1 (fr) | 2003-09-19 | 2006-02-03 | Aventis Pharma Sa | Solvat acetonique du dimethoxy docetaxel et son procede de preparation |
| JP2007509909A (ja) | 2003-10-31 | 2007-04-19 | アルタナ ファルマ アクチエンゲゼルシャフト | 呼吸器疾患の治療のためのｂｈ４の使用 |
| JP5184783B2 (ja) | 2003-11-17 | 2013-04-17 | バイオマリン ファーマシューティカル インコーポレイテッド | テトラヒドロビオプテリン、及びテトラヒドロビオプテリン類似体の製造方法 |
| PL1708690T3 (pl) | 2003-11-17 | 2017-01-31 | Biomarin Pharmaceutical Inc. | Leczenie fenyloketonurii za pomocą BH4 |
| EP1687308B1 (en) | 2003-11-17 | 2019-06-12 | Merck & Cie | Process for preparating (6R)-L-erythrotetrahydrobiopterin hydrochloride crystalline form B from other crystalline forms |
| KR20070084270A (ko) | 2004-11-17 | 2007-08-24 | 바이오마린 파머수티컬 인크. | 안정한 정제 제형물 |
| JP2008523090A (ja) * | 2004-12-08 | 2008-07-03 | バイオマリン ファーマシューティカル インコーポレイテッド | 新生児肺高血圧症の治療のための方法および組成物 |
| BRPI0609421B1 (pt) | 2005-04-28 | 2021-06-01 | Shiratori Pharmaceutical Co., Ltd. | Processos para produção de um composto 1,1-bis-alquil sulfonila, para produção de um composto aldeído, e para produção de um derivado de hidrazona |
| US20080075666A1 (en) | 2006-08-25 | 2008-03-27 | Dudley Samuel C Jr | Methods and compositions for treating diastolic dysfunction |
| LT2545939T (lt) * | 2007-04-11 | 2021-03-10 | Biomarin Pharmaceutical Inc. | Tetrahidrobiopterinas, skirtas gydyti ligas, susijusias supadidėjusiu fenilalanino kiekiu |
| EA017064B1 (ru) | 2008-03-10 | 2012-09-28 | Такеда Фармасьютикал Компани Лимитед | Кристаллическое производное бензимидазола |
| WO2010017570A2 (de) | 2008-08-12 | 2010-02-18 | Orpha Swiss Gmbh | Pharmazeutische darreichungsform enthaltend tetrahydrobiopterin |
| CN102256976A (zh) | 2008-12-23 | 2011-11-23 | 贝林格尔.英格海姆国际有限公司 | 有机化合物的盐形式 |
| CA2771432A1 (en) | 2009-08-20 | 2011-02-24 | Novartis Ag | Heterocyclic oxime compounds |
| EP2562176B1 (en) | 2010-04-22 | 2018-08-15 | Nihon University | Medicinal agent and beverage/food for preventing cerebral dysfunction and improving same |
| US9884909B2 (en) * | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| CN103458900A (zh) | 2011-03-01 | 2013-12-18 | 鲁必康研究私人有限公司 | 四氢生物蝶呤的稳定组合物 |
| US9216178B2 (en) * | 2011-11-02 | 2015-12-22 | Biomarin Pharmaceutical Inc. | Dry blend formulation of tetrahydrobiopterin |
| CN104736539B (zh) * | 2012-05-07 | 2017-09-01 | 白鸟制药株式会社 | 墨蝶呤和四氢乳酰蝶呤的制造法 |
| EP3468534A4 (en) | 2016-06-13 | 2020-02-05 | Meharry Medical College | MODULATION OF THE NITROGEN OXIDE SYNTHASE SIGNAL PATH FOR ORAL HEALTH |
| WO2018019931A1 (en) | 2016-07-29 | 2018-02-01 | Dipharma S.A. | Pharmaceutical composition kit comprising sapropterin dihydrochloride |
| MA46972A (fr) | 2016-11-29 | 2019-10-09 | Censa Pharmaceuticals Inc | Forme polymorphe de sépiaptérine |
| MA46973A (fr) | 2016-11-29 | 2019-10-09 | Censa Pharmaceuticals Inc | Polymorphes de sépiaptérine et leurs sels |
| TWI765936B (zh) | 2016-11-29 | 2022-06-01 | 美商東京威力科創Ｆｓｉ股份有限公司 | 用以對處理腔室中之微電子基板進行處理的平移與旋轉夾頭 |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| JP7811085B2 (ja) | 2017-09-01 | 2026-02-04 | ピーティーシー セラピューティクス エムピー，インコーポレイテッド | セピアプテリンを含む医薬組成物及びその使用 |
| AU2019277372B2 (en) | 2018-05-30 | 2024-12-19 | Ptc Therapeutics Mp, Inc. | Pharmaceutically acceptable salts of sepiapterin |
| EP3801534B1 (en) | 2018-05-30 | 2026-02-18 | PTC Therapeutics MP, Inc. | Treatment of phenylketonuria with sepiapterin |
| FI3801536T3 (fi) | 2018-05-30 | 2024-08-29 | Ptc Therapeutics Mp Inc | Sepiapteriinin antaminen ilman ruokaa käytettäväksi menetelmässä sepiapteriinin plasma-altistuksen lisäämiseksi |
| IL290321B1 (en) | 2019-08-05 | 2026-04-01 | Ptc Therapeutics Inc | Use of spiapterin and its metabolites for radiation exposure treatment |
| IL291565B1 (en) | 2019-09-25 | 2026-04-01 | Ptc Therapeutics Inc | Method for treating phenylalanine irregularity |
-
2017
- 2017-11-28 MA MA046973A patent/MA46973A/fr unknown
- 2017-11-28 AU AU2017366879A patent/AU2017366879C1/en active Active
- 2017-11-28 JP JP2019548534A patent/JP7148533B2/ja active Active
- 2017-11-28 MX MX2019006206A patent/MX386520B/es unknown
- 2017-11-28 IL IL266955A patent/IL266955B2/en unknown
- 2017-11-28 CN CN202310843616.4A patent/CN116903624A/zh active Pending
- 2017-11-28 EP EP17876202.7A patent/EP3548497A4/en active Pending
- 2017-11-28 US US16/464,771 patent/US11072614B2/en active Active
- 2017-11-28 KR KR1020197015403A patent/KR102561697B1/ko active Active
- 2017-11-28 CN CN201780084821.XA patent/CN110248948B/zh active Active
- 2017-11-28 WO PCT/US2017/063517 patent/WO2018102315A1/en not_active Ceased
- 2017-11-28 BR BR122021026889A patent/BR122021026889A8/pt not_active Application Discontinuation
- 2017-11-28 KR KR1020257010115A patent/KR20250051124A/ko active Pending
- 2017-11-28 CA CA3043502A patent/CA3043502A1/en active Pending
- 2017-11-28 KR KR1020237025450A patent/KR102789662B1/ko active Active
- 2017-11-28 IL IL301470A patent/IL301470A/en unknown
-
2019
- 2019-05-28 MX MX2021011676A patent/MX2021011676A/es unknown
- 2019-05-28 MX MX2021011683A patent/MX2021011683A/es unknown
- 2019-06-10 CO CONC2019/0006018A patent/CO2019006018A2/es unknown
-
2021
- 2021-06-09 US US17/342,910 patent/US11773097B2/en active Active
-
2022
- 2022-05-23 AU AU2022203481A patent/AU2022203481B2/en active Active
- 2022-09-22 JP JP2022151886A patent/JP2023002532A/ja active Pending
-
2023
- 2023-08-21 US US18/236,095 patent/US12269829B2/en active Active
-
2024
- 2024-01-18 AU AU2024200344A patent/AU2024200344B2/en active Active
- 2024-05-30 JP JP2024087740A patent/JP2024123011A/ja active Pending
-
2025
- 2025-01-15 US US19/021,475 patent/US20250230164A1/en active Pending
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