JP2019534270A5 - - Google Patents

Info

Publication number

JP2019534270A5

JP2019534270A5 JP2019520036A JP2019520036A JP2019534270A5 JP 2019534270 A5 JP2019534270 A5 JP 2019534270A5 JP 2019520036 A JP2019520036 A JP 2019520036A JP 2019520036 A JP2019520036 A JP 2019520036A JP 2019534270 A5 JP2019534270 A5 JP 2019534270A5

Authority

JP

Japan

Prior art keywords

dry powder

powder according

medicament

weight

dry

Prior art date

2017-10-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000000843 powder Substances 0.000 claims 36
• 239000003814 drug Substances 0.000 claims 13
• 229940121375 antifungal agent Drugs 0.000 claims 10
• 239000003429 antifungal agent Substances 0.000 claims 10
• 239000000546 pharmaceutical excipient Substances 0.000 claims 8
• 238000004519 manufacturing process Methods 0.000 claims 7
• 239000002245 particle Substances 0.000 claims 6
• 230000029058 respiratory gaseous exchange Effects 0.000 claims 6
• 206010017533 Fungal infection Diseases 0.000 claims 5
• 208000031888 Mycoses Diseases 0.000 claims 5
• 239000003381 stabilizer Substances 0.000 claims 5
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 4
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 4
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
• 210000002345 respiratory system Anatomy 0.000 claims 4
• 239000002775 capsule Substances 0.000 claims 3
• 239000011163 secondary particle Substances 0.000 claims 3
• 206010006474 Bronchopulmonary aspergillosis allergic Diseases 0.000 claims 2
• PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims 2
• 230000009798 acute exacerbation Effects 0.000 claims 2
• 208000006778 allergic bronchopulmonary aspergillosis Diseases 0.000 claims 2
• 125000002091 cationic group Chemical group 0.000 claims 2
• 229910052751 metal Inorganic materials 0.000 claims 2
• 239000002184 metal Substances 0.000 claims 2
• 239000011780 sodium chloride Substances 0.000 claims 2
• 229910052938 sodium sulfate Inorganic materials 0.000 claims 2
• 235000011152 sodium sulphate Nutrition 0.000 claims 2
• 150000003852 triazoles Chemical group 0.000 claims 2
• BLUGYPPOFIHFJS-UUFHNPECSA-N (2s)-n-[(2s)-1-[[(3r,4s,5s)-3-methoxy-1-[(2s)-2-[(1r,2r)-1-methoxy-2-methyl-3-oxo-3-[[(1s)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamid Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 BLUGYPPOFIHFJS-UUFHNPECSA-N 0.000 claims 1
• WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
• VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims 1
• LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
• QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
• 208000007934 ACTH-independent macronodular adrenal hyperplasia Diseases 0.000 claims 1
• 201000002909 Aspergillosis Diseases 0.000 claims 1
• 208000036641 Aspergillus infections Diseases 0.000 claims 1
• 201000003883 Cystic fibrosis Diseases 0.000 claims 1
• ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
• 239000005642 Oleic acid Substances 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 239000013078 crystal Substances 0.000 claims 1
• 229940112141 dry powder inhaler Drugs 0.000 claims 1
• QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
• 229960004130 itraconazole Drugs 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
• 150000004291 polyenes Chemical class 0.000 claims 1
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
• 229920000053 polysorbate 80 Polymers 0.000 claims 1
• 229940068968 polysorbate 80 Drugs 0.000 claims 1
• 230000000241 respiratory effect Effects 0.000 claims 1
• 208000023504 respiratory system disease Diseases 0.000 claims 1
• 238000001694 spray drying Methods 0.000 claims 1
• 150000005846 sugar alcohols Chemical class 0.000 claims 1
• 239000000725 suspension Substances 0.000 claims 1