IL265913B2 - Respirable Dry Powder Comprising Itraconazole In Crystalline Form And Its Use For Manufacturing A Medicament For Treating Fungal Infection - Google Patents
Respirable Dry Powder Comprising Itraconazole In Crystalline Form And Its Use For Manufacturing A Medicament For Treating Fungal InfectionInfo
- Publication number
- IL265913B2 IL265913B2 IL265913A IL26591319A IL265913B2 IL 265913 B2 IL265913 B2 IL 265913B2 IL 265913 A IL265913 A IL 265913A IL 26591319 A IL26591319 A IL 26591319A IL 265913 B2 IL265913 B2 IL 265913B2
- Authority
- IL
- Israel
- Prior art keywords
- dry powder
- itraconazole
- formulation
- dry
- formulations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Otolaryngology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662408376P | 2016-10-14 | 2016-10-14 | |
| PCT/US2017/056497 WO2018071757A1 (en) | 2016-10-14 | 2017-10-13 | Antifungal dry powders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL265913A IL265913A (en) | 2019-06-30 |
| IL265913B1 IL265913B1 (en) | 2024-03-01 |
| IL265913B2 true IL265913B2 (en) | 2024-07-01 |
Family
ID=60186406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL265913A IL265913B2 (en) | 2016-10-14 | 2017-10-13 | Respirable Dry Powder Comprising Itraconazole In Crystalline Form And Its Use For Manufacturing A Medicament For Treating Fungal Infection |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US11116722B2 (https=) |
| EP (1) | EP3525759A1 (https=) |
| JP (1) | JP7085538B2 (https=) |
| KR (1) | KR102408798B1 (https=) |
| CN (1) | CN109996536B (https=) |
| AU (1) | AU2017341815B2 (https=) |
| CA (1) | CA3039485A1 (https=) |
| IL (1) | IL265913B2 (https=) |
| MX (1) | MX388733B (https=) |
| NZ (1) | NZ752353A (https=) |
| RU (1) | RU2766086C2 (https=) |
| WO (1) | WO2018071757A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2017144619A (ru) * | 2010-09-29 | 2019-02-20 | Пулмэтрикс, Инк. | Катионы одновалентных металлов сухих порошков для ингаляций |
| EP3781125A1 (en) * | 2018-04-18 | 2021-02-24 | Pulmatrix Operating Company, Inc. | Antifungal formulations for pulmonary administration comprising itraconazole |
| AU2019256453B2 (en) * | 2018-04-18 | 2024-10-17 | Cipla Usa Inc. | Methods of treating fungal infections |
| WO2021092349A1 (en) * | 2019-11-08 | 2021-05-14 | Scynexis, Inc. | Lipid-based formulations of scy-078 salts |
| CN111658610B (zh) * | 2020-07-31 | 2022-05-24 | 上海方予健康医药科技有限公司 | 一种供雾化器用的三氮唑类抗真菌药物的混悬液 |
| IT202000030443A1 (it) | 2020-12-10 | 2022-06-10 | Zambon Spa | Polvere inalabile comprendente voriconazolo in forma cristallina |
| IT202000030437A1 (it) | 2020-12-10 | 2022-06-10 | Zambon Spa | Metodo per la realizzazione di una polvere inalabile comprendente voriconazolo |
| WO2022187222A1 (en) * | 2021-03-03 | 2022-09-09 | Pulmatrix Operating Company, Inc. | Dihydroergotamine dry power formulations and methods of use |
| WO2023086013A2 (en) * | 2021-11-09 | 2023-05-19 | Agency For Science, Technology And Research | A salt-based antifungal powder platform formulation for aerosolization |
| EP4452235A1 (en) * | 2021-12-20 | 2024-10-30 | Pulmatrix Operating Company, Inc. | Dry powder formulations of narrow spectrum kinase inhibitors |
| KR20250053839A (ko) | 2022-06-21 | 2025-04-22 | 호비온 사이언티아 리미티드 | 당과 지질 복합입자를 포함하는 흡입용 결정형 약학 조성물 및 제조방법 |
| WO2024040175A1 (en) | 2022-08-18 | 2024-02-22 | Pulmatrix Operating Company, Inc. | Methods for treating cancer using inhaled angiogenesis inhibitor |
| CN120112290A (zh) | 2022-08-31 | 2025-06-06 | 普马特里克斯营业公司 | 使用伊曲康唑干粉的方法 |
| AU2024345688A1 (en) * | 2023-09-20 | 2026-04-09 | Cystetic Medicines, Inc. | Use of a dry powder inhaler to treat or prevent pulmonary fungal infections |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002054868A2 (en) * | 2000-12-21 | 2002-07-18 | Inhale Therapeutic Syst | Pulmonary delivery of polyene antifungal agents |
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| US4069819A (en) | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
| US4097620A (en) | 1977-05-02 | 1978-06-27 | Xerox Corporation | Magnetic toner particle coating process |
| US4916134A (en) | 1987-03-25 | 1990-04-10 | Janssen Pharmacuetica N.V. | 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]phenyl]triazolones |
| IT1228459B (it) | 1989-02-23 | 1991-06-19 | Phidea S R L | Inalatore con svuotamento regolare e completo della capsula. |
| US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
| US6448401B1 (en) * | 2000-11-20 | 2002-09-10 | Bristol-Myers Squibb Company | Process for water soluble azole compounds |
| ITMI20010357U1 (it) | 2001-06-28 | 2002-12-30 | Plastiape Spa | Dispositivo inalatore |
| MXPA05007156A (es) | 2002-12-31 | 2005-09-21 | Nektar Therapeutics | Formulacion farmaceuticas aerosolizable para terapia para infecciones fungicas. |
| CA2523475C (en) | 2003-05-28 | 2013-02-05 | Nektar Therapeutics | Pharmaceutical formulation comprising a water-insoluble active agent |
| US20050048127A1 (en) | 2003-07-22 | 2005-03-03 | Larry Brown | Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof |
| GB0327723D0 (en) | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
| US8513204B2 (en) | 2004-06-21 | 2013-08-20 | Novartis Ag | Compositions comprising amphotericin B, mehods and systems |
| US9061027B2 (en) | 2004-08-27 | 2015-06-23 | Board Of Regents, The University Of Texas System | Enhanced delivery of drug compositions to treat life threatening infections |
| GB0425758D0 (en) | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
| ITMI20051999A1 (it) | 2005-10-21 | 2007-04-22 | Eratech S R L | Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita' |
| US20120128728A1 (en) | 2005-12-28 | 2012-05-24 | Novartis Pharma Ag | Compositions Comprising Amphotericin B |
| JP2009538927A (ja) * | 2006-05-30 | 2009-11-12 | エラン ファーマ インターナショナル，リミティド | ナノ粒子状のポサコナゾール製剤 |
| MX2009001533A (es) | 2006-08-11 | 2009-02-18 | Panacea Biotec Ltd | Particulas para el suministro de ingredientes activos, procedimiento de elaboracion y sus composiciones. |
| US20110142914A1 (en) | 2007-12-06 | 2011-06-16 | Cytotech Labs, Llc | Inhalable compositions having enhanced bioavailability |
| NO2252275T3 (https=) | 2008-02-13 | 2018-04-28 | ||
| EP2095816A1 (en) | 2008-02-29 | 2009-09-02 | Schlichthaar, Rainer, Dr. | Nanosuspension with antifungal medication to be administered via inhalation with improved impurity profile and safety |
| EP2172193A1 (en) | 2008-10-02 | 2010-04-07 | Capsulution Nanoscience AG | Improved nanoparticulate compositions of poorly soluble compounds |
| AU2011296343B2 (en) | 2010-08-30 | 2015-12-10 | Pulmatrix Operating Company, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| BR112013033239A2 (pt) | 2011-06-22 | 2016-09-06 | Vyome Biosciences | pró-farmácos de conjugado baseado em atifungicos e antibacterianos |
| EP2601973A1 (en) * | 2011-12-09 | 2013-06-12 | Laboratoires SMB SA | Dry powder formulation of azole derivative for inhalation |
| US9801855B2 (en) | 2012-03-07 | 2017-10-31 | National Institute Of Pharmaceutical Education And Research (Niper) | Nanocrystalline solid dispersion compositions and process of preparation thereof |
| WO2014106727A1 (en) | 2013-01-03 | 2014-07-10 | Vectura Limited | Inhaler and formulation |
| WO2014130922A1 (en) | 2013-02-25 | 2014-08-28 | Trustees Of Boston University | Compositions and methods for treating fungal infections |
| JP6473738B2 (ja) * | 2013-04-01 | 2019-02-20 | パルマトリックス，インコーポレイテッド | チオトロピウム乾燥粉末 |
| CN104398497B (zh) * | 2014-10-29 | 2017-11-24 | 中山大学 | 伊曲康唑吸入粉雾剂及其制备方法 |
| MX2017009112A (es) * | 2015-01-14 | 2018-06-15 | Respira Therapeutics Inc | Metodos y dispositivos de dispersion de polvo. |
| ES2936415T3 (es) | 2017-04-17 | 2023-03-16 | Respira Therapeutics Inc | Inhalador de dosis unitaria de polvo seco |
-
2017
- 2017-10-13 EP EP17791259.9A patent/EP3525759A1/en active Pending
- 2017-10-13 CN CN201780063648.5A patent/CN109996536B/zh active Active
- 2017-10-13 MX MX2019004322A patent/MX388733B/es unknown
- 2017-10-13 WO PCT/US2017/056497 patent/WO2018071757A1/en not_active Ceased
- 2017-10-13 RU RU2019114112A patent/RU2766086C2/ru active
- 2017-10-13 IL IL265913A patent/IL265913B2/en unknown
- 2017-10-13 JP JP2019520036A patent/JP7085538B2/ja active Active
- 2017-10-13 US US16/341,152 patent/US11116722B2/en active Active
- 2017-10-13 CA CA3039485A patent/CA3039485A1/en active Pending
- 2017-10-13 NZ NZ752353A patent/NZ752353A/en unknown
- 2017-10-13 AU AU2017341815A patent/AU2017341815B2/en active Active
- 2017-10-13 KR KR1020197013649A patent/KR102408798B1/ko active Active
-
2023
- 2023-12-29 US US18/400,054 patent/US20240285523A1/en not_active Abandoned
-
2025
- 2025-02-13 US US19/052,958 patent/US20250221928A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002054868A2 (en) * | 2000-12-21 | 2002-07-18 | Inhale Therapeutic Syst | Pulmonary delivery of polyene antifungal agents |
Non-Patent Citations (7)
| Title |
|---|
| CONTE JR, JOHN E., ET AL., INTRAPULMONARY PHARMACOKINETICS AND PHARMACODYNAMICS OF ITRACONAZOLE AND 14-HYDROXYITRACONAZOLE AT STEADY STATE., 31 October 2004 (2004-10-31) * |
| CONWAY, STEVEN P., ET AL., PHARMACOKINETICS AND SAFETY OF ITRACONAZOLE IN PATIENTS WITH CYSTIC FIBROSIS., 31 May 2004 (2004-05-31) * |
| DURET, CHRISTOPHE, ET AL., NEW INHALATION-OPTIMIZED ITRACONAZOLE NANOPARTICLE-BASED DRY POWDERS FOR THE TREATMENT OF INVASIVE PULMONARY ASPERGILLOSIS., 31 October 2012 (2012-10-31) * |
| DURET, CHRISTOPHE, ET AL., NEW RESPIRABLE AND FAST DISSOLVING ITRACONAZOLE DRY POWDER COMPOSITION FOR THE TREATMENT OF INVASIVE PULMONARY ASPERGILLOSIS., 30 May 2012 (2012-05-30) * |
| KUMAR, SUMIT, ET AL., IN VITRO AND IN VIVO PERFORMANCE OF DIFFERENT SIZED SPRAY?DRIED CRYSTALLINE ITRACONAZOLE., 5 September 2014 (2014-09-05) * |
| PIZZIMENTI, STEFANO, ET AL., ITRACONAZOLE AS ‘BRIDGE THERAPY’TO ANTI-IGE IN A PATIENT WITH SEVERE ASTHMA WITH FUNGAL SENSITISATION., 3 May 2013 (2013-05-03) * |
| WARK, PETER ALEXANDER BLANCH, ET AL., ANTI-INFLAMMATORY EFFECT OF ITRACONAZOLE IN STABLE ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS: A RANDOMIZED CONTROLLED TRIAL., 31 May 2003 (2003-05-31) * |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2019114112A3 (https=) | 2021-02-12 |
| CN109996536B (zh) | 2023-03-07 |
| KR102408798B1 (ko) | 2022-06-13 |
| MX2019004322A (es) | 2019-12-11 |
| AU2017341815B2 (en) | 2023-06-15 |
| AU2017341815A1 (en) | 2019-05-02 |
| US20240285523A1 (en) | 2024-08-29 |
| JP7085538B2 (ja) | 2022-06-16 |
| IL265913B1 (en) | 2024-03-01 |
| IL265913A (en) | 2019-06-30 |
| CN109996536A (zh) | 2019-07-09 |
| BR112019007459A2 (pt) | 2019-07-16 |
| EP3525759A1 (en) | 2019-08-21 |
| JP2019534270A (ja) | 2019-11-28 |
| RU2766086C2 (ru) | 2022-02-07 |
| NZ752353A (en) | 2023-06-30 |
| US20200129428A1 (en) | 2020-04-30 |
| US11116722B2 (en) | 2021-09-14 |
| MX388733B (es) | 2025-03-20 |
| KR20190068591A (ko) | 2019-06-18 |
| US20250221928A1 (en) | 2025-07-10 |
| RU2019114112A (ru) | 2020-11-16 |
| CA3039485A1 (en) | 2018-04-19 |
| WO2018071757A1 (en) | 2018-04-19 |
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