MX2019004322A - Polvos secos antifungicos. - Google Patents

Polvos secos antifungicos.

Info

Publication number
MX2019004322A
MX2019004322A MX2019004322A MX2019004322A MX2019004322A MX 2019004322 A MX2019004322 A MX 2019004322A MX 2019004322 A MX2019004322 A MX 2019004322A MX 2019004322 A MX2019004322 A MX 2019004322A MX 2019004322 A MX2019004322 A MX 2019004322A
Authority
MX
Mexico
Prior art keywords
dry powders
antifungal
antifungal dry
excipients
stabilizer
Prior art date
Application number
MX2019004322A
Other languages
English (en)
Inventor
C Sung Jean
M Perry Jason
L Hava David
Clifford Saunders Robert
S Tracy Hillary
Emmet O'connor Andrew
Original Assignee
Pulmatrix Operating Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pulmatrix Operating Co Inc filed Critical Pulmatrix Operating Co Inc
Publication of MX2019004322A publication Critical patent/MX2019004322A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Abstract

La invención se refiere a formulaciones en polvo seco que comprenden partículas secas respirables que contienen 1) un agente antifúngico en forma de partículas cristalinas, 2) un estabilizante y 3) uno o más excipientes. La invención también se refiere a los polvos secos descritos en este documento para su uso en el tratamiento de la aspergilosis. La invención también se refiere a los polvos secos descritos en este documento para su uso en tratamiento de la aspergilosis broncopulmonar alérgica (ABPA) . La invención también se relaciona con polvos secos descritos en este documento para su uso en el tratamiento de una exacerbación aguda de una enfermedad respiratoria en un individuo.
MX2019004322A 2016-10-14 2017-10-13 Polvos secos antifungicos. MX2019004322A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662408376P 2016-10-14 2016-10-14
PCT/US2017/056497 WO2018071757A1 (en) 2016-10-14 2017-10-13 Antifungal dry powders

Publications (1)

Publication Number Publication Date
MX2019004322A true MX2019004322A (es) 2019-12-11

Family

ID=60186406

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019004322A MX2019004322A (es) 2016-10-14 2017-10-13 Polvos secos antifungicos.

Country Status (13)

Country Link
US (1) US11116722B2 (es)
EP (1) EP3525759A1 (es)
JP (1) JP7085538B2 (es)
KR (1) KR102408798B1 (es)
CN (1) CN109996536B (es)
AU (1) AU2017341815B2 (es)
BR (1) BR112019007459A2 (es)
CA (1) CA3039485A1 (es)
IL (1) IL265913B1 (es)
MX (1) MX2019004322A (es)
NZ (1) NZ752353A (es)
RU (1) RU2766086C2 (es)
WO (1) WO2018071757A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011308865B2 (en) * 2010-09-29 2017-01-05 Pulmatrix, Inc. Monovalent metal cation dry powders for inhalation
JP2021522161A (ja) * 2018-04-18 2021-08-30 パルマトリックス オペレーティング カンパニー，インコーポレイテッド イトラコナゾールを含む肺内投与のための抗真菌配合物
AU2019256453A1 (en) * 2018-04-18 2020-11-12 Cipla Technologies LLC Methods of treating fungal infections
WO2021092349A1 (en) * 2019-11-08 2021-05-14 Scynexis, Inc. Lipid-based formulations of scy-078 salts
IT202000030443A1 (it) 2020-12-10 2022-06-10 Zambon Spa Polvere inalabile comprendente voriconazolo in forma cristallina
IT202000030437A1 (it) 2020-12-10 2022-06-10 Zambon Spa Metodo per la realizzazione di una polvere inalabile comprendente voriconazolo
WO2023086013A2 (en) * 2021-11-09 2023-05-19 Agency For Science, Technology And Research A salt-based antifungal powder platform formulation for aerosolization
WO2023122522A1 (en) * 2021-12-20 2023-06-29 Pulmatrix Operating Company, Inc. Dry powder formulations of narrow spectrum kinase inhibitors
WO2023247952A1 (en) 2022-06-21 2023-12-28 Hovione Scientia Limited Crystalline pharmaceutical composition for inhalation comprising sugar and lipid composite particles and process for manufacture
WO2024040175A1 (en) 2022-08-18 2024-02-22 Pulmatrix Operating Company, Inc. Methods for treating cancer using inhaled angiogenesis inhibitor
WO2024049982A2 (en) 2022-08-31 2024-03-07 Pulmatrix Operating Company, Inc. Methods of using itraconazole dry powders

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069819A (en) 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
US4097620A (en) 1977-05-02 1978-06-27 Xerox Corporation Magnetic toner particle coating process
US4916134A (en) 1987-03-25 1990-04-10 Janssen Pharmacuetica N.V. 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]phenyl]triazolones
IT1228459B (it) 1989-02-23 1991-06-19 Phidea S R L Inalatore con svuotamento regolare e completo della capsula.
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US20040176391A1 (en) 2002-12-31 2004-09-09 Nektar Therapeutics Aerosolizable pharmaceutical formulation for fungal infection therapy
US6448401B1 (en) * 2000-11-20 2002-09-10 Bristol-Myers Squibb Company Process for water soluble azole compounds
KR100743404B1 (ko) * 2000-12-21 2007-07-30 넥타르 테라퓨틱스 폴리엔 항균제의 폐 전달
ITMI20010357U1 (it) 2001-06-28 2002-12-30 Plastiape Spa Dispositivo inalatore
AU2004251623B2 (en) 2003-05-28 2010-03-18 Novartis Ag Spray drying of an alcoholic aqueous solution for the manufacture of a water-in-soluble active agentmicroparticle with a partial or complete amino acid and/or phospholipid coat
JP2007508240A (ja) 2003-07-22 2007-04-05 バクスター・インターナショナル・インコーポレイテッド 低分子量有機分子の小球状粒子ならびにその調製方法および使用方法
GB0327723D0 (en) * 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
US8513204B2 (en) 2004-06-21 2013-08-20 Novartis Ag Compositions comprising amphotericin B, mehods and systems
EP1789018A1 (en) 2004-08-27 2007-05-30 The Dow Chemical Company Enhanced delivery of drug compositions to treat life threatening infections
GB0425758D0 (en) * 2004-11-23 2004-12-22 Vectura Ltd Preparation of pharmaceutical compositions
ITMI20051999A1 (it) 2005-10-21 2007-04-22 Eratech S R L Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita'
US20120128728A1 (en) 2005-12-28 2012-05-24 Novartis Pharma Ag Compositions Comprising Amphotericin B
SG170047A1 (en) * 2006-05-30 2011-04-29 Elan Pharma Int Ltd Nanoparticulate posaconazole formulations
JP2010500340A (ja) 2006-08-11 2010-01-07 パナセア バイオテック リミテッド 活性成分を送達するための粒子、その製造方法、および組成物
US20110142914A1 (en) 2007-12-06 2011-06-16 Cytotech Labs, Llc Inhalable compositions having enhanced bioavailability
NO2252275T3 (es) 2008-02-13 2018-04-28
EP2095816A1 (en) 2008-02-29 2009-09-02 Schlichthaar, Rainer, Dr. Nanosuspension with antifungal medication to be administered via inhalation with improved impurity profile and safety
EP2172193A1 (en) 2008-10-02 2010-04-07 Capsulution Nanoscience AG Improved nanoparticulate compositions of poorly soluble compounds
WO2012030664A1 (en) * 2010-08-30 2012-03-08 Pulmatrix, Inc. Dry powder formulations and methods for treating pulmonary diseases
CN103857440B (zh) 2011-06-22 2018-09-25 维奥姆生物科学有限公司 基于缀合物的抗真菌和抗细菌前药
EP2601973A1 (en) * 2011-12-09 2013-06-12 Laboratoires SMB SA Dry powder formulation of azole derivative for inhalation
EP2822539B1 (en) 2012-03-07 2018-11-21 National Institute Of Pharmaceutical Education And Research (NIPER) Nanocrystalline solid dispersion compositions
WO2014106727A1 (en) 2013-01-03 2014-07-10 Vectura Limited Inhaler and formulation
WO2014130922A1 (en) 2013-02-25 2014-08-28 Trustees Of Boston University Compositions and methods for treating fungal infections
MX2015013845A (es) * 2013-04-01 2016-05-09 Pulmatrix Inc Polvos secos de tiotropio.
CN104398497B (zh) * 2014-10-29 2017-11-24 中山大学 伊曲康唑吸入粉雾剂及其制备方法
JP2018501903A (ja) * 2015-01-14 2018-01-25 レスピラ セラピューティクス インコーポレイテッドＲｅｓｐｉｒａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． パウダー分散方法および装置
EP3612259B1 (en) 2017-04-17 2022-11-09 Respira Therapeutics, Inc. Unit dose dry powder inhaler

Also Published As

Publication number Publication date
CN109996536A (zh) 2019-07-09
CN109996536B (zh) 2023-03-07
AU2017341815B2 (en) 2023-06-15
AU2017341815A1 (en) 2019-05-02
RU2019114112A (ru) 2020-11-16
EP3525759A1 (en) 2019-08-21
KR102408798B1 (ko) 2022-06-13
RU2766086C2 (ru) 2022-02-07
BR112019007459A2 (pt) 2019-07-16
WO2018071757A1 (en) 2018-04-19
US20200129428A1 (en) 2020-04-30
CA3039485A1 (en) 2018-04-19
US11116722B2 (en) 2021-09-14
IL265913B1 (en) 2024-03-01
RU2019114112A3 (es) 2021-02-12
NZ752353A (en) 2023-06-30
KR20190068591A (ko) 2019-06-18
JP7085538B2 (ja) 2022-06-16
JP2019534270A (ja) 2019-11-28
IL265913A (en) 2019-06-30

Similar Documents

Publication Publication Date Title
MX2019004322A (es) Polvos secos antifungicos.
MX2020006595A (es) Oxadiazoles fungicidas.
IL274297A (en) Pyrazolo-piperidine-converted indole-2-carboxamides, preparations containing them and their uses
IL263355A (en) Nicotine particles and preparations
TW201637267A (en) Powder, electrode and battery comprising such a powder
IL283539A (en) 3,3-difluoroallylamines or their salts and pharmaceutical preparations containing them
IL272055A (en) 8,1-naphthyridinone compounds and their uses
MX2017015127A (es) Particulas modificadas por carbohidratos y formulaciones en particulas para modular una respuesta inmunitaria.
IL265770A (en) Conjugates are intended for sstr and particles and their formulations
IL271852A (en) Solid powder supplements containing quercetin, a process for their preparation and their formulations
IL281938A (en) Stable compositions of semaglutide and uses thereof
IL268959A (en) Antibodies with cystine mutation, preparations containing them and their uses
MX2020003761A (es) Particulas solidas de simeticona y forma de dosificacion de estas.
GB202002129D0 (en) stable freshening compositions and products comprising the same
MX2016017142A (es) Dispersion solida de allisartan isoproxilo y composicion farmaceutica que comprende la misma.
IL268997A (en) Preparations containing agonists for the PGI2 receptor and processes for their preparation
EP3717552A4 (en) COMPOSITIONS CONTAINING WATER-SOLUBLE SALT PARTICLES AND POROUS MATERIALS MADE THEREOF
EP4041084A4 (en) NANOCOMPOSITE PARTICLE AND ITS USES
CL2018002542A1 (es) Na2-imp deshidratada como agente antiaglomerante
MX2020003513A (es) Composiciones de ingredientes activos que comprenden n-alquenoil-n-alquilglucamidas y el uso de los mismos.
Hoshyaripour Volcanic ash particles hold clues to their history and effects
IL266898B (en) Solid powder preparations, a process for their preparation, their formulations and their use
Monga The regulation of business rescue practititoners in South Africa.
WO2017112997A9 (pt) Composições cosméticas compreendendo combinação sinérgica de partículas absorvedoras e adsorvedoras de suor e usos das mesmas
EP3634406C0 (en) 3,4,5-TRISUBSTITUTED-1,2,4-TRIAZOLES AND 3,4,5-TRISUBSTITUTED-3-THIO-1,2,4-TRIAZOLES AND USES THEREOF