RU2766086C2 - Противогрибковые сухие порошки - Google Patents

Противогрибковые сухие порошки Download PDF

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Publication number
RU2766086C2
RU2766086C2 RU2019114112A RU2019114112A RU2766086C2 RU 2766086 C2 RU2766086 C2 RU 2766086C2 RU 2019114112 A RU2019114112 A RU 2019114112A RU 2019114112 A RU2019114112 A RU 2019114112A RU 2766086 C2 RU2766086 C2 RU 2766086C2
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RU
Russia
Prior art keywords
dry powder
antifungal
itraconazole
powder according
respirable dry
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RU2019114112A
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English (en)
Russian (ru)
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RU2019114112A (ru
RU2019114112A3 (https=
Inventor
Джэйсон М. ПЕРРИ
Джин К. СУНГ
Дэвид Л. ХЭЙВА
Роберт Клиффорд САУНДЕРС
Хиллари С. ТРЭЙСИ
Эндрю Эммет О'КОННОР
Original Assignee
Пулматрикс Оперэйтинг Компани, Инк.
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Publication of RU2019114112A3 publication Critical patent/RU2019114112A3/ru
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
RU2019114112A 2016-10-14 2017-10-13 Противогрибковые сухие порошки RU2766086C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662408376P 2016-10-14 2016-10-14
US62/408,376 2016-10-14
PCT/US2017/056497 WO2018071757A1 (en) 2016-10-14 2017-10-13 Antifungal dry powders

Publications (3)

Publication Number Publication Date
RU2019114112A RU2019114112A (ru) 2020-11-16
RU2019114112A3 RU2019114112A3 (https=) 2021-02-12
RU2766086C2 true RU2766086C2 (ru) 2022-02-07

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RU2019114112A RU2766086C2 (ru) 2016-10-14 2017-10-13 Противогрибковые сухие порошки

Country Status (12)

Country Link
US (3) US11116722B2 (https=)
EP (1) EP3525759A1 (https=)
JP (1) JP7085538B2 (https=)
KR (1) KR102408798B1 (https=)
CN (1) CN109996536B (https=)
AU (1) AU2017341815B2 (https=)
CA (1) CA3039485A1 (https=)
IL (1) IL265913B2 (https=)
MX (1) MX388733B (https=)
NZ (1) NZ752353A (https=)
RU (1) RU2766086C2 (https=)
WO (1) WO2018071757A1 (https=)

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CN112423755A (zh) * 2018-04-18 2021-02-26 希普拉技术有限责任公司 治疗真菌感染的方法
WO2021092349A1 (en) * 2019-11-08 2021-05-14 Scynexis, Inc. Lipid-based formulations of scy-078 salts
CN111658610B (zh) * 2020-07-31 2022-05-24 上海方予健康医药科技有限公司 一种供雾化器用的三氮唑类抗真菌药物的混悬液
IT202000030443A1 (it) 2020-12-10 2022-06-10 Zambon Spa Polvere inalabile comprendente voriconazolo in forma cristallina
IT202000030437A1 (it) 2020-12-10 2022-06-10 Zambon Spa Metodo per la realizzazione di una polvere inalabile comprendente voriconazolo
BR112023017538A2 (pt) * 2021-03-03 2023-11-07 Pulmatrix Operating Co Inc Formulações de pó seco de di-hidroergotamina e métodos de uso
EP4429643A4 (en) * 2021-11-09 2025-11-12 Agency Science Tech & Res Salt-based platform antifungal powder formulation for aerosolization
US20250049717A1 (en) * 2021-12-20 2025-02-13 Pulmatrix Operating Company, Inc. Dry powder formulations of narrow spectrum kinase inhibitors
CA3260232A1 (en) 2022-06-21 2023-12-28 Hovione Scientia Limited CRYSTALLINE PHARMACEUTICAL COMPOSITION FOR INHALATION COMPRISING PARTICLES COMPOSITE OF SUGAR AND LIPID AND MANUFACTURING PROCESS
WO2024040175A1 (en) 2022-08-18 2024-02-22 Pulmatrix Operating Company, Inc. Methods for treating cancer using inhaled angiogenesis inhibitor
JP2025529125A (ja) 2022-08-31 2025-09-04 パルマトリックス オペレーティング カンパニー,インコーポレイテッド イトラコナゾール乾燥粉末を使用する方法
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WO2012030664A1 (en) * 2010-08-30 2012-03-08 Pulmatrix, Inc. Dry powder formulations and methods for treating pulmonary diseases
EA201400679A1 (ru) * 2011-12-09 2014-10-30 Лаборатуар Смб Са Композиция сухого порошка производного азола для ингаляции
CN104398497A (zh) * 2014-10-29 2015-03-11 中山大学 伊曲康唑吸入粉雾剂及其制备方法

Also Published As

Publication number Publication date
US20250221928A1 (en) 2025-07-10
RU2019114112A (ru) 2020-11-16
AU2017341815A1 (en) 2019-05-02
CN109996536B (zh) 2023-03-07
JP2019534270A (ja) 2019-11-28
US20200129428A1 (en) 2020-04-30
MX388733B (es) 2025-03-20
JP7085538B2 (ja) 2022-06-16
IL265913B2 (en) 2024-07-01
KR102408798B1 (ko) 2022-06-13
CN109996536A (zh) 2019-07-09
RU2019114112A3 (https=) 2021-02-12
IL265913A (en) 2019-06-30
IL265913B1 (en) 2024-03-01
WO2018071757A1 (en) 2018-04-19
BR112019007459A2 (pt) 2019-07-16
KR20190068591A (ko) 2019-06-18
AU2017341815B2 (en) 2023-06-15
NZ752353A (en) 2023-06-30
EP3525759A1 (en) 2019-08-21
CA3039485A1 (en) 2018-04-19
MX2019004322A (es) 2019-12-11
US20240285523A1 (en) 2024-08-29
US11116722B2 (en) 2021-09-14

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