JP2019533475A5 - - Google Patents

Info

Publication number

JP2019533475A5

JP2019533475A5 JP2019531513A JP2019531513A JP2019533475A5 JP 2019533475 A5 JP2019533475 A5 JP 2019533475A5 JP 2019531513 A JP2019531513 A JP 2019531513A JP 2019531513 A JP2019531513 A JP 2019531513A JP 2019533475 A5 JP2019533475 A5 JP 2019533475A5

Authority

JP

Japan

Prior art keywords

seq

amino acid

acid sequence

cdr

bispecific antibody

Prior art date

2017-08-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 125000003275 alpha amino acid group Chemical group 0.000 claims description 64
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• 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims description 34
• 238000000034 method Methods 0.000 claims description 27
• 102100040678 Programmed cell death protein 1 Human genes 0.000 claims description 24
• 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 24
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• 108090000623 proteins and genes Proteins 0.000 claims description 24
• 108060003951 Immunoglobulin Proteins 0.000 claims description 22
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• 108020004707 nucleic acids Proteins 0.000 claims description 12
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• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
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